This presentation will give you brief introduction of bioelectronic medicines.

1. BIOELECTRONIC
MEDICINES
Presented By:
Vikas Shrivastav
M.Pharm (Pharmaceutics)
DIPSAR

2. CONTENTS
 INTRODUCTION
 DEFINITION
 HOW IT WORKS
 CHALLENGES
 ADVANTAGES
 VAGUS NERVE STIMULATION
 RHEUMATOID ARTHRITIS

3. BIOELECTRONIC MEDICINES
 INTRODUCTION
 Bioelectronic medicine is a revolution in the field of therapeutics. It takes advantage of
the body's natural electrical impulses and signals to treat a disease.
 Bioelectronic medicine is an exciting new field at the intersection of molecular
medicine, neuroscience and bioengineering. It has the potential to revolutionize the
way we treat disease through the development of nerve-stimulating devices that
interact with the central and peripheral nervous systems.
 While early clinical applications have worked broadly across entire nerves, the ultimate
vision is of miniaturized, implantable closed-loop systems that detect and deliver
precision neuromodulation of specific nerve fibers in order to treat a wide variety of
disorders.

4. BIOELECTRONIC MEDICINES
 DEFINITION
 Bioelectronic medicine are a tiny implanted device treating disease by
changing the electric pulses in nerves to and from specifc organ.
 Aims
 To having effective treatment of the disease with fewer side effects. which is
found in the case of conventional medicines.

5. BIOELECTRONIC MEDICINES
 How it Works
 Bioelectronic medicines work by transmitting electrical impulses along nerve
fibres as against to normal generic medicines which work on molecular
mechanisms.
 It directly modulates the natural language of the body’s nervous systems—
electrical impulses and action potentials.
 The bioelectronic medicine opens a plethora of possibilities to cure diseases
because different action nerves can be targeted to cure a wide variety of
diseases. For example
1. Asthma could be treated while targeting the nerves that control bronchi constriction.
2.Scheming nerves in the pancreas could regulate insulin production to manage diabetes.
3.Nerves leading towards ovaries or tumours could be targeted to treat infertility and cancer.

6. BIOELECTRONIC MEDICINES
 CHALLENGES
 Targeting a specific nerve can be tedious as they are mostly found in the
bundles.
 Discover the exact effect and signalling of any nerve could be rather
challenging.
 Testing of the implanted device for its battery life and longevity is
also going to be arduous.

7. BIOELECTRONIC MEDICINES
 ADVANTAGES
 The properly explored and implemented this idea can reduce the cost of
medicine manufactured.
 Bioelectronic medicines is that it requires minimum invasion for treatment
and also will cause the least hindrance in the normal routine of the patient.
 Bioelectric medicine can also be used as an early detection of disease.
 Bioelectronic medicine restores the balance during disease condition by
blocking or stimulating the nerve impulse.
 Bioelectronic medicines may also allow patients and their physi- cians to
monitor health in real time

8. BIOELECTRONIC MEDICINES
 VAGUS NERVE STIMULATION
 It is a 10th Cranial nerve found in neck.
 A breakthrough research development occurred when vagus nerve was
focused.
 Vagus nerve comprises of around lakhs of sensory and motor fibres leading
to organs such as heart, lungs, pancreas, liver, kidney etc.
 Stimulating the vagus nerve has produced encouraging results in animal
models in a range of diseases as it controls involuntary functions, such as
breathing, digestion and heart rate.

9. BIOELECTRONIC MEDICINES
 RHEUMATOID ARTHRITIS
 A chronic inflammatory disease causes stiff, swollen and painful
joints, including those in the hands and feet.
 In July 2016, a clinical trial proved that when a part of the vagus nerve
was electrically stimulated with an implantable bioelectronic device, there
was a significant reduction in the symptoms in several patients of
rheumatoid arthritis (RA)
 These patients also included those who failed to respond to any of the
generic medicine for treatment (including methotrexate, tumour necrosis
factor [TNF] agonists and biologics), with no serious side effects.
 Stimulating part of the vagus nerve that leads to the spleen for one to 4
min daily inhibited production of TNF, an inflammatory molecule
targeted by many pharmaceutical drugs.

10. REFERENCE
 https://www.futuremedicine.com/journals/bem/aims#:~:text=Aims%20and%20Scope,central
%20and%20peripheral%20nervous%20systems.
 New insights into bioelectronic medicines: A new approach to tackle diabetic peripheral
neuropathy pain in clinics
 Bioelectronic Medicine—Novel Way to Treat Diseases.
 https://www.google.com/search?q=bioelectronic+medicine&sxsrf=ALeKk00RpJemIXwyW-
 https://www.google.com/search?q=rheumatoid+arthritis&tbm=isch&ved=2ahUKEwjfm4-
ZurnvAhWT2XMBHUK-Ay8Q2-

11. THANK YOU