This document summarizes a study of water quality in the Kentucky River watershed from 2001-2006. The author thanks their advisors Dr. Buddhi Gyawali, Jeremy Sandifer, and Ms. Cynthia Rice for guidance. The study analyzed how land use, such as agriculture, mining, and urbanization, impacted water quality. High levels of metals and nutrients were found near mining and urban areas, while low dissolved oxygen levels occurred by agricultural land. The author used GIS data and trend analysis to link changes in water quality parameters to land activities affecting the watershed.