This document discusses Breakthrough Breast Cancer's efforts to expand their major donor database. It outlines their past, present, and future approach to major giving. It identifies six focal areas for developing their pool of high value donors: strategy, culture, identifying prospects, prioritizing prospects, tracking progress, and using their database effectively. Specific tips are provided on profiling prospects, screening existing donor data, creating metrics to measure success, and conducting prospect research. Useful online resources for fundraising and research are also listed.