The document discusses two scientific articles about transcription factors and their role in cell differentiation and human traits. The first article describes research on transcription factor EBF-1 that found it plays a key role in determining cell identity and preventing B cells from becoming T cells or other immune cells. The second article discusses a new methodology for understanding how genetic variants influence traits by studying their effects on transcription rather than protein translation. This could help develop personalized medicine approaches and new therapies.

1. “Between B Cells and T Cells: transcription factor EFB-1”
And “Understanding the Effects of Genes On Human
Traits”
Daniela Marín Rivera
Medicine student
III Semester
Molecular Biology

4. Introduction
The transcription is the
process responsable to
the sintesis of the
molecular of RNA from
the genetic information
contained in a DNA.
This point is important
because the different
s trancriptions factors
can to change the
response on the cell.

5. Between B and T cells : transcription
factor EBF-1 reminds who they are
Sciencedaily. July ,23 ,2013
The receptor EBF-1 was described
previously by Rudolf Grosschedl
and his colleagues were able to
prove as early as 1995, but its only
significance level was immune cells
inactivation of T in his presence.

6. Between B and T cells : transcription
factor EBF-1 reminds who they are
Sciencedaily, july,23,2013
Decided to use mice for further
experiments on the
mechanisms of this
transcription factor and took
samples of mice in late phase of
development and transferred to
mice lacking immune system
and inactived the factor
transcription EFB-1
Image taken from:
http://www.bioblogia.com/2011/02/los-ratones-que-carecen-de-las-
bacterias-normales-del-intestino-tienen-diferencias-en-el-desarrollo-
cerebral-y-el-comportamiento/

7. .
Between B and T cells : transcription
factor EBF-1 reminds who they are
Sciencedaily, July, 23,2013
After three months they managed
to identify the presence of B cells
in these mice but discovered they
had forgotten their identity by the
factor inactivation of transcription.
And in place of B cells were T cells
and natural murderers, still
important this new finding, and
considering it as a breakthrough in
order to control certain
pathologies.

8. .
Between B and T cells : transcription
factor EBF-1 reminds who they are
Sciencedaily, July, 23,2013
http://vivesana.blogspot.com/2013/03/document
al-ruleta-genetica-el-juego-de.html
Knowing the activity of this transcription
factor could be very useful because it can
induce the cell to change identity and take
another route of action.
Image taken from :

9. PERSONAL OPINION
.
I believe this
discovery can be very
important in different
pathologies and long
term this new
knowledge allows cells
to be reprogrammed
as pathological loss of
specific types of cells.
http://edith-
jules.blogspot.com/2011_02_01_archive.html
Image taken from :

10. Understanding the Effects of Genes On
Human Traits
Sciencedaily, july, 31,2013
A new methodology for insight into the
most common diseases in the human
would be a new way of developing
medicine, and to understand the genetic
influences for such serious diseases
locate an effective treatment for each
person.

11. Understanding the Effects of Genes On
Human Traits
Sciencedaily, july, 31, 2013
The focus of this new methodology known as personalized medicine will
be on the effects of disease-associated genomic variants on DNA-to-RNA
transcription, instead of the challenging question of effects on RNA-to-
protein translation.
http://anestesiar.org/2010/citocromo-p450-
cyp450-y-farmacogenetica/
Image taken from :

12. Understanding the Effects of Genes On
Human Traits
Sciencedaily, july, 31, 2013
Thanks to this methodology, we can now better
understand the effect of genetic variants on
translation of RNA to protein - a powerful way
of developing biomarkers for personalized
medicine and new therapies.

13. Understanding the Effects of Genes On
Human Traits
Sciencedaily, july, 31, 2013
Understanding the genome and their
influence will be the objective of this
research there and generate
appropriate treatments in diseases
affecting the majority of the
population.
http://laterapiacelular.com/terapia-celular/
Image taken from :

14. PERSONAL OPINION
Personally feel that this
methodology would be a
breakthrough and personalized
medicine would be ideal for any
country, however the costs of
studying any disease from the
genome would be very high and
difficult to achieve but I think that
the methodology would be very
useful and would be achieved
control multiple common diseases
in the population.

15. .
The goal of medicine today is not supplying
drugs that can produce damage to other
organs, the goal is to identify the problem
from the genome and from there find
appropriate solutions.

16. The medical objective is to know the DNA of every person and to know
that at one point influences is very important as transcription and
interaction with transcription factors thus generating a variety of
possibilities for each person in their cure.
MEDICAL UTILITY
http://es.123rf.com/photo_11420525_las-palabras-curar-el-cancer-en-
las-cadenas-de-adn-que-representan-la-importancia-de-la-
investigacio.html
Image taken from :

17. Many studies related to the human genome genomic
influences have shown many common complex diseases
such as asthma, diabetes, cancer or concerted
ezquizofrenia and is indispensable as this variant affects
the health.
MEDICAL UTILITY

18. MEDICAL UTILITY
Both events have great
medical importance both
differentiation of the
immune system such as
knowledge of the genome
and in the immune system
for example could be the
cure for diseases of a type of
cell and induce the system to
produce inactivated factor
transcription
However, discovering a
genetic variant predisposing
to a disease is only a first
step. To apply this
knowledge towards
prevention or
cure, including tailoring
treatment to the patient's
genetic profile, needs to
know how this genetic
variant affects health

19. BIBLIOGRAPHY
-Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB.
Facultad de Medicina, 2012. 78-84.P
-Robert Nechanitzky, Duygu Akbas, Stefanie Scherer, Ildiko
Györy, Thomas Hoyler, Senthilkumar Ramamoorthy, Andreas
Diefenbach, Rudolf Grosschedl. Transcription factor EBF1 is essential for
the maintenance of B cell identity and prevention of alternative fates in
committed cells. Nature Immunology, 2013.
-http://www.sciencedaily.com/releases/2013/07/130723113745.htm
-Quan Li, Angeliki Makri, Yang Lu, Luc Marchand, Rosemarie
Grabs, Marylene Rousseau, Houria Ounissi-Benkalha, Jerry
Pelletier, Francis Robert, Eef Harmsen, Thomas J. Hudson, Tomi
Pastinen, Constantin Polychronakos, Hui-Qi Qu.Genome-wide search for
exonic variants affecting translational efficiency. Nature
Communications, 2013; 4 DOI
-http://www.sciencedaily.com/releases/2013/07/130731164757.htm