Robert Hooke discovered cells in 1665 when examining a slice of cork under his microscope. He saw that cork had a honeycomb-like structure consisting of many small compartments, which were later termed cells. All organisms are made of cells, with some being single-celled and others multicellular. Cells have a plasma membrane, nucleus, cytoplasm, and various organelles that allow them to carry out functions necessary for life. The basic components and structures of cells were described.
The best explaining PowerPoint presentation for the class 10 chapter Control and Coordination. This ppt will give you a detailed conceptual understanding of the chapter in a very easy language.
This presentation is made in accordance with the NCERT textbook of Biology for Class 11. It deals with the introduction and characteristics of living organisms as well as concepts of nomenclature..
FOR FURTHER DETAILS YOU CAN WATCH THE RELATED VIDEO AT THE GIVEN LINK
https://www.youtube.com/channel/UCxo06Nj-QWo_7SNvMyDnJCQ?view_as=subscriber
The best explaining PowerPoint presentation for the class 10 chapter Control and Coordination. This ppt will give you a detailed conceptual understanding of the chapter in a very easy language.
This presentation is made in accordance with the NCERT textbook of Biology for Class 11. It deals with the introduction and characteristics of living organisms as well as concepts of nomenclature..
FOR FURTHER DETAILS YOU CAN WATCH THE RELATED VIDEO AT THE GIVEN LINK
https://www.youtube.com/channel/UCxo06Nj-QWo_7SNvMyDnJCQ?view_as=subscriber
The Fundamental Unit Of Life Class - 9NehaRohtagi1
This PowerPoint Presentation will help the students of Class - 9 to understand that How a Cell Divides and the Organization Of Nucleas and so on. This Slide Presentation will clear your doubts and help you to score good marks in the examinations.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. HISTORY
In 1665 Robert Hooke examined the slice of
cork by self designed microscope .
Cork is a substance which comes from bark of
tree.
By microscope cork resembled the structure
of a honey comb consisting of many little
compartments.
This was very important invention in the history
of science that living things appear to consist
of separate small units.
The word cell use to describe this unit in
biology .
3. In1839 Purkinje discovered some fluid
substance in the cell termed protoplasm.
In 1940 with the discovery of electron
microscope complex structure of cell and
various organelles could understand.
4. CELL
All organisms around us are made up of cells.
Some organisms are made up of single cell called
unicellular organism .e.g. Amoeba.
Many cells grouped together in a single body and
perform various functions called multicellular
organisms .
Some organisms have different kinds of cells with
different shape and size.
Each living cell has a capacity to perform certain
basic function . That are characteristics of all living
forms .
All living cell perform this basic function.
5. As we know there is a division of labour in
multicellular organism such as human being ,
means different part of our body perform different
part of our body perform different functions .
A single cell also perform different functions with
the help of its component which is known as cell
organelles .
These organelles together constitute the basic unit
called the cell.
6. STRUCTURE OF A CELL
A cell have 3 features –
Plasma membrane
Nucleus
Cytoplasm
Plasma membrane
Cell membrane is the outer most covering of the cell
that separate the content of the from its external
environment .
Structure
The plasma membrane is flexible made up of
organic molecules –
Lipid
Protein
7. We can observe the structure of plasma only
through an electron microscope .
The flexibility of cell membrane also enable the cell
to engulf the food and other material from its
external environment . This process is known as
endocytosis. Ex :- Amoeba enquires its food through
this process.
8. Cell wall
In plants cells addition to the plasma membrane
another rigid outer covering called the cell wall.
Structure
This is made up of complex substance cellulose .
It provide strength to plant.
Functions
Cell walls permit the cell of plant , fungi and
bacteria to with stand very dilute external media
without bursting .
It take water by osmosis.
9. Function of plasma membrane
Separation of content of cell.
Permit the entry and exit of material .
Prevent movement of some other material called
selectively permeable membrane .
Some substance like carbon dioxide , oxygen can
move across the cell membrane by a process
called diffusion. In diffusion substance move from a
region of high concentration to low concentration.
10. Use of diffusion – waste product can excrete out by
the cell like carbon dioxide , Respiration.
Movement of water through semi permeable
membrane is called osmosis.
Use of osmosis –
Transportation of water
Transportation of dissolve substance
Transportation of nutritious substance
Transportation/excretion of waste product
Examples of osmosis – unicellular fresh water organism
and most plant cell absorb water by plant root.
11. Use of diffusion – waste product can excrete out by
the cell like carbon dioxide , Respiration.
Movement of water through semi permeable
membrane is called osmosis.
Use of osmosis –
Transportation of water
Transportation of dissolve substance
Transportation of nutritious substance
Transportation/excretion of waste product
Examples of osmosis – unicellular fresh water organism
and most plant cell absorb water by plant root.
12. NUCLEUS
Nucleus is a darkly coloured spherical or oval
dot like structure near the Centre of each cell.
Structure
Double layer covering of nucleus – Nuclear
membrane.
Functions of nuclear membrane – porous and
transfer the material from nucleus to cytoplasm.
13. Chromosomes are rod shapely structure.
Parts of chromosomes – DNA and protein.
DNA – genes and chromatin .
Function of Nucleus – cellular reproduction
Types of nucleus –
Organisms with poorly defined nuclear membrane
is known as prokaryotes .
Organisms with well defined nuclear membrane is
known as eukaryotes.
15. CYTOPLASM
The cytoplasm is the fluid content inside the plasma
membrane. It contains many specialized cell
organelles .
CELL ORGNELLES
Large and complex cells of multicellular organism
need a lot of chemical activities to support their
complicated structure and functions.
To perform these activities membrane bounded
little structures are present called organelles, this is
the feature of eukaryotic cell
These organelles are visible only with electron
microscope.
16. TYPES OF CELL
PROKARYOTIC CELL
Size:generally small
Nuclear region :poorly
defined, nuclear membrane is
absent.
Chromosome : single
Membrane-bounded cell
organelles absent .
EUKARYOTIC CELL
Size:generally large
Nuclear region :well defined ,
nuclear membrane is present.
Chromosomes : more than
one.
Membrane-bounded cell
organelles present.
17. These organelles are :
1. Endoplasmic reticulum
2. Golgi apparatus
3. Lysosomes
4. Mitochondria
5. Plastids
6. Vacuoles
ENDOPLASMIC RETICULUM (ER)
It is a large network of membrane bound tubes and
sheets.
18. Structure
Long tubules and round or oval vesicles.
Type
Rough Endoplasmic Reticulum (RER)
Looking rough under microscope because it contains
particles called ribosomes attached to its surface.
Ribosomes : sight of protein manufacturer
depending on need.
Smooth Endoplasmic Reticulum (SER)
Size of SER –
Varies in size
Smooth in different cells and forms network system.
19. Functions Of Endoplasmic Reticulum
Transport of material like protein within the cell
organs .
Providing a surface framework for some
biochemical activities of cell.
Detoxifying many poison and drugs .
GOLGI APPARATUS
It was discovered by Camilo Golgi by his name is
called Golgi Apparatus .
20. Structure
Membrane bounded vesicles arrange
approximately parallel to each other called cistern.
It is also connected with the membrane of ER so its
also complex cellular membrane system.
Functions
Storage
Modifications
Packaging of products in vesicles
Formation of lysosomes
21. LYSOSOMES
It is known as waste disposal system of the cell .
Helps to keep the cell clean by digesting any
foreign material like bacteria or food.
It contains powerful digestive enzymes which help
to digest foreign materials .
It is also known as suicide bags of a cell.
Structure
Membrane bound sacs, filled with objective
enzymes.
22. MITOCHONDRIA
Mitochondria are known as power house of the
cell.
It release energy for various chemical activities.
Structure
It have 2 membrane covering outer membrane
is very porous while inner one is deeply folded .
These folds create a large surface area for
formation of ATP.
23. Functions
ATP is Adenosine triphosphate .
It produce energy so it is known as the energy
currency of the cell.
It is a organelle of sense because it produce DNA
PLASTIDS
Plastids are present only in plant cells.
Types
Chromoplast – coloured plastids–green , yellow etc.
Leucoplast – white or colourless plastids .
24. Structure
The internal organization of the plastids consist of
numerous membrane layers embedded in a
material called the stroma.
Functions
It contains pigment chlorophyll known as
chromoplast and leucoplast .
Chloroplast contain pigment chlorophyll used for
photosynthesis , it is found in the chromoplast.
Leucoplast is used for storage.
Plastids work like mitochondria because its own
DNA and Ribosomes
25. VACUOLES
Vacuoles are storage sac for solid or liquid
contents.
In plant cells there is very large central
vacuole , providing rigidity to cell.
26. CONCLUSION
Cells have a basic structural organization with the
help of membrane and organelles.
Cells perform functions like respiration, obtaining
nutrition, forming new proteins and cleaning of
waste materials etc.
Thus cell is the fundamental structural and
functional unit of life.