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- 1. WHO GLIOBLASTOMAs L v S s IDHWilDType IDHMutant Nos EPITHELOID u JOINS tog GianiCeu GlioSAR v GlioblasyoMA GOMA GLIOBLASTOMA IPRimitive NEURONAL VUNDERUMBRELLA OF COMPONENT IDHUILDMPEGl.io BLAST Previously LOFIENHARBOUR Klas GLIOBLASTOMAIPNET like BRAEVbooEMUTATION COMPONENT Histology 7 HOMERWRIGHTROSSETTE GAINOFSYNAMOPHYSIN v lossOFGFAPEXPRESSION TENDENCY OFCRANIOSPINALFLUID Dissemination
- 2. liaoDEND.RO GLIOMAS FOR DIAGNOSIS of a OliaoDENDRo Glioma ANAPLASTIC oligo DENDRA GLIOMA Is IDHFamilyMuy Arion 1 WHOLEARM Loss OFIp 199 IN ABSENCE Of DELETIONS MUTANTR13211IDHI IDO SEQUENCING OFID HIGDON1322172 1 ABSENCE OF THESE Facilities 1 Typical OliaoDENDRo GLIOMA SHOULD BE 1DIAGNOSE Nos THESE Tumours Histologic Aly Mimics Pilocytic AstRocytomA DYSEMBRYO Plastic Neuro ERM7 CLEAR CELL EPENDY MoMA
- 3. PEDIATRIC Diffuse GLIOMAS I DiffuseGrowth Midlinelocation ThalamusBrainstem spinal Cord CHARACTERIZE By 113 K2t Mutation to DIFFUSEMIDLINEGLIOMA NEURONAL MIXEDNEURONAL GLIAL Tumors 1 a DiffuseLEPIO MENINGEAL NEW MULTI NODULAR GlioNEURONAL TUMOR VACULATED TUMOR OFCEREBRUM S 1004 0 BRAF Fusion tnt Deletionof chromosomealumIp
- 4. EMBROYONALTumors CiaMcAmplification s PRESENT APSEN7 1 I EMBRoyNAl7 tMULTILAYER ROSETTE FUMORI Histology OF ElAN7R IFHistology TMR ETMR MEDULLOERTHELIOM I I DIAGNOSEAs Diasgnas ers I t EMBYONALT Nos MEDULCOEPITHELIOMA Atypical TERATOIDIRHABDOIDTumor 1 Molecular AlienationMustleepresent IEICHER INI I om BRGI NERVESHEATHTumors MENINGIOMAS i GRADE I GRADETIOM L ATYPICAL MPNST MPNSTIPERINEURAL I f EPITHELOIDYPE DIFFERENRIMION BRAINInvasion BRAINInvasion Mitotic Count Of4 oh Moree MPNST MALIGNANT PERIPHERALNERVE SHEATH TUMOR
- 5. SOLITARY FIBROUS TUMOR HEMAN Gio PERICYTOMA I SHARE 7 INVERSIONOF12913 fusing NAB2ESTA 764 ENES NOWDIVIDEDINTO GRADES GRADE 1 GRADE GRADE LESS CELLULAR MORECELLULAR 5onMoneMitosis HIGHLYCollaaenous less Callagenous PenloHPf
- 6. LOW GRADE GLIOMA CLASSIFIED Ab PilocyeicASTRO 410mA WHO GRADE I om Il INCLUDE SUB EPENDYMAL Giggs hey PiloMyxoidASTROCYTOMA Diff ASTROCYTOMA MIC Mutarion Ras MAPKSignal PATWAY a t v t NF 1 SOMEHAVEPointy Mutation IN NON NFL PATIENTS Imagination rFUSION OF RasGTPase BRAFVGOOLE BRAE Protein 1 RIAA1549 LEADS10 Activation of Rasparaway I Acriume I Result OpticPatwayTumor MAPK R3K m7oR Result loss ofBRAE Paveway REUNION PFS 104193 POOR Survival AFTER cyme 274 ORRT BRUH DABRAFENIB SUBEPENDYMAL GIANT CELLASTROCYTOMA If.figiyoREvER0liMvs
- 7. PEDIATRIC HIGHGRADE Gliomas 10144 I GBM WHO GRADE II ANAPLASTIC AserocytomA WHOGRADE TI GlioMAstosis CEREBRI Diffuse Intrinsic PONTINE Gliomas IDHI MUTATION RARE IN YOUNG CHILDREN MORE COMMON LATEADOLESCENCE ADULTHARBOUR PEDIATRICS t t 19132MUTATION NON R132Muraniow 664 ofPts K27M MUTANT DIFFUSE MIDLINE GLIOMA DIFFUSE Intrinsic PONTINE Glioma IPI INFANT HIGHGRADE Gliomas Classification Alc70MARKERS V V ALR ROSI NIRK Ras MAPKDRIVENMIDIINERoslmn.PK iffy 53.8 1 254 4294 looyegary 933 Spying 223.4t
- 8. BiAllelic Mismmen REPAIRDEFICIENCY HianGRADEGliomas MUTATION DMMRD DRUG NivolumAB MONOCLONAL ANTIBODY PDIRECEMOR
- 11. MEDULLOBLASTOMA Age73 9yrs WNT ARISE FROM BRAINSTEM SHH ARISE FROM GRANULAR LAYER OF CEREBELLUM GROUP 4 Unipolar BRUSHIELLS DRUG VisMODEaib PHASE1 TRIAL SHH Stay 11 EXCELLENT OUTCOMES SHH a VERY HIGHRiskDISEASE
- 12. POORPROGNOSIS GROUP 37 goy.gs At 5YEARS L V S Be 3 3 37 PoorPROGNOSIS GROUP 4 LACK OFGadoliniumENHANCE of 0N MRI v s un up 4y PROGNOSIS BASED ON MOLEGULAR MARKERS UNI GROUP NONMETASTATIC GROUP 4 I WHOLE CHROMOSOME 11loss 04WHOLE CHROMOSOME 17GAIN a LowRiskGroup 790Survivor HIGHRisk DISEASE Patients With METASTATICSHH04GROUP 4Tomo o 75 Survival VERYHighRisk MYC AMPLIFIED GRouP3IME7AseAeicDisEAs 5oy.fu Ruin oh SHHTumors WITH 71953Mutation
- 13. EMBRYONAL TUMORS TERM PNEI REMOVED NEW ADDED E7MR 49 MC ALTERED TUMORS CONTAINS EMBRYONAL TUMOR WITH ABUDANT NEURO Phil MEDULLO EPITHELIOMA TRUEROSETTES EPENDYMOBIASTOMA PNET DESCRIBED IN FOURNEW CNS types 2 CNS NEUROBLASTOMA GNSEWING CNSHigy I FoxRz AGNATION SARCOMAICICAHERATION GRADENEURO Epithelial TUMORIMNIALTERN CNS HIGH GRADE7 I BCOR ALTERATION A
- 14. AIypical TERATOID RHABDoiD TUMOR TRD SEEN IN YOUNG CHILDREN TYPES BuypunpuetnisMMAlion AIM AIM ATRI SMAREBYE TYRTUMORS SHHTumors NYC SMARCBIloss of FUNCTION INFRAIENIORIAL SUPRATENTORIAL SUPRATENTORIAL INFRATENTORIAL O 1yR OLDER CHILDREN