1. The coomon carotid artery
a) topography
- carotid sinus
- carotid body
2. Neurovascular bundles of the neck
3. The external carotid artery
4. The internal carotid artery
- arterial supply of the brain
5. Arterial anastomoses head and neck
6. Veins of the head and neck
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Anatomy of Blood vessels & Nerves of pectoral cavityEneutron
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a) anterior and posterior branches of the thoracic nerves
b) the phrenic nerve
c) the thoracic part of the sympathetic trunk
d) the thoracic part of the vagus (10th) nerve
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The upper limb is divided into several anatomical regions, each with distinct structures and functions.
Understanding these anatomical regions is essential for healthcare professionals, anatomists, and individuals studying the upper limb for medical or educational purposes. Each region plays a specific role in the overall function and movement of the upper limb.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
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Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Blood supply of head & neck. Arterial & venous anastomoses
1. The Department of Human anatomyThe Department of Human anatomy
Blood Supply
(Arteries and Veins) of
Head and Neck
Arterial and venous
anastomoses
2. PLANPLAN
1.1. The coomon carotid arteryThe coomon carotid artery
a)a) topographytopography
-- carotid sinuscarotid sinus
-- carotid bodycarotid body
2. Neurovascular bundles of the neck2. Neurovascular bundles of the neck
3. The external carotid artery3. The external carotid artery
4.4. The internal carotid arteryThe internal carotid artery
-- arterial supply of the brainarterial supply of the brain
5.5. Arterial anastomoses head and neckArterial anastomoses head and neck
6. Veins of the head and neckeins of the head and neck
3. Topicality:Topicality:
Knowledge of blood supply of theKnowledge of blood supply of the
brain is important for you, becousebrain is important for you, becouse
cerebro-vascular pathology is ancerebro-vascular pathology is an
actual problem in all countries.actual problem in all countries.
Vascular disease of the brain is 30-Vascular disease of the brain is 30-
50% of diseases of the vascular50% of diseases of the vascular
system. Mortality from ynsultsystem. Mortality from ynsult is 12-is 12-
15% of total mortality.15% of total mortality.
4. The branches of aortic archThe branches of aortic arch
Aortic arch has threeAortic arch has three
major branchesmajor branches
1)1) BrachiocephalicBrachiocephalic
trunc (artery)trunc (artery) divided into:divided into:
Right subclavianRight subclavian
Right common carotidRight common carotid
2)2) Left common carotidLeft common carotid
divided into:divided into:
External carotidExternal carotid
Internal carotidInternal carotid
3)3) Left subclavianLeft subclavian
6. The common carotidThe common carotid
arteryartery
The common
carotid artery
runs upwards
in the neck to
the upper
border of the
thyroid
cartilage.
Then it divides
into external
and internal
carotid
arteries.
7. Attention:
to stop
bleeding of the
common
carotid artery,
need to
pressed the
artery to the
сarotic
tubercle of the
sixth cervical
vertebra.
Carotid triangle
is formed
8. Carotid Sinus-Carotid Sinus- this is the small balloonthis is the small balloon
like structure at the start of thelike structure at the start of the
internal carotid artery. The dilationinternal carotid artery. The dilation
sometimes extends to the commonsometimes extends to the common
carotid artery. The carotid sinus iscarotid artery. The carotid sinus is
a barometer that monitors arteriala barometer that monitors arterial
blood pressure.blood pressure.
Carotid Body-Carotid Body- this is a small oval massthis is a small oval mass
located at the bifurcation of thelocated at the bifurcation of the
common carotid artery, betweencommon carotid artery, between
the two branches – internal andthe two branches – internal and
external carotid arteries. It is aexternal carotid arteries. It is a
chemoreceptor that monitors thechemoreceptor that monitors the
oxygen levels in the blood.oxygen levels in the blood.
.
.
Carotid Reflex Zone
9. I (main) underunder
m.sternocleidomastoideusm.sternocleidomastoideus
and consists of:and consists of:
- a. carotis communis
- v. jugularis interna
- n. vagus
NeurovascularNeurovascular
bundle of the neckbundle of the neck
II (in the lateral triangle)in the lateral triangle)
- a. subclavia- a. subclavia
-- v. subclaviav. subclavia
- pars supraclavicularis
plexus brachialis
10. I. Front (anterior) group:
- superior Thyroid Artery
- the Lingual Artery ( lies in the triangle
Pirogov)
- Facial Artery
II. Posterior group:
- the Occipital Artery
- the Posterior Auricular Artery
- Sternocleidomastoideus Branch
III. Medial group:
- the Ascending Pharyngeal Artery
IV. Terminal branches
- superficial Temporal Artery
- the Maxillary Artery
Major branches of the Maxillary Artery:
1. Infraorbital artery
2. Posterior superior alveolar artery
3. Inferior alveolar artery
The external carotid artery
It supplies structures external to the skull.
12. The Internal Carotid ArteryThe Internal Carotid Artery it has 4it has 4
parts:parts:
AA .. Cervical,Cervical, BB. Petrous,. Petrous, CC. Cavernous,. Cavernous, DD. Cerebral. Cerebral
Inside the skull the
internal carotid artery
gives off the
ophthalmic artery
which supplies the
optic nerve, eye, orbit
and scalp. The internal
carotid arteries are two of
the four main arteries
that supply blood to
the brain.
The internal carotid artery has no branches outside the skull and
enters the skull through the carotid canal.
15. The arterial cerebral circulation is normallyThe arterial cerebral circulation is normally
divided into anterior cerebral circulation anddivided into anterior cerebral circulation and
posterior cerebral circulation. There are twoposterior cerebral circulation. There are two
main pairs of arteries that supply the cerebralmain pairs of arteries that supply the cerebral
arteries and the cerebellum: Internal carotidarteries and the cerebellum: Internal carotid
arteries and vertebral arteries.arteries and vertebral arteries.
Arterial Supply of the Brain
The components:
The Circle of Willis is a part of the cerebral
circulation and is composed of the following
arteries:
-Anterior cerebral artery (left and right)
-Anterior communicating artery
-Internal carotid artery (left and right)
-Posterior cerebral artery (left and right)
-Posterior communicating artery (left and right)
The basilar artery and middle cerebral arteries,
supplying the brain, are also considered part of
the circle.
16. Arterial anastomoses head andArterial anastomoses head and
neckneck
Anastomosis ensure the normal functioning collaterals andAnastomosis ensure the normal functioning collaterals and
if the blood flow in VBS is reduced they prevent theif the blood flow in VBS is reduced they prevent the
development of neurological disorders.development of neurological disorders.
A.A. Intersystem between branches a. carotis externa and a.Intersystem between branches a. carotis externa and a.
subclavia:subclavia:
1. a. thyroidea superior + a. thyroidea inferior1. a. thyroidea superior + a. thyroidea inferior
2. rr. occipitales + rr. musculares2. rr. occipitales + rr. musculares
3. Circulus arteriosi cerebri3. Circulus arteriosi cerebri (The Circle of Willis)(The Circle of Willis)
B.B. Intersystem between branches a. carotis externa and a.Intersystem between branches a. carotis externa and a.
carotis interna:carotis interna:
1. a. angularis + a. dorsalis nasi1. a. angularis + a. dorsalis nasi
2. a. zygomaticoorbitalis + a. supraorbitalis et a.lacrimalis2. a. zygomaticoorbitalis + a. supraorbitalis et a.lacrimalis
C.C. AAnastomoses within the pool a. carotis internanastomoses within the pool a. carotis interna
1. a.a. palpebrales laterales+ a.a. palpebrales mediales1. a.a. palpebrales laterales+ a.a. palpebrales mediales
2. a. communicans anterior2. a. communicans anterior
17. D. AD. Anastomoses within the pool a. carotisnastomoses within the pool a. carotis
externaexterna
11. a.sublingualis(br. a. lingualis)+ a.submentalis (br.. a.sublingualis(br. a. lingualis)+ a.submentalis (br.
a. facialis).a. facialis).
22.. a.palatina ascdendens(br.a.facialis)+ a.pharyngeaa.palatina ascdendens(br.a.facialis)+ a.pharyngea
ascdendens(br.a.carotis externa).ascdendens(br.a.carotis externa).
33.rr.occipitalis(br.a.occipitalis).rr.occipitalis(br.a.occipitalis)
+rr.occipitalis(br.a.auricularis posterior)+rr.occipitalis(br.a.auricularis posterior)
+rr.temporalis superficialis(br.a.carotis externa).+rr.temporalis superficialis(br.a.carotis externa).
44. a.transversa faciei (br.a.temporalis superficialis)+. a.transversa faciei (br.a.temporalis superficialis)+
br. a. facialis(a.carotis externa).br. a. facialis(a.carotis externa).
55.a.mentalis(a.maxillaris)+a.labialis inferior et.a.mentalis(a.maxillaris)+a.labialis inferior et
a.submentalis (br. a. facialis).a.submentalis (br. a. facialis).
19. C.C. Between equal branches oppositeBetween equal branches opposite
sidessides
1.1. r. infrahyoideus (br.a.thyroidea superior a.carotisr. infrahyoideus (br.a.thyroidea superior a.carotis
externa).externa).
22. r. cricothyroideus (br.a.thyroidea superior a.carotis. r. cricothyroideus (br.a.thyroidea superior a.carotis
externa).externa).
33. r. suprahyoideus (br.a.lingualis a.carotis externa).. r. suprahyoideus (br.a.lingualis a.carotis externa).
44. rr.dorsalis lingue (br.a.lingualis a.carotis externa).. rr.dorsalis lingue (br.a.lingualis a.carotis externa).
5.5. aa. labialis superior et inferior (br.a.facialis a.carotisaa. labialis superior et inferior (br.a.facialis a.carotis
externa).externa).
66. rr. occipitalis (br.a.occipitalis a.carotis externa).. rr. occipitalis (br.a.occipitalis a.carotis externa).
77. r. parietalis (br.. r. parietalis (br.a.temporalis superficialisa.temporalis superficialis a.carotisa.carotis
externa).externa).
88. a. supratrohlearis (br. a.ophthalmica. a. supratrohlearis (br. a.ophthalmica a.carotisa.carotis
externa).externa).
20. The Veins of the Head andThe Veins of the Head and
NeckNeckThe veins, which return the blood from the head
and neck, are:
1. Internal Jugular. The jugular veins are veins
that bring deoxygenated blood from the head
back to the heart via the superior vena cava.
It is somewhat dilated at its origin, and this
dilatation is called the superior bulb.
It also has a common trunk into which drains the
anterior branch of the retromandibular vein, the
facial vein, and the lingual vein.
It runs down the side of the neck in a vertical
direction, being at one end lateral to the internal
carotid artery, and then lateral to the common
carotid, and at the root of the neck, it unites with
the subclavian vein to form the brachiocephalic
vein (innominate vein); a little above its
termination is a second dilatation, the inferior
bulb.
2. External Jugular.
3. Anterior Jugular.
4 Vertebral
•.
21. TheThe
exstracranialexstracranial
tributaries of thetributaries of the
Internal JugularInternal Jugular
veinvein
1.The facial vein and the1.The facial vein and the
deep facial vein.deep facial vein.
2 The angular vein.2 The angular vein.
3. The retromandidular3. The retromandidular
vein.vein.
4. The superficial temporal4. The superficial temporal
vein.vein.
5. The maxillary vein.5. The maxillary vein.
6. The lingual vein6. The lingual vein
7. The superior thyroid vein7. The superior thyroid vein
22. The intracranial tributaries ofThe intracranial tributaries of
thethe Internal Jugular veinInternal Jugular vein
The venous drainage of the head and neck begins as
drainage of the brain. There are:
23. Venous sinusesVenous sinuses
Name Drains to
Inferior sagittal sinus Straight sinus
Superior sagittal sinus
Typically becomes right
transverse sinus
Straight sinus
Typically becomes left
transverse sinus
Occipital sinus Confluence of sinuses
Confluence of sinuses
Reference point, not an
actual sinus
Sphenoparietal sinuses Cavernous sinuses
Cavernous sinuses
Superior and inferior
petrosal sinuses
Superior petrosal sinus Transverse sinuses
Transverse sinuses Sigmoid sinus
Inferior petrosal sinus Sigmoid sinus
Sigmoid sinuses Internal jugular vein
24. The cerebralThe cerebral
veinsveins
TheThe cerebral veinscerebral veins areare
divisible into superficialdivisible into superficial
and deep groups.and deep groups.
The superficial veins areThe superficial veins are
the:the:
a) superior cerebral veinsa) superior cerebral veins
b) inferior cerebral veinsb) inferior cerebral veins
c)c) middle cerebral vein.middle cerebral vein.
The deep veins are the:The deep veins are the:
a) internal cerebral veinsa) internal cerebral veins
b) great cerebral veinsb) great cerebral veins
25. The ophthalmic veins drain the constituentsThe ophthalmic veins drain the constituents
of the orbit.of the orbit.
1. The superior ophthalmic vein.1. The superior ophthalmic vein.
2. The inferior ophthalmic vein.2. The inferior ophthalmic vein.
The ophthalmic veins
26. The diploic veins The emissaryThe diploic veins The emissary
veinsveinsThe diploic veins are theThe diploic veins are the
thinwallrd veins embeddedthinwallrd veins embedded
into the cancellous boneinto the cancellous bone
of calvaria.of calvaria.
1.1. The frontal diploic vein.The frontal diploic vein.
2.2. The anterior temporalThe anterior temporal
diploic vein.diploic vein.
3.3. The posterior temporalThe posterior temporal
diploic vein.diploic vein.
4.4. The occipital diploic veinThe occipital diploic vein
TheThe emissary veinsemissary veins areare
valveless veins whichvalveless veins which
normally drain from the duralnormally drain from the dural
venous sinuses into veins thatvenous sinuses into veins that
lie outside the skull.lie outside the skull.
1. The parietal emissary veins.1. The parietal emissary veins.
2. The mastoid emissary veins.2. The mastoid emissary veins.
3. The condylar emissary veins.3. The condylar emissary veins.
4. The occipital emissary veins.4. The occipital emissary veins.