BLOOD TESTIES BARRIER PPT BY - SADIA FHATIMA ( MBBS 1ST YR ) - M56BOOKSTORE

1. BLOOD-TESTIS BARRIER

2. What is blood-testis barrier ?
 It is formed by tight junction between adjacent sertoli cells.
 Divides the seminiferous epithelium into basal and apical
compartment of seminiferous tubule.
 It is formed near basal lamina.
 Prevents the passing of many large molecules from interstitial
tissue and part of tubule near basal lamina to the region near
tubular lumen.

3.  The walls of seminiferous tubule are lined by primitive germ cell
and sertoli cells.
 Large complex glycogen containing cells stretch from basal
lamina of tubule to lumen.
 It goes under extensive restructure during semniferous epithelial
cycle of spermatogenesis stage IV.
 Transfer preleptone spermatocytes at the barrier.
 New blood-testis barrier is created behind spermatocytes while
old Blood-testis barrier above transiting cells undergoes timely
degeneration.

4. Main function
 To create an isolated environment for seminiferous
tubule where spermatogenesis occurs by preventing the
entry of substance, the Blood-testis barrier helps to
protect developing sperm cells from harmful toxins ,
pathogen and body’s immune response.
REGULATORY HORMONES
1. Testosterone
2. Follicle – Stimulating hormone.

5. Clinical significance
 Dysfunction of Blood-Testis barrier can affect male fertility that disrupts
the integrity on basis of :
Infection
Inflammation.
Exposure to toxins

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