The presentation has three parts: UNITE for Diabetes Philippines CPG recommendations on medical nutrition therapy (MNT), improving adherence to MNT and use of SMS.
http://www.our-diabetic-life.com Intake of large amount of carbohydrates can spike your blood glucose level. Right amount of carbohydrate can make your glucose level under control.
Kidneys are the vital organs in the human body. Its main function is to remove the waste products from our body. At the stages of kidney disease it can’t completely remove toxins, excess salt, water, etc. So these waste products build up in the body and create problems. At the stages of kidney disease we have to follow a healthy renal diet without overloading kidneys. Here we are providing a general diet for kidney disease patients also who are prone to kidney disease. By making simple changes in lifestyle & diet we can improve renal health. Here also provided three simple tests to check for kidney diseases.
The presentation has three parts: UNITE for Diabetes Philippines CPG recommendations on medical nutrition therapy (MNT), improving adherence to MNT and use of SMS.
http://www.our-diabetic-life.com Intake of large amount of carbohydrates can spike your blood glucose level. Right amount of carbohydrate can make your glucose level under control.
Kidneys are the vital organs in the human body. Its main function is to remove the waste products from our body. At the stages of kidney disease it can’t completely remove toxins, excess salt, water, etc. So these waste products build up in the body and create problems. At the stages of kidney disease we have to follow a healthy renal diet without overloading kidneys. Here we are providing a general diet for kidney disease patients also who are prone to kidney disease. By making simple changes in lifestyle & diet we can improve renal health. Here also provided three simple tests to check for kidney diseases.
case presentation of hypoglycemia, Approach to hypoglycemia, pathophysiology, differential diagnosis, treatment and management, comparison and case presentation
Lecture on DKA in pregnancy - presented at JGH Obstetrics & Gynaecology Teaching Jan 2020. Fictional details have been used to anonymise any resemblance to persons living or passed.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
3. Socio-Economic HistorySocio-Economic History
Married with 5 children
High school graduate
Permanent residence in Taguig
Works as a security guard
◦ Wakes up early and prefer foods that are
easy to prepare (ex; noodles, canned
goods, fried)
Smoker (quitted a year ago)
Alcoholic for 28 years (17-45 yrs of age)
4. Medical HistoryMedical History
Present Illness: CKD stage 5
secondary to Hypertensive
Nephrosclerosis
Anemia
Hyperkalemia
Metabolic Acidosis
UGIB
Chief Complaint: Generalized weakness
5. Medical HistoryMedical History
Past Illness: known hypertensive for
more than 20 years.
◦ One month prior to admission
Gradual onset of on and off epigastric, burning
in character.
Nausea
Occasional vomiting of previously ingested
food
Progressive body weakness and myalgia
6. Medical HistoryMedical History
◦ Two days Prior to Admission
Gradual onset of on and off epigastric, burning
in character.
Vomiting (coffee-ground material)
Epistaxis
Increased sleeping time.
◦ Past surgeries: None
◦ Allergies: None
◦ Past Hospitalization: Yes
7. Medical HistoryMedical History
Physical State of Health
◦ Loss of appetite PTA
◦ Gastric pain caused by UGIB (resolving)
◦ No elimination/ excretion problem
Family Medical History
◦ The patient’s mother is hypertensive
8. Theoretical considerationTheoretical consideration
Chronic Kidney disease
is a progressive and
irreversible damage of
the functioning unit of
kidneys, the nephrons.
◦ Function of Nephrons;
Filtration
Iso-osmotic reabsorption
Osmotic concentrator
Electrolyte reabsorption
Water reabsorption
9. EtiologyEtiology
Immunological, metabolic, renal vascular.
Primary tubular and congenital disorders.
Vascular lesions that can lead to renal
ischemia and kidney tissue.
Chronic Glomerular disease, such as
glomerulonephritis.
Chronic infections, such as chronic
pyelonephritis
11. Stages of CKDStages of CKD
Stage Description GFR, mL/min
per 1.73m2
Action
1 Kidney damage with
normal or high GFR
>90 Diagnosis and
treatment, slowing
progression, CVD
risk reduction
2 Kidney damage with
mild decrease in
GFR
60-89 Estimating
progression
3 Moderate decrease
GFR
30-59 Evaluating and
treating
complications
4 Severe decrease in
GFR
15-29 Preparation for
kidney replacement
therapy
5 Kidney failure <15 or dialysis Kidney replacement
(if uremia present)
The patients GFR is 2.9 thus, belongs to stage 5
14. What is Dialysis?What is Dialysis?
is a way of maintaining the patients’
regular excretion of the body’s waste
products.
Works on the principles of the
diffusion and osmosis of solutes and
fluid across a semi-permeable
membrane.
Examples are Hemodialysis and
Peritoneal Dialysis
16. Assessment of NutritionalAssessment of Nutritional
StatusStatus
Anthropometry
◦ % Standard weight= (69 kg/ 63 kg) x 100
=109.5%
◦ BMI= 69/ 1.702
=23.88
◦ % weight change= 1.5% less
17. Assessment of NutritionalAssessment of Nutritional
StatusStatus
Biochemical Assessment
Laboratory Results Normal Values Actual Values Variance Rationale for
Variance
BUN 2.60-6.48 mmol/L 94.13 mmol/L 87.65 mmol/L or
higher
Failure in kidney
functions
Creatinine 53.00-115.00
umol/L
3202 umol/L 3087 umol/L or
higher
Failure in kidney
functions
RBC 4.3-5.9 x 106
/mm3
2.25 x 106
/mm3
3.65 x 106
/mm3
or
less
Anemia (reduced
EPO roduction)
Hemoglobin 13.6-17 g/L 6 g/L 11 g/L or lower Anemia (reduced
EPO roduction)
Hematocrit 39-49% 19% 30% or lower Anemia (reduced
EPO roduction)
GFR <greater than 130
mL/min per
1.73m2
2.9 mL/min per
1.73m2
127.1 L/min per
1.73m2
Renal Failure
(CKD stage 5)
Potassium 3.8- 5 mmol/L 6.9 mmol/L 1.9 mmol/L or
higher
Hyperkalemia
18. Assessment of NutritionalAssessment of Nutritional
StatusStatus
Clinical Assessment
Body parts Clinical sign Possible
Nutrient
Deficiency
Others
Conjunctivae pale Vitamin A Low
hemoglobin/RBC
Nailbeds pale Zinc Low
hemoglobin/RBC
Tongue
(posterior)
Blackish
discoloration
Riboflavin/Niacin Presence of
infection
Mouth Uremic
Breathe
- Caused by uremia
Vascular system High blood
pressure
- Caused by alcohol
and smoking
Muscular system Weakness - Low
hemoglobin/RBC
19. Dietary AssessmentDietary Assessment
DBW= (170-100) -10%
= 70 - 7= 63 kg
TER= 63 x 35 (method II)= 2205 kcal or
2200 kcal
CPF distribution (60-15-25)
CHO= 2200 x 0.6=1323/4= 330.75 g or 330 g
PRO= 2200 x 0.15= 330/4= 82.5 or 85g
FAT= 2200 x 0.25= 550/9= 61.1 or 60 g
20. Dietary AssessmentDietary Assessment
Prior to Admission
◦ Kcal=2240, CHO=334g, PRO=74g, FAT=
67.5g
• CHO % Adequacy= 334/330 x 100
= 101.21%
• PRO % Adequacy= 74/85 x 100
= 87.1%
• FAT % Adequacy= 67.5/60 x 100
=112.5%
• Energy % Adequacy= 2240/2200 x 100
= 101.18
21. Dietary AssessmentDietary Assessment
During Confinement
◦ Kcal=1900, CHO=334g, PRO=74g, FAT=
67.5g
TER= 63 x 30= 1900 kcal
PRO= 63 x 1.1= 70 g
PRO kcal= 70 x 4= 280 kcal
Non PRO kcal= 1900-280= 1620 kcal
CHO: 1620 x 0.7= 1134 - 148 (dialysate)=
986/ 4=246.5 or 245 g
FAT: 1620 x 0.3= 486/9= 55 g
22. Dietary AssessmentDietary Assessment
CHO % adequacy= 164/245 x 100
=66.94%
PRO % adequacy= 56/70 x 100
= 80%
FAT % adequacy= 30/55 x 100
= 54.5%
Calorie % adequacy= 946/1900 x 100
= 49.8%
During Confinement % adequacy
23. Nutrient-Drug InteractionNutrient-Drug Interaction
Name of Drug Indication Possible Interactions
NaHCO3 Metabolic acidosis Neutralizing gastric acid
Amlodipine Osteodystrophy Inhibit the transport of calcium into
myocardial and vascular smooth
muscles
Clonidine Hypertension Inhibits cadioacceleration and
vasoconstriction
Kalimate Hyperkalemia Exchanges sodium ions for
potassium
Lactulose Q8 Uremia inhibits diffusion of ammonia from
the colon , lowers pH
Furosemide Uremia Inhibits the reabsorption of sodium
and chloride from the loop of Henle
and distal renal tube.
Erythropoetin 4000 ‘u Anemia Stimulates erythropoesis
Vitamin K tablets Hypokalemia Synthesis of blood coagulation
factors
24. Nutritional Care PlanNutritional Care Plan
Identification of Problem
Parameters Medical Problems Nutritional Problem
Anthropometry None None (Normal BMI)
Biochemical Accumulation of BUN
and Creatinine
Anemia
Hyperkalemia
Uremic syndrome
Dietary Metabolic acidosis Gastric pain
Drug and Nutrient
Interaction
Furosemide causes
hypokalemia
Weakness
Others Hypertensive
UGIB
Nausea, Vomiting
25. Nutrient Implications andNutrient Implications and
ReccomendationsReccomendations
Should have enough energy and
protein to maintain the patients DBW.
Two thirds of the protein must come
from sources of High Biological Value
(HBV) to assure the essential amino
acid requirements.
Regular monitoring of lab results is
essential to evaluate the patient’s
condition while in hemodialysis
26. Diet PrescriptionDiet Prescription
TER= 63 x 30= 1900 kcal
PRO= 63 x 1.1= 70 g
PRO kcal= 70 x 4= 280 kcal
Non PRO kcal= 1900-280= 1620 kcal
CHO: 1620 x 0.7= 1134 - 148 (dialysate)=
986/ 4=246.5 or 245 g
FAT: 1620 x 0.3= 486/9= 55 g