BioDec, based near Bologna, Italy, provides top-notch services, solutions, and consulting in the field of lab data management and in postgenomics "in silico" research. The presentation summarizes our main achievements and describes our commercial offer.
RNA centric research is of growing importance for medicine and molecular biology. Increasing amounts of data from deep sequencing experiments create a demand for automatic analysis and interpretation solutions.
The RNA-Workbench offers a wide range of tools covering classic RNA-bioinformatics as well as RNA-seq fields. Predefined workflows for the annotation of non-coding RNAs or identification of differentially expressed genes are subsets of over 50 included tools from the categories RNA structure analysis, RNA alignment, RNA annotation, RNA-protein interaction, ribosome profiling, RNA-seq analysis and RNA target prediction. RNA specific visualisation solutions for dot-bracket plots and secondary structures are part of the workbench.
In contrast to pre-existing solutions, our community driven approach allowes us to include classic RNA-bioinformatics tools often with the direct support of the tool-authors. These contributions enable us to provide excellent documentation, training material and interactive tours demonstrating the functionality of the workbench.
Building on the Galaxy framework the workbench offers sophisticated analyses to users without command line knowledge, while emphasising reproducibility, customization and effortless scale up to larger infrastructures. The workbench is implemented as Galaxy Docker flavour and therefore easily extendable by additional tools, workflows, tours or training data, that can be installed from the Galaxy ToolShed. The workbench will be further improved and maintained in an ongoing community effort.
This document is a template for a company profile that provides information about a business. It includes sections for business contact details, an introduction to the company's history and services, its strategy and goals, management structure, customers and completed projects. The profile template can be customized with a company's specific information to share details about the business. It is available in MS Word format and can be printed, emailed or provided on disk.
AL-FARAJ Co was established in 1989 to provide maintenance and construction services. It has since expanded to offer various civil, mechanical, electrical, and road construction services. The company aims to provide high quality and timely services through a qualified workforce and latest technologies. It has completed numerous projects for multinational and local clients. AL-FARAJ prioritizes safety, quality, and customer satisfaction in all of its work. It has various subsidiaries and a large inventory of equipment and tools to execute civil infrastructure and construction projects.
Trans Pratama Group is a transportation company operating in Java, Indonesia since 1951. It has over 1,600 vehicles and 11 branches across Java. The company provides cargo delivery services for destinations across Java, transporting goods ranging from 25-60 tons. Trans Pratama Group prides itself on safety, punctuality, and customer satisfaction, aiming to be the leading integrated transportation solution.
Introduction to SlideShare for BusinessesSlideShare
As the global hub of professional content, SlideShare can help you or your business amplify its reach, get discovered by targeted audiences and capture more professional opportunities. Learn why you should use SlideShare for your business
Zenith Technologies is a privately owned automation company founded in 1998 with 325 employees across multiple global locations including Ireland, UK, USA, Singapore and India. It provides automation services for regulated process industries including consultancy, systems integration and support. Zenith has a quality management system registered with the NSAI that is based on ISO9001 and GAMP guidelines. It has experience with various automation platforms and sample projects in industries like pharmaceuticals, chemicals and food & beverage. Zenith also offers customized training programs and managed services including 24/7 support, project management and validation support. A case study showed cost reductions through managed services over three years.
Biggest Automotive Brand in India, know more about us. Click to view the company profile, also this sets a basic format of a company profile should look like. More fancy coffee tables and company profiles are also uploaded to cover all genres and presentation styles. Thanks
Regards
Big Boy Toyz Team
RNA centric research is of growing importance for medicine and molecular biology. Increasing amounts of data from deep sequencing experiments create a demand for automatic analysis and interpretation solutions.
The RNA-Workbench offers a wide range of tools covering classic RNA-bioinformatics as well as RNA-seq fields. Predefined workflows for the annotation of non-coding RNAs or identification of differentially expressed genes are subsets of over 50 included tools from the categories RNA structure analysis, RNA alignment, RNA annotation, RNA-protein interaction, ribosome profiling, RNA-seq analysis and RNA target prediction. RNA specific visualisation solutions for dot-bracket plots and secondary structures are part of the workbench.
In contrast to pre-existing solutions, our community driven approach allowes us to include classic RNA-bioinformatics tools often with the direct support of the tool-authors. These contributions enable us to provide excellent documentation, training material and interactive tours demonstrating the functionality of the workbench.
Building on the Galaxy framework the workbench offers sophisticated analyses to users without command line knowledge, while emphasising reproducibility, customization and effortless scale up to larger infrastructures. The workbench is implemented as Galaxy Docker flavour and therefore easily extendable by additional tools, workflows, tours or training data, that can be installed from the Galaxy ToolShed. The workbench will be further improved and maintained in an ongoing community effort.
This document is a template for a company profile that provides information about a business. It includes sections for business contact details, an introduction to the company's history and services, its strategy and goals, management structure, customers and completed projects. The profile template can be customized with a company's specific information to share details about the business. It is available in MS Word format and can be printed, emailed or provided on disk.
AL-FARAJ Co was established in 1989 to provide maintenance and construction services. It has since expanded to offer various civil, mechanical, electrical, and road construction services. The company aims to provide high quality and timely services through a qualified workforce and latest technologies. It has completed numerous projects for multinational and local clients. AL-FARAJ prioritizes safety, quality, and customer satisfaction in all of its work. It has various subsidiaries and a large inventory of equipment and tools to execute civil infrastructure and construction projects.
Trans Pratama Group is a transportation company operating in Java, Indonesia since 1951. It has over 1,600 vehicles and 11 branches across Java. The company provides cargo delivery services for destinations across Java, transporting goods ranging from 25-60 tons. Trans Pratama Group prides itself on safety, punctuality, and customer satisfaction, aiming to be the leading integrated transportation solution.
Introduction to SlideShare for BusinessesSlideShare
As the global hub of professional content, SlideShare can help you or your business amplify its reach, get discovered by targeted audiences and capture more professional opportunities. Learn why you should use SlideShare for your business
Zenith Technologies is a privately owned automation company founded in 1998 with 325 employees across multiple global locations including Ireland, UK, USA, Singapore and India. It provides automation services for regulated process industries including consultancy, systems integration and support. Zenith has a quality management system registered with the NSAI that is based on ISO9001 and GAMP guidelines. It has experience with various automation platforms and sample projects in industries like pharmaceuticals, chemicals and food & beverage. Zenith also offers customized training programs and managed services including 24/7 support, project management and validation support. A case study showed cost reductions through managed services over three years.
Biggest Automotive Brand in India, know more about us. Click to view the company profile, also this sets a basic format of a company profile should look like. More fancy coffee tables and company profiles are also uploaded to cover all genres and presentation styles. Thanks
Regards
Big Boy Toyz Team
This document summarizes various proteomics resources available at the EBI and ExPASy. It describes databases such as UniProt, IntAct, Reactome, and PRIDE that provide protein sequence and functional information, molecular interaction data, pathways information, and proteomics identifications respectively. It also outlines tools available at ExPASy including Hits, Prosite, SWISS-MODEL, SwissDock, and neXtProt which allow investigation of protein domains, motifs, homology modeling, protein-ligand docking, and human protein information. Additionally, it mentions STRING and VenomZone for protein-protein interaction and venom data, and various other tools for predictions, analyses, and working with proteomics data.
This document discusses software tools for molecular biology. It begins with an introduction to the structure software for identifying genetically homogeneous groups. It then lists related data analysis software called DAMBE. The bulk of the document lists and briefly describes 10 popular molecular biology software tools, including Serial Cloner, Artemis, Molecular Weight Calculator, SeqVerter, Geneious, Foxit Reader, Fast PCR, ApE, Cn3D, and BioToolKit. It concludes by stating that molecular biology software allows analyzing nucleic acid information from biological and chemical perspectives and applying models to develop hypotheses.
Metagenome is the entire genetic information of microorganism at specific site/time. Analysis of metagenomic data could be achieved by two approaches; 1) amplicon (16s RNA gene) data analysis and whole genome metagenomics data analysis. Here we focus on 16S rRNA amplicon using Mothur Pipeline for analysis of metagenomics data.
This document provides an overview of downstream analyses that can be performed after variant identification and filtering in a typical variant calling pipeline. It discusses visualization of variant data in each gene to identify potential causative variants. It also mentions association studies as another type of downstream analysis where variants are tested for association with disease phenotypes. The goal of downstream analyses is to help prioritize variants for further investigation.
Functional annotation assigns functions to the genomic elements found by structural annotation, by relating them to biological processes such as the cell cycle, cell death, development, metabolism, etc. It may also be used as an additional quality check by identifying elements that may have been annotated by error. These annotations come in two types, parameter annotations and return type annotations. One large benefit is that they can provide much needed explanation to the reader as to what type a function parameter expects or a function returns. In this example, adding a string explanation to two vague parameters.
The document provides an overview of Chip-seq data analysis. It discusses the Chip-seq technology, visualization of genomic data, command line analysis including quality checking, alignment, peak calling, annotation, and motif finding. It also discusses downstream analysis such as comparing samples, analyzing region occupancy, and web resources for Chip-seq analysis.
Code sharing for microbiomics analysis is proposed through standardized R packages and GitHub. This facilitates reproducible, efficient and collaborative analysis. Examples of standardized preprocessing, diversity analysis and visualization tools are provided. The microbiome package and wiki provide ready-made analysis examples to build upon.
Publicly available tools and open resources in BioinformaticsArindam Ghosh
This document provides an overview of several freely available bioinformatics tools and open resources. It describes the purpose and function of popular tools for database searching (BLAST, FASTA), sequence alignment (Clustal Omega), visualization (RasMol), molecular dynamics simulation (GROMACS), genome browsing (Ensembl), and protein modeling (MODELLER). These tools are commonly used for tasks like extracting meaningful biological information from databases, comparing sequences, understanding phylogenetic relationships, displaying molecular structures, simulating protein dynamics, and building protein models. The document provides links to each tool's homepage for further information.
Apollo is a web-based application that supports and enables collaborative genome curation in real time, allowing teams of curators to improve on existing automated gene models through an intuitive interface. Apollo allows researchers to break down large amounts of data into manageable portions to mobilize groups of researchers with shared interests.
The i5K, an initiative to sequence the genomes of 5,000 insect and related arthropod species, is a broad and inclusive effort that seeks to involve scientists from around the world in their genome curation process, and Apollo is serving as the platform to empower this community.
This presentation is an introduction to Apollo for the members of the i5K Pilot Project working on species of the order Hemiptera.
Bioinformatics combines biology, chemistry, statistics, and computer science to analyze and interpret biological data. It uses algorithms and techniques of computer science to solve complex biological problems. Some key areas of bioinformatics include organizing biological knowledge, performing sequence analysis, predicting protein structure, genome annotation, and comparative genomics. Bioinformatics is essential for applications like pharmaceutical research, gene therapy, forensic analysis, and understanding biological pathways and networks in systems biology.
Functional genomics uses genome-wide experimental approaches to assess gene function on a large scale. It analyzes gene expression through techniques like transcriptomics and proteomics. Transcriptomics analyzes gene expression profiles through RNA sequencing or microarray analysis. Microarray analysis involves hybridizing fluorescently-labeled cDNA or cRNA to microarrays containing DNA probes to measure gene expression levels across thousands of genes simultaneously. Functional genomics provides a global understanding of gene function and molecular interactions through integrated omics approaches.
Genome in a Bottle - Towards new benchmarks for the “dark matter” of the huma...GenomeInABottle
The document discusses Genome in a Bottle (GIAB) and its efforts to characterize human genomes and provide reference materials and benchmarks to evaluate genome sequencing and variant calling. Specifically, it summarizes how GIAB has characterized 7 human genomes, provides extensive public sequencing data for benchmarking, and is now using linked and long reads to expand the small variant benchmark set, develop a structural variant benchmark, and perform diploid assembly of difficult regions. It also shows how new benchmarks that include more difficult regions have revealed errors in previous benchmarks and reduced performance metrics for variant calling tools.
Presentation in the "Whole genome sequencing for clinical microbiology:Translation into routine applications" Symposium , Basel , Switzerland, 2 Sep 2017
Web Apollo Tutorial for the i5K copepod research community.Monica Munoz-Torres
Introduction to Web Apollo for the i5K i5K copepod research community. WebApollo is genome annotation editor; it provides a web-based environment that allows multiple distributed users to review, edit, and share manual annotations. This presentation includes information specific to the projects of the Global Initiative to sequence the genomes of 5,000 species of arthropods, i5K. Let's get started!
SooryaKiran Bioinformatics is a global bioinformatics solutions provider that focuses on customized bioinformatics services and products. It develops algorithms and software for biological sequence analysis, structure prediction, and other areas. Key products include tools for sequence generation, analysis, and homology identification. The company collaborates with research institutions and has provided solutions for SNP analysis, genome analysis, and mitochondrial DNA analysis to clients around the world.
This document provides an introduction to bioinformatics and biological databases. It defines bioinformatics as the use of computers to analyze biological data like DNA sequences. The aims of bioinformatics include developing databases of all biological information and software for tasks like drug design. Biological databases store complex biological data and can be primary databases containing raw sequences/structures or secondary databases containing derived data. Examples of primary databases include GenBank, EMBL, Swiss-Prot and PDB, while secondary databases include motif, domain, gene expression and metabolic pathway databases. Maintaining accurate, up-to-date biological databases is important for biological research and applications.
DIYA: An annotation pipeline for any genomics labAndrew Stewart
The document describes DIYA, an open source pipeline for annotating genomic sequences. The pipeline takes DNA contigs as input and produces a fully annotated sequence as output. It is modular and expandable. The pipeline includes steps for assembly, gene prediction, BLAST searches, and identification of non-coding RNA and tRNA. The software is designed to be decentralized and accessible for smaller genomics labs.
This document provides an introduction and overview of the field of bioinformatics. It discusses how bioinformatics combines computer science and biology to analyze large amounts of biological data. Specifically, it mentions that bioinformatics uses algorithms and techniques from computer science to solve complex biological problems related to areas like molecular biology, genomics, drug discovery, and more. It also outlines some of the key applications of bioinformatics like sequence analysis, protein structure prediction, genome annotation, and comparative genomics. Finally, it provides brief descriptions of important biological databases and resources that bioinformaticians use to store and analyze genomic and protein sequence data.
Generating privacy-protected synthetic data using Secludy and MilvusZilliz
During this demo, the founders of Secludy will demonstrate how their system utilizes Milvus to store and manipulate embeddings for generating privacy-protected synthetic data. Their approach not only maintains the confidentiality of the original data but also enhances the utility and scalability of LLMs under privacy constraints. Attendees, including machine learning engineers, data scientists, and data managers, will witness first-hand how Secludy's integration with Milvus empowers organizations to harness the power of LLMs securely and efficiently.
Skybuffer SAM4U tool for SAP license adoptionTatiana Kojar
Manage and optimize your license adoption and consumption with SAM4U, an SAP free customer software asset management tool.
SAM4U, an SAP complimentary software asset management tool for customers, delivers a detailed and well-structured overview of license inventory and usage with a user-friendly interface. We offer a hosted, cost-effective, and performance-optimized SAM4U setup in the Skybuffer Cloud environment. You retain ownership of the system and data, while we manage the ABAP 7.58 infrastructure, ensuring fixed Total Cost of Ownership (TCO) and exceptional services through the SAP Fiori interface.
This document summarizes various proteomics resources available at the EBI and ExPASy. It describes databases such as UniProt, IntAct, Reactome, and PRIDE that provide protein sequence and functional information, molecular interaction data, pathways information, and proteomics identifications respectively. It also outlines tools available at ExPASy including Hits, Prosite, SWISS-MODEL, SwissDock, and neXtProt which allow investigation of protein domains, motifs, homology modeling, protein-ligand docking, and human protein information. Additionally, it mentions STRING and VenomZone for protein-protein interaction and venom data, and various other tools for predictions, analyses, and working with proteomics data.
This document discusses software tools for molecular biology. It begins with an introduction to the structure software for identifying genetically homogeneous groups. It then lists related data analysis software called DAMBE. The bulk of the document lists and briefly describes 10 popular molecular biology software tools, including Serial Cloner, Artemis, Molecular Weight Calculator, SeqVerter, Geneious, Foxit Reader, Fast PCR, ApE, Cn3D, and BioToolKit. It concludes by stating that molecular biology software allows analyzing nucleic acid information from biological and chemical perspectives and applying models to develop hypotheses.
Metagenome is the entire genetic information of microorganism at specific site/time. Analysis of metagenomic data could be achieved by two approaches; 1) amplicon (16s RNA gene) data analysis and whole genome metagenomics data analysis. Here we focus on 16S rRNA amplicon using Mothur Pipeline for analysis of metagenomics data.
This document provides an overview of downstream analyses that can be performed after variant identification and filtering in a typical variant calling pipeline. It discusses visualization of variant data in each gene to identify potential causative variants. It also mentions association studies as another type of downstream analysis where variants are tested for association with disease phenotypes. The goal of downstream analyses is to help prioritize variants for further investigation.
Functional annotation assigns functions to the genomic elements found by structural annotation, by relating them to biological processes such as the cell cycle, cell death, development, metabolism, etc. It may also be used as an additional quality check by identifying elements that may have been annotated by error. These annotations come in two types, parameter annotations and return type annotations. One large benefit is that they can provide much needed explanation to the reader as to what type a function parameter expects or a function returns. In this example, adding a string explanation to two vague parameters.
The document provides an overview of Chip-seq data analysis. It discusses the Chip-seq technology, visualization of genomic data, command line analysis including quality checking, alignment, peak calling, annotation, and motif finding. It also discusses downstream analysis such as comparing samples, analyzing region occupancy, and web resources for Chip-seq analysis.
Code sharing for microbiomics analysis is proposed through standardized R packages and GitHub. This facilitates reproducible, efficient and collaborative analysis. Examples of standardized preprocessing, diversity analysis and visualization tools are provided. The microbiome package and wiki provide ready-made analysis examples to build upon.
Publicly available tools and open resources in BioinformaticsArindam Ghosh
This document provides an overview of several freely available bioinformatics tools and open resources. It describes the purpose and function of popular tools for database searching (BLAST, FASTA), sequence alignment (Clustal Omega), visualization (RasMol), molecular dynamics simulation (GROMACS), genome browsing (Ensembl), and protein modeling (MODELLER). These tools are commonly used for tasks like extracting meaningful biological information from databases, comparing sequences, understanding phylogenetic relationships, displaying molecular structures, simulating protein dynamics, and building protein models. The document provides links to each tool's homepage for further information.
Apollo is a web-based application that supports and enables collaborative genome curation in real time, allowing teams of curators to improve on existing automated gene models through an intuitive interface. Apollo allows researchers to break down large amounts of data into manageable portions to mobilize groups of researchers with shared interests.
The i5K, an initiative to sequence the genomes of 5,000 insect and related arthropod species, is a broad and inclusive effort that seeks to involve scientists from around the world in their genome curation process, and Apollo is serving as the platform to empower this community.
This presentation is an introduction to Apollo for the members of the i5K Pilot Project working on species of the order Hemiptera.
Bioinformatics combines biology, chemistry, statistics, and computer science to analyze and interpret biological data. It uses algorithms and techniques of computer science to solve complex biological problems. Some key areas of bioinformatics include organizing biological knowledge, performing sequence analysis, predicting protein structure, genome annotation, and comparative genomics. Bioinformatics is essential for applications like pharmaceutical research, gene therapy, forensic analysis, and understanding biological pathways and networks in systems biology.
Functional genomics uses genome-wide experimental approaches to assess gene function on a large scale. It analyzes gene expression through techniques like transcriptomics and proteomics. Transcriptomics analyzes gene expression profiles through RNA sequencing or microarray analysis. Microarray analysis involves hybridizing fluorescently-labeled cDNA or cRNA to microarrays containing DNA probes to measure gene expression levels across thousands of genes simultaneously. Functional genomics provides a global understanding of gene function and molecular interactions through integrated omics approaches.
Genome in a Bottle - Towards new benchmarks for the “dark matter” of the huma...GenomeInABottle
The document discusses Genome in a Bottle (GIAB) and its efforts to characterize human genomes and provide reference materials and benchmarks to evaluate genome sequencing and variant calling. Specifically, it summarizes how GIAB has characterized 7 human genomes, provides extensive public sequencing data for benchmarking, and is now using linked and long reads to expand the small variant benchmark set, develop a structural variant benchmark, and perform diploid assembly of difficult regions. It also shows how new benchmarks that include more difficult regions have revealed errors in previous benchmarks and reduced performance metrics for variant calling tools.
Presentation in the "Whole genome sequencing for clinical microbiology:Translation into routine applications" Symposium , Basel , Switzerland, 2 Sep 2017
Web Apollo Tutorial for the i5K copepod research community.Monica Munoz-Torres
Introduction to Web Apollo for the i5K i5K copepod research community. WebApollo is genome annotation editor; it provides a web-based environment that allows multiple distributed users to review, edit, and share manual annotations. This presentation includes information specific to the projects of the Global Initiative to sequence the genomes of 5,000 species of arthropods, i5K. Let's get started!
SooryaKiran Bioinformatics is a global bioinformatics solutions provider that focuses on customized bioinformatics services and products. It develops algorithms and software for biological sequence analysis, structure prediction, and other areas. Key products include tools for sequence generation, analysis, and homology identification. The company collaborates with research institutions and has provided solutions for SNP analysis, genome analysis, and mitochondrial DNA analysis to clients around the world.
This document provides an introduction to bioinformatics and biological databases. It defines bioinformatics as the use of computers to analyze biological data like DNA sequences. The aims of bioinformatics include developing databases of all biological information and software for tasks like drug design. Biological databases store complex biological data and can be primary databases containing raw sequences/structures or secondary databases containing derived data. Examples of primary databases include GenBank, EMBL, Swiss-Prot and PDB, while secondary databases include motif, domain, gene expression and metabolic pathway databases. Maintaining accurate, up-to-date biological databases is important for biological research and applications.
DIYA: An annotation pipeline for any genomics labAndrew Stewart
The document describes DIYA, an open source pipeline for annotating genomic sequences. The pipeline takes DNA contigs as input and produces a fully annotated sequence as output. It is modular and expandable. The pipeline includes steps for assembly, gene prediction, BLAST searches, and identification of non-coding RNA and tRNA. The software is designed to be decentralized and accessible for smaller genomics labs.
This document provides an introduction and overview of the field of bioinformatics. It discusses how bioinformatics combines computer science and biology to analyze large amounts of biological data. Specifically, it mentions that bioinformatics uses algorithms and techniques from computer science to solve complex biological problems related to areas like molecular biology, genomics, drug discovery, and more. It also outlines some of the key applications of bioinformatics like sequence analysis, protein structure prediction, genome annotation, and comparative genomics. Finally, it provides brief descriptions of important biological databases and resources that bioinformaticians use to store and analyze genomic and protein sequence data.
Generating privacy-protected synthetic data using Secludy and MilvusZilliz
During this demo, the founders of Secludy will demonstrate how their system utilizes Milvus to store and manipulate embeddings for generating privacy-protected synthetic data. Their approach not only maintains the confidentiality of the original data but also enhances the utility and scalability of LLMs under privacy constraints. Attendees, including machine learning engineers, data scientists, and data managers, will witness first-hand how Secludy's integration with Milvus empowers organizations to harness the power of LLMs securely and efficiently.
Skybuffer SAM4U tool for SAP license adoptionTatiana Kojar
Manage and optimize your license adoption and consumption with SAM4U, an SAP free customer software asset management tool.
SAM4U, an SAP complimentary software asset management tool for customers, delivers a detailed and well-structured overview of license inventory and usage with a user-friendly interface. We offer a hosted, cost-effective, and performance-optimized SAM4U setup in the Skybuffer Cloud environment. You retain ownership of the system and data, while we manage the ABAP 7.58 infrastructure, ensuring fixed Total Cost of Ownership (TCO) and exceptional services through the SAP Fiori interface.
Main news related to the CCS TSI 2023 (2023/1695)Jakub Marek
An English 🇬🇧 translation of a presentation to the speech I gave about the main changes brought by CCS TSI 2023 at the biggest Czech conference on Communications and signalling systems on Railways, which was held in Clarion Hotel Olomouc from 7th to 9th November 2023 (konferenceszt.cz). Attended by around 500 participants and 200 on-line followers.
The original Czech 🇨🇿 version of the presentation can be found here: https://www.slideshare.net/slideshow/hlavni-novinky-souvisejici-s-ccs-tsi-2023-2023-1695/269688092 .
The videorecording (in Czech) from the presentation is available here: https://youtu.be/WzjJWm4IyPk?si=SImb06tuXGb30BEH .
HCL Notes und Domino Lizenzkostenreduzierung in der Welt von DLAUpanagenda
Webinar Recording: https://www.panagenda.com/webinars/hcl-notes-und-domino-lizenzkostenreduzierung-in-der-welt-von-dlau/
DLAU und die Lizenzen nach dem CCB- und CCX-Modell sind für viele in der HCL-Community seit letztem Jahr ein heißes Thema. Als Notes- oder Domino-Kunde haben Sie vielleicht mit unerwartet hohen Benutzerzahlen und Lizenzgebühren zu kämpfen. Sie fragen sich vielleicht, wie diese neue Art der Lizenzierung funktioniert und welchen Nutzen sie Ihnen bringt. Vor allem wollen Sie sicherlich Ihr Budget einhalten und Kosten sparen, wo immer möglich. Das verstehen wir und wir möchten Ihnen dabei helfen!
Wir erklären Ihnen, wie Sie häufige Konfigurationsprobleme lösen können, die dazu führen können, dass mehr Benutzer gezählt werden als nötig, und wie Sie überflüssige oder ungenutzte Konten identifizieren und entfernen können, um Geld zu sparen. Es gibt auch einige Ansätze, die zu unnötigen Ausgaben führen können, z. B. wenn ein Personendokument anstelle eines Mail-Ins für geteilte Mailboxen verwendet wird. Wir zeigen Ihnen solche Fälle und deren Lösungen. Und natürlich erklären wir Ihnen das neue Lizenzmodell.
Nehmen Sie an diesem Webinar teil, bei dem HCL-Ambassador Marc Thomas und Gastredner Franz Walder Ihnen diese neue Welt näherbringen. Es vermittelt Ihnen die Tools und das Know-how, um den Überblick zu bewahren. Sie werden in der Lage sein, Ihre Kosten durch eine optimierte Domino-Konfiguration zu reduzieren und auch in Zukunft gering zu halten.
Diese Themen werden behandelt
- Reduzierung der Lizenzkosten durch Auffinden und Beheben von Fehlkonfigurationen und überflüssigen Konten
- Wie funktionieren CCB- und CCX-Lizenzen wirklich?
- Verstehen des DLAU-Tools und wie man es am besten nutzt
- Tipps für häufige Problembereiche, wie z. B. Team-Postfächer, Funktions-/Testbenutzer usw.
- Praxisbeispiele und Best Practices zum sofortigen Umsetzen
Introduction of Cybersecurity with OSS at Code Europe 2024Hiroshi SHIBATA
I develop the Ruby programming language, RubyGems, and Bundler, which are package managers for Ruby. Today, I will introduce how to enhance the security of your application using open-source software (OSS) examples from Ruby and RubyGems.
The first topic is CVE (Common Vulnerabilities and Exposures). I have published CVEs many times. But what exactly is a CVE? I'll provide a basic understanding of CVEs and explain how to detect and handle vulnerabilities in OSS.
Next, let's discuss package managers. Package managers play a critical role in the OSS ecosystem. I'll explain how to manage library dependencies in your application.
I'll share insights into how the Ruby and RubyGems core team works to keep our ecosystem safe. By the end of this talk, you'll have a better understanding of how to safeguard your code.
TrustArc Webinar - 2024 Global Privacy SurveyTrustArc
How does your privacy program stack up against your peers? What challenges are privacy teams tackling and prioritizing in 2024?
In the fifth annual Global Privacy Benchmarks Survey, we asked over 1,800 global privacy professionals and business executives to share their perspectives on the current state of privacy inside and outside of their organizations. This year’s report focused on emerging areas of importance for privacy and compliance professionals, including considerations and implications of Artificial Intelligence (AI) technologies, building brand trust, and different approaches for achieving higher privacy competence scores.
See how organizational priorities and strategic approaches to data security and privacy are evolving around the globe.
This webinar will review:
- The top 10 privacy insights from the fifth annual Global Privacy Benchmarks Survey
- The top challenges for privacy leaders, practitioners, and organizations in 2024
- Key themes to consider in developing and maintaining your privacy program
Project Management Semester Long Project - Acuityjpupo2018
Acuity is an innovative learning app designed to transform the way you engage with knowledge. Powered by AI technology, Acuity takes complex topics and distills them into concise, interactive summaries that are easy to read & understand. Whether you're exploring the depths of quantum mechanics or seeking insight into historical events, Acuity provides the key information you need without the burden of lengthy texts.
Ocean lotus Threat actors project by John Sitima 2024 (1).pptxSitimaJohn
Ocean Lotus cyber threat actors represent a sophisticated, persistent, and politically motivated group that poses a significant risk to organizations and individuals in the Southeast Asian region. Their continuous evolution and adaptability underscore the need for robust cybersecurity measures and international cooperation to identify and mitigate the threats posed by such advanced persistent threat groups.
Webinar: Designing a schema for a Data WarehouseFederico Razzoli
Are you new to data warehouses (DWH)? Do you need to check whether your data warehouse follows the best practices for a good design? In both cases, this webinar is for you.
A data warehouse is a central relational database that contains all measurements about a business or an organisation. This data comes from a variety of heterogeneous data sources, which includes databases of any type that back the applications used by the company, data files exported by some applications, or APIs provided by internal or external services.
But designing a data warehouse correctly is a hard task, which requires gathering information about the business processes that need to be analysed in the first place. These processes must be translated into so-called star schemas, which means, denormalised databases where each table represents a dimension or facts.
We will discuss these topics:
- How to gather information about a business;
- Understanding dictionaries and how to identify business entities;
- Dimensions and facts;
- Setting a table granularity;
- Types of facts;
- Types of dimensions;
- Snowflakes and how to avoid them;
- Expanding existing dimensions and facts.
Cosa hanno in comune un mattoncino Lego e la backdoor XZ?Speck&Tech
ABSTRACT: A prima vista, un mattoncino Lego e la backdoor XZ potrebbero avere in comune il fatto di essere entrambi blocchi di costruzione, o dipendenze di progetti creativi e software. La realtà è che un mattoncino Lego e il caso della backdoor XZ hanno molto di più di tutto ciò in comune.
Partecipate alla presentazione per immergervi in una storia di interoperabilità, standard e formati aperti, per poi discutere del ruolo importante che i contributori hanno in una comunità open source sostenibile.
BIO: Sostenitrice del software libero e dei formati standard e aperti. È stata un membro attivo dei progetti Fedora e openSUSE e ha co-fondato l'Associazione LibreItalia dove è stata coinvolta in diversi eventi, migrazioni e formazione relativi a LibreOffice. In precedenza ha lavorato a migrazioni e corsi di formazione su LibreOffice per diverse amministrazioni pubbliche e privati. Da gennaio 2020 lavora in SUSE come Software Release Engineer per Uyuni e SUSE Manager e quando non segue la sua passione per i computer e per Geeko coltiva la sua curiosità per l'astronomia (da cui deriva il suo nickname deneb_alpha).
HCL Notes and Domino License Cost Reduction in the World of DLAUpanagenda
Webinar Recording: https://www.panagenda.com/webinars/hcl-notes-and-domino-license-cost-reduction-in-the-world-of-dlau/
The introduction of DLAU and the CCB & CCX licensing model caused quite a stir in the HCL community. As a Notes and Domino customer, you may have faced challenges with unexpected user counts and license costs. You probably have questions on how this new licensing approach works and how to benefit from it. Most importantly, you likely have budget constraints and want to save money where possible. Don’t worry, we can help with all of this!
We’ll show you how to fix common misconfigurations that cause higher-than-expected user counts, and how to identify accounts which you can deactivate to save money. There are also frequent patterns that can cause unnecessary cost, like using a person document instead of a mail-in for shared mailboxes. We’ll provide examples and solutions for those as well. And naturally we’ll explain the new licensing model.
Join HCL Ambassador Marc Thomas in this webinar with a special guest appearance from Franz Walder. It will give you the tools and know-how to stay on top of what is going on with Domino licensing. You will be able lower your cost through an optimized configuration and keep it low going forward.
These topics will be covered
- Reducing license cost by finding and fixing misconfigurations and superfluous accounts
- How do CCB and CCX licenses really work?
- Understanding the DLAU tool and how to best utilize it
- Tips for common problem areas, like team mailboxes, functional/test users, etc
- Practical examples and best practices to implement right away
OpenID AuthZEN Interop Read Out - AuthorizationDavid Brossard
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Programming Foundation Models with DSPy - Meetup SlidesZilliz
Prompting language models is hard, while programming language models is easy. In this talk, I will discuss the state-of-the-art framework DSPy for programming foundation models with its powerful optimizers and runtime constraint system.
Unlock the Future of Search with MongoDB Atlas_ Vector Search Unleashed.pdfMalak Abu Hammad
Discover how MongoDB Atlas and vector search technology can revolutionize your application's search capabilities. This comprehensive presentation covers:
* What is Vector Search?
* Importance and benefits of vector search
* Practical use cases across various industries
* Step-by-step implementation guide
* Live demos with code snippets
* Enhancing LLM capabilities with vector search
* Best practices and optimization strategies
Perfect for developers, AI enthusiasts, and tech leaders. Learn how to leverage MongoDB Atlas to deliver highly relevant, context-aware search results, transforming your data retrieval process. Stay ahead in tech innovation and maximize the potential of your applications.
#MongoDB #VectorSearch #AI #SemanticSearch #TechInnovation #DataScience #LLM #MachineLearning #SearchTechnology
In the rapidly evolving landscape of technologies, XML continues to play a vital role in structuring, storing, and transporting data across diverse systems. The recent advancements in artificial intelligence (AI) present new methodologies for enhancing XML development workflows, introducing efficiency, automation, and intelligent capabilities. This presentation will outline the scope and perspective of utilizing AI in XML development. The potential benefits and the possible pitfalls will be highlighted, providing a balanced view of the subject.
We will explore the capabilities of AI in understanding XML markup languages and autonomously creating structured XML content. Additionally, we will examine the capacity of AI to enrich plain text with appropriate XML markup. Practical examples and methodological guidelines will be provided to elucidate how AI can be effectively prompted to interpret and generate accurate XML markup.
Further emphasis will be placed on the role of AI in developing XSLT, or schemas such as XSD and Schematron. We will address the techniques and strategies adopted to create prompts for generating code, explaining code, or refactoring the code, and the results achieved.
The discussion will extend to how AI can be used to transform XML content. In particular, the focus will be on the use of AI XPath extension functions in XSLT, Schematron, Schematron Quick Fixes, or for XML content refactoring.
The presentation aims to deliver a comprehensive overview of AI usage in XML development, providing attendees with the necessary knowledge to make informed decisions. Whether you’re at the early stages of adopting AI or considering integrating it in advanced XML development, this presentation will cover all levels of expertise.
By highlighting the potential advantages and challenges of integrating AI with XML development tools and languages, the presentation seeks to inspire thoughtful conversation around the future of XML development. We’ll not only delve into the technical aspects of AI-powered XML development but also discuss practical implications and possible future directions.
Nordic Marketo Engage User Group_June 13_ 2024.pptx
BioDec Srl Company Profile
1. Introducing BioDec ...
● Bioinformatic turnkey
solutions
BioDec S.r.l.
● Bioinformatics consulting
Via Calzavecchio 20/2 ● Biosequence DB
I-40033 Casalecchio di Reno (BO)
annotation pipelines
info@biodec.com
www.biodec.com ● Web applications
● System integration
Close ties to UniBo Biocomputing Unit
(www.biocomp.unibo.it)
2. Business Activities
Bioinformatic turnkey solutions
• Integrated solutions:
• Bioinformation / Lab Data Management System - CMS-
based lab data, diary and workflow management;
• Molecular Anthropology - Haplogroup tree browsers;
• Plone4bio - CMS-based biosequence management and
annotation software.
• Decoders (predictors).
Bioinformatics Consulting
• Development, engineering and integration of custom software;
• Annotated databases of biosequences (e.g. genomes).
Our Forte
• Bioinformation management;
• Machine-learning methods and annotation pipelines;
• Web applications.
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3. Bioinformation Management System
A bundle including Plone4Bio, the annotated databases, and
BioDec's own lab data management software, to collect, manage and
analyse laboratory data from specific molecular biology techniques.
• Lab diary, recording aims and conditions of the experiment, including
structured pages for the recording of experimental data, specific
of each technique. Data may include digital images, and may be
shared within a working group or an organization according to
flexible, entirely user-defined security levels. Presently supports:
●
Immunogenic assays (due 1st quarter 2010);
● Polymerase Chain Reaction techniques;
● Electrophoresis blot techniques.
• Customizable workflows are supported, and may differ for specific
techniques or Customer specifications, thus ensuring a full match
between the rules applied in the lab and the data lifecycle.
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7. Haplone
● An application for
the management
of molecular
antropology data
● Allows to store,
inspect, search
and retrieve data
through the
familiar interface
of a standard web
browser
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8. Haplone screenshots
● Population subsets can be
easily selected (by location,
haplogroup, sex, MRCA) using
simple query forms, whose
reports also provide basic
statistics and charts on the
selected sets.
● By leveraging on Plone access-
control features, the
application can handle
selective access to stored data,
allowing fine-grained control on
what it can be accessed by an
anonymous vs an
authenticated user, so it can be
used both for internal
information sharing and data
dissemination simultaneously.
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9. Haplone screenshots
● Data are stored in the
"Subject" data structure,
containing both personal and
molecular data.
● For each subject, the
application calculates on-the-
fly the haplogroup, based on
its tested UEPs, as well as the
most recent common ancestor
for each sexual lineage, based
on the stored population.
● The system also takes care of
checking data consistency and
flags the user for potential
errors, such as inconsistent or
conflicting UEPs or out-of-
range STRs within a given
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10. Plone4Bio
● A Plone-based (http://plone.net), feature-rich graphic
BioSQL browser, to search and explore data and
metadata (annotations) from biosequence databases.
May integrate custom-made predictors (“Decoders”);
● We publicly released the base version, including an
example predictor and documentation, as open-source
software, available from http://plone4bio.org;
● Plone4Bio is reliable and modular, and is the basis of
BioDec commercial software bundles.
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14. Plone4Bio commercial release
User-managed pipeline for biosequence analysis and comparison,
providing:
● Full CMS features: several standard and user-defined content
types (including files, pages, RSS feeds...);
● Full set of Decoders: to annotate biosequences from any
database;
● User-defined biosequences: customer's own biosequences
may be instantiated and populated;
● Annotated databases: our decoders have been used to
annotate and cross-link public databases sections from Uniprot,
NCBI and Ensembl, thus providing a reliable and meaningful
metadata set. Custom annotated databases are available on
request.
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15. Tools from machine learning
Known sequences (DB subsets) New sequence
TTCCPSIVARSNFNVCRLPGTPEAICATYTGCIIIPGATCPGDYAN
ANN, ANN,
General HMM,
HMM,
SVM Rules SVM
Known mapping
Prediction
Known • Artificial Neural Networks (ANNs)
structures • Hidden Markov Models (HMMs)
• Support Vector Machines (SVMs)
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16. BioDec Decoders
Protein sequence tools Protein Structure tools
● Transmembrane all-alpha sequence ● Interaction patch prediction
● Transmembrane all-beta sequence ● Fold recognition and modelling
● Signal peptide RNA tools
● GPI-anchoring prediction ● siRNA design
● Coiled-coil segment prediction
● Disordered region prediction Our toolbox is built to be MODULAR,
● Subcellular localization prediction so we can assemble analysis systems
according to your specifications.
● Sequence classification
Papers about our decoders have been published in journals such as
Bioinformatics, Journal of Molecular Biology, Nucleic Acids Research.
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17. A BioDec Decoder: ZenDock
● Interaction patch decoder
● Analyzes protein solvent-
exposed surface for putative
“interactor” residues,
returning a “fuzzy”
(probabilistic) answer.
● Interactors are correlated
and grouped into patches.
● Results are mapped on the
protein 3D structure and
made available through a Int non-Int
web interface.
Contact-shell profile
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18. Case study - Searching for the “membrane
fraction” of a bacterial proteome
• Angler, a Pipeline for the annotation of proteome biosequences
such as prokaryotic proteomes, is used to select candidates for
epitope selection.
• The annotation results (“Proteome Atlases”) are published in
annotated databases.
Angler classifies gram- Proteome Predictions:
negative proteome ✔ Signal peptides
sequences into nine
✔ Betabarrels
different classes, including Generate Classify:
✔ Alpha-helical TMP
the all-beta membrane profiles 9 classes
✔ Fold recognition
proteins and the soluble
✔ Coiled coils
secreted proteins, most
relevant to vaccine ✔ Disordered regions
Proteome
development.
Atlas
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19. Angler performance
EcoGene Knowledge Base (E. Coli K12)
Accuracy Coverage
All-alpha TMP 92.3% 92.6%
All-beta TMP 86.7% 75.0%
Soluble 96.9% 95.9%
All-alpha TMPs represent less than 20% of a proteome.
All-beta TMPs represent less than 5% of a proteome.
Outer Membrane Inner Membrane
β-barrel α-helices
Bilayer
Porin Bacteriorhodopsin
(Rhodobacter capsulatus) (Halobacterium salinarum)
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20. Case Study - siRNA Design
• Sirena, a siRNA design engine, used two very
large, consistent and independent data sets from
the literature: one for fitting, the other for testing.
• Based on machine-learning: Neural Network.
• Prediction is performed on a 19nt input window.
• Input is the sequence and the sequence composition for each
window in the mRNA sequence.
• Output is an estimated knock-down efficiency (Q).
• Around 70% of the reported candidates are expected to have
experimental knock-down efficiency greater than 80%.
• Successfully field-tested by TargetHerpes virologists.
TargetHerpes.org
20/25
21. Case study - Discovering new
receptors of pharmaceutical interest
I have a compound library active
on some receptors subclasses.
Q.: Which sequences in the
Human genome may be
targeted by my library?
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22. BioDec's approach
Train
● Find all known, classified
receptors.
● Build a MSA using both sequence
and 7TM-topology informations.
● From MSA, derive and partition a
classification tree.
● Train class-specific HMMs.
Predict
● Scan Human genome using our
“Septimus” tool to find putative
new 7TM-receptors.
● Classify using the class HMMs.
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23. Success
● Consistent 7TM prediction
for all the targets, useful for
receptor modelling.
● Some newly-classified
targets have been
succesfully validated.
– New targets
– New lead molecules
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24. Case study - blocking protein-protein interaction
● ZenDock: multiple analysis on each
available structure then consensus.
● Predicted a new potential interaction
site.
● Very good agreement between
prediction and experiments.
● Peptide found is now a new-drug lead.
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25. Thank you
BioDec S.r.l.
Via Calzavecchio 20/2
I-40033 Casalecchio di Reno (BO)
info@biodec.com
www.biodec.com
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