It includes new definition, pathophysiology, management of sepsis, septic shock and neutropenic sepsis and even newer evolving concepts or types of sepsis.
It includes new definition, pathophysiology, management of sepsis, septic shock and neutropenic sepsis and even newer evolving concepts or types of sepsis.
this slide is selection important part of thermal burn topic in
Tintinalli's Emergency Medicine
with this presentation you can have a great present in your collage.
A complete review for all medical students and doctors working in burn unit in any hospital. #Emergency #BurnProtocol #protocol #Burns #Abhishek #MUSTKNOW #knowledge #Medical #Health
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Toxic effects of heavy metals : Lead and Arsenicsanjana502982
Heavy metals are naturally occuring metallic chemical elements that have relatively high density, and are toxic at even low concentrations. All toxic metals are termed as heavy metals irrespective of their atomic mass and density, eg. arsenic, lead, mercury, cadmium, thallium, chromium, etc.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Salas, V. (2024) "John of St. Thomas (Poinsot) on the Science of Sacred Theol...Studia Poinsotiana
I Introduction
II Subalternation and Theology
III Theology and Dogmatic Declarations
IV The Mixed Principles of Theology
V Virtual Revelation: The Unity of Theology
VI Theology as a Natural Science
VII Theology’s Certitude
VIII Conclusion
Notes
Bibliography
All the contents are fully attributable to the author, Doctor Victor Salas. Should you wish to get this text republished, get in touch with the author or the editorial committee of the Studia Poinsotiana. Insofar as possible, we will be happy to broker your contact.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
5. 5
Skin Form & Function
• Largest body organ
• More than just a passive covering
• Functions:
• Sensation
• Protection
• Temperature regulation
• Fluid retention
• Metabolic (vit D synthesis and excretory function)
• Social( self-image, social image)
https://slideplayer.com/slide/
5754434/
6. Initial Evaluation
Initial evaluation of the burned patient
involves four crucial assessments:
•airway management
•evaluation of other injuries
•estimation of burn size
•and diagnosis of CO and cyanide
poisoning.
7. Initial Evaluation
• Perioral burns and singed nasal hairs necessitate
further evaluated for mucosal injury,
• Signs of impending respiratory compromise may
include a hoarse voice, wheezing, or stridor;
• subjective dyspnea is a particularly concerning
symptom and should trigger prompt elective
endotracheal intubation.
8. Initial Evaluation
• Burned patients should be first considered trauma
patients, especially when details of the injury are
unclear.
• Primary survey
• An early and comprehensive secondary survey must
be performed on all burn patients, but especially
those with a history of associated trauma such as
with a motor vehicle collision
9. Estimating Burn Size
• Superficial or first-degree burns should not be
included when calculating the %TBSA, and
thorough cleaning of soot and debris is mandatory
to avoid confusing
• Wallace rule of nine
• Laud Browder
• Rule of the Palm
10.
11. Metabolic Poisoning
• Carbon Monoxide (CO) affinity for hemoglobin is
approximately 200 – 250 times more than oxygen
• Administration of 100% oxygen is the gold standard
for treatment of CO poisoning
• Hydrogen cyanide toxicity patients may have a
persistent lactic acidosis or ST elevation on
electrocardiogram (ECG).
• Treatment consists of sodium thiosulfate,
hydroxocobalamin, and 100% oxygen
12. Classification of Burn
• Burns are commonly classified as thermal,
electrical, or chemical burns, with thermal
burns consisting of flame, contact, or scald
burns.
• Flame burns are not only the most common
cause but also the highest cause of mortality
13. Electrical Burn
• Electrical burns are classified as low-voltage ( < 1000
volts) and high-voltage injuries (1000 volts and higher).
• There may be instant death from cardiac or respiratory
arrest or ventricular fibrillation from alteration of the
action potentials of nerves and muscles.
• Cardiac arrhythmia
• Compartment syndrome
• Rhabdomyolysis
• fasciotomies should be performed even in cases of
moderate clinical suspicion
14. Chemical Burn
• Chemical burns are less common but potentially severe
burns.
• Careful removal and irrigation for minimum of 30mins
• Lye powder should be swept away to avoid activating
the aluminum hydroxide with water
• Formic acid has been known to cause hemolysis and
hemoglobinuria, and hydrofluoric acid causes
hypocalcemia.
• Calcium-based therapies are the mainstay of treating
hydrofluoric acid burns
15. Burn Depth
• Superficial (First degree) – Involves only
epidermis, Red, Heal in ~7 days
• Partial Thickness (Second degree) – Extends into
the dermis, Salmon pink Heal in ~7 to 21 days
• Full Thickness (Third degree) Through epidermis,
dermis into underlying structures Thick, dry, Pearly
gray or charred black,
• Fourth degree burn – Involves underlying
structures , same finding as 3rd degree burn with
involved bone, muscle and tendon.
16. Burn Depth
• Zone of coagulation – of necrosis in the center is
irreversibly damaged.
• ischemia or stasis where vascular spasms and
intravascular micro-thrombi result in compromised
perfusion with potential to progressive conversion
to tissue death.
• Zone of hyperemia, heal with minimal or no
scarring and is most like a superficial or first-degree
burn.
17. Prognosis
• The Baux score (mortality risk equals age plus
%TBSA) was used for many years to predict
mortality in burns.
• Analysis of multiple risk factors for burn mortality
has validated age and %TBSA as the strongest
predictors of mortality.
• However, age and burn size, as well as inhalation
injury, continue to be the most robust indicators for
burn mortality
19. Resuscitation
• For pediatrics, the simplest approach is to deliver a
weight-based maintenance IV fluid with glucose
supplementation in addition to the calculated
resuscitation fluid with lactated Ringer’s.
• The burn (and/or inhalation injury) drives an
inflammatory response that leads to capillary leak.
• Continuation of fluid volumes should depend on the
time since injury, urine output, and mean arterial
pressure (MAP).
20. Resuscitation
Other adjuncts
• High-dose ascorbic acid (vitamin C) may decrease
fluid volume requirements and ameliorate
respiratory embarrassment during resuscitation.
• Plasmapheresis may also decrease fluid
requirements in patients who require higher
volumes than predicted to maintain adequate urine
output and MAP
21. Transfusion
• A large multicenter study of blood
transfusions in burn patients found that
increased numbers of transfusions were
associated with increased infections and
higher mortality in burn patients, even when
correcting for burn severity.
22. Inhalation Injury and
Ventilator Management
• Inhalation injury decreases lung compliance and
increases airway resistance work of breathing
• Treatment of inhalation injury consists primarily of
supportive care.
• Aggressive pulmonary toilet and routine use of
nebulized bronchodilators such as albuterol are
recommended
• Inhaled nitric oxide may also be useful as a last
effort in burn patients with severe lung injury who
are failing other means of ventilatory support.
23. A classic study by Navar et al :
• burned patients with inhalation injury
required an average of 5.76 mL/kg/% burn,
vs. 3.98 mL/kg/% burn for patients without
inhalation injury, and this has been
corroborated by subsequent studies
24. Treatment of Burn Wound
Exposure method
• Allow daily inspection and any cracks in the eschar are
dressed with Vaseline gauzeor or sofra tulle
• In full thickness burns, exposure end as soon as the
eschar is broken
Dressing
• Occlusive dressing prevents bacterial contamination,
reduces pain and evaporative fluid loss and increases
the rate of re-epitheliazation.
• Providone-iodine: effective against gram positive
organisms and fungi. It is painful and causes excessive
drying of eschar.
• Honey: Honey prevent bacterial contamination and
promote healing
26. Treatment of Burn Wound
• Early excision and skin grafting - Classically between
3-7 days
• Larger burn – meshed autografted skin
• Areas of cosmetic importance – use nonmeshed sheet
grafts ensure optimal results
• For excision of burns in areas such as the face, eyelids,
or hands, a pressurized water dissector may offer more
precision but is time consuming.
• Xenograft and cadaveric graft function as well as
allograft for temporary wound coverage.
• Amniotic Membrane
27.
28. Burn in Specific Areas
Face
• Adequate cleaning of the face, exposure dressing with
antibacterial lotions/ creams.
Neck:
• Exposure treatment is ideal
• Flexion contracture – keep the neck extended by placing
a pillow under the shoulders.
• soft and hard neck collars and fabricated splints can be
use later
• Circumferential burn can form a tourniquet effect as the
edema progresses.
• Escharotomies are rarely needed within the first 8 hours
following injury and should not be performed unless
indicated
29.
30.
31. Burn in Specific Areas
• Axillae:
• Keep the arm in abduction.
• bulky axillary dressings are useful.
• Negative pressure wound therapy (NPWT), may benefit
patient requiring excision and grafting.
• Crucifix splint may be used in children
The Hands:
• dressed the fingers and the web spaces separately with
Vaseline gauze.
• Splint wrist in extension, Metacarpophalangeal joint and
90 degree flexion, interphalangeal joint in extension
32. Burn in Specific Areas
Perinerum
• Treated by exposure
• In children gallows splint ensures adequate
immobilization and exposure.
• Adults are nursed in supine position with the hip
joints in abduction.
The legs and feet: These must be elevated to
encourage venous drainage.
33. Nutrition
• Nutritional support may be more important in
patients with large burns than in any other patient
population
• Adjuncts such as metoclopramide promote
gastrointestinal motility.
• if other measures for gastric feeding are
unsuccessful, advancing the tube into the small
bowel with nasojejunal feeding can be attempted.
34. Nutrition
• Harris-Benedict equation, is a commonly used
formula in nonburned population.
• The Harris-Benedict equation may be inaccurate in
burns of less than 40% TBSA, and in these patients,
the Curreri formula may be more appropriate.
• This formula estimates caloric needs to be 25
kcal/kg/d plus 40 kcal/%TBSA/d.
35. Nutrition
• β-Blocker use in pediatric patients decreases heart rate
and resting energy expenditure
• There may be benefits to β-blockade in adult patients.
• Insulin may have a metabolic benefit in burn patients
• Oral hypoglycemic and prevent hyperglycemia and
prevent muscle catabolism.
• A recent double-blind, randomized study of
oxandrolone showed decreased length of stay, improved
hepatic protein synthesis, and no adverse effects on
endocrine function,
36. Causes of death in burn patients
• Hypovolaemic shock in the
first 48 hours.
Renal failure
• (i) Pre-renal from
hypovolaemia .
• (ii) Acute tubular necrosis from
myogtobinuria or
hemoglobinuria
• Sepsis may be a local infection
or septicemia often with
endotoxic shock.
• Tetanus may also occur.
Respiratory tract infection
accounts for 50 % of bum
sepsis and 50% of deaths.
• Pulmonary problems: Laryngo-
tracheo-bronchitis, laryngeal
oedema, pulmonary oedema,
pneumonia
• Some studies have reported an
incidence of over 50% of multi-
Organ failure in deaths after bum
injury.
38. Complications
• Late complications of burns are usually related to
consequences of poor healing of the burn wound and
include
• Unstable scars and chronic burn wounds.
• Burn scar hypertrophy and Keloids
• Burn scar contractures and deformities
• Dyschromic scars (hypo-, hyper-, & de-pigmentation)
• Bum Scar metaplasia and Marjolin's ulcers
• Loss of body parts.
• Psychiatric problems including PTSD
39. Rehabilitation
• Patients should be taught exercises they can do
themselves to maintain full range of motion.
• Psychological rehabilitation is equally important in
the burn patient.
• Depression, posttraumatic stress disorder, concerns
about image, and anxiety are essential.
40. Radiation
• Radioactive material results in both acute injury from
immediate exposure and more prolonged injury from
delayed exposure to radioactive fallout or
contamination.
• The explosion results in a direct pressure wave and an
indirect wind drag
• After initial evaluation and decontamination by
removing clothing, a useful way to estimate exposure is
by determining the time to emesis.
• Patients who do not experience emesis within 4 hours of
exposure are unlikely to have severe clinical effects.
41. • Irrigation fluid should be collected to prevent
radiation spread into the water supply.
42. Prevention
•Burns is preventable, the common
denominator in most instances being
ignorance, carelessness and poverty
•Smoke alarms are known to decrease
mortality from structural fires.
Unexpected neurologic symptoms should raise the level of suspicion, and an arterial carboxyhemoglobin level must be obtained because pulse oximetry can be falsely
elevated.
100% oxygen reduces the half-life of CO from 250 minutes in room air to 40 to 60 minutes
Cyanide inhibits cytochrome oxidase, which is required for oxidative phosphorylation.15
Late complications, may arise several months or years after the accident.
(i) Cataract especially when the head is a contact point. (ii) Spinal cord transecuon leading to paraplegia or quadriplegia, Abnormal gait, impotence, bladder dysfunction a
(iv) Convulsion, (v) Intractable headache, (vi) Deformities.
Offending agents can be systemically absorbed and may cause specific metabolic derangements.
1st degree burn Tender, Blanches under pressure, Possible swelling, no blisters,
2nd degree burn Moist, shiny Painful, Blisters may be present
3rd degree burn May bleed from vessel damage, Painless, Hair pulls out easily, Require grafting
The zone of coagulation is the most severely burned portion and is typically in the center of the wound
of early bum wound excision and closure with skin or its substitute that has played the most pivotal rote in the survival
of the burned patient mitant illness make the outlook worse. Outcome is also worse at the extremes of age ( < 3 years and > 60 years) and those with severe base deficit
in the first 24 hou
The concept behind continuous fluid requirements is simple. The burn (and/or inhalation injury) drives an inflammatory response that leads to capillary leak; as plasma leaks into the extravascular space, crystalloid administration maintains the intravascular volume
Children they do not have sufficient glycogen stores to maintain an adequate glucose level in response to the inflammatory response.
Inhalation injury and pneumonia combined increases mortality by up to 60% over burns alone.
Smoke inhalation causes injury in two ways: by direct heat injury to the upper airways and inhalation of combustion products into the lower airways.
increased fluid requirement during resuscitation most common
eliminates pain from multiple dressing changes, reduces infection and allows the patient to be mobilized more rapidly.
The strategy of early excision and grafting in burned patients revolutionized survival outcomes in burn care
Not only did it improve mortality, but early excision also decreased
Nursing the patient in a recliner with elevation at 30 to 45 degrees head-up facilitates resolution of the edema over a few days.
Warning signs of impending compartment syndrome may include paresthesias, pain, decreased capillary refill, and progression to loss of distal pulses; in an intubated patient,
Digital escharotomies do not usually result in any meaningful salvage of functional tissue and are not recommended
The fingers must be observed for adequacy of circulation
The limbs must be elevated and physical and occupational hand therapy started immediately.