This document summarizes a lecture on cell physiology, specifically cell signaling. It discusses the main types of cell signaling including autocrine, paracrine, and endocrine signaling. It also describes the basic process of cell signaling, including ligand binding to a receptor which causes a conformational change and activation of the receptor, leading to a response in the target cell. Finally, it discusses the main classes of receptors, including intracellular receptors and cell surface receptors, providing examples of each type.
This Presentation provides an outline knowledge about Cellular Communication, Steps involved, Its Types, Signal Transduction, Secondary Messenger , Receptors with some Interesting Facts and Current Trends. An assignment for the subject, Cellular and Molecular Pharmacology, 1st year M.Pharm, 1st semester.
This Presentation provides an outline knowledge about Cellular Communication, Steps involved, Its Types, Signal Transduction, Secondary Messenger , Receptors with some Interesting Facts and Current Trends. An assignment for the subject, Cellular and Molecular Pharmacology, 1st year M.Pharm, 1st semester.
Types of Receptors
Receptors are protein molecules in the target cell or on its surface that bind ligands. There are two types of receptors: internal receptors and cell-surface receptors.
Assignment on Need of cell signaling, Steps in cell signaling, Intercellular signaling pathways, Types of intercellular signaling pathways, Intracellular signaling pathways, Receptors, Intercellular and intracellular signaling pathways. Classification of receptor family and molecular structure ligand gated ion channels; Gprotein coupled receptors, tyrosine kinase receptors and nuclear receptors.
Signal transduction in plant defence responsesrkravikirankt
Plant respond to the attack of diseases by triggering various bio-molecules insider their system to combat the infection and establishment of the pathogens. these response operate in specified pathways mediated by many enzymes starting from the infection site to the nucleus which together constitute the signal transduction pathway.
In biology, cell signaling is part of any communication process that governs basic activities of cells and coordinates multiple-cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis.
g protein coupled receptors, ion channels, types of receptors, wnt signalling, cell signalling, tranduction pathway, disorders regarding the signalling
The presentation aims to provide basics of bio signalling to the viewers. The various mechanisms of signalling in cells along with the details about G signalling are covered under this ppt.
Classification of receptors family by vivek sharmaAnimatedWorld
Definition- Receptor are the biologic molecule to which drug bind and produces a measurable response.
So, enzyme and structural proteins can be considerd to be pharmacologic receptors.
Majorly receptor are of 4 types and the molecule or a drug interact to receptor to give response often called as ligand.
The type of receptor a ligand will bind is depend on the nature of ligand.
Hydrophilliic ligand binds to the receptor found on the cell surface.
Hydrophobic ligand can enter the cell membrane to intract the receptor present on inside the cells.
Classification of Receptors
A. Cell surface receptor
Ligand-gated Ion Channel
G Protein Coupled Receptor
Enzyme linked Receptor
B. Intracellular Receptor
Nuclear Receptor
Types of Receptors
Receptors are protein molecules in the target cell or on its surface that bind ligands. There are two types of receptors: internal receptors and cell-surface receptors.
Assignment on Need of cell signaling, Steps in cell signaling, Intercellular signaling pathways, Types of intercellular signaling pathways, Intracellular signaling pathways, Receptors, Intercellular and intracellular signaling pathways. Classification of receptor family and molecular structure ligand gated ion channels; Gprotein coupled receptors, tyrosine kinase receptors and nuclear receptors.
Signal transduction in plant defence responsesrkravikirankt
Plant respond to the attack of diseases by triggering various bio-molecules insider their system to combat the infection and establishment of the pathogens. these response operate in specified pathways mediated by many enzymes starting from the infection site to the nucleus which together constitute the signal transduction pathway.
In biology, cell signaling is part of any communication process that governs basic activities of cells and coordinates multiple-cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis.
g protein coupled receptors, ion channels, types of receptors, wnt signalling, cell signalling, tranduction pathway, disorders regarding the signalling
The presentation aims to provide basics of bio signalling to the viewers. The various mechanisms of signalling in cells along with the details about G signalling are covered under this ppt.
Classification of receptors family by vivek sharmaAnimatedWorld
Definition- Receptor are the biologic molecule to which drug bind and produces a measurable response.
So, enzyme and structural proteins can be considerd to be pharmacologic receptors.
Majorly receptor are of 4 types and the molecule or a drug interact to receptor to give response often called as ligand.
The type of receptor a ligand will bind is depend on the nature of ligand.
Hydrophilliic ligand binds to the receptor found on the cell surface.
Hydrophobic ligand can enter the cell membrane to intract the receptor present on inside the cells.
Classification of Receptors
A. Cell surface receptor
Ligand-gated Ion Channel
G Protein Coupled Receptor
Enzyme linked Receptor
B. Intracellular Receptor
Nuclear Receptor
A receptor is a protein molecule usually found embedded within the plasma membrane surface of a cell that receives chemical signals from outside the cell and when such chemical signals bind to a receptor, they cause some form of cellular/tissue response.
Receptor is a macromolecule whose function is to recognize and respond to chemical signal
There are 3 types of receptors. Those are:
i. Internal /Intracellular/Cytoplasmic receptors:
found in the cytoplasm of the cell
respond to hydrophobic ligand molecules
ii. Cell-surface / transmembrane receptors/ cell specific proteins
performs signal transduction, converting an extracellular signal into an intracellular signal.
iii. Nuclear receptor
Located in the nucleus of the cell
i. Internal /Intracellular/Cytoplasmic receptors
Steriod receptor
ii. Cell-surface / transmembrane receptors/ cell specific proteins
G-protein- coupled receptor
Enzyme- linked receptor/ tyrosin kinase receptor
Ion channel- linked receptor/ ligand gated receptor
iii. Nuclear receptor
Thyroid receptor
Cell signaling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis
cell signaling is part of any communication process that governs basic activities of cells and coordinates multiple-cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
Basim Zwain Lectures - Cell Physiology-2
1. BASIM ZWAIN LECTURES
MEDICAL PHYSIOLOGY
CELL PHYSIOLOGY - 2
Professor Dr. Basim Zwain
Faculty of Medicine
Jabir ibn Hayyan Medical University
basimzwain@jmu.edu.iq
2. CELL PHYSIOLOGY
Types of Cell Signaling
1. Autocrine signaling – e.g. cytokine
interleukin-1 in monocytes
2. Paracrine and juxtacrine signaling- e.g
fibroblast growth factors
3. Endocrine signaling (various hormones)
4. CELL PHYSIOLOGY
Cell Signaling Events
A ligand or primary messenger binds a
receptor associated with a target cell.
Ligand binding results in conformational
change and activation of the receptor.
The activated receptor elicits a response in
target cell, either directly or indirectly through
production of second messenger.
Target cell responses include alterations in
cellular metabolism and in gene transcription.
5. CELL PHYSIOLOGY
Types of Receptor Classes
1. Intracellular receptors located in the
cytoplasm or nucleus of the target cell
1. Cell surface receptors
6. CELL PHYSIOLOGY
Intracellular receptors are bound by lipophilic
ligands, which diffuse through plasma membrane.
Ligand binding alters the receptor’s conformation,
exposing the receptor’s DNA-binding domain.
Receptors bind specific gene promoter elements and
activate transcription of specific genes that results in
the synthesis of specific proteins.
An example is estrogen receptor in uterine smooth
muscle cells.
7. CELL PHYSIOLOGY
There are four types of cell surface receptors:
a. Nicotinic cholinergic receptors are linked to ligand-gated
ion channels (eg, nicotinic AchRs).
b. Catalytic receptors are transmembrane proteins
that have intrinsic enzymatic (eg, serine or tyrosine
kinase) activity.
c. Other receptors are linked to proteins with
enzymatic activity. (eg, cytokine receptor signaling
through cytoplasmic tyrosine kinase).
d. G-protein-linked receptors
8. CELL PHYSIOLOGY
G-protein-linked receptors have an extracellular
ligand-binding domain and an intracellular domain
that binds G-proteins. After ligand binding, receptors
interact with G-proteins which are heterodimeric
consist of α, β, and γ subunits that dissociate. G-proteins
α-subunits bound to GTP interact with and
activate specific membrane-bound enzymes, result in
production of 2nd messengers that elicit responses
in target cells. Adenylate cyclase & phospholipase
systems are examples.
9. CELL PHYSIOLOGY
CLINICAL CONSIDERATIONS
–Cholera toxin alters G-protein so that guanosine
triphosphatase (GTPase) is unable to hydrolyze GTP,
resulting in increased production of cAMP. Elevated
cAMP in intestinal epithelial cells results in massive
gut secretion of water and electrolytes, resulting in
severe diarrhea and dehydration.
–Pseudohypoparathyroidism results from a defective
G-protein causes decreased cAMP levels with
symptoms of hypoparathyroidism with normal or
slightly elevated parathyroid hormone levels.
10. CELL PHYSIOLOGY
CLINICAL CONSIDERATIONS
–Pertussis toxin blocks the activity of G1,
allowing adenylate cyclase to stay active
and increase cAMP.