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Connexin Proteins & Skin Diseases )   (  By Prof .  Dr . Mahmoud Yousry M .  Abdel - Mawla* Professor of Dermatology & Venereology. Zagazig Faculty of Medicine,EGYPT .
CELL-TO-CELL COMMUNICATION   ,[object Object],[object Object],[object Object]
Fig. (1) : Cell-to-cell junctions
Gap Junctional Intercellular Communication(GJIC) ,[object Object],[object Object]
Gap Junction, Connexon and Connexin   ,[object Object],[object Object],[object Object],[object Object]
Fig. (2) : Connexin, connexon and gap junction
 
Connexin Nomenclature   ,[object Object]
Table (1  : (  Connexin nomenclature and sites of expression . N= name, Cx = connexin and kDa = kilodaltons
Connexin Biosynthesis &Degradation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fig. (5)  :  Connexin life cycle
Role Of Gap Junction In Different Systems   ,[object Object],Skin Tissue inflammation  and repair system Immune system Reproductive system Auditory system Cardiovascular system Ocular  system Digestive system Nervous system
 
Skin and Connexin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Connexin Expression and Human Skin Development   ,[object Object],Fig . (6)   : Gap junction distribution during human skin development .
Connexin and Wound Healing ,[object Object]
Connexins in Skin Disorders (Connexinopathies)
Evidences upon role of connexin in keratinocytes proliferation & differentiation ,[object Object],[object Object]
[object Object],[object Object]
Erythrokeratoderma variabilis (EKV)   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fig   .(7) :  EKV Migratory  erythematous lesions   Fig. (9) (a) A patient with EKV (b) The same patient after 3 weeks. Note that shapes of the  lesions have greatly changed over  time.  Fig. (8) :  EKV Hyperkeratotic  fixed plaques on legs and buttocks
Aetiology and pathogenesis   ,[object Object],[object Object],[object Object]
[object Object],[object Object]
Palmoplantar keratoderma and sensorineural hearing loss  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Fig  . (10) : KID syndrome
Aetiology and pathogenesis   ,[object Object]
Hidrotic ectodermal dysplasia (HED) syndrome ,[object Object],[object Object],[object Object]
Aetiology and pathogenesis   ,[object Object],[object Object]
Psoriasis ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Connexin and skin tumours ,[object Object],[object Object]
[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Gap junction as a  therapeutic target
Gap junction as a target in cancer chemoprevention and chemotherapy   ,[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Gap junction as a target for two human teratogenes   ,[object Object],[object Object]
Gap junction as a target in wound healing   ,[object Object]
Gap junction as a target in gene therapy   ,[object Object]
SUMMARY AND CONCLUSION ,[object Object],[object Object]
[object Object],[object Object]
[object Object]
Thank You

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C O N N E X I N P P T T T T T T T

  • 1. Connexin Proteins & Skin Diseases ) ( By Prof . Dr . Mahmoud Yousry M . Abdel - Mawla* Professor of Dermatology & Venereology. Zagazig Faculty of Medicine,EGYPT .
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  • 3. Fig. (1) : Cell-to-cell junctions
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  • 6. Fig. (2) : Connexin, connexon and gap junction
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  • 9. Table (1 : ( Connexin nomenclature and sites of expression . N= name, Cx = connexin and kDa = kilodaltons
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  • 11. Fig. (5) : Connexin life cycle
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  • 17. Connexins in Skin Disorders (Connexinopathies)
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  • 21. Fig .(7) : EKV Migratory erythematous lesions Fig. (9) (a) A patient with EKV (b) The same patient after 3 weeks. Note that shapes of the lesions have greatly changed over time. Fig. (8) : EKV Hyperkeratotic fixed plaques on legs and buttocks
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  • 26. Fig . (10) : KID syndrome
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  • 37. Gap junction as a therapeutic target
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