Hypogonadism is a decreased functional activity of the gonads that results in a failure of the testes to produce androgen, sperm, or both. It can occur at any age, with consequences depending on when it starts - before birth, before puberty, or after puberty. There are two types, primary involving the testes and secondary involving the hypothalamus or pituitary gland. Causes include genetic conditions, tumors, infections, physical damage to the testes from conditions like mumps, and certain medications or medical treatments that can damage the testes.

1. Definition and etiology
By/ Israa Kamel Mohamed

2. 
Hormonal control for
male reproduction

3. 
Not only for sexual
function!

4. 
Definition
What is hypogonadism ?!
Decreased functional
activity of the gonades
Failure of the testes to
produce androgen,
sperm, or both.
Male hypogonadism ?

5. 
It may occur at any age, and consequences
differ according to the age at onset.
 In an infant before birth sexual ambiguity may result.
 Before puberty puberty does not progress
 After puberty infertility and sexual dysfunction.

6. Two basic
types
1ry 2ry
Etiology
 Testicular
 Receptors
 Hypothalamus
 Pitutary

7. 
Testosterone
Metabolism

8. 
Hypothalamic causes

9. Skull base fractures Tumors: Craniopharyngioma Sarcoidosis
Anorexia Nervosa
TB
Stress

10. 
Pituitary causes
Empty sella syndrome
Hyperprolactinemia

11. Pituitary tumors
Panhypopituitarism

12. 
Primary causes
Klinfelter syndrome
cryptorchidism
Mumps orchitis

13. 
Bilateral
testicular
damage
Hemochromatosis
Radiotherapy

14. Opiates
Obesity

15. 
End organ resistance
Morri’s syndrome
(androgen insensitivity
syndrome)
-male karyotyping.
-female phenotyping.
-male level of testosterone
-Insensitivity to receptors.

16. 