The document describes IB-ASAP (Imaging Biomarkers Automated Structured Assembly Pipeline), a software workflow for quantitative imaging. It aims to improve radiologist workflows by organizing data storage, preparing data, running processing algorithms, managing results, and notifying users. The software is fully automated, vendor independent, and compatible with DICOM standards. It is being used to help quantify and understand cardiovascular remodeling as part of the cvREMOD project and to aid in diagnosis, treatment planning, monitoring and prevention of diseases.

1. Imaging Biomarkers Automated
Structured Assembly Pipeline
(IB-ASAP)
CARLOS PÉREZ CASTILLO
www.cuantificacionquironvalencia.es
www.quiron.es

2. Digital Radiology
• The workspace of radiologists
has changed dramatically with
the development and Engineers
implementation of digital imaging Radiologists
Radiologist’s Workspace Technology
Multidisciplinary collaboration
New workflows
New challenges…

3. Imaging Biomarkers
 Objective characteristics extracted from
medical images
 Indicators and measures of normal
biological processes, diseases or
responses to therapeutic interventions
 Obtained before a lesion or biological
process becomes evident in the
radiological observation, by analyzing
properties and multivariate combination
of medical images and data
 Non invasive

4. Purpose: Workflow improvement

5. Brain: Morphometry
 Sequence optimization for brain morphometry

6. Brain: Functional MRI
Schizophrenia Brain injury Other diseases
Auditory Patients with Tumours, language
hallucinations mobility restriction disorders

7. Brain: Neuro-tractography
o Diffusion Tensor Imaging
o Neuronal Pathway
o Surgical Planning

8. Prostate: Diffusion
microscopic mobility of tissue water
Healthy tissue Pathological tissue

9. Prostate: Perfusion
Overlay a
vascular
permeability
parametric map
on anatomical
images

10. Prostate: Spectroscopy
Biochemical and metabolic profile of the gland.
Indicators of tumor presence :
-increased choline
- regional reduction in the levels of citrate

11. Data Pipeline

12. Workflow Description
DICOM
Organized Data Post- Post- Post-
images and
data storage preparation processing Processing Processing
data reception Notifications
and Algorithms Results Results
classification Execution Management Management

13. IB-ASAP
 The developments have provided
an innovative service that follows
an organized process, as a proper
technological support to leverage
the usability and ease the
development and
implementation of quantitative
imaging
 In addition, the software is fully
automated, vendor independent
and compatible with DICOM
standards

14. cvREMOD (CENIT-E)
 Quantify and understand the
mechanisms of cardiovascular
remodeling, improving the
knowledge of the
pathophysiological mechanisms
 Apply new imaging and modeling
technologies
 Help with diagnosis
 Optimize planning and
personalized treatment decisions
 Improve the monitoring and
prevention of future diseases

15. Thank you
 Supported by grants from SERAM (Sociedad
Española de Radiología Médica)
 The authors also thank the Radiology Department of
Hospital Quirón Valencia for their help and
continuous support with image acquisition and for
the clinical validation