Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.[10] High blood pressure usually does not cause symptoms.[1] Long-term high blood pressure, however, is a major risk factor for coronary artery disease, stroke, heart failure, atrial fibrillation, peripheral vascular disease, vision loss, chronic kidney disease, and dementia
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.[10] High blood pressure usually does not cause symptoms.[1] Long-term high blood pressure, however, is a major risk factor for coronary artery disease, stroke, heart failure, atrial fibrillation, peripheral vascular disease, vision loss, chronic kidney disease, and dementia
Incidence and Epidemiology of Cardiovascular Disease: Doug Levy
Presentation by Lee Goldman, MD, at TCT 2011 conference. Goldman is dean of the faculties of health sciences and medicine and executive vice president of Columbia University Medical Center. For more information, go to http://cumc.columbia.edu/newsroom or call 212-305-3900.
MLB players have lower mortality rates than the general populationΔρ. Γιώργος K. Κασάπης
As researchers try to understand the long-term impact of playing professional sports, a new study finds that major league baseball players tended to fare better than the general population. Other studies have found, for instance, that MLB players also tend to have better health outcomes than professional football players, possibly because NFL players also tend to weigh more. Looking at data from nearly 10,500 players from 1906 through 2006, scientists found that compared to the general U.S. male population, MLB players had significantly lower rates of death. A longer career meant lower rates of death from overall causes, but was associated with higher rates of cancer deaths. Playing baseball professionally requires athletes to be in good physical health, but more research is needed to better understand the study's findings.
Coronary Artery Disease and Menopause: A Consequence of Adverse Lipid Changesiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Incidence and Epidemiology of Cardiovascular Disease: Doug Levy
Presentation by Lee Goldman, MD, at TCT 2011 conference. Goldman is dean of the faculties of health sciences and medicine and executive vice president of Columbia University Medical Center. For more information, go to http://cumc.columbia.edu/newsroom or call 212-305-3900.
MLB players have lower mortality rates than the general populationΔρ. Γιώργος K. Κασάπης
As researchers try to understand the long-term impact of playing professional sports, a new study finds that major league baseball players tended to fare better than the general population. Other studies have found, for instance, that MLB players also tend to have better health outcomes than professional football players, possibly because NFL players also tend to weigh more. Looking at data from nearly 10,500 players from 1906 through 2006, scientists found that compared to the general U.S. male population, MLB players had significantly lower rates of death. A longer career meant lower rates of death from overall causes, but was associated with higher rates of cancer deaths. Playing baseball professionally requires athletes to be in good physical health, but more research is needed to better understand the study's findings.
Coronary Artery Disease and Menopause: A Consequence of Adverse Lipid Changesiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Ascending aortic aneurysm and its clinical significance: A case reportApollo Hospitals
Aorta, the major conductance vessel of the body, can be affected by a variety of pathologic processes leading to aneurysm, dissection, or ischemic syndromes. There has been a drastic increase in the incidence of aortic aneurysm making it the 18th most common cause for death.
When ignored, the patients’ condition might worsen leading to death due to rupture and hemorrhage. Here we report a case of ascending aortic aneurysm affecting the aortic root and proximal part of ascending aorta. Conscious awareness of this pathological process augments a great deal to radiologists and sonographers during various imaging techniques and rescues the patient from aneurysm-related deaths.
Notes and references alan moelleken md lawsuit terms cottage hospital santa b...Alan Moelleken
These documents are for inquiry into medical terms. They are basic and do not represent the expanding knowledge of medical terms, anti-trust, jury lawsuits, trial cases and legal and medical case law in courts.
Join Doc Andrew to see the research that supports plant based diet recommendations. Address common misconceptions. Ask questions @DenverWWAD or join current discussions at #PlantBased, #PlantBasedRx, or #CulinaryRx.
Also, enjoy bonus learning with these topic-related, 2-minute podcasts by Dr. Andrew:
"The Plant Based Diet and How to Get Started"
https://soundcloud.com/denverwwad/healthcast-23
"Eat Your Way to the Finish Line"
https://soundcloud.com/denverwwad/healthcast-4
Andrew Freeman, MD, FACC, FACP is a cardiologist and Assistant Professor of Medicine at National Jewish Health, Denver, Colorado. He is part of the leadership of both the local and national American College of Cardiology.
Dr. Freeman founded the Denver chapter of the Walk with a Doc program and is the leader of Walk with a Doc-Colorado.
Walk with a Doc-Denver is a free health improvement and community empowerment initiative. Local doctors and a team of healthcare professionals--all volunteers--host Saturday walks that include expert talks, health screenings, refreshments, and motivational giveaways. For more info visit: Denver.WalkWithADoc.org
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
3. Braverman A. C., Schermerhorn M. (2019), Braunwald’s
Heart Disease: A Textbook Of Cardiovascular Medicine,
Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
• Aortic root = aortic valve sinotubular junction
• Aortic isthmus = aortic arch joins descending aorta (~
ligamentum arteriosum): vulnerable to deceleration
trauma transition between ascending aorta (mobile)
and arch, descending aorta (relatively fixed)
• Abdominal aorta normally < diameter than thoracic
4. Creager M. A., Loscalzo J. (2018), Harrison's Principles of Internal Medicine, J. Larry Jameson, et al., Editors, McGraw-Hill, pp. 1917-1923
5. Lang R. M., Goldstein S. A., Kronzon I., et al. (2016), "ASE’s Comprehensive
Echocardiography", Elsevier
6. Otto C. M., Schwaegler R. G., Freeman R. V. (2016), Echocardiography Review Guide Companion To The Textbook Of Clinical Echocardiography, Elsevier, pp. 334-354
7. Armstrong W. F., Ryan T. (2019), Feigenbaum’s Echocardiography, Wolters Kluwer
8. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart,
Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
(in IMH, the D-dimer may not be elevated)
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AORTIC ANEURYSMS
PHUNG HUY HOANG, MD MSc
A p r i l 2 0 2 0
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OVERVIEW
• Aneurysm (Greek aneurysma) = a pathologic dilation of a segment of a blood vessel
• ≠ Ectasia: modest generalized dilation and elongation of the aorta that occurs with aging1
• 2nd most frequent disease of the aorta after atherosclerosis1
• 19th most common cause of death, 15th most common in those older than 652
• Abnormal aortic dilation = in diameter ≥ 50% (x1.5) than expected for same segment in
unaffected individuals of same age and sex3
• Discription = size, location, morphology, cause
• Thoracoabdominal aortic aneurysm (3-10%): descending thoracic aneurysms extending
distally to involve the abdominal aorta4
1. Goldstein S. A., Evangelista A., Abbara S., et al. (2015), J Am Soc Echocardiogr, 28 (2), pp. 119-82
2. National Center for Injury Prevention and Control. WISQARS leading causes of death reports, 1999–2007. 2015
3. Karthikesalingam A., Bahia S. S., Patterson B. O., et al. (2013), Eur J Vasc Endovasc Surg, 46 (5), pp. 533-41
4. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
11. Teo E. P., Isselbacher E. M. (2019), Essential Echocardiography A Companion To Braunwald’s
Heart Disease, Scott D. Solomon, Justina C. Wu, Linda D. Gillam, Editors, pp. 354-369
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• Fusiform: more common, symmetrically dilated with involvement of the entire aortic
circumference.
• Saccular: focal outpouching, intact but dilated aortic wall involving all layers
• Pseudoaneurysms (“false” aneurysms): bleeding contained periaortic hematoma in
continuity with the aortic lumen.
13. Teo E. P., Isselbacher E. M. (2019), Essential Echocardiography A Companion To Braunwald’s
Heart Disease, Scott D. Solomon, Justina C. Wu, Linda D. Gillam, Editors, pp. 354-369
14. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
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OVERVIEW
• risk of cardiovascular events (mostly unrelated to aneurysm): common risk factors (e.g.
smoking or hypertension), pathways (e.g. inflammation) // risk of cardiovascular
comorbidities at the time of aneurysm diagnosis
• Aortic aneurysm identified at any location assessment entire aorta and aortic valve at
baseline and during follow-up (I-C)
Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
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PATHOPHYSIOLOGY
• Chronic aortic wall inflammation
• Increased local expression of proteinases
• Degradation of structural connective tissue proteins
17. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
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ABDOMINAL
AORTIC ANEURYSM
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ABDOMINAL AORTIC ANEURYSM (AAA)
Overview
• Abdominal aorta ≥ 3.0 cm in diameter1
• Most common form of aortic aneurysms2,5
• Most AAAs (>80-90%): infrarenal aorta2,5, most small AAA5
• 10%: may involve pararenal or visceral aorta extend into thoracoabdominal segment2
• Strongly associated with: age (most occurring ≥ 60 years), male (x5), cigarette smoking,
emphysema, hypertension, hyperlipidemia, diabetes, family history (20%) 2,3.4,5
• Coexisting thoracic aortic aneurysm (25%), iliac and popliteal aneurysms4
1. Moll F. L., Powell J. T., Fraedrich G., et al. (2011), Eur J Vasc Endovasc Surg, 41 Suppl 1, pp. S1-S58
2. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
3. Chaikof E. L., Brewster D. C., Dalman R. L., et al. (2009), J Vasc Surg, 50 (4 Suppl), pp. S2-49
4. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
5. Shah J., Braverman A. C. (2009), The Washington Manual Cardiology Subspeciatly Consult, Phillip S. Cuculich, Andrew M. Kates, Thomas M. De Fer, Editors, Wolters Kluwer, pp.
497-518.
20. Lederle F. A. (2016), Goldman-Cecil Medicine, Lee Goldman , Andrew I. Schafer, Editors, Elsevier Saunders, pp. 492-497
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ABDOMINAL AORTIC ANEURYSM (AAA)
Clinical features
• Develop insidiously over several years (0.2 to 0.3 cm/year, as aortic diameter )1
• Back or abdominal pain: most common presenting symptom (severe, abrupt in onset, with
describing a ripping or tearing pain)
• Symptoms rarely, except:
• Distal thromboembolism (from mural thrombi, 2-5%)
• Rapid expansion
• Impending rupture, or rupture
• Physical examination
• Insensitive in detecting (30-40%)2
• Abdominal palpation: pulsatile epigastric or periumbilical mass
1. Moll F. L., Powell J. T., Fraedrich G., et al. (2011), Eur J Vasc Endovasc Surg, 41 Suppl 1, pp. S1-S58
2. Chaikof E. L., Brewster D. C., Dalman R. L., et al. (2009), J Vasc Surg, 50 (4 Suppl), pp. S2-49
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ABDOMINAL AORTIC ANEURYSM (AAA)
Clinical features
• Predicting rupture
• Aneurysm diameter (most important), wall tension, wall stiffness, peak wall stress
• Female > male at same diameter
• RUPTURE INTO
• Peritoneal cavity: acute hemorrhage, severe abdominal pain, hypotension
• Retroperitoneum: temporarily contained periaortic hematoma (± Cullen, Grey Turner sign,
iliopsoas sign, compress the femoral nerve), severe abdominal or back pain may radiate to
flank or groin
• Aortoenteric fistulas (unexplained, high volume GI bleeding)
• Aortovenous fistulas (cause high-output HF, leg swelling)
• Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
• Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
• Prince L. A., Johnson G. A. (2016), Tintinalli’s Emergency Medicine A Comprehensive Study Guide, Judith E. Tintinalli, et al., Editors, McGraw Hill, pp. 416-420
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ABDOMINAL AORTIC ANEURYSM (AAA)
Diagnostic imaging
• US
• Can detect AAAs with high accuracy (> 90%) + inexpensive, noninvasive, avoids
radiation and contrast agents preferred over CT in screening CT
• CT, MRI
• Detect and measurement of aneurysm diameter accurately
• Useful in demonstrating relationship of AAA to renal, visceral, iliac arteries + patterns of
mural thrombus, calcifcation, or coexisting occlusive atherosclerosis influence AAA
repair
• Aassess AAA variants (inflammatory AAAs, mycotic aneurysms)
24. Prince L. A., Johnson G. A. (2016), Tintinalli’s Emergency Medicine A Comprehensive Study Guide, Judith E. Tintinalli, et al., Editors, McGraw Hill, pp. 416-420
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ABDOMINAL AORTIC ANEURYSM (AAA)
Treatment indications
• Small AAA < 5.5cm and slow growth (<1cm/y): can be observed safely = imaging surveillance
(various sizes strategy)3,4
• Smoking cessation (slow growth)
• Control hypertension
• Statins and ACE-inhibitors may be considered (IIb-B) ( aortic complications in small AAA)3,4
• REPAIR INDICATIONS (individualize!)
• Asymptomatic, >5.0-5.5 cm in diameter
• Symptomatic of any size
• Rapid growth (>1 cm/yr)
1. Moll F. L., Powell J. T., Fraedrich G., et al. (2011), Eur J Vasc Endovasc Surg, 41 Suppl 1, pp. S1-S58
2. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
3. Chaikof E. L., Brewster D. C., Dalman R. L., et al. (2009), J Vasc Surg, 50 (4 Suppl), pp. S2-49
4. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
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ABDOMINAL AORTIC ANEURYSM (AAA)
Treatment
Size (cm) Interval
2.5-2.9 7y
3.0-3.9 3y
4.0-4.9 12m
5.0-5.4 6m
1. Chaikof E. L., Brewster D. C., Dalman R. L., et al. (2009), J Vasc Surg, 50 (4 Suppl), pp. S2-49
2. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
Size (cm) Interval
2.5-2.9 4y
3.0-3.9 3y
4.0-4.4 2y
> 4.5 1y
SVS 2009 ESC 2014
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ABDOMINAL AORTIC ANEURYSM (AAA)
Screening
• Most frequent mode of detection: incidental
• Screening = ultrasound + repair of AAAs > size threshold reduced AAA-related deaths
• SVS (2009): recommends a one-time screening for AAAs in all men and women 65 or older
with a history of tobacco use or a family history of AAA1
• ESC (2014)2
• Recommended in all men >65 yo (I-A)
• Considered in women >65 yo + history of current/past smoking (IIb-C)
• NOT recommended in female nonsmokers without familial history (III-C)
• Considered in first-degree siblings of a patient with AAA (IIa-B)
• Duplex ultrasound for screening of peripheral artery disease and peripheral aneurysms (IIa-
C)21. Chaikof E. L., Brewster D. C., Dalman R. L., et al. (2009), J Vasc Surg, 50 (4 Suppl), pp. S2-49
2. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
28. Bertino R. E., Mustafaraj E. (2018), Diagnostic Ultrasound, Carol M. Rumack , Deborah Levine, Editors, Elsevier, pp. 432-470
29. Bertino R. E., Mustafaraj E. (2018), Diagnostic Ultrasound, Carol M. Rumack , Deborah Levine, Editors, Elsevier, pp. 432-470
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ABDOMINAL AORTIC ANEURYSM (AAA)
Prognosis
• 30-50% of ruptured AAAs die before hospitalization
• An additional 30-40% die after reaching a hospital but before treatment
• Operative mortality rate for open surgical repair after AAA rupture: 40-50%, may be lower
with EVAR
• Moll F. L., Powell J. T., Fraedrich G., et al. (2011), Eur J Vasc Endovasc Surg, 41 Suppl 1, pp. S1-S58
• Chaikof E. L., Brewster D. C., Dalman R. L., et al. (2009), J Vasc Surg, 50 (4 Suppl), pp. S2-49
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THORACIC
AORTIC ANEURYSM
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THORACIC AORTIC ANEURYSM (TAA)
Overview
• Cause, natural history, treatment vary ∈ location of TAA
• Prevalence1:
• Aortic root or ascending aortic: most common (60%)
• Descending aorta (35%)
• Aortic arch (<10%)
• Majority descending TAA: atherosclerotic2
1. Goldstein S. A., Evangelista A., Abbara S., et al. (2015), J Am Soc Echocardiogr, 28 (2), pp. 119-82
2. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
33. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
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THORACIC AORTIC ANEURYSM (TAA)
Pathogenesis
CAUSES OF TAAS
• Heritable disorders
• Genetic (congenital) disorders
• Degenerative (“atherosclerotic”)
• Mechanical
• Inflammatory infectious diseases
(syphilis and aortitis)
Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp.
1295-1327
RISK FACTORS FOR TAAS
• Smoking
• Hypertension
• Age
• COPD
• CAD
• Family history
35. Shah J., Braverman A. C. (2009), The Washington Manual Cardiology Subspeciatly Consult, Phillip S. Cuculich, Andrew M. Kates, Thomas M. De Fer, Editors, Wolters Kluwer, pp. 497-
518
36. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
37. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
38. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
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THORACIC AORTIC ANEURYSM (TAA)
Manifestation
• Most TAAs: asymptomatic, discovered incidentally
• Suggested physical findings
• Local mass effect
• obstruction of SVC or innominate vein, trachea, bronchus, esophagus
• persistent chest or back pain (compression of intrathoracic structures or erosion into
bone)
• Progressive AR
• Systemic embolization (caused by mural thrombus or atheroembolism)
• Infected TAAs ~ pain, fever, and fistulas
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THORACIC AORTIC ANEURYSM (TAA)
Manifestation
• Most serious complications
• Dissection (more common)
• Rupture
• Rupture into
• Pleural cavity (usually left) or into the mediastinum: hypotension
• Esophagus: hematemesis
• Bronchus or trachea: hemoptysis
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THORACIC AORTIC ANEURYSM (TAA)
Diagnosis
• Chest radiographs
• Widened mediastinum, prominent aortic knob, displaced trachea
• Small TAA; Aneurysms involving sinuses of Valsalva and aortic root may not be seen
• TTE: sinuses of Valsalva and often the proximal ascending aorta, aortic arch, and proximal
descending aorta
• TEE: can image most of the thoracic aorta (a small blind spot/ mid-high ascending)
• Contrast-enhanced CT and MRA: provide outstanding detail of aortic and branch vessel
anatomy in TAA disease
Echocardiogram: generally measures internal diameter ≠ CT, MRI measure external diameter
(expected to be 0.2-0.4 cm > internal diameter*,**)
* Goldstein S. A., Evangelista A., Abbara S., et al. (2015), J Am Soc Echocardiogr, 28 (2), pp. 119-82
** Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), Circulation, 121 (13), pp. e266-369
42. Creager M. A., Loscalzo J. (2018), Harrison's Principles of Internal Medicine, J. Larry Jameson, et al., Editors, McGraw-Hill, pp. 1917-1923
43. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
44. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
45. Click to edit Master title style
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THORACIC AORTIC ANEURYSM (TAA)
Natural history
• Relatively indolent, # 1-2 mm/yr // marked individual variability1,2
• RAPID GROWTH INFLUENCING FACTORS1,2
• MFS, BAV disease > degenerative aneurysms
• Larger aneurysms > smaller ones
• Descending aorta (2 mm/yr) > ascending aorta (1 mm/yr)
• Dissected TAAs > without dissection
• RISK FACTORS FOR RUPTURE OF TAAS3
• Aortic diameter (most important), rapid aneurysm growth, aortic dissection
• Older age, cigarette smoking, underlying diseases (COPD), family history
1. Oladokun D., Patterson B. O., Sobocinski J., et al. (2016), Eur J Vasc Endovasc Surg, 51 (5), pp. 674-81
2. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
3. Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), Circulation, 121 (13), pp. e266-369
46. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
47. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
48. Paradigm of“Guilt by Association”for detection of silent thoracic aortic aneurysms
Elefteriades J. A., Sang A., Kuzmik G., et al. (2015), Open Heart, 2 (1), pp. e000169
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THORACIC AORTIC ANEURYSM (TAA)
Treatment indications
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
3. Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), Circulation, 121 (13), pp. e266-369
Threshold (cm)
Degenerative aneurysm ≥5.5
Bicuspid aortic valve ≥5.5
Bicuspid aortic valve with risk factors or low surgical risk ≥5.0
Bicuspid aortic valve requiring aortic valve replacement >4.5
Marfan syndrome ≥5.0
Marfan syndrome with risk factors >4.5
Loeys-Dietz syndrome 4.0-4.5
Familial thoracic aortic aneurysm syndromes 4.5-5.0
Turner syndrome >2.5 cm/m2
ROOT AND ASCENDING
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THORACIC AORTIC ANEURYSM (TAA)
Treatment indications
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
3. Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), Circulation, 121 (13), pp. e266-369
• Bicuspid aortic valve
• with risk factors = family history of dissection, growth rate ≥ 0.5 cm/yr, coarctation of
the aorta, hypertension, root phenotype
• low surgical risk (<4%)
• Marfan syndrome with risk factors = family history of aortic dissection, rapid aortic growth
(>3 mm/yr), severe AR or MR
• If pregnancy desired, consider prophylactic aortic surgery for aortic diameter of 4.0-4.5
cm
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THORACIC AORTIC ANEURYSM (TAA)
Treatment indications
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
3. Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), Circulation, 121 (13), pp. e266-369
Threshold (cm)
Isolated aortic arch aneurysm ≥5.5
May be considered in patients with aortic arch aneurysm who already have an
indication for surgery of an adjacent aneurysm located in the ascending or
descending aorta
ARCH
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THORACIC AORTIC ANEURYSM (TAA)
Treatment indications
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
3. Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), Circulation, 121 (13), pp. e266-369
Threshold (cm)
TEVAR when anatomy suitable ≥5.5
When TEVAR is not technically possible, surgery should be considered ≥6.0
DESCENDING
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53
Size criteria apply only to
asymptomatic aneurysms!
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THORACIC AORTIC ANEURYSM (TAA)
Prognosis
• < 50% with rupture arrive at the hospital alive
• Mortality at 24 hours reaches 75%
Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp.
1295-1327
55. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
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ACUTE AORTIC SYNDROME
PHUNG HUY HOANG, MD MSc
A p r i l 2 0 2 0
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CLASSIFICATION
Aortic rupture
(Classic) Aortic dissection (80-90%)
Intramural hematoma (IMH) (10-20%)
Penetrating atherosclerotic ulcer (PAU) (5%)
• Creager M. A., Loscalzo J. (2018), Harrison's Principles of Internal Medicine, J. Larry
Jameson, et al., Editors, McGraw-Hill, pp. 1917-1923
• Nienaber C. A., Powell J. T. (2012), Eur Heart J, 33 (1), pp. 26-35b
58. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
59. Mussa F. F., Horton J. D., Moridzadeh R., et al. (2016), JAMA, 316 (7), pp. 754-63
60. Lang R. M., Goldstein S. A., Kronzon I., et al. (2016), "ASE’s Comprehensive Echocardiography", Elsevier
61. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
62. Click to edit Master title style
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CLASSIC AORTIC DISSECTION
63. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
NEW CLASSIFICATION
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AORTIC DISSECTION
Overview
• Intimal disruption dissection plane in media
• May propagate
• Anterograde (or less often retrograde)
• Adventitial disruption may lead to rupture OR distal tear(s) results in blood reentering
aortic lumen (more frequently)
• A very high early mortality1.
• Factors associated with delay in diagnosis: female, transfer from another hospital, fever,
normal BP2
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-
1327
2. Nienaber C. A., Clough R. E. (2015), The Lancet, 385 (9970), pp. 800-811
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AORTIC DISSECTION
Overview
• Age occurrence1
• Type A 50-60 years
• Type B 60-70 years
• Men > women (2:1-5:1)2
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-
1327
2. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
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AORTIC DISSECTION
Pathophysiology
• Hypothesis
• Primary tear/aortic intima blood from aortic lumen penetrating into diseased media
dissection
• Primary rupture of vasa vasorum hemorrhage in aortic wall subsequent intimal
disruption intimal tear
• Malperfusion: dynamic (overpressurized false lumen), static (dissection flap, hematoma,
embolism, or thrombosis stenosis or occlusion), or mixed
• Dissected aorta may NOT be dilated
• Inflammatory response to thrombus/media initiate further necrosis + apoptosis of smooth
muscle cells + degeneration of elastic tissue potentiates risk of medial rupture
• Subsequent aneurysm formation
67. Cotarlan V., Austin J. J. (2015), Principles of Critical Care, Gregory A. Schmidt Jesse B.
Hall, John P. Kress, Editor, McGraw Hill Education, pp. 356-368
68. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of
Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of
Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
69. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
70. Cotarlan V., Austin J. J. (2015), Principles of Critical Care, Gregory A. Schmidt Jesse B.
Hall, John P. Kress, Editor, McGraw Hill Education, pp. 356-368
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AORTIC DISSECTION
Causes and pathogenesis
• 75% of all patients with aortic dissection have hypertension1
• MFS: high risk for aortic root aneurysm and especially type A dissection1,2
• BAV: important risk factor for ascending aortic aneurysm and dissection3
• Late pregnancy or early postpartum period (most have unknown underlying aortopathy)4
• TAA have risk for aortic dissection, with risk for dissection and rupture = aortic diameter, age,
sex, body size, and rate of aortic growth, mechanical and hemodynamic factors5
1. Pape L. A., Awais M., Woznicki E. M., et al. (2015), J Am Coll Cardiol, 66 (4), pp. 350-8
2. Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), Circulation, 121 (13), pp. e266-369
3. Wojnarski C. M., Svensson L. G., Roselli E. E., et al. (2015), Ann Thorac Surg, 100 (5), pp. 1666-73; discussion 1673-4
4. Wanga S., Silversides C., Dore A., et al. (2016), Can J Cardiol, 32 (1), pp. 78-85.
5. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
72. Shah J., Braverman A. C. (2012), The Washington Manual Of Critical Care, Warren Isakow Marin H. Kollef, Editor, Lippincott Williams & Wilkins, pp. 155-162.
73. Click to edit Master title style
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AORTIC DISSECTION
Classification
• Based on location of dissection: 2 major classifcation schemes DeBakey and Stanford
• ∈ risk of sudden death from the dissection, highest in type A1
• Based on duration from symptoms onset
• Occurence1,2
• Ascending 65% (15% of transverse arch and 5% of descending aortic tears will involve the
ascending aorta by retrograde dissection)
• Descending 30%
• Aortic arch < 10%
• Isolated abdominal aortic dissection rare (1%), associated with existing AAA or an iatrogenic
cause
1. Cotarlan V., Austin J. J. (2015), Principles of Critical Care, Gregory A. Schmidt Jesse B. Hall, John P. Kress, Editor, McGraw Hill Education, pp. 356-368
2. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp.
1295-1327
74. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
75. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
• Acute dissections: very high-risk lesions with an estimated mortality for type A of 50% for the
first 48 hours (~1% per hour)
Cotarlan V., Austin J. J. (2015), Principles of Critical Care, Gregory A. Schmidt Jesse B. Hall, John P. Kress, Editor, McGraw Hill Education, pp. 356-368
76. Shah J., Braverman A. C. (2012), The Washington Manual Of Critical Care, Warren Isakow Marin H. Kollef, Editor, Lippincott Williams & Wilkins, pp. 155-162.
77. Click to edit Master title style
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AORTIC DISSECTION
Clinical manifestations
• Abrupt onset of severe chest or back pain (90%)
• Chest pain: more commonly ~ Type A
• Back or abdomen pain: more commonly ~ Type B
• “Painless” aortic dissection in (4-15%) of patients, more common in those with diabetes,
previous aortic aneurysm, prior cardiac surgery1,2
• Blood pressure
• Hypertension
• Hypotension (cardiac tamponade, acute aortic rupture, CHF related to acute severe AR)
• Pseudohypotension (altered arm circulation due to dissection)
• Normotension
1. Hagan P. G., Nienaber C. A., Isselbacher E. M., et al. (2000), JAMA, 283 (7), pp. 897-903
2. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
3. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
4. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
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AORTIC DISSECTION
Clinical manifestations
• Pulse deficits, AR, neurologic manifestations: more characteristic of ascending than
descending dissection2
• Absence NOT RULE OUT!!
1. Hagan P. G., Nienaber C. A., Isselbacher E. M., et al. (2000), JAMA, 283 (7), pp. 897-903
2. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp.
1295-1327
79. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
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AORTIC DISSECTION
Clinical manifestations
• Complications related to the dissection
• HF (<10%) acute AR (incomplete coaptation, aortic leaflet prolapse dissection flap,
extensive or circumferential dehiscing intimal flap into LVOT/diasystole, preexisting AR)
• Syncope (9%) acute hypotension (cardiac tamponade, severe AR, or aortic rupture),
obstruction of a cerebral vessel, or activation of cerebral baroreceptors
• Neurological deficits (6%) persistent or transient ischemic stroke, spinal cord ischemia,
ischemic neuropathy, hypoxic encephalopathy
• Acute MI (10-15%, mostly invole RCA) false lumen or dissection flap compressing coronary
ostium
• Abdominal vascular complications and malperfusion (mesenteric, renal,…)
1. Hagan P. G., Nienaber C. A., Isselbacher E. M., et al. (2000), JAMA, 283 (7), pp. 897-903
2. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp.
1295-1327
81. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of
Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
82. Cotarlan V., Austin J. J. (2015), Principles of Critical Care, Gregory A. Schmidt Jesse B. Hall, John P. Kress, Editor, McGraw Hill Education, pp. 356-368
83. Newby D., Grubb N. (2018), Davidson’s Principles and Practice of Medicine, Stuart H Ralston, et al., Editors, Elsevier, pp. 441-544
84. The mechanisms by which acute aortic dissection cause
death:
• intrapericardial rupture and tamponade
• acute aortic insufficiency
• free rupture into left pleural space
• occlusion of a branch of the aorta
Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster,
et al., Editors, McGraw-Hill, pp. 2157-2194
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AORTIC DISSECTION
Laboratory findings
• CXR
• Abnormal aortic contour or widening of the aortic silhouette in 80% of cases
• Pleural effusions 20%
• Normal chest radiograph CANNOT EXCLUDE presence of aortic dissection1,2
• ECG: nonspecifc, indicate acute complications (myocardial ischemia or infarction, low-voltage
QRS complexes ~ hemopericardium)
• Patients with high probability (risk score 2 or 3) of AD D-dimers not recommended (III-C)3
1. Hagan P. G., Nienaber C. A., Isselbacher E. M., et al. (2000), JAMA, 283 (7), pp. 897-903
2. Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), Circulation, 121 (13), pp. e266-369.
3. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
86. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
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AORTIC DISSECTION
Laboratory findings
• Diagnostic methods: TTE (initial), CECT (1st choice for definitive), MRI, TEE
• In case of initially (-) imaging + persistence of suspicion repetitive imaging (CT or MRI)
is recommended (I-C)
• In case of uncomplicated Type B AD treated medically repeated imaging (CT or MRI)
during 1st days is recommended (I-C)
Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
88. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
89.
90. Ptaszek L. M., Isselbacher E. M., Spooner A. E. (2012), Irwin and Rippe’s Intensive Care Medicine Richard S. Irwin , James M. Rippe, Editors, Wolters Kluwer, pp. 358-373
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AORTIC DISSECTION
Evaluation
• Hemodynamic state
• Pre-test probability
• Choice of imaging diagnostic modality
92. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
93. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
94. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of
Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
95. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
96. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
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AORTIC DISSECTION
Management
Minimize effects of dissection // rapidly evaluating patient’s candidacy for surgical repair, if
indicated
• Medical therapy (ALL PATIENTS)
• Blood pressure control
• Pain relief
• Complications management
• Definitive treatment
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AORTIC DISSECTION
Management
• MEDICAL THERAPY (ALL PATIENTS)
• Blood pressure control
• Reduced to as low a level as possible, target HR # 60 bpm
• Care should be taken to avoid vasodilators, in absence of negative chronotropic
medications (may induce reflex tachycardia dP/dt extend dissection)
• If hypotension persists: pressors of choice = norepinephrine or phenylephrine
• Coacine intoxication: selective beta blockers (esmolol), or mixed agents (labetalol)
(non-selective beta blockers alone unopposed alpha stimulation worsening
hypertension)*
• Pain relief patient comfort, adrenergic tone
*Manning W. J., Blac J. H. (2019), UpToDate
99. Cotarlan V., Austin J. J. (2015), Principles of Critical Care, Gregory A. Schmidt Jesse B. Hall, John P. Kress, Editor, McGraw Hill Education, pp. 356-368
100. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
Use only in presence of beta blocker
101. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp. 2157-2194
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AORTIC DISSECTION
Management
• Medical therapy
• COMPLICATIONS MANAGEMENT*
• Cardiac tamponade
• Urgent pericardiocentesis: may be harmful > beneficial (can precipitate hemodynamic
collapse and death)
• If marked hypotension aspiration of minimum volume of fluid raise BP to lowest
level acceptable
• Definitive treatment (Endovascular therapy, Surgery)
* Nienaber Christoph A., Eagle Kim A. (2003), Circulation, 108 (6), pp. 772-778
103. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
104.
105. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
106. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
107. Mussa F. F., Horton J. D., Moridzadeh R., et al. (2016), JAMA, 316 (7), pp. 754-63
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AORTIC DISSECTION
Follow-up
• Lifestyle modifcations, education
• Control of patient’s blood pressure
• Regular imaging
• Screening patient and 1st degree relatives for heritable disorders
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AORTIC DISSECTION
Follow-up
CONTROL OF PATIENT’S BLOOD PRESSURE
• Lowest level capable of sustaining normal organ function (sensorium, urine output,…)
• Life-long
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AORTIC DISSECTION
Follow-up
REGULAR IMAGING
• Close observation for development of late aneurysm
• Risk factors: aortic dilation, hypertension, nonresection of false lumen, larger false lumen
diameter (>22 mm), entry tear diameter > 10 mm, partial false lumen thrombosis1
• CT scan at 3 months in 6 months annually if stable2
• Known patent false lumens: must be watched very closely (estimated aortic expansion
rate of 1-4.3 mm/y)1,2
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Cotarlan V., Austin J. J. (2015), Principles of Critical Care, Gregory A. Schmidt Jesse B. Hall, John P. Kress, Editor, McGraw Hill Education, pp. 356-368
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AORTIC INTRAMURAL
HEMATOMA (IMH)
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IMH
Overview
• Hematoma develops in medial layer of aortic wall + no evidence of intimal flap or false lumen
• Imaging studies: circular or crescentic thickening ≥ 5 mm in aortic wall1
• Higher incidence in Asian studies than Western cohorts2
• Occurrence1
• Ascending 30%
• Arch 10%
• Descending 60-70%
• Result from rupture of vasa vasorum mural hemorrhage
• Classifed as type A or type B (as for classic aortic dissection)
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Harris K. M., Braverman A. C., Eagle K. A., et al. (2012), Circulation, 126 (11 Suppl 1), pp. S91-6
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IMH
Overview
• Tend to be older, have more atherosclerotic disease > AD
• 2/3 of IMH cases: type B (≠ AD)
Ptaszek L. M., Isselbacher E. M., Spooner A. E. (2012), Irwin and Rippe’s Intensive Care Medicine Richard S. Irwin , James M. Rippe, Editors, Wolters Kluwer, pp. 358-373.
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IMH
Pathophysiology
• Rupture of vasa vasorum in aortic wall (may be
the result of medial degeneration)
• Invasion of a PAU beyond internal elastic lamina
of the vessel, compromising the integrity of media
Mussa F. F., Horton J. D., Moridzadeh R., et al. (2016), JAMA, 316 (7), pp. 754-63
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IMH
Risk factors, presentation
• Symptoms, risk factors = aortic dissection
• Ascending IMH AR, hemopericardium, rupture, BUT malperfusion less common1
• Proximity of IMH to adventitia frequent coexistence of pleural effusion, pericardial
effusion, periaortic hematoma, higher risk for aortic rupture2
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Harris K. M., Braverman A. C., Eagle K. A., et al. (2012), Circulation, 126 (11 Suppl 1), pp. S91-6
116. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
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IMH
Natural history
• Progression to AD (in type A IMH, may be as high as 25-50%)
• Complete resolution of the hematoma
• Persistence and stabilization of the hematoma
• Progression to aortic aneurysm
Shah J., Braverman A. C. (2009), The Washington Manual Cardiology Subspeciatly Consult, Phillip S. Cuculich, Andrew M. Kates, Thomas M. De Fer, Editors,
Wolters Kluwer, pp. 497-518
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IMH
Diagnosis
• TTE: very low sensitivity
• Diagnosis
• TEE: focal crescentic or circumferential aortic wall thickening ≥ 5 mm, eccentric aortic lumen,
displaced intimal calcifcation, areas of echolucency within aortic wall, no intimal flap or flow in
aortic wall
• NCECT = area of high attenuation (bleeding)/wall of aorta
• CECT = low attenuation (no contrast material enters the wall)
• MRI
• IMH has a smooth lumen and curvilinear wall ≠ Aneurysm with mural thrombus
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Harris K. M., Braverman A. C., Eagle K. A., et al. (2012), Circulation, 126 (11 Suppl 1), pp. S91-6
119. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
120. Lang R. M., Goldstein S. A., Kronzon I., et al. (2016), "ASE’s Comprehensive Echocardiography", Elsevier.
121. Click to edit Master title style
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IMH
Management
Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
• Elderly patients or those with significant
comorbidities: initial medical treatment with a
‘wait-and-watch strategy’ (optimal medical therapy
with blood pressure and pain control and repetitive
imaging) may be a reasonable option, particularly
in the absence of aortic dilation (< 50 mm) and IMH
thickness < 11 mm
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IMH
Prognosis
• Overall long-term prognosis of IMH more favourable than AD1
• TYPE A IMH2
• High risk for complications = aortic dissection (25-50%), hemopericardium, rupture, with
• Mortality > 30% with medical therapy alone
• TYPE B IMH
• Average 30-day mortality rate 4% (medically treated) and 16% (those require surgery)3
• Complete resolution > 50%3
• Predictors of resolution = younger age, smaller aortic diameter (<4-4.5 cm), hematoma
thickness < 1 cm, postoperative use of beta blockers2,3
1. Timperley J., Ferguson J. D., Niccoli G., et al. (2003), American Journal of Cardiology, 91 (6), pp. 777-780
2. Harris K. M., Braverman A. C., Eagle K. A., et al. (2012), Circulation, 126 (11 Suppl 1), pp. S91-6
3. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
123. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
124. Click to edit Master title style
124
PENETRATING ATHEROSCLEROTIC
AORTIC ULCER (PAU)
125. Lang R. M., Goldstein S. A., Kronzon I., et al. (2016), "ASE’s Comprehensive Echocardiography", Elsevier.
126. Click to edit Master title style
126
PAU
Overview
• Atherosclerotic lesion penetrates through internal elastic lamina into the media
• Often associated with a variable degree of IMH formation
• May lead to pseudoaneurysm, dissection, aortic rupture, late aneurysm
• Single or multiple
• Range from 5-25 mm in diameter and 4-30 mm in depth1
• More common: middle to distal descending > arch, ascending, abdominal2
• Typically elderly, + coexisting vascular disease, + concomitant aneurysmal dilation of the
aorta elsewhere (especially abdominal)1,3
• Uncertain natural history
1. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
2. Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
3. Shah J., Braverman A. C. (2009), The Washington Manual Cardiology Subspeciatly Consult, Phillip S. Cuculich, Andrew M. Kates, Thomas M. De Fer, Editors, Wolters Kluwer, pp.
497-518.
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127
PAU
Imaging
• CT, MRI, TEE, aortography
• Focal aortic ulceration, associated IMH, a calcifed, displaced intima
• Diffcult to differentiate: PAU + IMH ≠ IMH + ulcerlike projection
Lang R. M., Goldstein S. A., Kronzon I., et al. (2016), "ASE’s
Comprehensive Echocardiography", Elsevier.
128. Lang R. M., Goldstein S. A., Kronzon I., et al. (2016), "ASE’s Comprehensive
Echocardiography", Elsevier.
CT, computed tomography: IMH, intramural
hematoma; MRI, magnetic resonance imaging; PAU,
penetrating atherosclerotic ulcer; TEE,
transesophageal echocardiography; ULP, ulcer-like
projections
Numbers 1, 2, and 3 refer to first-line, second-line,
and third-line imaging modalities
129. Braverman A. C., Schermerhorn M. (2019), Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes, et al., Editors, Elsevier, pp. 1295-1327
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PAU
Management
Erbel R., Aboyans V., Boileau C., et al. (2014), Eur Heart J, 35 (41), pp. 2873-926
131. CHIEF REFERENCES
1. Braverman A. C., Schermerhorn M. (2019), "Diseases of the Aorta", Braunwald’s Heart Disease: A Textbook Of Cardiovascular Medicine, Douglas P. Zipes,
et al., Editors, Elsevier, pp. 1295-1327.
2. Cotarlan V., Austin J. J. (2015), "Aortic Dissection", Principles of Critical Care, Gregory A. Schmidt Jesse B. Hall, John P. Kress, Editor, McGraw Hill
Education, pp. 356-368.
3. Creager M. A., Loscalzo J. (2018), "Diseases of the Aorta", Harrison's Principles of Internal Medicine, J. Larry Jameson, et al., Editors, McGraw-Hill, pp.
1917-1923.
4. Elefteriades J. A., Olin J. W., Halperin J. L., et al. (2017), "Diseases Of The Aorta", Hurst’s The Heart, Valentin Fuster, et al., Editors, McGraw-Hill, pp.
2157-2194.
5. Erbel R., Aboyans V., Boileau C., et al. (2014), "2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and
chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the
European Society of Cardiology (ESC)", Eur Heart J, 35 (41), pp. 2873-926.
6. Hiratzka L. F., Bakris G. L., Beckman J. A., et al. (2010), "2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and
management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force
on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of
Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic
Surgeons, and Society for Vascular Medicine", Circulation, 121 (13), pp. e266-369.
7. Johnson G. A., Prince L. A. (2016), "Aortic Dissection and Related Aortic Syndromes", Tintinalli’s Emergency Medicine A Comprehensive Study Guide, Judith
E. Tintinalli, et al., Editors, McGraw Hill, pp. 412-416.
8. Lederle F. A. (2016), "Diseases Of The Aorta", Goldman-Cecil Medicine, Lee Goldman , Andrew I. Schafer, Editors, Elsevier Saunders, pp. 492-497.
9. Mussa F. F., Horton J. D., Moridzadeh R., et al. (2016), "Acute Aortic Dissection and Intramural Hematoma: A Systematic Review", JAMA, 316 (7), pp.
754-63.
10. Nienaber C. A., Clough R. E. (2015), "Management of acute aortic dissection", The Lancet, 385 (9970), pp. 800-811.
11. Nienaber C. A., Powell J. T. (2012), "Management of acute aortic syndromes", Eur Heart J, 33 (1), pp. 26-35b.
132. CHIEF REFERENCES
12. Prince L. A., Johnson G. A. (2016), "Aneurysmal Disease", Tintinalli’s Emergency Medicine A Comprehensive Study Guide, Judith E. Tintinalli, et al., Editors,
McGraw Hill, pp. 416-420.
13. Ptaszek L. M., Isselbacher E. M., Spooner A. E. (2012), "Acute Aortic Syndromes", Irwin and Rippe’s Intensive Care Medicine Richard S. Irwin , James M.
Rippe, Editors, Wolters Kluwer, pp. 358-373.
14. Shah J., Braverman A. C. (2012), "Aortic Dissection", The Washington Manual Of Critical Care, Warren Isakow Marin H. Kollef, Editor, Lippincott Williams
& Wilkins, pp. 155-162.
15. Shah J., Braverman A. C. (2009), "Diseases of the Aorta", The Washington Manual Cardiology Subspeciatly Consult, Phillip S. Cuculich, Andrew M. Kates,
Thomas M. De Fer, Editors, Wolters Kluwer, pp. 497-518.
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DISEASES OF AORTIC
PHUNG HUY HOANG, MD MSc
A p r i l 2 0 2 0