IT IS CAUSED DUE TO VITAMIN B-1 DEFICIENCY.

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3. • It is of four major types:
DRY BERI-BERI
WET BERI-BERI
CEREBRAL BERI-BERI
INFANTILE BERI-BERI
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5. • It develops when diet chronically contains
slightly less than the thiamin requirement
 SYMPTOMS:
1. Poor appetite
2. Peripheral neuropathy
3. Fatigue
4. Severe muscular weakness
5. Deep muscle pain
6. Pain on contact with the skin.
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7. It develops when the thiamin deficiency is
more severe.
 SYMPTOMS:
It is characterized primarily by:
1. Edema of extremities
2. Heart enlargement
3. Cardiac insufficiency
 OTHER SYMPTOMS:
1. Tachycardia
2. Bradycardia
3. Palpitation.
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9. It is also called as: WERNICKE-
KORSAKOFF’S SYNDROME.
Caused due to severe deficiency of
Thiamin.
PECULARITY:
Seen most commonly in alcoholics
compared to the general population; the
chronic heavy alcohol consumption
interferes with the intestinal absorption if
thiamin.
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10. Also can get worsen by a mutation in
the gene for transketolase that results in
reduced affinity of transketolase for
TPP.
SYMPTOMS:
Gastrointestinal symptoms:
1. Anorexia
2. Nausea
3. Ataxia
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11.  Neurological symptoms:
1. Loss of memory
2. Depression
3. Mental confusion
4. Ataxia
 Ophthalmological symptoms:
1. Nystagmus
2. Double vision
 Skeletal symptoms:
1. Peripheral paralysis
2. Muscular weakness
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13.  Observed in breastfed infants born to mother
suffering from thiamin deficiency.
 The breast milk of these mothers is deficient in
thiamin.
 SYMPTOMS:
1. Cardiac dilation(enlargement of heart)
2. Tachycardia
3. Convulsions
4. Edema
5. Vomiting
6. Abdominal colic
7. In acute condition, infant may die due to cardiac
failure.
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