2. Cellular adaptation is the ability of cells to respond to various types
of stimuli and adverse environmental changes.
Cellular adoption is, Reversible changes of cells in,
Size, number, phenotype,
metabolic activity and function
To give in response to change in their environment
Cellular Adoption
3. These adaptations include;
Hypertrophy (enlargement of individual cells),
Hyperplasia (increase in cell number),
Atrophy (reduction in size and cell number),
Metaplasia (transformation from one type of epithelium to another), and
Dysplasia (disordered growth of cells).
Cells must constantly adapt, even under normal conditions, to
changes in their environment.
Cellular Adoption
4. Hypertrophy (enlargement of individual cells)
It’s the increase in the size of cells lead to caused increased in size of organ .
No new cells generation, just increased the size of the cells.
Synthesis of more structural components.
Due to increased demand or stimulation by hormones & growth factors.
Example, as in the enlargement of the breast and induction of lactation by
pregnancy.
1. Hypertrophy
5. Causes of Hypertrophy
• Could be Physiologic and
pathologic
Enlargement of uterus
pregnancy, action of estrogenic
hormones.
Hypertrophy of heart the most
common stimulus is chronic
hemodynamic overload
1. Hypertrophy
Hypertrophy
Physiologic Pathologic
Hypertrophy of cardiac muscle,
Hypertrophy of smooth muscle,
Pregnancy
6. Hyperplasia (increase in cell number)
It’s the increasing of cells numbers, lead to caused increased in
size of tissue / organ .
Generation of new cells, and increased the size of the cells.
Synthesis of more structural components.
2. Hyperplasia
7. Causes of Hyperplasia
• Could be Physiologic and pathologic
Physiologic hyperplasia: Occurs due to a normal
stressor.
For example, increase in the size of the breasts during
pregnancy
Increase in thickness of endometrium during menstrual
cycle
and liver growth after partial resection.
Pathologic hyperplasia: Occurs due to an abnormal
stressor.
2. Hyperplasia
8. Atrophy (reduction in size and cell number)
Shrinking in size of the cell by the loss of cell substance is known
as Atrophy
Atrophy (Reduced size of an organ or tissue, resulting from a
decrease in cell size and number)
Atrophy is the progressive degeneration or shrinkage of muscle or
nerve tissue.
Mostly occurred in fetus in infants
3. Atrophy
9. • Nutritional (starvation) atrophy
• Caused by starvation or
malnutrition
• Seen in proteins calorie
malnutrition (marasmus), due to
utilization of muscle protein as
an energy source.
3. Atrophy
10. • Loss of endocrinal stimulation
• After menopause: Loss of estrogen stimulation
• Menopause is the time that marks the end of menstrual cycles.
• Physiological atrophy of endometrium, (female reproductive part)
epithelium and breast.
3. Atrophy
12. Metaplasia (transformation from one type of epithelium to another)
Metaplasia is the replacement of one differentiated somatic cell type
with another differentiated somatic cell type in the same tissue.
Metaplasia is a process whereby one type of mature tissue is
replaced by another type of mature tissue not indigenous to that
organ or tissue.
Example; Squamous metaplasia
4. Metaplasia
13. A term used to describe the presence of abnormal cells within a tissue
or organ.
Dysplasia is not cancer, but it may sometimes become cancer.
Dysplasia can be mild, moderate, or severe, depending on how abnormal
the cells look under a microscope and how much of the tissue or organ is
affected.
5. Dysplasia
Phenotype: In genetics, the phenotype is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological properties, its behavior, and the products of behavior.
This causes your muscles to grow bigger in response to exercise, especially high-intensity weight training. Most of the time, muscle hypertrophy is a good thing; it signals that your muscles are growing normally or responding normally to resistance-training exercise.
The modern description of hypertrophic cardiomyopathy is credited to the London pathologist, Robert Donald Teare who likened the disease to "a tumour of the heart" and published his observations in the British Heart Journal 50 years ago.
This causes your muscles to grow bigger in response to exercise, especially high-intensity weight training. Most of the time, muscle hypertrophy is a good thing; it signals that your muscles are growing normally or responding normally to resistance-training exercise.
The modern description of hypertrophic cardiomyopathy is credited to the London pathologist, Robert Donald Teare who likened the disease to "a tumour of the heart" and published his observations in the British Heart Journal 50 years ago.
Endometrial hyperplasia is a condition in which the endometrium (lining of the uterus) is abnormally thick. These cells appear normal under a microscope. They are not cancer, but may become cancer.
These cells appear normal under a microscope. They are not cancer, but may become cancer.
Regeneration of liver following partial hepatectomy. Various growth factors and interleukins are important in such hyperplasia
This causes your muscles to grow bigger in response to exercise, especially high-intensity weight training. Most of the time, muscle hypertrophy is a good thing; it signals that your muscles are growing normally or responding normally to resistance-training exercise.
The modern description of hypertrophic cardiomyopathy is credited to the London pathologist, Robert Donald Teare who likened the disease to "a tumour of the heart" and published his observations in the British Heart Journal 50 years ago.
This causes your muscles to grow bigger in response to exercise, especially high-intensity weight training. Most of the time, muscle hypertrophy is a good thing; it signals that your muscles are growing normally or responding normally to resistance-training exercise.
The modern description of hypertrophic cardiomyopathy is credited to the London pathologist, Robert Donald Teare who likened the disease to "a tumour of the heart" and published his observations in the British Heart Journal 50 years ago.
Menopause is the time that marks the end of
There are three stages of menopause: perimenopause, menopause and postmenopause your menstrual cycles.
Atherosclerosis thickening or hardening of the arteries. It is caused by a buildup of plaque in the inner lining of an artery. Plaque is made up of deposits of fatty substances, cholesterol, cellular waste products, calcium, and fibrin. As it builds up in the arteries, the artery walls become thickened and stiff.
These cells appear normal under a microscope. They are not cancer, but may become cancer.
Regeneration of liver following partial hepatectomy. Various growth factors and interleukins are important in such hyperplasia
These cells appear normal under a microscope. They are not cancer, but may become cancer.
Regeneration of liver following partial hepatectomy. Various growth factors and interleukins are important in such hyperplasia