This document summarizes a case study on the fatigue failure of a universal joint yoke and drive shaft in a power transmission system. Spectroscopic, metallographic, hardness, and finite element analyses were conducted on both components. The universal joint yoke was made of AISI 5049H low alloy steel and failed due to fatigue at stress concentration points. The drive shaft was made of AISI 94B30H boron steel and its surface hardness was lower than the inner surface, indicating failure originated at the surface. The conclusion was that both failures were due to fatigue and modifications could be made to strengthen high stress areas.