Care of the Patient with Diabetes in Haiti Symposia, presented in Milot, Haiti at Hôpital Sacré Coeur.
CRUDEM’s Education Committee (a subcommittee of the Board of Directors) sponsors one-week medical symposia on specific medical topics, i.e. diabetes, infectious disease. The classes are held at Hôpital Sacré Coeur and doctors and nurses come from all over Haiti to attend.
Nursing Management · Monitor blood sugar and use a sliding scale to treat high levels of glucose · Educate patient about diabetes · Examine feet .
Diagnosis involves measuring blood glucose levels. Ongoing specialized assessment and evaluation for complications are essential for diabetes management.
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A review of the investigation and management of diabetic ketoacidosis in newly diagnosed type I diabetes. Patient details have been changed and anonymised to protect the identity of the individual.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
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Care of the Patient with Diabetes in Haiti Symposia - The CRUDEM Foundation
1. Care of the Patient
with Diabetes
Rosa Matonti RN, MSN, CDE, CNS
Inpatient Diabetes Educator
University of New Mexico Hospital
Pager 505-951-4352 Office 505-925-6100
rmatonti@salud.unm.edu
Sacred Coeur Hospital, Milot, Haiti
2. Objectives
At the end of the session the learner will be
able to:
• Explain the role of counter regulatory
hormones in maintaining glucose levels.
• Describe the importance of glucose control
during illness and recovery
• Differentiate between type 1 and type 2
diabetes.
3. Prevalence of Diabetes
• National Statistics
– Among people greater than 18 years of
age in the US in 2007, 8% were
diagnosed with diabetes.
– In comparison, in Haiti diabetes affects
7.4% in men and 11.1% in women.
– In the US diabetes is expected to
increase 60% in the next 22 years
Baptiste, ED, et. al. (2006). Glucose intolerance and other cardiovascular risk factors in Haiti.
Diabetes Metabolism; 32: 443-451.
Wild S, Roglie G, Greene A, Sicree R, King H. (2006) Global prevalence of diabetes; estimates
for the year 2000 and projections for 2030. Diabetes Care. 27(5): 1047-1053.
5. Pathophysiology of Glucose
Regulation
• Food eaten, carbohydrates converted into
glucose
• Regulation of blood glucose depends on
the liver
• 60% of glucose from food is converted to
glycogen
• When liver cells are saturated additional
glucose is converted to fat
• Peripheral muscle cells also store glucose
6.
7. History of Insulin
• 1921 Nicolae Paulescu first to isolate insulin
(pancrein)
• Spring 1921 Banting traveled to Toronto
• Banting and Best isolated beta cells from dogs,
producing isletin (insulin).
• Took 6 weeks to extract isletin
• Went to using fetal calf pancreas
• Next Banting invited James Collip (biochemist) to
purify the extract.
• January 11, 1922, Leonard Thompson was given
first injection of insulin.
• Collip improved the extract and the second dose
was given on January 23, 1922
• April 1922 Eli Lilly combined efforts with Banting
• Won Nobel Prize in 1923
9. Important Functions of Insulin
• Insulin allows glucose into the cell
• Enhances uptake of glucose by the
liver
• Prevents the breakdown of stored
glycogen back to glucose.
10. Important Functions of Insulin
• Insulin secreted continuously is the basal
rate.
• Insulin response after a meal is a bolus.
• Insulin affects protein and mineral
metabolism
• Enhances fat storage and prevents fats
from being used for energy
11. Physioloic Insulin Secretion
Normal 24-Hour Profile
1. Nutritional Insulin
(µU/mL) 50
Insulin
25
0
Breakfast Lunch Supper
2. Basal Insulin:
Suppresses Glucose
150 Prandial Glucose Production Between
Meals And Overnight
Glucose
(mg/dL)
100
50
0 Basal Glucose
7 8 9 101112 1 2 3 4 5 6 7 8 9
A.M. P.M.
Time of Day
12. Insulin Requirements in Health
and Illness
Correction
Nutritional
Prandial
Units
Basal
Healthy Sick/Eating Sick/NPO
Clement S, et al. Diabetes Care. 2004;27:553–591.
13. Counterregulatory Hormones
Raises Blood Source Action of
Sugar Hormone
Glucagon pancreas’ alpha Stimulates
cells glycogenolysis
gluconeogenosis
Epinephrine Adrenal gland’s Causes rapid rise
medulla in blood glucose in
times of stress
Cortisol Adrenal gland’s Maintains blood
cortex glucose levels
during fasting and
stress
Growth Hormone Pituitary gland Causes slow rise
in blood glucose
14. To Review:
• Control of blood glucose depends on:
– Insulin is secreted with high blood
glucose and helps glucose enter the
cells and inhibits the liver from
converting glycogen back to glucose.
– Counterregulatory hormones are
stimulated by low blood glucose and
act to raise blood glucose.
15.
16. Physiology of the Stress Response
• Stress is anything that • Stress Response
activates the body’s – How bodies have adapted
mechanism’s to adapt to help survive sudden
– Emotional stress danger.
– Physical stress – Increased secretion of
counterregulatory
• Illness
hormones.
• Infection
• Increase oxygen
• Surgery availability and
• Trauma delivery.
• Contribute to release
of glucose from the
liver
• Oppose the action of
insulin
18. New ADA Diagnostic Criteria: 2010
• HgbA1c≥ 6.5%
• ot specified as the preferred test
N
• ust use NGSP certified method
M
• Fasting blood glucose of 126 mg/dl or higher
• fter 8 hr. fast
A
• A 75 gm glucose tolerance test with a two hour
glucose value ≥ 200mg/dl.
• andom glucose ≥ 200 mg/dl with symptoms
R
Diabetes Care 2010; 33 (supplement 1): S11
19. Pathophysiology of Diabetes
Type 1 Diabetes
• 5-10% of population
• Beta cells are destroyed by autoimmune
response
• Some genetic predisposition but low
compared to type 2
• Usually those that develop are young peak
age between 12 and 14, but…….
• S/S develop abruptly and are due to high
blood glucose which leads to osmotic
pressure.
20. Signs and Symptoms of Type 1
• Weight loss
• Polyphagia
• Polydipsia
• Polyuria
• Lack of energy and sleepiness
• Blurred vision
21. Pathophysiology of Diabetes
Type 2 Diabetes
• 90% of the population
• More common in those over 40 but…..
• Overweight or obese
• Sedentary
• Strong genetic predisposition
• Greater amongst certain ethnicities, i.e.
African Americans, Native Americans,
Latinos, and Pacific Islanders
• Women who have a Hx of Gestational
Diabetes
22. Differences between Type 1 and 2
• Type 1 is an autoimmune response and a
loss of beta cell function
• Type 2 is a dysfunction in glucose
regulation, i.e.
– Decreased insulin production
– Increased insulin resistance
23. Two Theories on How Type 2
Develops
1. Defect in the beta cells causes the
pancreas to secrete less insulin, resulting
in hyperglycemia.
2. Initial problem is insulin resistance in
muscle tissues, fat cells, and the liver. As
a result the beta cells increase secretion
of insulin to keep blood glucose in normal
range.
24. Signs and Symptoms of Type 2
• Polyphagia
• Polydipsia
• Polyuria
• Blurred vision
• Fatigue
• Frequent infections
• Slow wound healing
26. Serious Consequences of Type 1
Ketoacidosis
– hyperglycemia over 300 mg/dL
– low bicarbonate level (<15 mEq/L)
– acidosis (pH <7.30)
– ketonemia and ketonuria
– Nausea/ vomiting
– difficulty breathing (Kussmaul’s
breathing)
– fruity odor on breath
– confusion
27. Serious Consequences of Type 2
Hyperosmolar Hyperglycemic state (HHS)
– Plasma glucose level of 600 mg/dL or greater
– Effective serum osmolality of 320 mOsm/kg or
greater
– Profound dehydration (8-12 L) with elevated
serum urea nitrogen (BUN)-to-creatinine ratio
– Small ketonuria and absent-to-low ketonemia
– Bicarbonate concentration greater than 15 mEq/
L
– Some alteration in consciousness
28. Comparison of DKA and HHS
DKA HHS
Mild Moderate Severe
Plasma Glucose (mg/ >250 >250 >250 >600
dL)
Arterial ph 7.25-7.30 7.00-<7/24 <7.00 >7.30
Serum bicarbonate 15-18 10-<15 <10 >15
(mEq/L)
Urine Ketones Positive Positive Positive Small
Serum Ketones Positive Positive Positive Small
Effective Serum Variable Variable Variable >320 mOso/
Osmolality kg
Anion Gap >10 >12 >12 <12
Alteration in Sensorium Alert Alert/drowsy Stuperous/ Stuperous/
or mental obdundation coma coma
Umpierrez, GE et.al. Diabetic Ketoacidosi and Hyperglycemic Hyperosmolar Syndrome. 2002
Diabetes Spectrum. 15 (1) 28-36
29. Criteria for Resolution of DKA
and HHS
DKA HHS
BG < 200 mg/dL BG < 300 mg/dL
Serum bicarb ≥ 18 mEq/L Improvement in mental
status
Venous pH > 7.3 Serum osmolality <320
mOso/kg
Anion gap ≤ 12 mEq/L
30. Effects of Hypoglycemia
• Early phases alpha cells release glucagon
• Glucagon stimulates hepatocytes
• Glycogen to glucose
• Hepatic gluconeogenesis
• Lead to a rise in blood glucose
Lien L.F et.al. (eds) Glycemic Control in the Hospitalized Patient. Springer
Science+Business Media, LLC: New York; 2011.
31. Signs and Symptoms of
Hypoglycemia
Can vary from patient to patient
• At first patient may feel
– Nervous
– Sweaty
– Shaky or
– Dizzy
• Later
− Angry or confused
− Feel off balance
− Have difficulty talking
− Loss of consciousness
32. Treatment Options for
Hypoglycemia
• Rule of 15 s
– 15 grams of carbohydrate
– Will raise blood glucose 15 mg/dl
– In about 15 minutes
• Examples of 15 grams of oral carbohdyrate
− 4 ounces of regular juice or soda
− 3 to 4 hard candies
− box of raisins
− 3-4 teaspoons of sugar
− 1 teaspoon of jelly
33. Treatment Options for
Hypoglycemia
• If patient unable to swallow and IV present
– IV 50% dextrose bolus
• If unable to swallow and no IV
– Inject 1 mg of Glucagon
34. Prevention of Hypoglycemia
• Insulin or medication dosages
• Blood glucose targets
• Blood glucose monitoring frequency
35. How do we care for people
diagnosed with Diabetes?
36. Inpatient Glycemic Goals
ICU Non-ICU Non-ICU
Preprandial Maximal
AACE/ADA 140 mg/dL-180 mg/ < 140 mg/dL < 180 mg/dL
dL
Moghissi, E.S. et. al. American Association of Clinical Endocrinologists and
American Diabetes Association Consensus Statement on Inpatient Glycemic Control
Endocrine Practice. 2009:15 (4): 1-17.
37. Outpatient Goals of Treatment*
• Blood pressure < 130/80
• LDL < 100 mg/dl (<70 if pre-existing
cardiac dx)
• HDL >40 mg/dl in men and > 50 mg/
dl in women
• Triglycerides < 150 mg/dl
• HgA1c < 7%
Diabetes Care 2010; 33 (supplement 1): S11
38. Goals of Treatment
Self Blood Glucose Monitoring
(For Healthy Non-Pregnant Adults)
ADA AACE
• Premeal blood glucose: • Premeal blood glucose:
90 – 130 mg/dl <110 mg/dl
• Peak post meal blood • Peak 2 hour post meal
glucose: <180 mg/dl blood glucose: <140
• HbA1c <7% mg/dl
• HbA1c <6.5%
Moghissi, E.S. et. al. American Association of Clinical Endocrinologists and
American Diabetes Association Consensus Statement on Inpatient Glycemic Control
Endocrine Practice. 2009:15 (4): 1-17.
Diabetes Care 2010;33 (supplement): S11
39. Goals of Treatment SBGM*
Higher target goals for those with:
• Advanced complications
• Life-limiting comorbid illness
• Cognitive or functional impairments
• Hypoglycemic unawareness
• Young children
• Lower goals for pregnant women
Diabetes Care 2010; 33 (supplement 1): S11
40. Take away from the presentation
• Counterregulatory hormones and the
autonomic system affect blood glucose
levels.
• Differences in type 1 versus type 2
diabetes.
• Importance of adhering to blood glucose
goals to decrease morbidity and mortality.