Vitamin B12 deficiency is common worldwide and can increase the risk of heart disease by raising levels of homocysteine in the blood. Symptoms of severe B12 deficiency include tingling in hands and feet, memory loss, anxiety, and difficulty breathing. Risk factors for heart disease include smoking, high blood pressure, high cholesterol, poor diet, lack of exercise, and obesity. A B12 deficiency can lead to nerve damage and heart disease can lead to heart attacks or strokes. Maintaining a healthy diet with foods like liver, fish, meat, dairy and fortified cereals along with exercise and not smoking can help reduce the risk of heart disease.