CEPI's 100 Days Mission aims to develop a vaccine within 100 days from when a pathogen is sequenced or the need for a vaccine is recognized to initial availability. This would have allowed for vaccines to be available months earlier in the COVID-19 pandemic. CEPI is pursuing several strategies to achieve this goal, including developing prototype vaccine libraries for multiple virus families, building more distributed global manufacturing capacity, and rethinking clinical trial and regulatory approaches to allow for more real-world evidence collection in emergencies. The goal is extremely ambitious but CEPI believes that with vision and collaboration, significant improvements in response time are possible.
Background:
COVID-19 vaccine, the world is expecting it early because the rate of infection across the world is much higher than expected. India is the second-worst affected country hit by the epidemic, with over 1. 2 million cases. The virus spreading rapidly and to the majority of the world's population is susceptible for it. The scientists and medical researchers all around the world are working relentlessly for the development of a safe and effective vaccine. Thanks to the COVID-19 warriors & entire medical researchers and scientists for their involvement towards the humanity.
What is Vaccine:
A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. a vaccine is a preparation that helps to protect against certain diseases. vaccines contain a dead or weakened form of a microbe. Vaccination is a simple, safe, and effective method of protecting people against risky diseases, before they come into contact with them.
Background:
COVID-19 vaccine, the world is expecting it early because the rate of infection across the world is much higher than expected. India is the second-worst affected country hit by the epidemic, with over 1. 2 million cases. The virus spreading rapidly and to the majority of the world's population is susceptible for it. The scientists and medical researchers all around the world are working relentlessly for the development of a safe and effective vaccine. Thanks to the COVID-19 warriors & entire medical researchers and scientists for their involvement towards the humanity.
What is Vaccine:
A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. a vaccine is a preparation that helps to protect against certain diseases. vaccines contain a dead or weakened form of a microbe. Vaccination is a simple, safe, and effective method of protecting people against risky diseases, before they come into contact with them.
In this section of the coronavirus pandemic series, we discuss the need for an effective COVID-19 vaccine to return to full normalcy. The slides would give a brief overview on how our immune systems work, and how a vaccine would train our immune system to recognize and fight the infection. Current vaccine platform technologies will be compared, and upcoming candidates will be highlighted for newer-generation vaccines. We'll also discuss in-depth on factors involving vaccine manufacturing, hesitancy & acceptance, and contingencies. The market capitalization of pharma companies involved in the development of the coronavirus vaccine will also be compared.
GLOBAL VACCINATION: HOW THE EVOLVING HEALTHCARE INFRASTRUCTURE IS SUPPORTING ...Anayasharma10
COVID-19 (coronavirus) vaccines have started becoming accessible in most countries and are probably a severe product in fighting the pandemic in 2021. Several vaccines are already in the development trails or phase three trials that have reported promising data in the initial phase, with some receiving authorization for use.
Part 2 Federal Response to Mass ImmunizationsAfter a natural disa.docxdewhirstichabod
Part 2: Federal Response to Mass Immunizations
After a natural disaster or an infectious disease outbreak, immunizations are necessary to reduce the risk of infection. This is because immunizations work with the body’s natural defenses to help the body safely develop immunity to a potentially life-threatening disease. The Centers for Disease Control and Prevention (CDC) has established protocols to initiate mass immunizations to reduce the risk and spread of infectious diseases.
Consider the CDC’s public health response to an infectious disease outbreak in the aftermath of a hurricane.
Using the readings for this week and the Internet, respond to the following:
What is the CDC’s procedure for mass immunizations that are necessary for certain types of infectious outbreaks such as influenza, mumps, and tetanus?
How does the CDC communicate information on mass immunization clinics to the public?
What is the procedure for establishing a mass immunization clinic for tetanus in the aftermath of a hurricane because of the likelihood of injuries during the cleanup? Is this similar to the protocol established for influenza? Compare the two protocols.
What are some of the controversies surrounding such vaccinations?
Be sure to use vocabulary that is relevant to the topic. Also be sure to cite your work appropriately whenever possible. You should follow the most recent APA guidelines when citing your work. Answer each question in complete detail in Question and Answer form
.
Rebecca Katz: Challenges in Global Health SecurityTHL
Professor Rebecca Katz, Director for Global Health Science and Security, Georgetown University, US, at One Health Security Conference, 14-15 Oct 2019, THL, Helsinki
Madhav Marathe and Anil Vullikanti will present a tutorial on computational epidemiology, along with Thomas L. Phillips Professor of Engineering Naren Ramakrishnan, at the 20th ACM SIGKDD Conference on Knowledge Discovery and Data Mining on August 24th, 2014 in New York City.
In this tutorial, the researchers will approach epidemics based on diffusion processes on complex networks, which are able to capture more realistic problems. They will provide a state of the art overview of computational epidemiology, a multi-disciplinary research area that overlaps different areas in computer science, including data mining, machine learning, high performance computing and theoretical computer science, as well as mathematics, economics and statistics.
More than 150 coronavirus vaccines are in development across the world—and hopes are high to bring one to market in record time to ease the global crisis.
The World Health Organization is also coordinating global efforts to develop a vaccine, with an eye toward delivering two billion doses by the end of 2021.
Hello guys , today I am discussing about various stages of vaccine development and types of vaccines already developed by various biotech companies all over the world and their current status in clinical trial till now .
Hope , Very early we can get a ideal corona virus vaccine which would be safe and effective to human and also eradicate this disease from the world .
For more information please follow these link :
https://www.nytimes.com/interactive/2...
https://www.precisionvaccinations.com...
https://www.who.int/publications/m/it...
The 10 most trusted vaccine solution providers, 2020Merry D'souza
In this edition, ‘The 10 Most Trusted Vaccine Solution Providers, 2020’ CIO Look has shortlisted various healthcare organizations which are playing an important role towards the global healthcare system.
The Diagnostic & Testing virtual conference held on the 11th June 2020 was an inspiring event examining the role of both molecular and rapid diagnostics in tackling disease, infection and reducing the impact of COVID-19 within our communities and hospitals. The virtual conference explored how health professionals, academics and industry are driving diagnostic and testing usage within laboratories, pharmacies and community practice.
The conference built upon the UK Diagnostics Summit held annually in London discussed how diagnostics and testing are tackling COVID-19, the technology in development, accuracy of COVID-19 tests as well as exploring current testing methods for cancer, diabetes, sepsis, urinary tract infections and HAI’S.
Assignment on Covid 19 | Tutors India.pptxTutors India
Tutors india thesis and dissertation writing help guarantees that your dissertation is confidential, and so you do not have to worry about it.
For #Enquiry:
World: https://www.tutorsindia.com
UK: https://www.tutorsindia.com/uk
UAE: https://tutorsindia.com/ae/
Australia:https://www.tutorsindia.com/au/
Newzealand: https://www.tutorsindia.com/nz/
(UK): +44-1143520021
Mail: info@tutorsindia.com
Mail: info@tutorsuk.co.uk
(Whatsapp): +91-8754446690
In this section of the coronavirus pandemic series, we discuss the need for an effective COVID-19 vaccine to return to full normalcy. The slides would give a brief overview on how our immune systems work, and how a vaccine would train our immune system to recognize and fight the infection. Current vaccine platform technologies will be compared, and upcoming candidates will be highlighted for newer-generation vaccines. We'll also discuss in-depth on factors involving vaccine manufacturing, hesitancy & acceptance, and contingencies. The market capitalization of pharma companies involved in the development of the coronavirus vaccine will also be compared.
GLOBAL VACCINATION: HOW THE EVOLVING HEALTHCARE INFRASTRUCTURE IS SUPPORTING ...Anayasharma10
COVID-19 (coronavirus) vaccines have started becoming accessible in most countries and are probably a severe product in fighting the pandemic in 2021. Several vaccines are already in the development trails or phase three trials that have reported promising data in the initial phase, with some receiving authorization for use.
Part 2 Federal Response to Mass ImmunizationsAfter a natural disa.docxdewhirstichabod
Part 2: Federal Response to Mass Immunizations
After a natural disaster or an infectious disease outbreak, immunizations are necessary to reduce the risk of infection. This is because immunizations work with the body’s natural defenses to help the body safely develop immunity to a potentially life-threatening disease. The Centers for Disease Control and Prevention (CDC) has established protocols to initiate mass immunizations to reduce the risk and spread of infectious diseases.
Consider the CDC’s public health response to an infectious disease outbreak in the aftermath of a hurricane.
Using the readings for this week and the Internet, respond to the following:
What is the CDC’s procedure for mass immunizations that are necessary for certain types of infectious outbreaks such as influenza, mumps, and tetanus?
How does the CDC communicate information on mass immunization clinics to the public?
What is the procedure for establishing a mass immunization clinic for tetanus in the aftermath of a hurricane because of the likelihood of injuries during the cleanup? Is this similar to the protocol established for influenza? Compare the two protocols.
What are some of the controversies surrounding such vaccinations?
Be sure to use vocabulary that is relevant to the topic. Also be sure to cite your work appropriately whenever possible. You should follow the most recent APA guidelines when citing your work. Answer each question in complete detail in Question and Answer form
.
Rebecca Katz: Challenges in Global Health SecurityTHL
Professor Rebecca Katz, Director for Global Health Science and Security, Georgetown University, US, at One Health Security Conference, 14-15 Oct 2019, THL, Helsinki
Madhav Marathe and Anil Vullikanti will present a tutorial on computational epidemiology, along with Thomas L. Phillips Professor of Engineering Naren Ramakrishnan, at the 20th ACM SIGKDD Conference on Knowledge Discovery and Data Mining on August 24th, 2014 in New York City.
In this tutorial, the researchers will approach epidemics based on diffusion processes on complex networks, which are able to capture more realistic problems. They will provide a state of the art overview of computational epidemiology, a multi-disciplinary research area that overlaps different areas in computer science, including data mining, machine learning, high performance computing and theoretical computer science, as well as mathematics, economics and statistics.
More than 150 coronavirus vaccines are in development across the world—and hopes are high to bring one to market in record time to ease the global crisis.
The World Health Organization is also coordinating global efforts to develop a vaccine, with an eye toward delivering two billion doses by the end of 2021.
Hello guys , today I am discussing about various stages of vaccine development and types of vaccines already developed by various biotech companies all over the world and their current status in clinical trial till now .
Hope , Very early we can get a ideal corona virus vaccine which would be safe and effective to human and also eradicate this disease from the world .
For more information please follow these link :
https://www.nytimes.com/interactive/2...
https://www.precisionvaccinations.com...
https://www.who.int/publications/m/it...
The 10 most trusted vaccine solution providers, 2020Merry D'souza
In this edition, ‘The 10 Most Trusted Vaccine Solution Providers, 2020’ CIO Look has shortlisted various healthcare organizations which are playing an important role towards the global healthcare system.
The Diagnostic & Testing virtual conference held on the 11th June 2020 was an inspiring event examining the role of both molecular and rapid diagnostics in tackling disease, infection and reducing the impact of COVID-19 within our communities and hospitals. The virtual conference explored how health professionals, academics and industry are driving diagnostic and testing usage within laboratories, pharmacies and community practice.
The conference built upon the UK Diagnostics Summit held annually in London discussed how diagnostics and testing are tackling COVID-19, the technology in development, accuracy of COVID-19 tests as well as exploring current testing methods for cancer, diabetes, sepsis, urinary tract infections and HAI’S.
Assignment on Covid 19 | Tutors India.pptxTutors India
Tutors india thesis and dissertation writing help guarantees that your dissertation is confidential, and so you do not have to worry about it.
For #Enquiry:
World: https://www.tutorsindia.com
UK: https://www.tutorsindia.com/uk
UAE: https://tutorsindia.com/ae/
Australia:https://www.tutorsindia.com/au/
Newzealand: https://www.tutorsindia.com/nz/
(UK): +44-1143520021
Mail: info@tutorsindia.com
Mail: info@tutorsuk.co.uk
(Whatsapp): +91-8754446690
Implicitly or explicitly all competing businesses employ a strategy to select a mix
of marketing resources. Formulating such competitive strategies fundamentally
involves recognizing relationships between elements of the marketing mix (e.g.,
price and product quality), as well as assessing competitive and market conditions
(i.e., industry structure in the language of economics).
Unveiling the Secrets How Does Generative AI Work.pdfSam H
At its core, generative artificial intelligence relies on the concept of generative models, which serve as engines that churn out entirely new data resembling their training data. It is like a sculptor who has studied so many forms found in nature and then uses this knowledge to create sculptures from his imagination that have never been seen before anywhere else. If taken to cyberspace, gans work almost the same way.
Kseniya Leshchenko: Shared development support service model as the way to ma...Lviv Startup Club
Kseniya Leshchenko: Shared development support service model as the way to make small projects with small budgets profitable for the company (UA)
Kyiv PMDay 2024 Summer
Website – www.pmday.org
Youtube – https://www.youtube.com/startuplviv
FB – https://www.facebook.com/pmdayconference
Cracking the Workplace Discipline Code Main.pptxWorkforce Group
Cultivating and maintaining discipline within teams is a critical differentiator for successful organisations.
Forward-thinking leaders and business managers understand the impact that discipline has on organisational success. A disciplined workforce operates with clarity, focus, and a shared understanding of expectations, ultimately driving better results, optimising productivity, and facilitating seamless collaboration.
Although discipline is not a one-size-fits-all approach, it can help create a work environment that encourages personal growth and accountability rather than solely relying on punitive measures.
In this deck, you will learn the significance of workplace discipline for organisational success. You’ll also learn
• Four (4) workplace discipline methods you should consider
• The best and most practical approach to implementing workplace discipline.
• Three (3) key tips to maintain a disciplined workplace.
Enterprise Excellence is Inclusive Excellence.pdfKaiNexus
Enterprise excellence and inclusive excellence are closely linked, and real-world challenges have shown that both are essential to the success of any organization. To achieve enterprise excellence, organizations must focus on improving their operations and processes while creating an inclusive environment that engages everyone. In this interactive session, the facilitator will highlight commonly established business practices and how they limit our ability to engage everyone every day. More importantly, though, participants will likely gain increased awareness of what we can do differently to maximize enterprise excellence through deliberate inclusion.
What is Enterprise Excellence?
Enterprise Excellence is a holistic approach that's aimed at achieving world-class performance across all aspects of the organization.
What might I learn?
A way to engage all in creating Inclusive Excellence. Lessons from the US military and their parallels to the story of Harry Potter. How belt systems and CI teams can destroy inclusive practices. How leadership language invites people to the party. There are three things leaders can do to engage everyone every day: maximizing psychological safety to create environments where folks learn, contribute, and challenge the status quo.
Who might benefit? Anyone and everyone leading folks from the shop floor to top floor.
Dr. William Harvey is a seasoned Operations Leader with extensive experience in chemical processing, manufacturing, and operations management. At Michelman, he currently oversees multiple sites, leading teams in strategic planning and coaching/practicing continuous improvement. William is set to start his eighth year of teaching at the University of Cincinnati where he teaches marketing, finance, and management. William holds various certifications in change management, quality, leadership, operational excellence, team building, and DiSC, among others.
Putting the SPARK into Virtual Training.pptxCynthia Clay
This 60-minute webinar, sponsored by Adobe, was delivered for the Training Mag Network. It explored the five elements of SPARK: Storytelling, Purpose, Action, Relationships, and Kudos. Knowing how to tell a well-structured story is key to building long-term memory. Stating a clear purpose that doesn't take away from the discovery learning process is critical. Ensuring that people move from theory to practical application is imperative. Creating strong social learning is the key to commitment and engagement. Validating and affirming participants' comments is the way to create a positive learning environment.
"𝑩𝑬𝑮𝑼𝑵 𝑾𝑰𝑻𝑯 𝑻𝑱 𝑰𝑺 𝑯𝑨𝑳𝑭 𝑫𝑶𝑵𝑬"
𝐓𝐉 𝐂𝐨𝐦𝐬 (𝐓𝐉 𝐂𝐨𝐦𝐦𝐮𝐧𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬) is a professional event agency that includes experts in the event-organizing market in Vietnam, Korea, and ASEAN countries. We provide unlimited types of events from Music concerts, Fan meetings, and Culture festivals to Corporate events, Internal company events, Golf tournaments, MICE events, and Exhibitions.
𝐓𝐉 𝐂𝐨𝐦𝐬 provides unlimited package services including such as Event organizing, Event planning, Event production, Manpower, PR marketing, Design 2D/3D, VIP protocols, Interpreter agency, etc.
Sports events - Golf competitions/billiards competitions/company sports events: dynamic and challenging
⭐ 𝐅𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐩𝐫𝐨𝐣𝐞𝐜𝐭𝐬:
➢ 2024 BAEKHYUN [Lonsdaleite] IN HO CHI MINH
➢ SUPER JUNIOR-L.S.S. THE SHOW : Th3ee Guys in HO CHI MINH
➢FreenBecky 1st Fan Meeting in Vietnam
➢CHILDREN ART EXHIBITION 2024: BEYOND BARRIERS
➢ WOW K-Music Festival 2023
➢ Winner [CROSS] Tour in HCM
➢ Super Show 9 in HCM with Super Junior
➢ HCMC - Gyeongsangbuk-do Culture and Tourism Festival
➢ Korean Vietnam Partnership - Fair with LG
➢ Korean President visits Samsung Electronics R&D Center
➢ Vietnam Food Expo with Lotte Wellfood
"𝐄𝐯𝐞𝐫𝐲 𝐞𝐯𝐞𝐧𝐭 𝐢𝐬 𝐚 𝐬𝐭𝐨𝐫𝐲, 𝐚 𝐬𝐩𝐞𝐜𝐢𝐚𝐥 𝐣𝐨𝐮𝐫𝐧𝐞𝐲. 𝐖𝐞 𝐚𝐥𝐰𝐚𝐲𝐬 𝐛𝐞𝐥𝐢𝐞𝐯𝐞 𝐭𝐡𝐚𝐭 𝐬𝐡𝐨𝐫𝐭𝐥𝐲 𝐲𝐨𝐮 𝐰𝐢𝐥𝐥 𝐛𝐞 𝐚 𝐩𝐚𝐫𝐭 𝐨𝐟 𝐨𝐮𝐫 𝐬𝐭𝐨𝐫𝐢𝐞𝐬."
RMD24 | Debunking the non-endemic revenue myth Marvin Vacquier Droop | First ...BBPMedia1
Marvin neemt je in deze presentatie mee in de voordelen van non-endemic advertising op retail media netwerken. Hij brengt ook de uitdagingen in beeld die de markt op dit moment heeft op het gebied van retail media voor niet-leveranciers.
Retail media wordt gezien als het nieuwe advertising-medium en ook mediabureaus richten massaal retail media-afdelingen op. Merken die niet in de betreffende winkel liggen staan ook nog niet in de rij om op de retail media netwerken te adverteren. Marvin belicht de uitdagingen die er zijn om echt aansluiting te vinden op die markt van non-endemic advertising.
Improving profitability for small businessBen Wann
In this comprehensive presentation, we will explore strategies and practical tips for enhancing profitability in small businesses. Tailored to meet the unique challenges faced by small enterprises, this session covers various aspects that directly impact the bottom line. Attendees will learn how to optimize operational efficiency, manage expenses, and increase revenue through innovative marketing and customer engagement techniques.
Digital Transformation and IT Strategy Toolkit and TemplatesAurelien Domont, MBA
This Digital Transformation and IT Strategy Toolkit was created by ex-McKinsey, Deloitte and BCG Management Consultants, after more than 5,000 hours of work. It is considered the world's best & most comprehensive Digital Transformation and IT Strategy Toolkit. It includes all the Frameworks, Best Practices & Templates required to successfully undertake the Digital Transformation of your organization and define a robust IT Strategy.
Editable Toolkit to help you reuse our content: 700 Powerpoint slides | 35 Excel sheets | 84 minutes of Video training
This PowerPoint presentation is only a small preview of our Toolkits. For more details, visit www.domontconsulting.com
Attending a job Interview for B1 and B2 Englsih learnersErika906060
It is a sample of an interview for a business english class for pre-intermediate and intermediate english students with emphasis on the speking ability.
Attending a job Interview for B1 and B2 Englsih learners
CEPI's 100 DAYS AMBITION - HOW DO WE DEVELOP A VACCINE IN 100 DAYS
1. Sensitivity: CEPI Internal
CEPI’s 100 Days Mission
Rapid response, scaling to billions and
enabling access to vaccines
Ranna Eardley-Patel
Sustainable Manufacturing Lead
Vaccine Technology Summit, London
September 15-16, 2022 #100DaysMission
2. Sensitivity: CEPI Internal
2
The Creation of CEPI
Launched at the World Economic Forum at Davos in 2017 as a global coalition to tackle epidemics
3. Sensitivity: CEPI Internal
Governments
Philanthropists
Regulators
Pharmaceutical
Industry
Civil society and
health
organisations
Academia
CEPI's unique connecting
role and extensive networks
allow it to pool and deploy
resources in ways that
nation states
often cannot.
A world in which epidemics and
pandemics are no longer a threat
to humanity.
Vision
To accelerate the development of
vaccines and other biologic
countermeasures against
epidemic and pandemic threats
so they can be accessible to all
people in need.
Mission
CEPI: A global partnership
4. Sensitivity: CEPI Internal
Lassa
Advancement of the first
ever Lassa virus vaccines
into Phase 1 trials
MERS
Advancement of the first
ever MERS vaccine into
Phase 2
Nipah
Advancement of the first
ever Nipah virus
vaccines into Phase 1
trials
Rift Valley Fever
Two vaccine candidates
undergoing preclinical
studies
Chikungunya
First Phase 3 trial of a
Chikungunya vaccine
Ebola
Supported clinical
development
contributing to two Ebola
vaccines achieving
licensure and WHO
prequalification
*Chikungunya was considered by WHO during its 2018 annual review but not shortlisted as a priority disease under the R&D Blueprint
COVID-19
Supported
development of
numerous COVID-19
vaccines & founding
member of the ACT
accelerator/COVAX
Monkeypox
No regrets
investments into
immunoassay
development and
reference antibody
standards prior to
PHEIC
Cross-cutting activities
Includes an array of
enabling projects to
develop standards and
assays, preclinical models,
establishment trial, lab and
manufacturing networks to
support trials as well as
preclinical studies, plus the
largest ever, multi-country
epidemiology study -
ENABLE Lassa
programme
CEPI’s key
achievements
2017-2022
21 vaccines candidates against 5* WHO R&D Blueprint short-listed pathogens
Disease X
Three rapid response
platforms advanced through
Phase I, with potential to
significantly improve speed of
vaccine development against
multiple pathogens
5. Sensitivity: CEPI Internal
2.0
Vision statement
A world in which epidemics and
pandemics are no longer a threat to
humanity
Mission statement
Accelerate the development of
vaccines and other biologic
countermeasures against epidemic
and pandemic threats so they can be
accessible to all people in need
Prepare
for known epidemic
and pandemic
threats
Transform
the response to the
next novel threat
Connect
to enhance and
expand global
collaboration
To develop a safe and effective vaccine in 100
days from the moment that a pathogen is
sequenced and/or the need for a vaccine is
recognised to initial availability for use.
aspiration
100
day
6. Sensitivity: CEPI Internal
If the world had developed a
coronavirus vaccine within 100 days,
the first injections might have been
given in April 2020, when there were
just
2.3 million
cases of COVID-19
rather than on the 8th December,
when
more than 68 million
people had already been infected with
the disease.
The need for speed
#100DaysMission
7. Sensitivity: CEPI Internal
Example metrics:
• Human-to-human transmission
confirmed, with failure of typical
control measures
• Unusual high # severe disease
cases or deaths (e.g., at hospitals
within country / area)
• New infectious diseases pathogen
identified as causative agent
Vaccine made available for
use by respective authorities
e.g., vaccine deployment for public
health intervention to control an
outbreak in agreement with
regulatory authorities
Alert trigger Vaccine available for
emergency use
100
days
We acknowledge this
goal is incredibly
ambitious and have
established it as a north
star, recognizing that
with vision and
collaboration, great
things are possible
CEPI’s aspiration is to develop a vaccine in 100
days from alert trigger to a vaccine available for
use
8. Sensitivity: CEPI Internal
Critical path towards vaccine availability
• Analysis of COVID-19 vaccine development timelines shows that manufacturing is on the critical path to get to first-in-
human
• Manufacturing scale-up and technology transfer is critical to make doses available and equitably accessible
Alert trigger Vaccine available for use
Billions of doses
manufactured
Equitable access
ensured
Candidate
development and
preclinical testing
Early clinical
trials
Large-scale
clinical trial
Regulatory
submissions
Process
development and
Phase I/II
manufacturing
Scale-up and
Phase IIb/III
manufacturing
Process
Qualification
Scale-up and -out,
technology
transfer
Saville, Melanie, et al. "Delivering Pandemic Vaccines in 100 Days—What Will It Take?." New England Journal of Medicine (2022).
9. Sensitivity: CEPI Internal
The paradigm shift will
involve systematic
front-loading of
preparedness
activities & breaking
the firewall between
development and
intervention
Readiness: Prepare
the toolkit,
infrastructure and
partnerships
Pre-outbreak
Development of rapid
response platforms,
vaccine libraries and
critical reagents
Response: Adapt,
create & test the
pathogen-specific
vaccine
Between outbreak
& initial vaccine
availability for use
Shift from prototype
vaccines to pathogen-
specific activities &
scale-up vaccine
manufacturing
Rollout and
review: Release
vaccine & expand
clinical evidence
Post initial
availability for use
Continued
surveillance after
initial authorisation
e.g., broken firewall
between development
and intervention
Response time can be 100 days under
specific circumstances
Point of outbreak Available for use
10. Sensitivity: CEPI Internal
#100DaysMission
Shorten every step of the
vaccine development process
If we combine the best-in-class work from
every stage, we could shave off around two
months (vs Pfizer’s record of 326 days).
Think of it as a Formula 1 pitstop. In the 1950s,
it took 60 seconds to change a wheel. Thanks
to incremental improvements over the years, it
now takes just two seconds – because every
step has been perfected.
1 2 3 4
11. Sensitivity: CEPI Internal
#100DaysMission
1 2 3 4
Vaccine libraries: What
has COVID-19 shown us?
Before COVID-19, scientists were already
working on vaccines against MERS and SARS
(also part of the coronavirus family).
What those scientists learned enabled them to
pivot quickly and respond at lightning speed
when COVID-19 emerged.
We can replicate this approach for other virus
families.
12. Sensitivity: CEPI Internal
#100DaysMission
Completing as many pieces of the puzzle as we can
before a new virus emerges (Disease X).
We need to develop a library of ‘prototype vaccines’ against virus families
that can be swiftly adapted.
CEPI* is prioritising vaccine libraries for up to 10 virus families that pose
the greatest risk to public health.
Our aim is to establish clinical proof of concept for vaccines against these
virus families over the next five years.
This is a mammoth task. We anticipate it being a shared global project
with CEPI playing a leadership/connecting role.
1 2 3 4
*By working with leading experts to systematically rank each family based on its Disease X potential. To do this, we’re looking at potential for outbreak transmission
or zoonotic spillover, ability to mutate, mode of transmission, and other factors.
13. Sensitivity: CEPI Internal
#100DaysMission
Building vaccine manufacturing
capacity closer to outbreaks.
A globally distributed network would enable
rapid access to vaccine doses in low- and
middle- income regions.
It could also allow for vaccine production to
take place closer to the source of an outbreak.
Plus promotion of vaccine uptake?
1 2 3 4
14. Sensitivity: CEPI Internal
#100DaysMission
Making a calculated shift in the
way we do clinical trials and
regulation.
In future emergencies, the rapid rollout of
vaccines based on pre-established safety data
should go hand-in-hand with the ongoing
review of real-world evidence of efficacy.
This represents a change in the traditional
mindset, but acceptable if no short-cuts are
made, only parallelisation.
1 2 3 4
15. Sensitivity: CEPI Internal
15
15
Which technical innovations do we need to enable equitable access to
essential or emergency vaccines ?
• Novel formulations and format that are easy to distribute and administer
• Lower cost of goods
• Globally distributed manufacturing including LMICs
• ?
Billions of doses
Ensure equitable access
16. Sensitivity: CEPI Internal
"Human ingenuity can render our careful projections
irrelevant and make our boldest aspirations seem timid."
—Melinda French Gates and Bill Gates, Gates Foundation Goalkeepers report
#100DaysMission