As advanced persistent threats (APTs) have become pervasive, governments and organizations have spent billions of dollars over the years fighting them. Meanwhile, actors have created a new breed of threat – “Advanced Persistent Manipulators” (APMs), to borrow a term coined by scholar Clint Watts at the Alliance for Securing Democracy in the United States. APMs have learned from APTs’ successes and taken advantage of the developments in information technology with an aim of manipulating information and influencing decision making. This presentation will explore Advanced Persistent Manipulator threats through a comparative study with advanced persistent threats. This comparison will examine motives, goals, and tactics, techniques and procedures (TTPs) related to each. It will further review the unique characteristics of APMs and current regulatory environments that affect efforts to defend against disinformation. Lastly, this presentation will offer countermeasures that governments and private organizations may want to consider when developing plans for defense against APM threats in the current and evolving threat environment.