This document discusses burns, including definitions, causes, symptoms, classifications, and treatment. It defines burns as coagulative necrosis due to abnormal heat exposure, which causes skin damage and fluid loss. Burns are classified as first, second, or third degree depending on depth of tissue damage. Treatment involves stopping further injury, providing pain relief, covering burns, monitoring for shock, and seeking medical help for severe or extensive burns. Airway burns require maintaining ventilation and protecting the airway.
A detailed study on burns /all about burns ( manag, treat, preven, diagnosis) martinshaji
this is a detailed study on burns , and all the aspects such as definition , management, types , home remedies ,clinical aspects & evaluation, surgical methods , images & newer findings etc ,I hope this will be useful among medical professionals and others,
please comment
thank u
A detailed study on burns /all about burns ( manag, treat, preven, diagnosis) martinshaji
this is a detailed study on burns , and all the aspects such as definition , management, types , home remedies ,clinical aspects & evaluation, surgical methods , images & newer findings etc ,I hope this will be useful among medical professionals and others,
please comment
thank u
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Salas, V. (2024) "John of St. Thomas (Poinsot) on the Science of Sacred Theol...Studia Poinsotiana
I Introduction
II Subalternation and Theology
III Theology and Dogmatic Declarations
IV The Mixed Principles of Theology
V Virtual Revelation: The Unity of Theology
VI Theology as a Natural Science
VII Theology’s Certitude
VIII Conclusion
Notes
Bibliography
All the contents are fully attributable to the author, Doctor Victor Salas. Should you wish to get this text republished, get in touch with the author or the editorial committee of the Studia Poinsotiana. Insofar as possible, we will be happy to broker your contact.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
2. Definition
Burn is a coagulative necrosis of the cell
protoplasm due to exposure to abnormal
physical or chemical agent associated with
peripheral vasodilatation leading to rapid
loss of fluid into and from the tissues.
3. Burns are caused by dry heat and scalds
are caused by wet heat.
Both burns and scalds damage the body by
removing the layer of skin that protects the
body from infection.
Symptoms
Extreme pain
Swelling around site of burn
Redness and blistering
5. First degree burn
Second degree
Superficial
Deep
Third degree
6. First Degree Burn
Affect only the outer layer of the skin.
red and painful.
They swell a little.
They turn white when you press on the skin.
7. Second degree burn:
Affect both the outer and underlying layer of
skin
thicker burns, are very painful and typically
produce blisters on the skin.
The skin is very red or splotchy, and may be
very swollen.
8. Third degree burn
Extend into deeper tissues.
They cause white or blackened, charred
skin that may be numb.
10. Calculating TBSA (extent)
ADULTS: RULE OF NINES
Head & neck 9 %
Anterior trunk 18 %
Posterior trunk 18 %
Bilateral anterior arm, forearm and hand 9 %
Bilateral posterior arm, forearm and hand 9 %
Genital region 1%
Bilateralanterior leg and foot 18 %
Bilateral posterior leg and foot 18 %
11. Children: Rule of Nine
A child under one year has 9 % taken from
the lower extremities and added to the head
region. Each year of life, 1 % is distributed
back to the lower extremities until age 9
when the head region is considered to be the
same as an adult.
12.
13. Stop further injury
Extinguish or remove burning clothing
Cold water lavage or soaks used for only 10 to
15 minutes for pain relief of second degree
burns of 10% or less of TBSA , avoid
hypothermia
14. If the skin is unbroken, run cool water over
the area of the burn or soak it in a cool
water bath (not ice water).
Keep the area submerged for at least 5
minutes. A clean, cold, wet towel will also
help reduce pain
15. Calm and reassure the person.
After flushing or soaking, cover the burn
with a dry, sterile bandage or clean
dressing.
Protect the burn from pressure and friction.
16. Ibuprofen or Acetaminophen
Moisturizing cream
Tetanus !!!
If a second-degree burn covers an area more
than 2 to 3 inches in diameter, or if it is
located on the hands, feet, face, groin,
buttocks, or a major joint, treat the burn as a
major burn
17. Major burns:
If someone is on fire, tell the person to stop, drop,
and roll.
Wrap the person in thick material to smother the
flames (a wool or cotton coat, rug, or blanket).
Douse the person with water.
Call 123.
18. Cover the burn area with a dry sterile bandage (if available)
or clean cloth. A sheet will do if the burned area is large.
If fingers or toes have been burned, separate them with
dry, sterile, nonadhesive dressings.
Elevate the body part that is burned above the level of the
heart.
Protect the burn area from pressure and friction.
19. Make sure the person is breathing.
Take steps to prevent shock.
Continue to monitor the person's vital signs
until medical help arrives.
20. Stop further injuy
Maintain ventilation
Administer humidified oxygen by mask
Examine airway looking for sign of inhalation inj.
Carbonaceous material in upper airway
Edema or inflammatory change in upper airway
Maintain airway
21. Stop further injury
Maintain ventilation
CPR if no pulse or heart action is
detectable
22. Intravenous fluid therapy (in Hospital)
Required for patients with burns greater than 20%
Secure a no. 16 or 18 plastic cannula in adequate vein
Place indwelling urethral catheter and attach to close
drainage system
Estimate fluid need for the 1st 24 hour (4 ml lactated
ringer ‘s sol. /kg body weight / % of TBSA ( ½ amount in
1st 8 hours then the rest of next 16 hour)
Plan administration to obtain 30-50 ml urine /hour in pt.
wt greater than 30 kg ( 1 ml urine / hour for pt less than
30 kg)
23. Maintain peripheral
circulation
Remove rings and bracelet
Clinical signs of impaired circulation
include
Cyanosis
Impaired capillary refilling
Progressive neurological
signs, i.e. parethesias and
deep tissue pain
24. Nasogastric intubation
Place tube and attach to suction if there is vomiting or
if burns involve more than 25% of TBSA
Analgesic medication
Given as needed
Give only intravenously and in small doses
Tetanus prophylaxis
25. Do Not
Do NOT apply ointment, butter, ice,
medications, cream, oil spray, or any
household remedy to a severe burn.
Do NOT breathe, blow, or cough on the burn.
Do NOT disturb blistered or dead skin.
26. Do NOT remove clothing that is stuck to the skin.
Do NOT give the person anything by mouth, if there is a
severe burn.
Do NOT immerse a severe burn in cold water. This can
cause shock.
Do NOT place a pillow under the person's head if there is an
airways burn. This can close the airways.
27. Electrical burn.
Low voltage
High voltage
1st separation from the electrical source
Evaluate cardio-vascular system
Evaluate peripheral circulation
Evaluate internal burn
Associated trauma
28. Chemical burn
Alkaline
Acids
Copious water lavage ( avoid water lavage for
Na metal H2so4 , HCL)
Prolonged eyes irrigation
Remove all contaminated cloth
Cover with oil
29. Radiation burns
bland ointment
Avoid dryness or irritating substance
Narcotics as needed for pain
Splinting of the involved area to reduce pain
with motion
30. Burn to airways
Causes:
inhaling smoke,
steam,
superheated air,
or toxic fumes, often in a poorly ventilated
space.
31. Symptoms:
Charred mouth; burned lips
Burns on the head, face, or neck
Wheezing
Change in voice
Difficulty breathing; coughing
Singed nose hairs or eyebrows
Dark, carbon-stained mucus
32. FIRST AID to airway burns
Call 123
improve the casualty’s air supply
recovery position