Acetic anhydride is a colorless liquid that smells like acetic acid. It is the simplest isolable anhydride of a carboxylic acid. Acetic anhydride was first synthesized in 1852 by heating potassium acetate with benzoyl chloride. It is widely used as a reagent in organic synthesis. Some key uses of acetic anhydride include preparing cellulose acetate fibers and plastic, acting as a dehydrating and acetylating agent in producing pharmaceuticals, dyes, perfumes and explosives, and esterifying food starch at concentrations up to 5%. Acetic anhydride is also versatile for acetylations by introducing acetyl groups to organic substrates.

1. ONLINE CLASS
Purvanchal University
Presenter: Mr. Yograj Podar

2. ACETIC ANHYDRIDE
[ Preparation and uses]
• Acetic anhydride, or ethanoic anhydride, is the chemical
compound with the formula (CH3CO)2O. Commonly
abbreviated Ac2O,
• it is the simplest isolable anhydride of a carboxylic acid
and is widely used as a reagent in organic synthesis.
• It is a colorless liquid that smells strongly of acetic acid,
which is formed by its reaction with moisture in the air

3. Properties

4. Preparations
 Acetic anhydride was first synthesized in 1852 by the French
chemist Charles Frédéric Gerhardt (1816-1856) by heating
potassium acetate with benzoyl chloride.

5. P2O5

6. WACKER
CHEMIE
PROCESS

8. Uses of Acetic anhydride in drug synthesis

12. • Preparations of Cellulose acetate fibers
and plastic vinyl acetate.
As Dehydrating and acetylating agent
in production of pharmaceuticals, dyes,
perfumes, explosives. ...
Esterifying agent for food starch (5%
max).
• Acetic anhydride is an
esterification agent for use in
prepn. of modified food starch
and for acetylation of
monoglycerides.
• Acetic anhydride is a versatile
reagent for acetylations, the
introduction of acetyl groups to
organic substrates.

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