This document discusses the potential role of DHEA supplementation in improving oocyte yield and quality in women with diminished ovarian reserve or poor ovarian response. It provides biological plausibility for how DHEA may act on granulosa cells and follicles to reduce apoptosis and recruit more developmentally competent oocytes. The document reviews literature on DHEA's effects and side effects, and discusses questions that still need answers around its role as an adjuvant treatment in assisted reproductive technologies.