Anisometropia is an unequal refractive state between the two eyes. It can be congenital or acquired later in life. Anisometropia above 4 diopters is not well tolerated and can cause issues. Aniseikonia refers to unequal image size between the two eyes, which can result from high anisometropia. It can cause symptoms like asthenopia. Treatment options include glasses, contact lenses, refractive surgery, or aniseikonic lenses.