This document discusses burns and soft tissue injuries. It provides statistics on burn injuries including over 1 million occurring per year in the US, with 46% due to fire/flame and 32% due to scalding. It also covers determining burn severity based on size, depth, age and location of the burn. Classification of burns as minor, moderate or major is discussed. Acute respiratory complications, inhalation injuries, and other associated injuries from burns are summarized.
Facial soft tissue injuries require careful examination and treatment due to the aesthetic and functional importance of the face. Key areas to inspect for injuries include the nasal septum, ears, eyes, and underlying structures. Injuries are classified by type such as contusions, abrasions, lacerations, and avulsions. Proper cleaning, debridement when needed, and primary closure within 24 hours helps reduce risks of infection and improve cosmetic results. Special considerations apply to repairing injuries around sensitive areas like the eyes, nose, ears, and lips.
This document discusses different types of soft tissue injuries and classifications systems used to categorize them. It describes closed wounds like contusions and hematomas versus open wounds. Classification systems like Gustilo and Tscherne grade soft tissue damage and help determine appropriate treatment and prognosis. The goal is to effectively communicate injury severity and anticipate complications to improve patient outcomes.
This document discusses fractures with associated soft tissue injuries. It begins by explaining that the prognosis of such fractures depends on the amount of energy transferred to the soft tissues and bone, the degree of contamination, and patient factors. It then classifies closed fractures based on the Tscherne classification of soft tissue injuries. This is followed by a discussion of open fractures, including the Gustilo-Anderson classification system. The document outlines principles for the treatment of closed and open fractures, including controlling swelling, serial examination for compartment syndrome, appropriate fixation, and antibiotic treatment. Surgical treatment principles like debridement, irrigation, and wound management are also described.
This document provides information on burn injuries including:
1. Burn injuries cause cell destruction of the skin layers and fluid/electrolyte depletion. Large burns over 25% of total body surface area can cause systemic effects impacting major body systems.
2. Burn size is classified as minor (<15% TBSA), moderate (15-25% TBSA) or major (>25% TBSA) based on characteristics such as burn depth, area, and presence of inhalation injury.
3. Initial management focuses on airway maintenance, fluid resuscitation to prevent shock, pain relief and infection prevention. Later phases emphasize wound care, nutrition, rehabilitation and scar management.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The facial nerve is the 7th cranial nerve with motor, sensory and parasympathetic fibers. It originates from 3 nuclei and has an intracranial and extracranial course through the facial canal and parotid gland. It gives off several branches including the chorda tympani, posterior auricular nerve, and 5 branches on the face. It is associated with 3 ganglia and is tested by movements of the forehead, eye closing, and cheek puffing. Injury can occur at different points along its course, causing varying degrees of motor and sensory deficits depending on the location of injury. Care must be taken during surgeries in the parotid and temporal regions to avoid damaging its branches.
This document provides information about open skull base approaches and craniofacial surgeries. It lists several professors and their work in this area. It also provides links to videos and papers on different surgical techniques for the skull base, including subcranial approaches, facial translocation, bicoronal approaches, mandibulotomy, and preauricular approaches. The document encourages accessing papers and videos to continue learning about these surgical procedures and approaches.
Facial soft tissue injuries require careful examination and treatment due to the aesthetic and functional importance of the face. Key areas to inspect for injuries include the nasal septum, ears, eyes, and underlying structures. Injuries are classified by type such as contusions, abrasions, lacerations, and avulsions. Proper cleaning, debridement when needed, and primary closure within 24 hours helps reduce risks of infection and improve cosmetic results. Special considerations apply to repairing injuries around sensitive areas like the eyes, nose, ears, and lips.
This document discusses different types of soft tissue injuries and classifications systems used to categorize them. It describes closed wounds like contusions and hematomas versus open wounds. Classification systems like Gustilo and Tscherne grade soft tissue damage and help determine appropriate treatment and prognosis. The goal is to effectively communicate injury severity and anticipate complications to improve patient outcomes.
This document discusses fractures with associated soft tissue injuries. It begins by explaining that the prognosis of such fractures depends on the amount of energy transferred to the soft tissues and bone, the degree of contamination, and patient factors. It then classifies closed fractures based on the Tscherne classification of soft tissue injuries. This is followed by a discussion of open fractures, including the Gustilo-Anderson classification system. The document outlines principles for the treatment of closed and open fractures, including controlling swelling, serial examination for compartment syndrome, appropriate fixation, and antibiotic treatment. Surgical treatment principles like debridement, irrigation, and wound management are also described.
This document provides information on burn injuries including:
1. Burn injuries cause cell destruction of the skin layers and fluid/electrolyte depletion. Large burns over 25% of total body surface area can cause systemic effects impacting major body systems.
2. Burn size is classified as minor (<15% TBSA), moderate (15-25% TBSA) or major (>25% TBSA) based on characteristics such as burn depth, area, and presence of inhalation injury.
3. Initial management focuses on airway maintenance, fluid resuscitation to prevent shock, pain relief and infection prevention. Later phases emphasize wound care, nutrition, rehabilitation and scar management.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The facial nerve is the 7th cranial nerve with motor, sensory and parasympathetic fibers. It originates from 3 nuclei and has an intracranial and extracranial course through the facial canal and parotid gland. It gives off several branches including the chorda tympani, posterior auricular nerve, and 5 branches on the face. It is associated with 3 ganglia and is tested by movements of the forehead, eye closing, and cheek puffing. Injury can occur at different points along its course, causing varying degrees of motor and sensory deficits depending on the location of injury. Care must be taken during surgeries in the parotid and temporal regions to avoid damaging its branches.
This document provides information about open skull base approaches and craniofacial surgeries. It lists several professors and their work in this area. It also provides links to videos and papers on different surgical techniques for the skull base, including subcranial approaches, facial translocation, bicoronal approaches, mandibulotomy, and preauricular approaches. The document encourages accessing papers and videos to continue learning about these surgical procedures and approaches.
This document discusses lateral temporal bone resection for tumors. It provides details on:
1. Performing a piecemeal resection including subtotal temporal bone resection, infratemporal fossa type A approach, and superficial parotidectomy to spare the facial nerve.
2. The importance of performing superficial parotidectomy to remove first level draining lymph nodes.
3. Exposing and transposing the facial nerve from the mastoid segment to the parotid segment during the surgery.
4. The dangers of removing tumors at Parisier's triangle, which contains the labyrinthine part of the facial nerve. Care must be taken to avoid injuring the nerve.
This document provides a historical overview of the development of surgical anatomy from ancient Greece to modern times. It discusses early anatomical depictions and dissections in Greece, Italy, and England and how they progressed from drawings and woodcuts to modern 3D digital models and animations. Religious restrictions initially limited dissections, but over time anatomy advanced, especially in Italy and England, as depictions became more detailed and realistic through various artistic mediums. The modern field incorporates areas like histology, radiology, and digital reconstruction.
Comparison of intraoral harvest sites for corticocancellous bone graftsDr. SHEETAL KAPSE
The study aimed to quantify the amount of bone that can be harvested from four intraoral donor sites - the mandibular symphysis, ascending ramus/body, coronoid process, and zygomatic maxillary buttress. Bone grafts were harvested from 59 cadavers and the volume, surface area, and thickness of each graft was measured. The ramus provided the greatest volume and surface area of bone, while the symphysis provided the thickest bone. The coronoid and zygomatic buttress provided little bone. The body/ramus harvests were associated with fewer sensory disturbances compared to the symphysis.
Materials used for maxillo facial construction2/endodontic coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Emotion Recognition from Frontal Facial ImageSakib Hussain
Emotion Recognition from Frontal Facial Image. A preliminary solution for detecting basic Emotions from frontal facial images. These images can be provided either directly or there is an option for this system where it will detect face from an image and them finish the recognition.
Reference : http://dspace.bracu.ac.bd:8080/xmlui/bitstream/handle/10361/2931/09101004.pdf?sequence=1
This document discusses various types of facial trauma and fractures. It provides details on examining and evaluating patients with facial trauma, including important physical exam findings. It also reviews specific fractures like orbital fractures, LeFort fractures, mandibular fractures, and nasal bone fractures. Radiographic signs of facial fractures and emergency management of airway and hemorrhage are also covered.
C-Spine Collar Clearance In The Obtunded Adult Blunt Trauma PatientSun Yai-Cheng
Cervical Spine Collar Clearance In The Obtunded Adult Blunt Trauma Patient A systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma
J Trauma Acute Care Surg. 2015;78: 430-441.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Pre anaesthetic assessment and preoperative fasting guidelinesAnor Abidin
The document outlines the key steps and objectives of pre-anaesthetic consultation:
- Evaluate the patient's medical condition and optimise any risk factors.
- Determine the anaesthetic technique and perioperative care plan.
- Obtain informed consent from the patient after discussing anaesthesia and the procedure.
- The assessment may involve medical history, physical exam, and targeted lab/imaging tests to evaluate risk.
- The goals are to ensure patient safety and provide preoperative counselling and risk assessment.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
This document provides information on transoral and transorbital approaches to the skull base from multiple experts. It begins with an overview of transoral approaches to the infratemporal fossa and parapharyngeal space, identifying important anatomical structures like the medial and lateral pterygoid muscles. It then discusses the transoral endoscopic view of these regions and landmarks like the internal carotid artery. Finally, it briefly mentions a transorbital endoscopic approach to the anterior cranial fossa that will be covered in more detail in a referenced book.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
This document discusses penetrating ocular injuries, including their causes, effects, diagnosis, and treatment. Penetrating injuries can be caused by sharp objects and usually result in full thickness wounds. They can lead to mechanical effects like lacerations and infections. Diagnosis involves external examination, tonometry, ophthalmoscopy, and sometimes ultrasound or CT scans. Treatment depends on the type and severity of injury but may include antibiotics, pressure reduction, wound suturing, and repair of ruptures or lacerations.
This document discusses reduction techniques for zygomatic bone fractures. It begins by describing the anatomy of the zygomatic bone and common types of zygomatic fractures. It then outlines various surgical approaches that can be used for open reduction of zygomatic fractures, including the temporal fossa, intraoral, percutaneous, malar hook, Carroll Girard screw, and lateral eyebrow approaches. Indications for surgery include depressed malar eminence, enophthalmos, infraorbital paresthesia, and inability to open the mouth. The conclusion recommends that technique choice depends on the location and degree of displacement of the fracture.
The document summarizes research on how bisphosphonates affect fracture healing. Bisphosphonates are commonly used to treat osteoporosis but their long-term use may delay fracture healing in some cases. Studies in humans found no effect on healing in most patients, but those using bisphosphonates long-term (over 10 years) showed delayed healing in about 26% of cases. Animal studies also suggest long-term bisphosphonate use may impair healing. The document reviews evidence from both human and animal studies on the implications of bisphosphonate use for fracture recovery.
Is lag screw fixation superior to plate fixation to treat fractures of the ma...Dr. SHEETAL KAPSE
This document summarizes a study comparing lag screw fixation versus plate fixation for treating fractures of the mandibular symphysis. The study reviewed 887 patient cases treated with either 2 lag screws or bone plates secured with screws. Results found no significant differences in healing outcomes, but lag screw fixation had fewer postoperative complications like wound dehiscence and need for hardware removal. Both techniques showed good outcomes, but lag screw application required more surgical skill while plates were easier for less experienced surgeons. The document reviews relevant past studies on plating techniques and biomechanics of mandible reconstruction.
Children at very low risk of brain injuriesSun Yai-Cheng
Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study
Lancet 2009; 374: 1160–70
Surgical management of vestibular schwannoma by drdhiru456Dr Dhirendra Patil
This document provides an overview of surgical management of vestibular schwannomas, including relevant anatomy, history, and descriptions of different surgical approaches. It focuses on describing the translabyrinthine approach, including the key stages of cortical mastoidectomy, bony labyrinthectomy, skeletonization of structures, tumor removal, and closure. Alternative approaches like the middle fossa approach are also summarized. The document contains detailed explanations and illustrations of each surgical step intended to inform surgeons performing these procedures.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
This document discusses lateral temporal bone resection for tumors. It provides details on:
1. Performing a piecemeal resection including subtotal temporal bone resection, infratemporal fossa type A approach, and superficial parotidectomy to spare the facial nerve.
2. The importance of performing superficial parotidectomy to remove first level draining lymph nodes.
3. Exposing and transposing the facial nerve from the mastoid segment to the parotid segment during the surgery.
4. The dangers of removing tumors at Parisier's triangle, which contains the labyrinthine part of the facial nerve. Care must be taken to avoid injuring the nerve.
This document provides a historical overview of the development of surgical anatomy from ancient Greece to modern times. It discusses early anatomical depictions and dissections in Greece, Italy, and England and how they progressed from drawings and woodcuts to modern 3D digital models and animations. Religious restrictions initially limited dissections, but over time anatomy advanced, especially in Italy and England, as depictions became more detailed and realistic through various artistic mediums. The modern field incorporates areas like histology, radiology, and digital reconstruction.
Comparison of intraoral harvest sites for corticocancellous bone graftsDr. SHEETAL KAPSE
The study aimed to quantify the amount of bone that can be harvested from four intraoral donor sites - the mandibular symphysis, ascending ramus/body, coronoid process, and zygomatic maxillary buttress. Bone grafts were harvested from 59 cadavers and the volume, surface area, and thickness of each graft was measured. The ramus provided the greatest volume and surface area of bone, while the symphysis provided the thickest bone. The coronoid and zygomatic buttress provided little bone. The body/ramus harvests were associated with fewer sensory disturbances compared to the symphysis.
Materials used for maxillo facial construction2/endodontic coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Emotion Recognition from Frontal Facial ImageSakib Hussain
Emotion Recognition from Frontal Facial Image. A preliminary solution for detecting basic Emotions from frontal facial images. These images can be provided either directly or there is an option for this system where it will detect face from an image and them finish the recognition.
Reference : http://dspace.bracu.ac.bd:8080/xmlui/bitstream/handle/10361/2931/09101004.pdf?sequence=1
This document discusses various types of facial trauma and fractures. It provides details on examining and evaluating patients with facial trauma, including important physical exam findings. It also reviews specific fractures like orbital fractures, LeFort fractures, mandibular fractures, and nasal bone fractures. Radiographic signs of facial fractures and emergency management of airway and hemorrhage are also covered.
C-Spine Collar Clearance In The Obtunded Adult Blunt Trauma PatientSun Yai-Cheng
Cervical Spine Collar Clearance In The Obtunded Adult Blunt Trauma Patient A systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma
J Trauma Acute Care Surg. 2015;78: 430-441.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Pre anaesthetic assessment and preoperative fasting guidelinesAnor Abidin
The document outlines the key steps and objectives of pre-anaesthetic consultation:
- Evaluate the patient's medical condition and optimise any risk factors.
- Determine the anaesthetic technique and perioperative care plan.
- Obtain informed consent from the patient after discussing anaesthesia and the procedure.
- The assessment may involve medical history, physical exam, and targeted lab/imaging tests to evaluate risk.
- The goals are to ensure patient safety and provide preoperative counselling and risk assessment.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
This document provides information on transoral and transorbital approaches to the skull base from multiple experts. It begins with an overview of transoral approaches to the infratemporal fossa and parapharyngeal space, identifying important anatomical structures like the medial and lateral pterygoid muscles. It then discusses the transoral endoscopic view of these regions and landmarks like the internal carotid artery. Finally, it briefly mentions a transorbital endoscopic approach to the anterior cranial fossa that will be covered in more detail in a referenced book.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
This document discusses penetrating ocular injuries, including their causes, effects, diagnosis, and treatment. Penetrating injuries can be caused by sharp objects and usually result in full thickness wounds. They can lead to mechanical effects like lacerations and infections. Diagnosis involves external examination, tonometry, ophthalmoscopy, and sometimes ultrasound or CT scans. Treatment depends on the type and severity of injury but may include antibiotics, pressure reduction, wound suturing, and repair of ruptures or lacerations.
This document discusses reduction techniques for zygomatic bone fractures. It begins by describing the anatomy of the zygomatic bone and common types of zygomatic fractures. It then outlines various surgical approaches that can be used for open reduction of zygomatic fractures, including the temporal fossa, intraoral, percutaneous, malar hook, Carroll Girard screw, and lateral eyebrow approaches. Indications for surgery include depressed malar eminence, enophthalmos, infraorbital paresthesia, and inability to open the mouth. The conclusion recommends that technique choice depends on the location and degree of displacement of the fracture.
The document summarizes research on how bisphosphonates affect fracture healing. Bisphosphonates are commonly used to treat osteoporosis but their long-term use may delay fracture healing in some cases. Studies in humans found no effect on healing in most patients, but those using bisphosphonates long-term (over 10 years) showed delayed healing in about 26% of cases. Animal studies also suggest long-term bisphosphonate use may impair healing. The document reviews evidence from both human and animal studies on the implications of bisphosphonate use for fracture recovery.
Is lag screw fixation superior to plate fixation to treat fractures of the ma...Dr. SHEETAL KAPSE
This document summarizes a study comparing lag screw fixation versus plate fixation for treating fractures of the mandibular symphysis. The study reviewed 887 patient cases treated with either 2 lag screws or bone plates secured with screws. Results found no significant differences in healing outcomes, but lag screw fixation had fewer postoperative complications like wound dehiscence and need for hardware removal. Both techniques showed good outcomes, but lag screw application required more surgical skill while plates were easier for less experienced surgeons. The document reviews relevant past studies on plating techniques and biomechanics of mandible reconstruction.
Children at very low risk of brain injuriesSun Yai-Cheng
Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study
Lancet 2009; 374: 1160–70
Surgical management of vestibular schwannoma by drdhiru456Dr Dhirendra Patil
This document provides an overview of surgical management of vestibular schwannomas, including relevant anatomy, history, and descriptions of different surgical approaches. It focuses on describing the translabyrinthine approach, including the key stages of cortical mastoidectomy, bony labyrinthectomy, skeletonization of structures, tumor removal, and closure. Alternative approaches like the middle fossa approach are also summarized. The document contains detailed explanations and illustrations of each surgical step intended to inform surgeons performing these procedures.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
Debunking Nutrition Myths: Separating Fact from Fiction"AlexandraDiaz101
In a world overflowing with diet trends and conflicting nutrition advice, it’s easy to get lost in misinformation. This article cuts through the noise to debunk common nutrition myths that may be sabotaging your health goals. From the truth about carbohydrates and fats to the real effects of sugar and artificial sweeteners, we break down what science actually says. Equip yourself with knowledge to make informed decisions about your diet, and learn how to navigate the complexities of modern nutrition with confidence. Say goodbye to food confusion and hello to a healthier you!
28. DETERMINATION OF
SEVERITY OF BURN
Size of the burn
Depth of the burn
Age of the patient
Part of the body burned
29. DETERMINATION OF
SEVERITY OF BURN
Size of the burn
Depth of the burn
Age of the patient
Part of the body burned
Past medical history
30. DETERMINATION OF
SEVERITY OF BURN
Size of the burn
Depth of the burn
Age of the patient
Part of the body burned
Past medical history
Associated injuries
31. ESTIMATING SIZE BY “RULE
OF NINES”
Each body part a multiple of “9”
Quick method
Best for average adults
38. ESTIMATING DEPTH OF
BURN
Second Characteristic Third
Normal or Decreased or
Sensation absent
Increased
Large fluid Thin-walled
Blisters
filled
Pink, will White,
blanch Color brown black
or red
Normal or Firm or
Texture
firm Leathery
52. Criteria For Inhalation Injury
“Closed-space” injury
Presence of noxious gases or fumes
Burns about the face, mouth, lips, posterior
pharynx
53. Criteria For Inhalation Injury
“Closed-space” injury
Presence of noxious gases or fumes
Burns about the face, mouth, lips, posterior
pharynx
Carbonaceous sputum
54. Criteria For Inhalation Injury
“Closed-space” injury
Presence of noxious gases or fumes
Burns about the face, mouth, lips, posterior
pharynx
Carbonaceous sputum
Hoarseness or stridor
55. Criteria For Inhalation Injury
“Closed-space” injury
Presence of noxious gases or fumes
Burns about the face, mouth, lips, posterior
pharynx
Carbonaceous sputum
Hoarseness or stridor
Rales, rhonchi, wheezes
56. Criteria For Inhalation Injury
“Closed-space” injury
Presence of noxious gases or fumes
Burns about the face, mouth, lips, posterior
pharynx
Carbonaceous sputum
Hoarseness or stridor
Rales, rhonchi, wheezes
Hypoxemia
80. CLASSIFICATION OF BURNS
MAJOR
Second Degree Burns Greater Than 25% Body
Surface Area
Third Degree Burns Greater Than 10%
81. CLASSIFICATION OF BURNS
MAJOR
Second Degree Burns Greater Than 25% Body
Surface Area
Third Degree Burns Greater Than 10%
All Electrical Burns
82. CLASSIFICATION OF BURNS
MAJOR
Second Degree Burns Greater Than 25% Body
Surface Area
Third Degree Burns Greater Than 10%
All Electrical Burns
All Inhalation Injury
83. CLASSIFICATION OF BURNS
MAJOR
Second Degree Burns Greater Than 25% Body
Surface Area
Third Degree Burns Greater Than 10%
All Electrical Burns
All Inhalation Injury
Complicated By Other Trauma
84. CLASSIFICATION OF BURNS
MAJOR
Second Degree Burns Greater Than 25% Body
Surface Area
Third Degree Burns Greater Than 10%
All Electrical Burns
All Inhalation Injury
Complicated By Other Trauma
Burns Involving Hands, Face, Ears, Feet,
Perineum
85. CLASSIFICATION OF BURNS
MAJOR
Second Degree Burns Greater Than 25% Body
Surface Area
Third Degree Burns Greater Than 10%
All Electrical Burns
All Inhalation Injury
Complicated By Other Trauma
Burns Involving Hands, Face, Ears, Feet,
Perineum
All Poor Risk Patients
86. CLASSIFICATION OF BURNS
MODERATE
Second Degree Burns 15-25% BSA
Third Degree Burns Less Than 10%
97. What Are You To Do?
Evaluate
Remove Burning Clothing
98. What Are You To Do?
Evaluate
Remove Burning Clothing
Remove Constrictive Rings/Bracelets
99. What Are You To Do?
Evaluate
Remove Burning Clothing
Remove Constrictive Rings/Bracelets
Follow Pulses in Burned Extremities
100. What Are You To Do?
Evaluate
Remove Burning Clothing
Remove Constrictive Rings/Bracelets
Follow Pulses in Burned Extremities
Watch for Hypoxia - Anxiety May Be Clue
101. What Are You To Do?
Evaluate
Remove Burning Clothing
Remove Constrictive Rings/Bracelets
Follow Pulses in Burned Extremities
Watch for Hypoxia - Anxiety May Be Clue
Protect From Hypothermia