A review of biotechnology, medical device, pharma and general healthcare crowd funding companies as well as the platforms they raised money using, with a particular focus on biotech therapeutic products. As healthcare systems evolve and Venture Capital remains limited, companies are forced to seek alternative and additional funds to promote the research and development of their product.
A brief review of the Boston startup ecosystem from the perspective of Jeff Bussgang of Flybridge and HBS, a former entrepreneur turned VC / Harvard faculty member.
2016 Overview of significant trends in the life sciences (Biotechnology, Pharmaceutical, Device and Diagnostics) industry with Regenerative Medicine feature articles.
This is part of the MaRS BioEntrepreneurship series.
Speaker: Lynne Zydowsky, Ph.D., Managing Principal Zydowsky Consultants
* Explore the development of regulated drugs and devices
* Understand where and how value is generated in the pharmaceuticals industry
* Appreciate the interplay between science and business in a biotech company
To download a copy of the audio for this presentation, please go to:
http://www.marsdd.com/bioent/oct16
For the event blog and Q+A, please see:
http://blog.marsdd.com/2006/10/17/bringing-together-art-and-science/
A brief review of the Boston startup ecosystem from the perspective of Jeff Bussgang of Flybridge and HBS, a former entrepreneur turned VC / Harvard faculty member.
2016 Overview of significant trends in the life sciences (Biotechnology, Pharmaceutical, Device and Diagnostics) industry with Regenerative Medicine feature articles.
This is part of the MaRS BioEntrepreneurship series.
Speaker: Lynne Zydowsky, Ph.D., Managing Principal Zydowsky Consultants
* Explore the development of regulated drugs and devices
* Understand where and how value is generated in the pharmaceuticals industry
* Appreciate the interplay between science and business in a biotech company
To download a copy of the audio for this presentation, please go to:
http://www.marsdd.com/bioent/oct16
For the event blog and Q+A, please see:
http://blog.marsdd.com/2006/10/17/bringing-together-art-and-science/
Entrepreneurship: Global Transformation EngineDonna Harris
The Internet Revolution is the Industrial Revolution of our time. With social, mobile and cloud technology, disruption is coming to every single industry. Anyone, anywhere can create the next great high growth company; and entrepreneurship is truly becoming a global phenomenon. With the massive changes coming to early stage capital markets, today's entrepreneurs will be more powerful and more disruptive than we can imagine.
Crowdfunding - Asset Classes and Crowd Driven ModelsGrow VC Group
Presentation held at CrowdFuture in Rome, October 27 2012. Markus talks about trends in modern finance, the emergence and background for crowdfunding, and the manifestation of macro trends such as the demand for democracy and efficiency in the world of finance. The discussion also touches on current trends and a future outlook on crowd driven investment models.
Markus talked about trends in modern finance, the emergence and background for crowdfunding, and the manifestation of macro trends such as the demand for democracy and efficiency in the world of finance. The discussion also touched on current trends and a future outlook on crowd driven investment models.
Crowd Valley COO Paul Higgins facilitated a workshop on crowdfunding in Berlin on May 25th with a group of entrepreneurs, investors, and finance professionals at the fifth SDW Gründer- und Unternehmerforum conference.
Mobile web africa 2012 presentation loren treismanLoren Treisman
Presentation delivered by Dr Loren Treisman at Mobile Web Africa 2012 in Johannesburg. This presentation focuses on tech innovation hubs, social tech projects in the health, agriculture and democracy space, the impact of both hubs and social projects, with case studies from Indigo Trust's grantees as well as a role for Foundations and the private sector in supporting this work.
"Crowdfunding for solar: model and implications for Thailand," presented by Sarinee Achavanuntakul at Chulalongkorn University, 31 July, 2013. Part of Thailand's Solar PV Roadmap Initiative - Economics/Finance Working Group #1:
Innovative Business Models and Financing Options for Distributed Solar Systems
Raising Capital from Life Science Investors SecureDocs
This slideshare was originally part of the webinar raising capital from life science investors, hosted by SecureDocs and Life Science Nation. These slides outline the best ways to research, locate, and connect with various types of potential life science investors.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Entrepreneurship: Global Transformation EngineDonna Harris
The Internet Revolution is the Industrial Revolution of our time. With social, mobile and cloud technology, disruption is coming to every single industry. Anyone, anywhere can create the next great high growth company; and entrepreneurship is truly becoming a global phenomenon. With the massive changes coming to early stage capital markets, today's entrepreneurs will be more powerful and more disruptive than we can imagine.
Crowdfunding - Asset Classes and Crowd Driven ModelsGrow VC Group
Presentation held at CrowdFuture in Rome, October 27 2012. Markus talks about trends in modern finance, the emergence and background for crowdfunding, and the manifestation of macro trends such as the demand for democracy and efficiency in the world of finance. The discussion also touches on current trends and a future outlook on crowd driven investment models.
Markus talked about trends in modern finance, the emergence and background for crowdfunding, and the manifestation of macro trends such as the demand for democracy and efficiency in the world of finance. The discussion also touched on current trends and a future outlook on crowd driven investment models.
Crowd Valley COO Paul Higgins facilitated a workshop on crowdfunding in Berlin on May 25th with a group of entrepreneurs, investors, and finance professionals at the fifth SDW Gründer- und Unternehmerforum conference.
Mobile web africa 2012 presentation loren treismanLoren Treisman
Presentation delivered by Dr Loren Treisman at Mobile Web Africa 2012 in Johannesburg. This presentation focuses on tech innovation hubs, social tech projects in the health, agriculture and democracy space, the impact of both hubs and social projects, with case studies from Indigo Trust's grantees as well as a role for Foundations and the private sector in supporting this work.
"Crowdfunding for solar: model and implications for Thailand," presented by Sarinee Achavanuntakul at Chulalongkorn University, 31 July, 2013. Part of Thailand's Solar PV Roadmap Initiative - Economics/Finance Working Group #1:
Innovative Business Models and Financing Options for Distributed Solar Systems
Raising Capital from Life Science Investors SecureDocs
This slideshare was originally part of the webinar raising capital from life science investors, hosted by SecureDocs and Life Science Nation. These slides outline the best ways to research, locate, and connect with various types of potential life science investors.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. WHY CROWDFUNDING?
• Longstanding tradition in US of generous support for research at places
like the Dana-Farber Cancer Institute or UC San Francisco
• Many of those donors want to take the next step by investing in companies
building on that research to develop treatments
• While most biotech companies are for-profit, creating therapies for
diseases and then bringing them to the market may appeal to the
crowd
• In particular: patients, friends and family, medical practitioners and researchers
for whom finding a cure for unmet diseases is an urgent and highly emotional
matter and may be more important than realizing a return on investment
• People are often willing to donate money to a not-for-profit charity
dedicated to medical or bioscience research.
• Crowdfunding appeals to this population as it might allow them to directly impact
on medical innovation in a fully transparent manner i.e. it will be clear to them
where their money is going and for what purpose
2
3. HOW TO ATTRACT INTEREST
• Studies show most important factors for investors are
1. Perceived market potential
2. Prior experience of the entrepreneur
3. Being personally moved by the idea of the business
• Crowdfunding is a form of ‘activism’ & a way to make an
impact by supporting US businesses that reflects the
investor’s own values
• Many feel it is important people beyond the very wealthy
have an opportunity to fund small businesses
• Driven by ‘potential to do good deeds’ rather than to realize a ROI
3
4. CURRENT CROWDFUNDING MARKET
• Jumpstart Our Business Startups (JOBS) Act in Fall of
2013 SEC released new regulations on crowdfunding
• Early-stage firms struggle to attract investors
• Terribly hard - more difficult than it ever has been
• Consulting firms help esoteric and complex work of biotech firms
• >250 "biotech" startups seeking capital on AngelList
• Mostly genomics, DIY, diagnostic, or life science service
• Several therapeutic startups, for example, Rodin
4
5. DRAWBACKS
• Time for innovation is lengthy
• High failure rate is unattractive
• Unsophisticated public may not understand
biotechnology/scientific propositions
• High-level of due diligence for individual investors
• Proprietary information rights & IP issues
• May prove unattractive to business angels
• Administrative burden of paperwork, registration,
regulation, tax
• No warranties for further funding round/no exit
5
6. TYPES OF FUNDING
Equity I
• Allows for accredited investors to view private investment opportunities on a
password-protected website
• Suit entrepreneurs who want to avoid public exposure of their fundraising
campaigns
Equity II
• Can raise an unlimited amount of capital from an unlimited number of accredited
investors
• All done through equity crowdfunding portals which make it simple to advertise their
offerings across the web
• Most popular type of equity crowdfunding, it exposes entrepreneurs to a huge
audience of potential investors (6-8 million accredited investors in US)
Equity III
• Allows unaccredited investors to participate (the 99%)
• With platforms to offer and sell securities online, entrepreneurs will enjoy the ability
to potentially reach out to over 50 million Americans
• More regulatory requirements to manage
6
7. ANGEL FUNDING MARKET
• Angel investing of $20bn per year across all sectors
• 21% start-ups in Healthcare services/Medtech
• 8% in Biotech (1500/yr)
• Fewer than 100 biotech startups are backed by angels with
more than $500K in any given year
• Angel investing driven locally or through networks around
successful pharma executives
7
9. POLIWOGG
• Healthcare specific, NY-based, well-connected
• Not individuals, focuses on equity investors
• <20 life science companies listed for crowdfunding, many
more in review ($1-$4million min)
• SEC limit on non-accredited investors of just $1million per
year (will eventually lift)
• Realize more value quickly with small donations – this will
help a startup appeal to serious investors
• Equity-based crowdfunding has volumes of paperwork,
very complex, prohibitively burdensome
• All-or-Nothing funding of $2m - $10m
9 www.poliwogg.com
10. INDIEGOGO
• International crowdfunding site where anyone can raise
money for film, music, art, charity, small businesses,
gaming, theater, and more
• Biotech Example: J147: Therapeutics for ALS
• Funding histopathology (microscopic tissue examination) lab work to
better analyze the results for study ongoing at Salk Institute
• Originally seeking $30K (see: J147 Crowd Funding Site)
10
www.indiegogo.com
11. WISEED
• European (Fr) equity-based crowdfunding website
• WiSEED community = 20,000 potential investors
• Vote on 10 projects/month, audit, choose 3, can raise $50,000 to
$685,000 against equity stake of 5-20% of company (min invest
of $100)
• All individual investments combined into a single holding
company, dedicated exclusively to this investment, in which
investors hold a stake. Platform monitors and maintain
communication
• Initial review, e-voting, due diligence (audit), valuation (not a
financial study but intended to give a value to the project, based
on the assumptions of revenues and expenses in relation to
expectations from market society)
• WiSEED has helped 27 companies raise $6+ million in equity
funding
11 www.wiseed.com
12. ROCKETHUB
• Keep all funds raised (not “all-or-nothing”)
• Reach goal: 4% commission fee + 4% credit card handling
fee
• Don’t reach goal: 8% commission fee + 4% credit card
handling fee
• Focus on art, science, business and social good projects
http://www.rockethub.com/abo1u2t
13. MEDSTARTR/MEDFUNDR
• Patient, doctors, companies funding healthcare innovation
• Most small funds $10k-$20k, nothing in biotech
• Mostly hardware/software, consumer, product/device
• Focus on small projects for small medical problems
www.medstartr.com 13
14. DODO FUNDING
• "Crowdfunding platform for biotech projects”
• Goal sum, 90 days, 5% commission to DoDo, uses PayPal
• “If selected by committee, get public exposure, marketing and
communication help…”
• Rewards:
• Acknowledgements in scientific papers
• Personal updates
• Insight into how research is going
• Finalize products
• Equity in the company
• All-or-Nothing platform
• Bioengineering, bioinformatics, DNA barcoding, education,
genomics, metagenomics, nanobiotechnology, proteomics,
synthetic biology, transcriptomics
www.dodofunding.com 14
15. CROWDCUBE
• Founded in 2010, London-based CrowdCube is the next
generation of business investment.
• It is a new way to fund start-ups and business expansion by
crowdfunding for equity, giving entrepreneurs a platform to connect
with people and raise venture capital.
• Mostly professional services, internet businesses,
consumer
www.crowdcube.com 15
16. SEEDRS
• Equity capital platform, very friends and family
• “For an investment of $150,000, between 20% and 40% of
your company's equity is what investors are likely to
expect.
• The average equity offered by startups on Seedrs is in the
10% to 50% range”
• $10,000 - $300,000 with 1-40% equity
16
www.seedrs.com
17. CONSANO
• Consano brings crowd-funding to the world of medical
research
• Donation based, focus on healing
• $25,000 - $1,500,000, 2 months time frame
• Receive money whether or not goal reached
• Only 15 projects listed on website
17
www.consano.org
18. BLAZEFUND
• Equity crowdfunding in business services, technology,
consumer, energy, software, internet, healthcare & life
sciences
• Equity shares
• Convertible debt
• Partnership options
• No real healthcare projects ongoing, did help Perle
• Many closed
18
www.blazefund.com
19. INVESTING ZONE
• Equity-based platform; 10-90% of company
• Projects ranging from $200,000 to $800,000
• Not healthcare specific in any way, no biotech
• “Adopted the principles of crowdfunding to connect
businesses with its network of angel investors”
19
www.investingzone.com
20. ONCOLOGYCROWD AU
• “There are few crowdfunding sites dedicated to scientific
research and even less to oncology which is surprising
considering the number of consumers that are passionate
about improving patient outcomes”
• Recently launched
• Oncology “Hive” networking platform coming soon
20
www.oncologycrowd.com.au
21. OTHER WEBSITES
1. Health Tech Hatch (hardware, $10K avg)
2. CircleUp (mostly consumer/retail)
3. iCrowd (rather basic platform)
4. RocketHub (mostly consumer/retail)
5. Petridish.org (DIY, science, nature)
6. Flintwave (Dutch crowdfunding, science focus)
7. IAmScientist (science and tech)
8. Longecity ($4K - $16K research funding)
9. Dragon Innovation (hardware products)
10. CrowdCure (life science projects)
11.OpenGenius (research projects)
12. PledgeIt (UK charity for leukemia and lymphoma)
13. TechMoola (crowdfunding for inventions, tech)
14. Experiment.com (was Microryza, science <$10K, lmtd)
15. Xconomy (news and analytics site)
16. Syndicate Room (equity crowdfunding)
17. Crowdnetic (tech/mrkt data for crowdfunding)
21
24. • Developers of innovative drugs against cancer
• Fundraising closed $1.1m on WiSEED
24
www.urodelia.com
25. • Cell Guidance Systems make research tools to aid stem
cell scientists
• Stem cells are being developed to provide treatments for
diseases increasing stroke, coronary disease, diabetes
and Parkinson's.
• CrowdCube, funded. $400,000 with 138 investors, 290%
target, 14.55% equity offered
25
www.cellgs.com
26. • French biotech developing first-in-class candidate-drugs
• Support neural repair in order to treat traumatic or severe
degenerative disorders of the CNS and to contribute to the
restoration of neurological function, and thus to improve the quality
of life of patients.
• In 2012, Neuronax used WiSEED to facilitate series ‘A’
financing of clinical trials in spinal cord injury.
• $1,234,000 in first funding, min of $100 per invest
26
www.neuronax.com
27. • Development of novel antimicrobial products
• Emerging crisis of antibiotic resistance for microbial pathogens in
the US & throughout the world
• Was seeking $2 - $3m in equity investment for XF-73 as of
late-2013 on CrowdCure
27
www.destinypharma.com
28. • Ambiotis is the first Contract Research Organization (CRO)
working on the active resolution of the inflammatory
process and making the proof of concept of innovative
compounds.
• WiSEED platform fund raising closed with $137,000
28
www.ambiotis.com
29. • Proprietary peptide therapy to generate new insulin
producing cells; reversing Type 1 & 2 diabetes
• BlazeFund to raise target $2m
29
www.perlebioscience.com
31. VENTURE HEALTH
• Investment portal for accredited investors
• 3 funded companies featured here
• Rani Therapeutics
• NFocus Neuromedical
• Channel Medsystems
31
www.venturehealth.com
32. Founded by Mir Imran, Rani Therapeutics is developing a
technology that would make biotherapeutics orally available
- removing the need for subcutaneous or intramuscular
injections. The company has successfully delivered a well-known,
commercially available antibody in a pre-clinical
model.
• Most Recent Financing: Raised its Series B in August of
2013, led by Google Ventures
• Venture Health: raised $2.6M
www.ranitherapeutics.com
32
33. • Founded by Mir Imran and Martin Dieck, Nfocus is
developing breakthrough solutions for neurovascular
disease, starting with brain aneurysms. Now completing
initial human trials in Europe, the company’s LUNA device
is demonstrating dramatic improvements in outcomes for
aneurysm patients.
• Exit: Acquired by Covidien on February 19, 2013 See
article here...
• Most Recent Financing: VentureHealth group: invested
$1.49M
www.nfocusneuro.com
33
34. • Founded by Dan Burnett, MD, Channel Medsystems is
creating the first truly office-based Global Endometrial Ablation
(GEA) technology, based on innovations in cryo-therapy. GEAs
are used to treat excessive menstrual bleeding as an
alternative to more invasive surgical procedures. Channel’s
device is designed to quickly and safely deliver therapy in a
single use, self-contained, hand-held device that is well
tolerated by the patient.
• Most Recent Financing: Raised $9.7M in April 2013, led by
Boston Scientific and Venture Health
• Venture Health: invested $875,000
www.channelmedsystems.com
34
35. RODIN THERAPEUTICS
• Novel treatment for Alzheimer's disease; drug inhibits
target to enhance the expression of genes critical for the
formation of new memories to slow cognitive decline and
improve QoL
• Seed of $1.7m Jul 1, 2013 - Atlas Venture, Proteros
Biostructures and Johnson & Johnson, Venture Health
35
www.rodintherapeutics.com
36. • About
• Small device reads and sequences DNA and converts it into binary
code using a tiny computer chip (malaria drug resistance)
• Campaign Hook
• By contributing to this campaign, you are furthering development of our
device and readying it for mass manufacture. Most importantly, you are
providing malaria tests for hundreds if not thousands of children in
Africa as part of a large clinical trial. We're also giving you an
opportunity to leave a legacy by helping to name our device, and
design the look and feel of it.
• Campaign Non-Financial Goals
• Support development and clinical trials; lab to field
• Campaign Financial Goals/Totals
• Indiegogo $18,035 of $50,000 (36%) Feb 12 – March 31, 2014 (47d)
36
http://www.indiegogo.com/projects/the-future-quantumdx-s-handheld-
dna-lab
37. • Rewards Promised
• $10 shout-out
• $25 sticker, email updates
• $35 t-shirt
• $50 Coffee mug
• $7,000 travel to UK, goody bag
• Deliverables Promised
• $145 Lab coat
• $75 Dx test to African child, famous photo
• $225 Dx test to 3 African children
• $695 Dx test to 10 African children, t-shirt, phone call
• $2,500 Dx test to African class, t-shirt, phone call
• $50,000 fund satellite clinical trial in new location
37
http://www.indiegogo.com/projects/the-future-quantumdx-s-handheld-
dna-lab
38. Marketing Materials
• Comprehensive, well-produced video
• Logos of news sources covering the company and with
quotes
• Bullet-point content with pictures on tech and device,
picture of team, discussing development and partners
• Campaign video from Pins and Needles Media
• Company also on Facebook, Twitter, Youtube, and has own
website
38
http://www.quantumdx.com/
39. • About
• Tech that measures DNA damage:
• “Exogen Biotechnology is a health startup aimed at developing cutting-edge
technologies for individuals to monitor damage to their DNA and to assess their DNA
repair capacities for the purposes of personalized and preventive health care”
• Campaign Hook
• “Campaign is not about the money, and the contributions for the perks will
hardly cover our expenses. This campaign is a citizen science project, and
our target is about gathering data to look at how age, medical conditions,
environmental and lifestyle factors correlate with DNA damage.”
• No FDA, research and info only
• Campaign Non-Financial Goals
• Gathering big data by covering some of the costs.
• Campaign Financial Goals/Totals
• Ingiegogo: $50k goal (January 25, 2014 – March 26, 2014)
• Achieved: $20k 3 days, $50k 10 days, $106k 60 days (212%)
39
www.exogen.com
40. • Rewards Promised
• $15 name on website
• $25 t-shirt
• Deliverables Promised
• $99 US kit (3 samples)
• $124 non-US kit (3 samples)
• $179 US kits (2x3 samples)
• $204 non-US Kits (2x3 samples)
• $359 US 4 kits over 1 year
• $459 non-US 4 kits over 1 year
• $399 family US kits (4x3 samples)
• $439 family non-US kits (4x3 samples)
• $999 US monthly tracker (12 kits)
• $1,299 non-US monthly tracker
• $5,000 monthly self-tracker, visit facilities and meet team
40
www.exogen.com
41. • Marketing Materials
• Comprehensive video with fancy transitions, music, graphics,
simulation of DNA breaking and device working, video of
scientists/labs, interviews
• Pictures and profiles of team & advisory board
• FAQ
• Updates
• Company is also on Facebook, Twitter, YouTube and has its own
website (with overview, team info, tutorial on DNA damage, and a
news blog)
41
www.exogen.com
42. • About
• Direct-to-consumer microbiome sequencing company (SF, CA)
• Campaign Hook
• Sequence your microbiome through citizen science
• Campaign Non-Financial Goals
• Citizen science, data acquisition and international outreach
• Campaign Financial Goals
• Indiegogo: goal $100k (Nov 15, 2012 – Feb 18, 2013)
• Achieved: $351k in 94 days (352%)
42
www.ubiome.com
43. • Rewards Promised
• $5 shout-out
• $25 t-shirt
• Deliverables Promised
• $79 GI Microbiome kit
• $89 GI Microbiome Kit + t-shirt
• $139 GI and Oral Microbiome kit + t-shirt
• $148 2x GI Microbiome kit (1 for you, 1 for Africa) + t-shirt
• $209 IBD: 3 GI kits for different time points
• $235 IBD: 3 GI kits for different time points + web app for personal experiments +
t-shirt
• $335 GI, Mouth, Skin, Nose and Genital Microbiome kits + t-shirt
• $1,337 5xkits to use at 5 different time points + personal guidance + t-shirt
• $10,000 consultation with scientists, visit lab, all kits
43
www.ubiome.com
44. • Marketing Materials
• Comprehensive video describing product, physiology, etc.
• Logos of selected press and news
• Quotes from Key Opinion Leaders
• Descriptions, content on microbes, body, how it works, pictures
• Advisory board
• Facebook (2,000+ likes), Twitter (5,400+ followers), YouTube (<5
videos), Website (welcome, how it works, order now, simple and
effective website)
• Mailing list, kit ordering
44
www.ubiome.com
45. • About
• Applied Integrin Sciences, Inc. discovers, develops and commercializes protein drug
therapies for cancer treatments that reduce solid tumor growth and progression, and
improve patient survival and quality of life. AIS is a socially responsible organization
in drug development and targets the ovarian cancer indication for the intraperitoneal
tumors as an orphan disease.
• Campaign Hook
• Involvement matters, impact will be huge, donation focused, 100% tax deductible
with matching partners
• Campaign Non-Financial Goals
• Accelerate the availability of drug discovered at Norris Cancer Center that fights
Ovarian, Breast & Prostate cancers. Need $200k to demonstrate “drugability” where
drug discovery becomes drug development. With $500k, will have drug manufactured
under FDA. With $1m will fulfill pre-requirements for investigational NDA with FDA,
begin human clinical trials. VC and pharma expected to finance after this phase.
• Campaign Financial Goals
• Raised $86,000 of $200,000 goal | Launched 8/29/2013 ended 12/16/2013 (109d)
• Tax deductible donation to cancer research
45
http://www.whenyouwish.com/project/boostcancersurvivalrates
46. • Rewards Promised
• $5 pen
• $10 shout out, email updates
• $20 ribbon signed by CEO
• $50 two free move tickets
• $50 coffee gift card ($25)
• $50 in memory of dead, shout out
• $100 in memory of loved one, name listed
• $150 just because (nothing)
• $250 your story featured on website w/ video/text
• $500 phone conversation w CEO, story featured
• $1,000 story of crowdfunding campaign, tips, stats, lessons learned
• $1,001 lunch w CEO and story featured
• $2,500 crwdfnd story PDF w tips, contacts, etc, your story, company logo as
sponsor
• $4,999 Dinner with scientists or CEO flies to you
• $5,000 sponsor, workshop w creative team from AIS that developed the
crowdfunding campaign, seminar on crowdfunding
46
http://www.whenyouwish.com/project/boostcancersurvivalrates
47. • Marketing Materials
• Executive summary
• Company purpose, market & opportunity, management & advisors, product &
technology, business model, financial, thesis
• http://www.whenyouwish.com/upload/fa820770-7066-476e-b335-e77815928266.pdf
• Fact sheet
• http://www.whenyouwish.com/upload/dd7291db-8c10-4486-87e7-fd532485da5a.pdf
• Development Funding Sought: Private equity (Series A), partnerships, grants for
aggregate commitments of $22.0 million are sought; distributed in three success‐based
milestone tranche investments to finance the company through Phase IIb clinical trials:
1) prepare for and file IND for Phase I/IIa human clinical trial ($3.0 million); 2) Conduct
Phase I/Iia clinical trial/mfn. drug doses ($5.0 million); 3) conduct Phase IIb clinical trial
($14 million).
• Presentation on company
• Non-Confidential science presentation
• http://www.whenyouwish.com/upload/9472f5f9-30bd-407d-ab10-0f915c71eca8.pdf
47
48. • Start A Cure is a fundraising project for cancer research
created by Malecare.
• New York, NY 501(c)3 nonprofit
• Raises funds and awareness, distributed 92% of funds
(cite 16-65% for most foundations and gov’t agencies
distribute)
• John’s Hopkins research on prostate cancer treatment ($8k, met
Dec ’13)
• www.facebook.com/StartACure
• Limited Twitter activity
• Contact: Darryl Mitteldorf darryl@malecare.org
48
https://startacure.com/
49. Name of Fund on .com website Organizer Raised # Pledgers Avg Pledge Goal
%
Goal
development of bioactive anti-cancer drug Beth Israel Deaconess $ 30 3 $10 $ 45,000 0%
Pre-clinical testing optimized prostate cancer NKT-'Gvax' vaccine Brigham & Women's $ 185 4 $46 $ 30,000 1%
Live-cell prostate cancer diagnostic Cellanyx $ 27 3 $9 $ 13,500 0%
Develop guide for how to diet after prostate cancer Dx Columbia University $ 20 2 $10 $ 50,000 0%
Characterize pathways in prostate cancer Dana Farber Cancer Inst $ 50 1 $50 $ 50,000 0%
Study to analyze prostate Dx, whites vs blacks John Hopkins professor $ 8,113 33 $246 $ 8,000 101%
testosterone therapy for prostate cancer John Hopkins professor $ 2,900 14 $207 $ 25,000 12%
PTEN biomarker for CT prostate cancer John Hopkins professor $ 105 3 $35 $ 50,000 0%
Zytiga and Xtandi drug development John Hopkins professor $ 480 5 $96 $ 30,000 2%
molecular raiotherapy for metastic prostate cancer John Hopkins professor $ 55 3 $18 $ 30,000 0%
Heat ablation w HPV vaccine for anal precancers LA Gay & Lesbian Center R&D $ 20 2 $10 $ 50,000 0%
genetic signature to identify men with risk of prostate cancer
progression MD Anderson Cancer Center, TX $ 75 1 $75 $ 50,000 0%
nanoparticle based thermal therapy and DD Medical Nanotechnologies, Inc. $ 440 9 $49 $ 10,000 4%
Probing porstate cancer metastasis by circulating tumor cells UCLA $ 316 5 $63 $ 50,000 1%
Using bacteria to cure prostate cancer University of California Irvine $ 15 1 $15 $ 50,000 0%
drug to augment effectiveness of androgen deprivation University of Pittsburgh $ 220 5 $44 $ 8,000 3%
Development of anti-insulin resistant drugs for obese University of Texas Anderson Cancer Center $ 26 2 $13 $ 45,000 0%
Fighting prostate cancer w breast cancer drugs University of Toronoto $ 198 4 $50 $ 30,000 1%
Cell-cell interaction in cancer development University of Washington $ 100 2 $50 $ 50,000 0%
49
Economics of cryotherapy for prostate cancer Winthrop University Hospital $ 10 1 $10 $ 35,000 0%
50. JOHN HOPKINS' PROSTATE STUDY
• Description of the study
• Limited social media presence
50
51. PHARMA SAFE (ROCKETHUB)
• Drug abuse deterrent alarm and lock (device)
• Rewards Promised
• $10 Thank You
• $25 label pin
• $100 t-shirt,
• Deliverables Promised
• $250 actual device
51
http://www.rockethub.com/projects/35359-pharmasafe
52. THE FLYING SYRINGE (ROCKETHUB)
• West Nile Virus proof-of-concept idea to genetically modify
mosquito populations
• Rewards Promised
• $5 Thank You
• $10 Wristband
• $25 email updates
• $50 t-shirt, wrist band
• $100 t-shirt, 3D molecule
• $250 Skype call
• $750 Skype call, virtual tour
• $1,500 Skype call, daytime visit
http://research.bergen.org/index.php/12-front-page-slider/
52
60-provita-rockethubm
53. NANOMEDICINE DRUGS FOR AIDS
VIRUS
• FAILED in 203: Only Raised $10
• http://www.rockethub.com/projects/11875-potential-nanomedicine-
drug-for-aids-virus
• Has rewards for up to $5K
53
54. • Kids with rare or incurable diseases
• Tax-deductible gift
• Rewards Promised
• $25 thank you
• $100 “adopt a drug candidate”
• $1,000 “adopt many drug candidates” for a classroom
• $3,000 “adopt many drug candidates” for a classroom, wrist band,
education website
• $5,000 “adopt many drug candidates” for a classroom, wrist band,
education website, 3 hours of Skype with scientist
• $10k all above, scientist comes to school to present, + family
dinner
• $25k dinner with director
54
55. SOME KEY CROWDFUNDING FOLKS
• Krist Weling, partner at law firm McDermott WIll & Emergy (lawyer)
• Thierry Merquiol, partner at France-based WiSeed (investor)
• Souleymane-Jean Galadima, associate at WiSeed (investor)
• Lorenzo Pellegrini, VC with Care Capital in Princeton, NJ (investor)
• Barbara Nelson, consultant, Nelson Biomedical (consultant)
• Gregory Simon, CEO, Poliwogg financial firms (investor)
• Elaine Warburton, CEO and cofounder of QuantuMDx (funding)
• Sylvain Costes, cofounder of Exogen (biotech)
• Jon Tang, cofounder of Exogen (biotech)
• David Miller, president of Biotech Stock Research in Seattle (research)
55
56. TAKEAWAY: KEY POINTS
• Helps to have network in place or expert support
• Exposure on funding website can be crucial
• Relevant content, news, interesting material (blog)
• Comprehensive video
• Many different donation amounts with different rewards
(some real, some feel-good)
• Heartstrings effect (bettering of society)
• Rewards do not have to be deliverables
• Meet the team, see the lab, view the science
• Facebook and Twitter involvement to expand crowd but is
not completely necessary
56
57. ABOUT THE AUTHOR
Rob Littlefield graduated from Columbia University in the City of New York
with a Master of Science degree in Biomedical Engineering and Bucknell
University with a Bachelor of Science degree in Biomedical Engineering. He
currently is a medical device senior market research analyst for GlobalData
Healthcare and lives in Waltham, MA with his wife, Lara, Founder and CEO
of BWD inc.
{ contact@roblittlefield.com }
57