Most people apply herbicides or weed killer at the wrong time of year. This is especially true for perennials. Why? First, you are probably most motivated in the springtime when you first get outside. Second, herbicide labels direct you to apply the herbicide when plants are "actively growing." If there's anytime when weeds are "actively growing," it's in the spring! If you do apply a weed killer to a perennial in spring when weeds are growing fast, you will see evidence of harm to the foliage. However, because sugars are pushing from the roots and rhizomes into the leaves, it can be very difficult for the herbicide to translocate to the roots and underground storage components of the plant. Therefore, you will see a "top-kill" of the invasive plant, but the plant likely will re-sprout. This video gives advice on how to avoid such problems.