This Journal Club presentation provides a summary and discussion of the following free access article published in UOG:
Callosal dysgenesis in fetuses with ventriculomegaly: levels of agreement between imaging modalities and postnatal outcome
Y. Li, J.A. Estroff, O. Khwaja, T.S. Mehta, T.Y. Poussaint, C.D. Robson, H.A. Feldman, J. Ware, D. Levine
Volume 40, Issue 5, Date: November 2012, pages 522–529
It can be accessed here: http://onlinelibrary.wiley.com/doi/10.1002/uog.11098/abstract
Myopic shift and preoperative axial length after congenital cataract surgery in Peruvian patients - The Association for Research in Vision and Ophthalmology Meeting (ARVO) 2018 Honolulu, Hawaii - Poster presentation
Case Review #2: 46 year old female with Prestige Disc ReplacementRobert Pashman
A 46 year old female presented with massive neck pain and a C5/6 disc herniation. Dr. Pashman treated her with an anterior cervical discectomy and placement of a Prestige Disc.
Case Review #5: 46 year old female treated with a Prestige DiscRobert Pashman
A 46 year old female presented with a C5/6 disc herniation. Dr. Pashman performed an anterior cervical discectomy and used the Prestige Disc. The goal was to preserve her C6/7 disc.
Case Review #4: Cervical Spine Surgery with Prestige DiscRobert Pashman
A 57 year old male presented after a C6/7 fusion. He had a 2nd level supra adjacent disc herniation. (two levels above the fusion). Dr. Pashman treated him with a Prestige Artificial Disc.
Myopic shift and preoperative axial length after congenital cataract surgery in Peruvian patients - The Association for Research in Vision and Ophthalmology Meeting (ARVO) 2018 Honolulu, Hawaii - Poster presentation
Case Review #2: 46 year old female with Prestige Disc ReplacementRobert Pashman
A 46 year old female presented with massive neck pain and a C5/6 disc herniation. Dr. Pashman treated her with an anterior cervical discectomy and placement of a Prestige Disc.
Case Review #5: 46 year old female treated with a Prestige DiscRobert Pashman
A 46 year old female presented with a C5/6 disc herniation. Dr. Pashman performed an anterior cervical discectomy and used the Prestige Disc. The goal was to preserve her C6/7 disc.
Case Review #4: Cervical Spine Surgery with Prestige DiscRobert Pashman
A 57 year old male presented after a C6/7 fusion. He had a 2nd level supra adjacent disc herniation. (two levels above the fusion). Dr. Pashman treated him with a Prestige Artificial Disc.
Sally was diagnosed with an orange size Meningioma brain tumor. The phenomenal neurosurgeons and other doctors removed her tumor at Mission Hospital. This is the story of her hospital experience.
Case Review #3: 44 year old male with a subadjacent disc herniationRobert Pashman
A 44 year old male presented after a C5/6 fusion. On MRI he was found to have a subadjacent disc herniation. Dr. Pashman treated the patient with a Prestige Artificial Disc.
Resultados preliminares do implante de um novo anel associado ao PRK para pre...Ferrara Ophthalmics
Dr. Sandro Coscarelli, Dr. Pablo Rodrigues, Dr. Guilherme Rocha e Dr. Leonardo Torquetti compilaram e compartilham seus resultados com o uso de Segmentos de Anel de Ferrara HM associado ao PRK para a correção da miopia de pacientes com corneas finas e contra indicados para as técnicas de Excimer Laser apenas.
20150918 E. Pompilii - Microarray in diagnosi prenatale: la complessità della...Roberto Scarafia
Eva Pompilii, MD
Genetic Counselor , TOMA Advanced Biomedical Assays, S.p.A.,
Gynepro Medical Bologna, Policlinico S.Orsola Malpighi Bologna
• OBJECTIVES:
At present, a precise guideline establishing chromosome microarray analysis (CMA) applications and platforms in the prenatal setting does not exist. The actual controversial
question is whether CMA technologies can or should shortly replace the standard karyotype in prenatal diagnosis practice
• CONCLUSIONS:
Presently CMA analysis can be considered a second-tier diagnostic test to be used after a standard karyotype in selected group of pregnancies, such as those with single
(apparently isolated) or multiple US fetal abnormalities, with de novo chromosomal rearrangements, even if apparently balanced, and those with supernumerary markers chromosomes
Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systemic review and meta-analysis
C. Scala, A. Familiari, A. Pinas, A.T. Papageorghiou, A. Bhide, B. Thilaganathan, A. Khalil
Volume 49, Issue 4, Date: April (pages 450–459)
Slides prepared by Dr Yael Raz (UOG Editor-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15943/full
This Journal Club presentation provides a summary and discussion of the following free access article published in UOG:
Postmortem examination of human fetal hearts at or below 20 weeks' gestation: a comparison of high-field MRU at 9.4 T with lower-field MRI magnets and stereomicroscopic autopsy
C. Votino, J. Jani, M. Verhoye, B. Bessieries, Y. Fierens, V. Segers, A. Vorsselmans, X. Kang, T. Cos, W. Fouldon, J. de Mey, M. Cannie.
Volume 40, Issue 4, Date: October 2012, pages 437-444
It can be accessed here: http://onlinelibrary.wiley.com/doi/10.1002/uog.11191/abstract
This Journal Club presentation provides a summary and discussion of the following free access articles published in UOG:
Prenatal diagnosis and outcome of fetal posterior fossa fluid collections
G. Gandolfi Colleoni, E. Contro, A. Carletti, T. Ghi, G. Campobasso, G. Rembouskos, G. Volpe, G. Pilu, P. Volpe.
Volume 39, Issue 6, Date: June 2012, pages 625–631
Brainstem–vermis and brainstem–tentorium angles allow accurate categorization of fetal upward rotation of cerebellar vermis
P. Volpe, E. Contro, F. De Musso, T. Ghi, A. Farina, A. Tempesta, G. Volpe, N. Rizzo, G. Pilu
Volume 39, Issue 6, Date: June 2012, 632–635
They can be accessed here:
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1469-0705/homepage/journal_club_2012.htm
UOG Journal Club: December 2013
Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review with meta-analysis
B.J. Voskamp, H. Fleurke-Rozema, K.O. Rengerink, R.J.M. Snijders, C.M. Bilardo, B.W.J. Mol and E. Pajkrt
Link to free access article:
http://onlinelibrary.wiley.com/doi/10.1002/uog.12541/abstract
Sally was diagnosed with an orange size Meningioma brain tumor. The phenomenal neurosurgeons and other doctors removed her tumor at Mission Hospital. This is the story of her hospital experience.
Case Review #3: 44 year old male with a subadjacent disc herniationRobert Pashman
A 44 year old male presented after a C5/6 fusion. On MRI he was found to have a subadjacent disc herniation. Dr. Pashman treated the patient with a Prestige Artificial Disc.
Resultados preliminares do implante de um novo anel associado ao PRK para pre...Ferrara Ophthalmics
Dr. Sandro Coscarelli, Dr. Pablo Rodrigues, Dr. Guilherme Rocha e Dr. Leonardo Torquetti compilaram e compartilham seus resultados com o uso de Segmentos de Anel de Ferrara HM associado ao PRK para a correção da miopia de pacientes com corneas finas e contra indicados para as técnicas de Excimer Laser apenas.
Similar to UOG Journal Club: Callosal dysgenesis in fetuses with ventriculomegaly: levels of agreement between imaging modalities and postnatal outcome
20150918 E. Pompilii - Microarray in diagnosi prenatale: la complessità della...Roberto Scarafia
Eva Pompilii, MD
Genetic Counselor , TOMA Advanced Biomedical Assays, S.p.A.,
Gynepro Medical Bologna, Policlinico S.Orsola Malpighi Bologna
• OBJECTIVES:
At present, a precise guideline establishing chromosome microarray analysis (CMA) applications and platforms in the prenatal setting does not exist. The actual controversial
question is whether CMA technologies can or should shortly replace the standard karyotype in prenatal diagnosis practice
• CONCLUSIONS:
Presently CMA analysis can be considered a second-tier diagnostic test to be used after a standard karyotype in selected group of pregnancies, such as those with single
(apparently isolated) or multiple US fetal abnormalities, with de novo chromosomal rearrangements, even if apparently balanced, and those with supernumerary markers chromosomes
Perinatal and long-term outcomes in fetuses diagnosed with isolated unilateral ventriculomegaly: systemic review and meta-analysis
C. Scala, A. Familiari, A. Pinas, A.T. Papageorghiou, A. Bhide, B. Thilaganathan, A. Khalil
Volume 49, Issue 4, Date: April (pages 450–459)
Slides prepared by Dr Yael Raz (UOG Editor-for-Trainees)
Link to free-access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.15943/full
This Journal Club presentation provides a summary and discussion of the following free access article published in UOG:
Postmortem examination of human fetal hearts at or below 20 weeks' gestation: a comparison of high-field MRU at 9.4 T with lower-field MRI magnets and stereomicroscopic autopsy
C. Votino, J. Jani, M. Verhoye, B. Bessieries, Y. Fierens, V. Segers, A. Vorsselmans, X. Kang, T. Cos, W. Fouldon, J. de Mey, M. Cannie.
Volume 40, Issue 4, Date: October 2012, pages 437-444
It can be accessed here: http://onlinelibrary.wiley.com/doi/10.1002/uog.11191/abstract
This Journal Club presentation provides a summary and discussion of the following free access articles published in UOG:
Prenatal diagnosis and outcome of fetal posterior fossa fluid collections
G. Gandolfi Colleoni, E. Contro, A. Carletti, T. Ghi, G. Campobasso, G. Rembouskos, G. Volpe, G. Pilu, P. Volpe.
Volume 39, Issue 6, Date: June 2012, pages 625–631
Brainstem–vermis and brainstem–tentorium angles allow accurate categorization of fetal upward rotation of cerebellar vermis
P. Volpe, E. Contro, F. De Musso, T. Ghi, A. Farina, A. Tempesta, G. Volpe, N. Rizzo, G. Pilu
Volume 39, Issue 6, Date: June 2012, 632–635
They can be accessed here:
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1469-0705/homepage/journal_club_2012.htm
UOG Journal Club: December 2013
Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review with meta-analysis
B.J. Voskamp, H. Fleurke-Rozema, K.O. Rengerink, R.J.M. Snijders, C.M. Bilardo, B.W.J. Mol and E. Pajkrt
Link to free access article:
http://onlinelibrary.wiley.com/doi/10.1002/uog.12541/abstract
AN ANALYSIS OF OUTCOMES IN TWIN PREGNANCIES WITH ACTIVE FETAL SURVEILLANCE AN...Apollo Hospitals
The incidence of multiple gestations is increasing with
increasing maternal age and use of assisted reproduction
techniques. Selective fetal reduction of multifetal pregnancies is now widely practiced to reduce the higher order multiples to twins based on evidence from nonrandomised studies which suggests that this will improve the perinatal outcome. The proportion of twin pregnancies with unique fetal and maternal problems is therefore increasing. Optimising maternal, fetal and perinatal outcomes in twin pregnancies continues to be a formidable challenge in the present day clinical practice.
This Journal Club presentation provides a summary and discussion of the following free access article published in UOG:
Neurodevelopmental outcome of fetuses with increased nuchal translucency and apparently normal prenatal and/or postnatal assessment: a systematic review
A. Sotiriadis, S. Papatheodorou, G. Makrydimas
Volume 39, Issue 1, Date: January 2012, pages 10–19.
This can be accessed here: http://onlinelibrary.wiley.com/doi/10.1002/uog.10143/abstract
This Journal Club presentation provides a summary and discussion of the following free access article published in UOG:
Perinatal outcome in women treated with progesterone for the prevention of preterm birth: a meta-analysis
A. Sotiriadis, S. Papatheodrou, G. Makrydimas
Volume 40, Issue 3, Date: September 2012, pages 257-266
It can be accessed here:
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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UOG Journal Club: Callosal dysgenesis in fetuses with ventriculomegaly: levels of agreement between imaging modalities and postnatal outcome
1. UOG Journal Club: November 2012
Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li Y, Estroff JA, Khwaja O, Mehta TS, Poussaint TY, Robson CD, Feldman HA,
Ware J, Levine D
Volume 40, Issue 5, Date: November 2012, pages 522–529
Journal Club slides prepared by Dr Aly Youssef
(UOG Editor for Trainees)
2. • Ventriculomegaly (lateral ventricles ≥ 10 mm) is often the first
ultrasonographic sign of corpus callosum (CC) abnormalities
• Corpus callosum abnormalities are often associated with central
nervous system (CNS), chromosomal, syndromic and other structural
abnormalities
• Main limitations of the existing studies on CC abnormalities are:
o the limited prenatal and/or postnatal assessment
o attrition is common due to termination of pregnancy or loss to
follow-up
• The actual data on the outcome of fetuses with callosal abnormalities
is limited and varies widely in the literature
3. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
The aim of the present study was to assess
neurodevelopmental outcome in fetuses diagnosed
with isolated and non-isolated callosal abnormalities
following referral for ventriculomegaly
4. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
Methods I
Sub-analysis of a prospective study including 430 fetuses referred for ventriculomegaly.
Ultrasound (transabdominal and/or transvaginal) and MRI performed in all cases in the axial
(A), coronal (B) and sagittal planes (C). Sub-analysis included fetuses with a diagnosis of
corpus callosal abnormalities after recruitment into the main study.
A B C
Ultrasound
Complete agenesis of
the corpus callosum at
26 weeks’ gestation in a
fetus with lateral
ventricular
measurement of 10 mm
MRI
5. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
Methods II
• Between 3–6 radiologists independently reviewed ultrasound and MR images
and final diagnoses decided by consensus
• All callosal abnormalities (hypoplasia, complete agenesis, partial agenesis) were
combined into a single group
• Patients with callosal abnormalities were further subdivided into two groups:
o Isolated (no additional abnormalities)
o Non-isolated (associated CNS, karyotypic, syndromic or other major
abnormalities)
• Pregnancy and postnatal outcomes in fetuses with callosal abnormalities
(including neurodevelopment at 6 months, 1, 2, and 3 years) were compared
between those with (non-isolated) and those without (isolated) other
abnormalities
6. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
Results I
430 women referred for ventriculomegaly
58 prenatal diagnosis of callosal abnormalities
(13%)
Isolated Non-isolated
14 44
(24%) (76%)
• The kappa statistic for preconference agreement was 0.76 for ultrasound readers and 0.78
for MRI readers, indicating that both investigations had a similar level of operator dependence
• There were more true positives and false positives by MRI readers than by ultrasound
readers
7. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
Results II
Prenatal consensus diagnosis
Characteristic Isolated callosal Non-isolated callosal P-value ‡
abnormalities abnormalities
(n = 14) (n = 44)
Prenatal assessment
Gestational age at imaging (weeks) 30.7 ± 4.8 (20–38) 26.2 ± 6.3 (19–38) 0.02
Abnormal karyotype 0 17 0.008
Ventricular diameter (mm) 15.8 ± 3.3 (11–21) 13.9 ± 5.6 (8–42) 0.02
Pregnancy outcome
Termination 2 12 0.48
Neonatal demise 0/12 1/31† > 0.99
Gestational age at birth (weeks) 39.6 ± 0.8 (39–41) 37.8 ± 1.6 (34–41) 0.003
Data shown as mean ± SD (range), n or n/total.
†One patient lost to birth outcome follow-up. ‡ Mann–Whitney test (continuous variables) or Fisher’s exact test (discrete variables).
8. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
Results III
Prenatal consensus diagnosis
Characteristic Isolated callosal Non-isolated P-value *
abnormalities callosal
(n = 14) abnormalities
(n = 44)
Neurodevelopmental outcome 0.003
Number with neurodevelopmental follow-up 12 27
Normal or mild delays that resolved 67% (8/12)§ 7% (2/27)
Mild delays that persisted 8% (1/12)§ 22% (6/27)
Moderate to severe delays/abnormalities 25% (3/12)§ 70% (19/27)
Data shown as n or % (n/total).
§ Includes children with postnatal CNS abnormalities that were not detected prenatally
* Fisher’s exact test (discrete variables)
9. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
Discussion
• Callosal abnormalities are present in a significant proportion of fetuses with
ventriculomegaly (13% in the present study)
• Normal neurodevelopment was observed in approximately two-thirds of fetuses
with isolated callosal abnormalities, and less than 10% of non-isolated cases
• Both ultrasound and MRI have substantial interrater agreement in the prenatal
diagnosis of CC anomalies, while MRI showed more true-positive and false-
positive diagnoses than did ultrasound
• Many associated anomalies in prenatally diagnosed isolated and non-isolated
callosal anomalies became apparent only later in gestation or postnatally.
This should be considered in counseling patients at the time of diagnosis of
callosal abnormalities.
10. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
Strengths of the study
• Study population embedded within a prospectively enrolled cohort of
fetuses
• Large sample size of patients with callosal abnormalities
• Standardized and specialist evaluations by pediatric neurologists and/or
pediatric psychologists
• Long period of postnatal follow-up (up to 5 years of age)
Limitations
• Population included is a part of a cohort of fetuses referred for
ventriculomegaly. Therefore, no data can be provided on prenatally
diagnosed callosal abnormalities without ventriculomegaly.
11. Callosal dysgenesis in fetuses with ventriculomegaly: levels
of agreement between imaging modalities and postnatal outcome
Li et al., UOG 2012
Discussion points
• Should all women with prenatal diagnosis of callosal abnormalities be
referred for expert ultrasound assessment?
• Should fetal karyotype determination be routinely offered to these
women?
• Should MRI be routinely performed in all cases with prenatal diagnosis
of callosal abnormalities?
• How can the present data guide the clinician in the counseling of women
with prenatal diagnosis of isolated and non-isolated CC abnormalities?
• Should these women be offered specialist evaluation later in pregnancy?