The document discusses the role of probiotics in managing gestational diabetes and other non-communicable diseases (NCDs). It highlights the potential benefits of specific strains like Lactobacillus rhamnosus and Bifidobacterium lactis in improving insulin sensitivity and immune function in the elderly. Additionally, it explores the impact of probiotics and prebiotics on weight management and cardiovascular health, particularly through postprandial triglyceride regulation.

1. Role of probiotics in gestational
diabetes and related NCDs:
What you should know
Dr. Anders Henriksson
Principal Application Specialist
DuPont Nutrition & Health, Australia/ New Zealand
Vitafoods Asia 2017

2. Ottman et al., 2012
Changes of gut microbiota through the life

3. 1/17/2012 3

4. 1/17/2012 4

5. Gestational diabetes
51/17/2012
Tutino et al (2014) Diabetic Medicine

6. 6
Location Prevalence according to IADPSG (%)
Singapore 25.1
Thailand, Bangkok 23.0
Hong Kong 14.4
Australia, Brisbane 12.4
Australia, Newcastle 15.3
Prevalence of GDMˠ
ˠ Sacks et al (2012) Diabetes Care

7. 1/17/2012 7
TM

9. Results suggest that
Lactobacillus rhamnosus HN001TM may reduce the prevalence of
gestational diabetes. Results suggests that a daily administration of this
strain from the first trimester of pregnancy may reduce a prevalence of
25% to as low as 8%
Lactobacillus acidophilus NCFM® may improve insulin sensitivity in obese
men with impaired insulin sensitivity or diabetes
Probiotic strains with such properties may reduce the prevalence and
severity of other symptoms of the metabolic syndrome
9

10. 1/17/2012 10

11. The friendly bug you will want
to catch in your golden years
Vitafoods Asia 2017
Dr. Anders Henriksson
Principal Application Specialist
DuPont Nutrition & Health, Australia/ New Zealand

12. The elderly represent the fastest growing population globally
By 2050, the global population of senior
persons is projected to more than double
its size in 2015, reaching nearly 2.1 billion
Common among the elderly:
United Nations Report : World Population Prospects, 2015
2
1
9
9
0
2
0
1
5
2
0
3
0
2
0
5
0
2
1
0
0
0
1
2
3
4
P ro je c te d g lo b a l p o p u la tio n
a g e d 6 0 ye a rs a n d a b o ve
Billion
0 .5
0 .9
2 .1
1 .4
3 .2
suboptimal diet including protein-undernutrition
changes in gut microbiota composition
declined immune function
increased susceptiblity to infections
decreased vaccine responses

13. Intestinal microbiota and age
31/17/2012
Source: Tomotari Mitsuoka. Intestinal Flora and Diet.

14. Probiotics may improve immune system function in the elderly
through different mechanisms which lead to health benefits
Beneficial changes in gut
microbiota composition
e.g. number of bifidobacteria
Cytokine production
Phagocytic
and cytotolytic
Activity Antibody
production
Secretion of
immuno-
modulatory
compounds
Direct impact on
immune cells
Modulation
of gut
microbiota
Innate immunity
function
Acquired immunity
function
Enhancement and balancing of local and
systemic immune response
Health Benefits
(e.g. reduced risk of infections,
improved vaccine response)
T-cell respose
4

15. Introduction to Bifidobacterium lactis HN019TM
5DUPONT - CONFIDENTIAL
Long history of safe use
B. lactis HN019™ is a well-characterised strain with documented
probiotic effects.
Excellent stability in dietary supplements and dairy products
Excellent stability in conditions of the human gastrointestinal tract (bile
and acid)
Health-related benefits, as presented in published clinical studies:
- Helps to reduce gastrointestial infections
- Helps to improve gastrointestinal transit
- Enhances the innate immunity (NK cell and phagoycyte activity)
- Enhances production of Immunoglobulin A, which may contribute to
an increased resistance against infections

16. AIM OF THE STUDY
Determine effects of probiotic intake on microbiota
composition in healthy elderly and the dose response
effect.
PRODUCT FORMULA
3 doses of Bifidobacterium lactis HN019™ in 250 ml of
milk
• 5 x 109 CFU (high)
• 1 x 109 CFU (medium)
• 6.5 x 107 CFU (low)
• Placebo (reconstituted skim milk)
SUBJECTS
20 healthy elderly (>60 years) in each group.
STUDY DESIGN
• Randomized, double-blind, placebo controlled study.
• 2 week run-in, 4 week intervention, 2-week wash-out
• Bacterial population levels detected in fecal samples
at 6 time points
PUBLICATION
Ahmed at al. J Nutr Health Aging. 2007 Jan-
Feb;11(1):26-31
Clinical evidence: impact of HN019TM on microbiota of elderly
▪ In all HN019™ dose groups, bifidobacterium
population increased significantly during
intervention when compared to pre-intervention
levels.
▪ Similarly lactobacilli and streptococci population
increased in high and medium dose groups
▪ Potentially harmful enterobacteria decreased
significantly in high and dose groups.
▪ No changes in placebo group.
6

17. Effects of Bifidobacterium animalis ssp. lactis HN019TM on cellular
immune function in healthy elderly: a systematic review and meta-
analysis
AIM OF THE STUDY
A systematic review and meta-analysis of 4 clinical trials to
determine the efficacy of probiotic Bifidobacterium lactis
HN019TM supplementation on cellular immune activity in healthy
elderly
STUDY DESIGN
Systematic review was conducted of Medline and EMBASE
databases for controlled trials reporting polymorphonuclear
(PMN) cell phagocytic capacity or natural killer (NK) cell
tumoricidal activity following HN019 use in the elderly.
METHODS
Random effects meta-analysis WAS performed with
standardized mean difference (SMD) and 95% confidence
interval between probiotic and control groups for each outcome
PUBLICATION
Miller et al. 2017 Nutrients
7

18. 4 studies were included out of 85 records
Study
N
(HN019:
Ctrl)
Mean
age
HN019
daily
dose (cfu)
Intervention
duration
Control
%PMN cell
phagocytic
capacity
%NK cell
tumoricidal
activity
Arunachalam,
2000
13;12 69 3x1011 6 weeks
Parallel
group + -
Chiang, 2000 27 60 5x1010 3 weeks
3 week
run-in + +
Gill, 2001a 15 69
5x1010
5x109 3 weeks
3 week
run-in + +
Gill, 2001b 14 70 5x109 3 weeks
3 week
run-in - +
Delivery vehicle in all studies was low fat milk
8

19. Daily consumption of B. lactis HN019TM enhances cellular immune activity
in healthy elderly adults (markers of immunosenescence)
Std diff in means + 95% CI Std diff in means + 95% CI
Pooled SMD for PMN
phagocytic capacity shows
large treatment effect in favor
of HN019™
Pooled SMD for NK cell
tumoricidal capacity shows
moderate treatment effect in
favor of HN019™
9

20. Will probiotics and prebiotics
be the future of weight
management?
Vitafoods Asia 2017
Dr. Anders Henriksson
Principal Application Specialist
DuPont Nutrition & Health, Australia/ New Zealand

21. Ottman et al., 2012
Changes of gut microbiota through the life

22. Smoothie contains 130 kcal/day
ingredient list in appendix
Stenman et al. EBioMedicine 2016
3
The investigational product (once per day)
B420™
▪ 12 g microcrystalline cellulose
▪ 1010 CFU/day B. lactis 420
Litesse® Ultra™
▪ 12 g Litesse® Ultra™ polydextrose
Litesse® Ultra™ + B420™
▪ 12 g Litesse® Ultra™ polydextrose
▪ 1010 CFU/day B. lactis 420
Placebo
▪ 12 g microcrystalline cellulose

23. 4
1.4 kg reduction of total Body Fat Mass compared to placebo…
Stenman et al. EBioMedicine 2016
Primary outcome: B420™ + Litesse® Ultra™ control total body fat mass
-4.5% (-1.4 kg)
in fat mass
P=0.02
-4% (-1.4 kg)
In fat mass
Statistical analyses:
ANCOVA values
Factorial analysis

24. 5
…of which 1,2 kg localized to trunk fat mass
Stenman et al. EBioMedicine 2016
-6.3% (-1,2 kg)
Statistical analyses:
ANCOVA values
Factorial analysis
-6.7% (-1.2 kg)
P = 0.008

25. 2.6 cm reduction in waist circumference
6
Stenman et al. EBioMedicine 2016
-2.7% (-2.6 cm)
-2.4% (-2.4 cm)
Statistical analyses:
ANCOVA values
Factorial analysis

26. 7
Stenman et al. EBioMedicine 2016
Evolution of lean body mass during the study (PP)
Month by month increase of lean body mass

27. 8
Stenman et al. EBioMedicine 2016
Exercise (metabolic equivalents)
No life style change – no increase in exercise level

28. Summary
Studies suggest that the microbiota has a role in
metabolic disease
Studies suggest that bifidobacteria minimize factors
that leads to onset of the metabolic syndrome
Recent clinical study using Bifidobacterium lactis
B420™ in combination with a prebiotic fiber
(Litesse® Ultra™) resulted loss of body fat mass
and increased proportion of lean body mass in
overweight or obese subjects

29. For health sake, increase your
fiber. Polydextrose and its
implications on obesity and
dyslipidemia.
Vitafoods Asia 2017
Ms. Kimberly Thong
Regional Product Manager
DuPont Nutrition & Health, ASEAN, SA & ANZ

30. Relation of postprandial triglyceride metabolism and
cardiovascular diseases
Cardiovascular disease risk factors are typically determined in the fasting
state
However, postprandial triglyceride levels are better predictor of
cardiovascular disease development than the fasting levels
Elevated circulated triglycerides increase oxidative stress and
inflammatory responses. These changes contributes to endothelial
dysfunction leading to cardiovascular diseases

31. Behavioural and metabolic risks as key players in the
aetiology of CVDs
Factors that promote CVD:
Behavioural risk factors:
1. tobacco use
2. physical inactivity
3. unhealthy diet (rich in salt, fat and calories)
4. harmful use of alcohol.
Metabolic risk factors:
1. raised blood pressure (hypertension)
2. raised blood sugar (diabetes)
3. raised blood lipids (e.g. cholesterol)
4. overweight and obesity.
Other risk factors: (for example: age, gender and inherited disposition)
Long-term exposure results in raised
blood pressure (hypertension), raised
blood sugar (diabetes), raised and
abnormal blood lipids
(dyslipidaemia) and obesity.
WHO: Global Atlas on Cardiovascular
Disease Prevention and Control, 2011

32. How Litesse® can help to manage non-fasting blood
triglycerides?

33. Polydextrose and lipid metabolism
Polydextrose is fermentable non-
viscous fiber, which has been shown
to possess lipid metabolism-
regulating effects:
• In animal studies: rats and
gerbils used, both long-term
and acute effect studied
• In clinical interventions, both
long-term and acute effect
studied
• In vitro mechanistic study
Total of 16 publications from the field:
• Tiihonen et al 2015: Human
intervention data
• Raza et al 2017: Animal in
vivo data
HO
CH2OH
O
OH
HO
O CH2
OR
OH
OH
O
CH2
O
OH O
O
OH
OH
O
CH2
CH2OH
O
OH
OH
O
O
HO
OH
OH
O
CH2OH
HO
HO
OH
OH
O
CH2OH
O
HO
OH
OH
O
CH2OH
CH2OH
O
OH
OH
HO
O CH2
O
OH
HO
O
O
HO
OH
OH
O
CH2
O

34. Postprandial triglyceride responses after a fatty meal in
healthy, hyper triglyceridemic and obese subjects
The effect of polydextrose supplementation
Tiihonen K, Rautonen N, Ahotupa M, Alhoniemi E and Vasankari T
Postprandial triglyceride responses after a hamburger meal were pronounced in
subjects with high baseline triglyceride levels
• 12.5-15 g polydextrose
decreased postprandial
triglyceride response in
the combined data of all
subjects
• Notably the decrease in
triglyceride response
was strongest in healthy
subjects

35. Litesse® improves gut microbiota in high fat fed mice
cecum
Control
Litesse®
Yellow: Bifidobacteria
Pink: Clostridiales
Green: Allobaculum
The effect of polydextrose supplementation
Ghulam Shere Raza, Heli Putaala, Ashley A. Hibberd, Esa Alhoniemi, Kirsti
Tiihonen, Kari Antero Mäkelä & Karl-Heinz Herzig
Bifidobacteria enriched at genus level in the group receiving Litesse®
Bifidobacteria have been observed to be disappearing during high-fat
feeding (Zhang et al 2010, ISME Journal)
Bifidobacteria have been suggested to enhance the function gut barrier
and prevent the translocation of the endotoxins through the barrier (Cani
et al 2007).
Clostridiales decreased at
genus level in the group
receiving Litesse®.
Clostridiales are known to
be increased in high-fat
diet (Magnusson 2015,
Neuroscience)
Allobaculum enriched at
genus level, and this has
been observed also in
weight-reduced obese
mice (Ravussin 2009,
Obesity). Number of
Allobaculum has been
observed to positively
correlate with HDL
cholesterol (Martinez
2009, Appl Environ
Microbiol)
Control

36. Conclusions based on animal, human and in vitro data
Polydextrose has shown to attenuate postprandial triglycerides response
after a fatty meal
Polydextrose ingestion long-term may increase HDL cholesterol without
elevating LDL cholesterol

37. 9
Value proposition of meal
replacement products
Value proposition of
Litesse®
• Low calorie
• Max 4 g sugars/100g
• High fibre 80g/100g
Litesse® provides the low calorie low sugar solution in
your product and helps build on the fibre halo

38. Litesse® to Help Bridge the fiber Gap
To add Litesse® across all Food & Beverage applications, both sweet and savory, please
speak to DuPont Nutrition & Health representative.
Reduced Sugar
Reduced Fat
Reduced Calories
Excellent Fiber Source
Satiating Effect
Low Glycemic Impact
Prebiotic

39. Understanding what’s driving
probiotics powerhouse in Asia –
A China Consumer Survey
Vitafoods Asia 2017
Michelle Lee
Regional Marketing Manager, ASEAN
DuPont Nutrition & Health

40. 2
Market Drivers for DS probiotics market in China
Macro-economy
• Robust macro-economy
performance and growing
consumer affluence
Market players
• Increased variety of probiotics
brands and products
Retail channels
• Rapid development of retail
channels especially online retailing
Consumers
• Customer base expansion - driven by
second-child policy and aging
population
• Growing consumer awareness of
consumer health products / probioticsSource: DuPont N&H China Market Sizing & Consumer Study

41. 3
Probiotics Retail Channels
1,889
3,140
1,950 2,007
950
1,656
385
8,675
6,819
5,724
3,577
2,895
2,237
649
0%
5%
10%
15%
20%
25%
30%
35%
40%
-
1,000
2,000
3,000
4,000
5,000
6,000
7,000
8,000
9,000
10,000
Online retailing Hospital Direct selling Pharmacy Mom-and-baby
store
Others Hyper/supermarket
2016 2021 CAGR
Retail Sales Value of DS Probiotics by Channel (Million RMB)
16.8%
12.3%
25.0%
11.0%
35.6%
24.0%
6.2%
Online Retailing – The Most Promising Channel
Source: DuPont N&H China Market Sizing & Consumer Study

42. 4
What’s the role of probiotic in consumers’ life?
Probiotic Health
Product
(DS Probiotics) Mild
Improve
Supplementary
BalancedConvenient
Preventive
Health care
Safe
Natural
Long term
use
Professional
Premium
High tech
Rest-
assuredEffective
Wide Application
0-3 yrs babies Health protector
4-18 yrs kids Experts to improve GI
health and immunity
24-50 yrs
adults
Best choice to improve
sub-health state
51-70 yrs
elderlies
Must have to protect &
support health
Source: DuPont N&H China Market Sizing & Consumer Study

43. 5
Which is the preferred format ?
0-3 yrs babies
4-18 yrs kids
24-50 yrs
adults
51-70 yrs
elderlies
powder
Capsules Tablets
Source: DuPont N&H China Market Sizing & Consumer Study

44. 6
Where do they buy?
Preferred by
mom & adults
Key Drivers:
1. Genuine product
2. Compare on-pack
information
3. Seek advice from in-
store staff
Key Drivers:
1. Convenience
(24/7)
2. Discounted
price
3. Home delivery
Ensure of no-
fake products
Drug stores/
Pharmarcy
Moms &
babies
stores
Direct
sales
Brick & Mortar Stores are the preferred purchase channel
E-retailer
Source: DuPont N&H China Market Sizing & Consumer Study
Likely to switch

45. 7
Summary : Gold standard for DS Probiotics
Reliable brand 2
Recommended by
doctors/experts
3
Safe with no side-effects 4
Good taste and texture5
Easy to absorb, highly
effective
1
Gold Standards
Source: DuPont N&H China Market Sizing & Consumer Study

46. Dealing with an aging Asia.
Overcoming muscle loss with
protein blends for the seniors.
Vitafoods Asia 2017
Dr. Wang Hongwei
Applied Nutrition Manager
DuPont Nutrition & Health, Greater China

47. 9/11/2017 2
All countries are aging at an unprecedented pace

48. 9/11/2017 3
Percentage of people aged 60 or over in 2016 and 2050

49. Muscle
（light
grey）
Fat
（dark
grey）
Roubenoff R et al.（2003）《老年学杂志》第58卷第11期，第1012-1017页，2003
(25 y and 75 y, apparently health）MRIa
Muscle loss with age
Aging related muscle loss and its adverse effects

50. Protein Quality of commonly consumed proteins
SUPRO Isolated Soy Protein
PDCAAS is the
globally recognized
method for
determining protein
quality based on
amino acid profile
and digestibility
(ISP)
Soy is a High Quality Protein - PDCAAS (Protein
Digestibility-Corrected Amino Acid Score)
✓PDCAAS = 1.00
✓Comparable to milk &
egg protein
✓Can be consumed
throughout the life
cycle
✓The only complete
vegetable protein
widely available
✓Isolated soy protein is
low in fat, saturated
fat, cholesterol-free
and lactose-free
Soy protein is a high quality protein

51. Study
Duration
(wk)
Lean Body Mass Gain
(kg)
Protein
(g/day)
Statistically
Different
( P ≤ 0.05)
Brown et al.
Nutr J 3:22, 2004. 9
Whey protein (+1.3)
Soy protein isolate (+1.2)
33 NO
Candow et al.
Int J Sport Nutr Exerc Metabol.
16:233-244, 2006.
6
Whey protein (+2.5)
Soy protein isolate (+1.7)
~ 85 NO
Kalman et al.
J Int Soc Sports Nutr. 23(4):4,
2007.
12
Whey protein (+0.5)
Soy protein Isolate (+0.5)
50 NO
acute
• Soy protein effective for building muscle in acute studies
chronic
• Soy protein effective for building muscle in chronic studies
• Soy and whey do not differ in chronic studies for lean body
mass gains (studies include both trained and untrained
subjects)
Soy protein effective for building muscle

52. Adapted from Paul et al., J Am Coll Nutr. 2010
Protein
Whey
Soy
Casein
Combined
Intermediate
Fast
Slow
Prolonged
Complete
Protein
Digestion
Rate
Lean Body
Mass Gains
High in
Leucine
High in
Arginine &
Glutamine
Antioxidant
Activity
Combining unique attributes of soy & dairy proteins
Soy and dairy protein are effective for building muscle and result in
similar lean body mass gains in prolonged clinical studies 1,2,3
1 Brown et al., Nutr J. 2004.
3 Kalman et al., J In Soc Sports Nutr. 2007.
3 Candow et al., Int J Sport Nutr Exerc. 2006.
Blending soy, whey, and casein
proteins may increase the anabolic
window for increased growth and
maximize muscle building
Why blend proteins?

53. Acute Study in Aging Adults
Aims:
Determine the
efficacy of a
protein blend in
older men for
prolonging blood hyperaminoacidemia
extending skeletal muscle protein synthesis
improving muscle protein turnover
Hypotheses The different digestion rates of the proteins
comprising the soy-dairy protein blend would result
in a more sustained hyperaminoacidemia as
compared to whey.
This prolonged hyperaminoacidemia would
lengthen the muscle protein synthetic response for
the protein blend as compared to whey.
Borack et al., J Nutr 2016.

54. In older adults, whey protein isolate and soy-dairy protein blend similarly
enhanced post exercise:
• mTORC1 signaling
• hyperaminoacidemia.
• muscle protein synthesis
• attenuation of muscle protein breakdown
Acute Study in Aging Adults
Results
Use of a soy-dairy protein blend may be a useful nutritional strategy for
maintaining muscle mass and function during aging while reducing the disability
associated with sarcopenia.
P re P o st D iffe re n ce
-0.2
-0.1
0.0
0.1
0.2
0.3
0.4
F ra c tio n a l B re a k d o w n R a te
Tim e%/hr
W P I
P B
* #
Similar increases in muscle protein synthesis Similar reduction in muscle protein breakdown
Whey
Blend
* Diff from rest
# Trt diff
Whey
Blend
Borack et al., J Nutr 2016.

55. Summary
• Soy-dairy blend supplementation demonstrated a potential for maximizing
the acute adaptive growth response of skeletal muscle to resistance
exercise.
• Extended soy-dairy protein supplementation enhanced lean mass gains
after resistance exercise, yielding a greater percentage of subjects that
experienced gains (>1.5 kg), while also improving blood lipid and lipoprotein
concentrations.
• Use of a soy-dairy protein blend may be a useful nutritional strategy for
maintaining muscle mass and function during aging while reducing the
disability associated with sarcopenia.
• High-quality soy protein provides benefits that go beyond muscle & makes
important contributions to overall health & wellness across the lifespan.

56. Soy versus dairy protein.
Strategies to lowering cholesterol
and improving gut microbiota
diversity.
Vitafoods Asia 2017
Dr. Wang Hongwei
Applied Nutrition Manager
DuPont Nutrition & Health, Greater China

57. Protein Quality of commonly consumed proteins
SUPRO Isolated Soy Protein
PDCAAS is the
globally recognized
method for
determining protein
quality based on
amino acid profile
and digestibility
(ISP)
Soy is a High Quality Protein - PDCAAS (Protein
Digestibility-Corrected Amino Acid Score)
✓PDCAAS = 1.00
✓Comparable to milk &
egg protein
✓Can be consumed
throughout the life
cycle
✓The only complete
vegetable protein
widely available
✓Isolated soy protein is
low in fat, saturated
fat, cholesterol-free
and lactose-free
Soy protein is a high quality protein

58. Soy Protein Meets or Exceeds Amino Acid Requirement
Patterns (FAO/WHO/UNU)
HIS = Histidine; ILE = Isoleucine; LEU = Leucine; LYS = Lysine; MET + CYS = Methionine + Cystine; PHE + TYR = Phenylalanine +
Tyrosine; THR = Threonine; TRY = Tryptophan; VAL = Valine
* Amino acid values for isolated soy protein based on analysis of SUPRO®Soy Brand Isolated Soy Protein provided by Protein
Technologies International.
† Suggested pattern of requirements from Energy and Protein Requirements, Report of the Joint FAO/WHO/UNU Expert Consultation.
Technical Report Series No. 724, 1985.
0
20
40
60
80
100
HIS ILE LEU LYS MET +
CYS
PHE +
TYR
THR TRY VAL
mg/gofProtein
0
20
40
60
80
100
HIS ILE LEU LYS MET +
CYS
PHE +
TYR
THR TRY VAL
mg/gofProtein
Typical Amino Acid Content
of Isolated Soy Protein*
2- to 5-Year Old Pattern†
10- to 12-Year Old Pattern†
Adult Pattern†
Soy protein is a high quality protein

59. • The soy-fed hamsters had a more diverse microbiota than those fed the milk diet.
• It has been suggested that increased microbial diversity in the gut microbiome is a
marker of metabolic health, where individuals with low richness have a higher
incidence of dyslipidemia, adiposity, and weight gain, insulin resistance, and
inflammation.
Alpha diversity indices from 16S rDNA sequences averaged by intestinal
section from hamsters consuming different dietary proteins. (mean
+/SDEV) Differing letters are significant by P ≤ 0.05.
milk
soy1
soy3
soy2
Journal of Nutrition 2016, doi: 10.3945/​jn.115.224196
Results: Microbial Diversity
Soy Protein Induced Microbiota Changes Compared to Milk

60. Results: Microbial Composition
Changes in gut microbiota between
differently processed soy proteins
were more similar to each other
and significantly different from milk
protein-fed hamsters
Journal of Nutrition 2016, doi: 10.3945/​jn.115.224196
Soy Protein Induced Microbiota Changes Compared to Milk

61. Soy Protein and Gut Microbiome
0
20
40
60
80
100
120
nonHDL VLDL
cholesterol(mg/dl)
milk
soy1
soy2
soy3
(mean +/SEM) Differing letters are significant by P ≤ 0.05.
a
a
b b b
b b b
Conclusions
• This is the first study to
compare the effects of
differently processed soy
proteins versus milk protein
on intestinal microbial
composition in hamsters
• Soy protein results in a) a more diverse intestinal microbial composition
and b) consistent shifts in some specific microbial families
• The significant decrease in the relatively triglyceride-enriched non-HDL
and VLDL particles in all soy groups versus the milk protein group,
suggests that soy protein consumption reduces hepatic lipogenesis