Biodiversity is declining at an exceptionally high rate, with extinctions occurring hundreds of times higher than historical levels. Human activities such as habitat loss, fragmentation, pollution, and climate change are major drivers of this decline. Most studies estimate that without protection, extinction rates could increase 1000 to 10,000 times above past averages in the near future due to these threats. Protecting biodiversity hotspots, which have lost at least 70% of their original habitat but contain many endemic species, could help slow this acceleration of extinctions.