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Breast Pathology
Introduction
Modified sweat glands.
Lobes and lobules of gland in fat tissue stroma.
Ducts emerge from acini of glands
Smaller ducts join to form lactiferous ducts
Lactiferous ducts merge just beneath the nipple to form a
lactiferous sinus.
Then individually open on nipple
LOBULE
► The nipple & areola is covered by stratified squamous
epithelium
► Numerous areolar glands (of Montgomery) become prominent
during pregnancy & function in nipple lubrication
► The squamous epithelium continuous into duct orifice and then
abruptly changes to double layered cuboidal epithelium
► A low flattened layer of contractile cells containing
myofilaments (myoepithelial cells) lie beneath the epithelium
Anatomy and histology
► The majority of the breast stroma consists of dense fibro-
connective tissue admixed with adipose tissue (interlobular
stroma) containing elastic fibers supporting the large ducts
► Lobules are enclosed by a breast specific hormonally responsive
loose, delicate myxomatous stroma ( intralobular stroma)
Anatomy and histology
One single ACINUS
(alveolus)
Epithelial cells
MYO-epithelial cells
Secretory epithelium
a. Changes with hormonal signals
b. Onset of menstruation
c. Pregnancy (glands begin to enlarge at
2nd month)
d. After birth, 1st secretion is colostrom
(contain antibodies)
e. after cessation of lactation
Anatomy and histology
50-50%
A. Numerous enlarged and dilated with minimal intervening stroma. B. Higher power
view: prominent epithelial cell enlargement, cytoplasmic vacuolization, and protrusion of
cells into the acinar lumen. Some of the cells have a hobnail appearance. Myoepithelial
cells are inconspicuous.
Postmenopausal breast tissue. A. This sample consists primarily of fatty stroma
with a few atrophic ductules. B. a few residual, atrophic lobular acini are evident
in a fibrotic stroma, which has replaced the normal, loose intralobular stroma.
► “Tail of Spence” = axillary tail
a. prolongation of upper, outer quadrant in
axillary direction ( along the milk line course)
b. Passes under axillary fascia
c. May be mistaken for axillary lymph nodes
► Fatty Tissue: surrounds surface, fills spaces between
lobes
a. Determines form & size of breast
b. No fatty deposit under nipple &
areola
Anatomy and histology
Thank you

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Breast introduction 1

  • 2. Introduction Modified sweat glands. Lobes and lobules of gland in fat tissue stroma. Ducts emerge from acini of glands Smaller ducts join to form lactiferous ducts Lactiferous ducts merge just beneath the nipple to form a lactiferous sinus. Then individually open on nipple
  • 3.
  • 4.
  • 5.
  • 7.
  • 8. ► The nipple & areola is covered by stratified squamous epithelium ► Numerous areolar glands (of Montgomery) become prominent during pregnancy & function in nipple lubrication ► The squamous epithelium continuous into duct orifice and then abruptly changes to double layered cuboidal epithelium ► A low flattened layer of contractile cells containing myofilaments (myoepithelial cells) lie beneath the epithelium Anatomy and histology
  • 9. ► The majority of the breast stroma consists of dense fibro- connective tissue admixed with adipose tissue (interlobular stroma) containing elastic fibers supporting the large ducts ► Lobules are enclosed by a breast specific hormonally responsive loose, delicate myxomatous stroma ( intralobular stroma) Anatomy and histology
  • 10.
  • 11. One single ACINUS (alveolus) Epithelial cells MYO-epithelial cells
  • 12. Secretory epithelium a. Changes with hormonal signals b. Onset of menstruation c. Pregnancy (glands begin to enlarge at 2nd month) d. After birth, 1st secretion is colostrom (contain antibodies) e. after cessation of lactation Anatomy and histology
  • 14. A. Numerous enlarged and dilated with minimal intervening stroma. B. Higher power view: prominent epithelial cell enlargement, cytoplasmic vacuolization, and protrusion of cells into the acinar lumen. Some of the cells have a hobnail appearance. Myoepithelial cells are inconspicuous.
  • 15. Postmenopausal breast tissue. A. This sample consists primarily of fatty stroma with a few atrophic ductules. B. a few residual, atrophic lobular acini are evident in a fibrotic stroma, which has replaced the normal, loose intralobular stroma.
  • 16. ► “Tail of Spence” = axillary tail a. prolongation of upper, outer quadrant in axillary direction ( along the milk line course) b. Passes under axillary fascia c. May be mistaken for axillary lymph nodes ► Fatty Tissue: surrounds surface, fills spaces between lobes a. Determines form & size of breast b. No fatty deposit under nipple & areola Anatomy and histology
  • 17.
  • 18.
  • 19.