This document discusses the biosynthesis of triacylglycerols, phospholipids, and sphingolipids. It explains that triacylglycerols are synthesized through acylation and reduction reactions in the liver and adipose tissue. Phospholipids like phosphatidylcholine and phosphatidylserine are synthesized through activation of precursors to CDP intermediates, which then react with diacylglycerol. Sphingomyelin is synthesized from ceramide and phosphatidylcholine. The biosynthesis pathways involve condensation, reduction, acylation, and addition of polar head groups to glycerol or sphingosine backbones.
BIOSYNTHESIS OF PHOSPHOLIPIDS
Phospholipids:-
These are compounds containing, in addition to fatty acid and glycerol, phosphoric acid, nitrogenous bases, and another substituent. Polar compounds composed of alcohol attached by phosphodiester bridge to either diacylglycerol or sphingosine.
Amphipathic in nature has a hydrophilic head (phosphate +alcohol
eg., serine, ethanolamine, and choline) and a long, hydrophobic tail
(fatty acids or derivatives ).
- CLASSIFICATION OF PHOSPHOLIPIDS:-
- Glycerophospholipids
- Spingophospholipids or Sphingomyelin
- SYNTHESIS OF PHOSPHOLIPIDS
- FUNCTIONS OF PHOSPHOLIPIDS
- FUNCTIONS OF SPHINGOLIPIDS
Triacylglycerol and compound lipid metabolismDipesh Tamrakar
Biosynthesis and metabolic regulation of triglyceride and other compound lipids: glycerophospholipids, sphingophospholipids, ether glycerolipids and glycolipids
BIOSYNTHESIS OF PHOSPHOLIPIDS
Phospholipids:-
These are compounds containing, in addition to fatty acid and glycerol, phosphoric acid, nitrogenous bases, and another substituent. Polar compounds composed of alcohol attached by phosphodiester bridge to either diacylglycerol or sphingosine.
Amphipathic in nature has a hydrophilic head (phosphate +alcohol
eg., serine, ethanolamine, and choline) and a long, hydrophobic tail
(fatty acids or derivatives ).
- CLASSIFICATION OF PHOSPHOLIPIDS:-
- Glycerophospholipids
- Spingophospholipids or Sphingomyelin
- SYNTHESIS OF PHOSPHOLIPIDS
- FUNCTIONS OF PHOSPHOLIPIDS
- FUNCTIONS OF SPHINGOLIPIDS
Triacylglycerol and compound lipid metabolismDipesh Tamrakar
Biosynthesis and metabolic regulation of triglyceride and other compound lipids: glycerophospholipids, sphingophospholipids, ether glycerolipids and glycolipids
Cholesterol is the major sterol in the animal tissues.
Cholesterol is present in tissues and in plasma either as free cholesterol or as a storage form, combined with a long-chain fatty acid as cholesteryl ester.
In plasma, both forms are transported in lipoproteins
removed from tissues by plasma high-density lipoprotein (HDL) and transported to the liver, where it is eliminated from the body either unchanged or after conversion to bile acids in the process known as reverse cholesterol transport
Cholesterol is the major sterol in the animal tissues.
Cholesterol is present in tissues and in plasma either as free cholesterol or as a storage form, combined with a long-chain fatty acid as cholesteryl ester.
In plasma, both forms are transported in lipoproteins
removed from tissues by plasma high-density lipoprotein (HDL) and transported to the liver, where it is eliminated from the body either unchanged or after conversion to bile acids in the process known as reverse cholesterol transport
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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Biosynthesis of Triacylglycerol, Phospholipids, Sphingolipids
1. Metabolism I
Unit 4:
Biosynthesis of
Triacylglycerol, Phospholipids,
Sphingolipids
Semester: II
Dr. Nibedita Pradhan
Department of Life Science
Kristu Jayanti College
May 2023
4. Phospholipids include:
(i) glycerophospholipids: the alcohol is glycerol
(ii) sphingophospholipids : the alcohol is sphingosine
Glycerophospholipids is derived from 1,2-diacylglycerol-
3-phosphate (or phosphatidic acid)
Glycerol
Sphingosine
OH
H2C
CH
HO
H2C OH
H
O
H
2
N
O
H
O
H
2
C
C
H
O
H
2
C
O
C
O
R
1
C
O
R
2
P
1,2-diacylglycerol-3-phosphate
5. ➢ The important glycerophospholipids are:
Phosphatidyl choline (lecithin)
Phosphatidyl ethanolamine (cephalin)
Phosphatidyl inositol
Phosphatidyl serine
Diphosphatidyl glycerol (cardiolipin)
Plasmalogen
➢ The only phosphosphingolipid is sphingomyelin
➢ Sphingomyelin is found predominantly in myelin sheath
6. ➢ Many different phospholipid species can be Constructed by
combining various fatty acids and polar Head groups with the
glycerol or sphingosine backbone
➢ All the biosynthetic pathways follow a few basic patterns.
➢ In general, the assembly of Phospholipids from simple precursors
requires
1. synthesis of the backbone molecule (glycerol or sphingosine);
2. attachment of fatty acid(s) to the backbone through an ester
or amide linkage;
3. addition of a hydrophilic head group to the backbone through
a phosphodiester linkage; and, in some cases,
4. Alteration or exchange of the headgroup to yield the final
phospholipid product.
➢ In eukaryotic cells, phospholipid synthesis occurs primarily on
the surfaces of the smooth endoplasmic reticulum and the
mitochondrial inner membrane.
➢ Some newly formed phospholipids remain at the site of
synthesis, but most are destined for other cellular locations.
7.
8.
9. Synthesis of lecithin
Lecithin is synthesized from activated choline and diacylglycerol
Activated form of choline is CDP-choline
A phosphate group is transferred from ATP to choline forming phosphocholine
A cytidyl group is transferred from CTP to phosphocholine forming CDP-choline
Phosphocholine is transferred from CDP-choline to diacylglycerol forming lecithin
10. Synthesis of Cephalin
Synthetic pathway for cephalin is similar to that for lecithin
Ethanolamine is activated to CDP ethanolamine
This reacts with diacylglycerol to form cephalin
11. Synthesis of phosphatidyl serine
Phosphatidyl serine is synthesized from CDP-diacylglycerol and serine
CDP-Diacylglycerol is formed from phosphatidic acid
CDP-Diacylglycerol reacts with serine to form phosphatidyl serine
12. Synthesis of phosphatidyl inositol
Phosphatidyl inositol is synthesized from CDP-diacylglycerol and inositol
CDP-Diacylglycerol is formed from phosphatidic acid
CDP-Diacylglycerol reacts with inositol to form phosphatidyl inositol
13.
14. Conversion of PS to PE
Glycerophospholipids can undergo interconversion
Serine residue of phosphatidyl serine can be decarboxylated to
ethanolamine
This converts phosphatidyl serine into phosphatidyl ethanolamine
15. Conversion of PE to PC
Ethanolamine residue of phosphatidyl ethanolamine can be methylated
Addition of three methyl groups converts ethanolamine into choline
Thus, phosphatidyl choline can be formed from phosphatidyl
ethanolamine
16. Synthesis of cardiolipin
Cardiolipin is diphosphatidyl glycerol
It is found only in mitochondria where it is synthesized from:
Two molecules of CDP-diacylglycerol, One molecule of glycerol-3-
phosphate
A phosphatidate group is transferred from CDP-diacylglycerol to
glycerol-3-phosphate; The product is phosphatidyl glycerol-3-
phosphate
The phosphate group is split off to form phosphatidyl glycerol
Phosphatidyl glycerol reacts with another molecule of CDP-
diacylglycerol
A phosphatidate group is transferred from CDP-diacylglycerol to
phosphatidyl glycerol
The product is diphosphatidyl glycerol
17.
18. Synthesis of plasmalogens
Plasmalogens are synthesized from:
1. Dihydroxyacetone phosphate
2. Acyl CoA
3. A long-chain alcohol
4. CDP-Ethanolamine
➢ At first, a fatty acyl group is added to C1 of
dihydroxyacetone phosphate (DHAP). Then, the acyl group
is replaced by an alkyl group. 1-Alkyl DHAP is then reduced
to 1-alkyl glycerol-3-phosphate
➢ An acyl group is added to C2 of 1-alkyl glycerol-3-phosphate
➢ The phosphate is removed from C3
➢ Phosphoethanolamine is added to C3
19.
20.
21.
22. ➢ In some plasmalogens, ethanolamine is replaced by choline or serine
➢ Ethanolamine plasmalogen is present in myelin
➢ Choline plasmalogen is abundant in cardiac tissue
➢ Serine plasmalogen is present in retina and white matter
➢ Platelet activating factor (PAF) is a specific type of plasmalogen
➢ It has an alkyl group (generally 16-carbon) at position 1
➢ The acyl group at position 2 is acetate
➢ Phosphocholine is present at position 3