This document discusses chronic fatigue syndrome (CFS) and anaplastic large cell lymphoma (ALCL). It begins with an introduction and table of contents on CFS and ALCL. It then provides 3 sections on CFS that discuss the origin and case study, symptoms, and treatment. Another 3 sections discuss ALCL and cover the origin and case study, symptoms, and treatment. The document concludes with an acknowledgment section.

1. Exploring the
unexplored
diseases/syndrome

2. Anisha Hajra
Member names
01 02 03
04
Anoushka
Mukherjee
Arhat Saurabh
Prasad
Aritra
bhattacharjee
05 06
Arnavkant Ojha
Arshiya
Bhattacharya

3. 1-Origin and case
study
TABLE OF CONTENTS
01 02 03
04
2-Symptoms 3-Treatment
4-Origin and case
study
05 06
5-Symptoms 6-Treatment
Chronic fatigue
syndrome
Chronic fatigue
syndrome
Chronic fatigue
syndrome
Anaplastic large
cell lymphoma Anaplastic large
cell lymphoma
Anaplastic large
cell lymphoma

4. Origin and
case study
of Chronic
fatigue
syndrome
01

5. Do you know what helps you make your point clear? Lists like
this one:
● They’re simple
● You can organize your ideas clearly
● You’ll never forget to buy milk!
And the most important thing: the audience won’t miss the
point of your presentation
THE SLIDE TITLE GOES HERE!

8. Symptoms
of chronic
fatigue
syndrome
02

9. Symptoms Of
Chronic
Fatigue
Syndrome
By Anouskha
Mukherjee

10. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is more
than feeling tired all the time. It comes with a lot of other symptoms that
can make it hard to handle daily life.. The fatigue and symptoms can
last 6 months or can go on for years. Sleep and rest don’t make it
better, either.
A doctor can help relieve your symptoms, but first, you need to get
diagnosed.
If you have ME/CFS, you’ll have these three “core” symptoms:
Reduced ability to do usual activities for six months or more because of
fatigue
Worsening of symptoms (difficulty thinking, problems sleeping, sore
throat, headaches, feeling dizzy, or severe tiredness). after usual
physical or mental activity
Trouble falling asleep or staying asleep
Along with the three symptoms, you must have one of these for a
diagnosis of chronic fatigue syndrome:
Problems with thinking and memory
Worsening of symptoms while standing or sitting upright; you might feel
lightheaded, dizzy or weak, and you may have blurred vision or see
spots.

11. Some categories of symptoms
Of unexplained muscle pain, quite similar to the pain caused by
fibromyalgia (in about 70% of people), often accompanied by significant
and unusual headaches;
Neurological or cognitive problems: confusion, short-term memory loss,
difficulty concentrating, disorientation, difficulty in visual focusing,
hypersensitivity to noise and light, etc.
Manifestations of the autonomic nervous system: difficulty standing
upright (standing, sitting, or walking), pressure drop when standing up,
feeling dizzy, extreme pallor, nausea, irritable bowel syndrome, frequent
urination, palpitations, cardiac arrhythmia, etc.
Neuroendocrine manifestations: instability of body temperature (below
normal, periods of sweating, feverish sensation, cold extremities,
intolerance to extreme temperatures), significant weight change, etc .;
Immune manifestations: frequent or recurrent sore throat, armpit, and
groin sensitive lymph nodes, recurrent flu symptoms, allergies or food
intolerances, etc.

12. Treatment
of chronic
fatigue
syndrome
03
By Arhat
Saurabh
Prasad

13. Chronic Fatigue Syndrome: Treatment.
Treatment:
There is no cure for chronic fatigue syndrome. Treatment focuses on symptom relief. The most disruptive or
disabling symptoms should be addressed first.
Medications:
Some problems associated with chronic fatigue syndrome can be improved with either prescription or
over-the-counter medications. Examples include:
Depression: Many people with long-term health problems, such as chronic fatigue syndrome, are also
depressed. Treating your depression can make it easier for you to cope with the problems associated with
chronic fatigue syndrome. Low doses of some antidepressants can also help improve sleep and relieve
pain.
Orthostatic intolerance: Some people with chronic fatigue syndrome, particularly adolescents, feel faint
or nauseated when they stand or sit upright. Medications to regulate blood pressure or heart rhythms
may be helpful.
Pain: If over-the-counter medications such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium
(Aleve) don't help enough, prescription drugs sometimes used to treat fibromyalgia might be options for
you. These include pregabalin (Lyrica), duloxetine (Cymbalta), amitriptyline or gabapentin (Neurontin).

14. Therapy:
Many people with chronic fatigue syndrome benefit from:
Counseling: Talking with a counselor can help build coping skills to deal with chronic illness, address
limitations at work or school, and improve family dynamics. It can also be helpful for managing
depression.
Addressing sleep problems: Sleep deprivation can make other symptoms more difficult to deal with.
Your doctor might suggest avoiding caffeine or changing your bedtime routine. Sleep apnea can be
treated by using a machine that delivers air pressure through a mask while you sleep.
Exercise: Aggressive exercise regimens often lead to worsened symptoms, but maintaining activities
that are tolerated is important to prevent deconditioning. Exercise regimens that start at a very low
intensity and increase very gradually over time may be helpful in improving long-term function.
Some home remedies and lifestyle changes to prevent CFS are that limiting or eliminating your caffeine
intake can help you sleep better and ease your insomnia. You should limit or avoid nicotine and alcohol too.
Try to avoid napping during the day if it’s hurting your ability to sleep at night. Create a sleep routine. Go to
bed at the same time every night and aim to wake up around the same time every day. In many cases, CFS can
trigger or be a symptom of depression. You may need low-dose antidepressant therapy or a referral to a mental
health provider. If lifestyle changes don’t give you a restful night’s sleep, your doctor may suggest a sleep aid.
Pain-reducing medication can also help you cope with aches and joint pain caused by CFS. Acupuncture, tai
chi, yoga, and massage are some of the alternative medicines and treatments that may help relieve the pain
associated with CFS.

15. Origin and
case study
of
anaplastic
large cell
lymphoma
04
By Aritra
Bhattacharjee

17. Symptoms
of
anaplastic
large cell
lymphoma
05
By Arnavkant Ojha

18. Symptoms of Anaplastic Large Cell
Lymphoma
Common symptoms of Lymphoma include swelling of
lymph nodes in your neck, in your armpits or your groin.
This is often but not always painless and often could be
associated with fevers, or unexplained weight loss, or
drenching night sweats and fever. Many individuals also
experience itchiness in their hands, lower legs or feet and
some also feel it throughout their body.

19. Patients often report that the itching tends to worsen while they
are lying in bed at night. Shortness of breath is also a major
symptom. These symptoms can start or get worse in just a few
weeks. The most common symptom is one or more painless
swellings. These swellings can grow very quickly. People with
Large Cell Lymphoma often die from infections, bleeding or organ
failure resulting from metastasis. Hodgkin Lymphoma cells can
spread from the lymph nodes where the cancer started to other
parts of the body. This spread is called metastasis. A serious
infection or sudden bleeding can lead up to death, even if
someone doesn’t appear very ill.

20. Treatment
of
anaplastic
large cell
lymphoma
06
By Arshiya Bhattacharya

21. Treatment
• Systemic ALCL is treated with standard chemotherapy.
• Other therapies include radiotherapy, stem cell transplants and steroid therapy.
• People with ALK-positive ALCL generally respond well to chemotherapy.
• Surgery is the most common treatment for primary ALCL.
• We may need radiation therapy if the cancer has spread to your lymph nodes.
• Primary cutaneous ALCL often returns within 5 years of treatment.
• You may need other forms of treatment if the localized tumours cant be removed
with surgery or if your cancer keeps returning.

22. Treatments
may include
• ORAL METHOTRAXATE
• BEXAROTENE
• BRENTUXIMAB VEDOTIN
• INTERFERON

23. ACKNOWLEDGEMENT
We would like to thank our Principal Ma’am Ms. Sonali
Sen, our School
DPS New town and our Biology Teacher Pooja Ma’am
for giving us
an opportunity to work on such an interesting topic and
to do research on
the same. We would like to thank our parents who have
guided us.
I would also like to thank my fellow group members for
their co-operation
and support which enabled me to complete the project
within the given time-frame.

24. Bibliography
• https://www.mediologiest.com/
• https://www.hopkinsmedicine.org/
• https://www.mayoclinic.org/diseases-
conditions/chronic-fatigue-syndrome/diagnosis-tre
• www.google.com
• www.wikipedia.com
• www.wikipedia.webMd.com

25. Thank
you!!!