Pythran is a tool that can be used to accelerate SciPy kernels by transpiling pure Python and NumPy code into efficient C++. SciPy developers have started using Pythran for some computationally intensive kernels, finding it easier to write fast code with than alternatives like Cython or Numba. Initial integration into the SciPy build process has gone smoothly. Ongoing work includes porting more kernels to Pythran and exploring combining it with CuPy for fast CPU and GPU code generation.