Basics of Thalassemia
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This document provides an overview of thalassemia, which has two main types: alpha and beta. Symptoms generally do not appear until 6 months of age and can include jaundice, fatigue, shortness of breath, and infections. Alpha thalassemia is caused by insufficient alpha hemoglobin chains and its severity depends on the number of gene mutations from one to four. Beta thalassemia is caused by insufficient beta chains and also increases in severity with more gene mutations from one to two. Treatments include frequent blood transfusions, stem cell transplants, family planning and genetic testing. Prevention involves avoiding certain fruits and vegetables.
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Thalassaemia
Thalassaemia is a blood disorder caused by the formation of abnormal haemoglobin, which destroys red blood cells. Thalassaemia alpha occurs primarily in people from Southeast Asia, the Middle East, China, and those of African descent, while thalassaemia beta is more common in those of Mediterranean origin, Chinese, Asians, and African Americans. Thalassaemia major causes stillbirths and in children results in bone deformities, jaundice, fatigue, stunted growth, and shortness of breath, and is treated through regular blood transfusions and folate supplements, whereas thalassaemia minor shows no symptoms.
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Thalassemia..
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Thalasemia
Thalassemia is a genetic blood disorder where the body makes an abnormal form of hemoglobin. It is inherited from carriers parents. If two carriers have a child, there is a risk the child will have thalassemia major and require monthly or biweekly blood transfusions. There are different types of thalassemia including beta and alpha forms. The disorder prevents red blood cells from carrying enough oxygen around the body. Approximately 7% of the global population are carriers and 300,000 to 500,000 children are born annually with severe forms, mostly in developing countries. Treatment involves regular blood transfusions and iron chelation therapy to remove excess iron from transfusions.
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Thalassemia
Thalassemia for medicine students or anyone interested in the disease.
Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form or inadequate amount of hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen. The disorder results in large numbers of red blood cells being destroyed, which leads to anemia.
A blood disorder involving lower-than-normal amounts of an oxygen-carrying protein.
Thalassemia is an inherited blood disorder characterized by less oxygen-carrying protein (hemoglobin) and fewer red blood cells in the body than normal.
Symptoms include fatigue, weakness, paleness, and slow growth.
Mild forms may not need treatment. Severe forms may require blood transfusions or a donor stem-cell transplant.
Alpha thalassemia
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
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thalassemia
Thalassemia is a blood disorder caused by variants or missing genes that affect hemoglobin production. There are two main types: alpha thalassemia affects alpha globin gene expression, while beta thalassemia is caused by a deficiency in beta globin production. People with beta thalassemia experience anemia and other health issues due to the lack of functional hemoglobin in red blood cells. Treatment involves regular blood transfusions combined with iron chelation therapy or bone marrow transplants in severe cases.
27 thalassemias
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Thalassemia..
Thalassemia is a hereditary blood disorder characterized by reduced or absent hemoglobin production. It is caused by mutations in either the alpha or beta globin genes and results in ineffective erythropoiesis and hemolytic anemia. The most common forms are thalassemia major, intermedia, and minor. Thalassemia major requires regular blood transfusions and chelation therapy to manage iron overload, while thalassemia minor is generally mild and asymptomatic. Testing includes complete blood count, blood smear, and hemoglobin electrophoresis to determine the type of thalassemia present. Management involves blood transfusions, chelation therapy, and in severe cases splenectomy or bone marrow transplant.
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Thalassemia is a genetic blood disorder where the body makes an abnormal form of hemoglobin. It is inherited from carriers parents. If two carriers have a child, there is a risk the child will have thalassemia major and require monthly or biweekly blood transfusions. There are different types of thalassemia including beta and alpha forms. The disorder prevents red blood cells from carrying enough oxygen around the body. Approximately 7% of the global population are carriers and 300,000 to 500,000 children are born annually with severe forms, mostly in developing countries. Treatment involves regular blood transfusions and iron chelation therapy to remove excess iron from transfusions.
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Thalassemia
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Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form or inadequate amount of hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen. The disorder results in large numbers of red blood cells being destroyed, which leads to anemia.
A blood disorder involving lower-than-normal amounts of an oxygen-carrying protein.
Thalassemia is an inherited blood disorder characterized by less oxygen-carrying protein (hemoglobin) and fewer red blood cells in the body than normal.
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Thalassemia
Thalassemia is a group of inherited blood disorders caused by reduced or absent globin chains. There are two main types - alpha and beta thalassemia. Alpha thalassemia results from reduced alpha globin production while beta thalassemia results from reduced beta globin production. Thalassemia is characterized by ineffective red blood cell production and increased red blood cell breakdown leading to anemia. Common complications include iron overload, bone and organ damage, and endocrine abnormalities. Treatment involves regular blood transfusions along with iron chelation therapy.
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Thalassemias are inherited blood disorders caused by a genetic defect that results in abnormal hemoglobin. There are two main types: alpha thalassemia involves a deficiency in alpha globin protein production and beta thalassemia involves a deficiency in beta globin protein production. Signs and symptoms range from mild to severe anemia depending on the severity of the disorder. Treatment involves lifelong blood transfusions, iron chelation therapy to remove excess iron, and folic acid supplements.
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1. Thalassemia is caused by a defective production of the globin portion of hemoglobin, resulting in an imbalance between alpha and beta globin chains.
2. There are two main types - alpha thalassemia affects alpha chain production while beta thalassemia affects beta chain production.
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thalassemia
Thalassemia is an inherited blood disorder that causes your body to have less hemoglobin than normal. Hemoglobin enables red blood cells to carry oxygen. Thalassemia can cause anemia, leaving you fatigued.
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The document discusses thalassemia, a group of inherited blood disorders characterized by reduced or absent globin chains. It covers the basics of alpha and beta thalassemia including genetic basis, classification, clinical outcomes, complications, and management approaches like transfusions, chelation therapy, splenectomy, and immunizations. Key points include the varying severity of alpha and beta thalassemia syndromes depending on which globin chains are affected, the risk of iron overload and related organ damage without proper chelation therapy, and the goal of splenectomy to reduce transfusion needs in severe cases.
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Thalassemia is a blood disorder that reduces hemoglobin production. There are two main types: alpha thalassemia affects alpha globin gene production, while beta thalassemia affects beta globin genes. Symptoms range from none to severe anemia, depending on the type. Thalassemia major requires regular blood transfusions and can lead to other issues like enlarged organs or bones problems if not properly treated. Thalassemia minor usually does not cause symptoms.
Beta thalassemia
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
thalassemia ppt.pptx
Thalassemia is a hereditary blood disorder caused by mutations or defects in genes that control the production of hemoglobin. There are two main types - alpha thalassemia affects alpha globin genes and beta thalassemia affects beta globin genes. Thalassemia major occurs when an individual inherits defective genes from both parents, resulting in severe anemia symptoms within the first two years of life. Management involves regular blood transfusions, iron chelation therapy to remove excess iron, and supplements. Complications can include heart and liver disease, bone abnormalities, and growth delays if left untreated.
Thalassemia.ppt
Brief Discussion on Thalassemia.
The content include Definition, classification, C/M, diagnosis and Management, it also include nursing responsibilities.
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Basics of Thalassemia
- 1. WELCOME
- 3. Thalassemia: Two main types: • Alpha • Beta
- 4. • Depend on type. • Symptoms will not show until the age of 6 months in most cases. • As neonates have fetal hemoglobin. Symptoms:
- 5. • Jaundice and pale skin • Drowsiness and fatigue • Chest pain • Cold hands and feet • Shortness of breath • Leg cramps • Rapid heart beat • Poor feeding • Delayed growth • Headaches • Dizziness and faintness • Greater susceptibility to infections Major symptoms are:
- 6. Pathophysiology: Alpha-Thalassemia • Arises due to insufficient synthesis of alpha-hemoglobin chains and an excess of beta chains. • Four genes on chromosome 16 that are required to produce the alpha region of hemoglobin, • Number of gene mutations corresponds to the severity 1. One gene mutation: No signs or symptoms 2. Two gene mutations: Mild signs and symptoms 3. Three gene mutations: Moderate to severe symptoms, 4. Four gene mutations: Often fatal before or shortly after childbirth.
- 7. Beta-Thalassemia • Due to insufficient synthesis of beta-hemoglobin chains and an excess of alpha chains. • There are two genes on chromosome 11 that are required to produce the beta region of the hemoglobin chain, • The number of gene mutations corresponds to the severity 1. One gene mutation: Mild signs or symptoms 2. Two gene mutations: Moderate to severe symptoms, referred to as beta-thalassemia major or Cooley’s anemia
- 9. Treatments: Frequent blood transfusions Stem cell transplant You can't prevent thalassemia because they're inherited Family planning Prenatal tests Family genetic studies Prevention:
- 10. Fruits/Vegetables that should be avoided or eliminated from the diet: • Prune juice. • Watermelon. • Spinach. • Leafy green vegetables. • Dates. • Raisins. • Broccoli.
- 11. Thank You