2. Mrs Pradnya Wadekar Bapat 2
Asava/Arishta
Asava/Arishta are the ayurvedic dosage form
processed by soaking the drug in powdered
form / decoction form (Kasaya), in a solution of
sugar or jaggery for a specific period of time to
undergo fermentation (Sadahan) leading to
formation of alcohol.
Arishta or Asava treatment is suggested for a
variety of diseases and conditions
The difference between arishta and asava is
simple arishta is prepared from the
essence/decoction of medicinal herbs while
asava is prepared from fresh herbs
3. Drug powdered (according to Patha)
Prepare decoction
Filter prepared Decoction
Into velssel, decoction + sugar /jaggery/honey, boil
+Dravyas+Dhatakai pushpa
Close the earthen lid sealed edges with clay
smeared cloth
Place vessel in cellar fro specific time period for
Sadhana
Filter
Arishta
Mrs Pradnya Wadekar Bapat 3
4. Into vessel, sugar /jaggery/honey, boil
+powdered drug (Patha)
Close the earthen lid sealed edges with clay smeared cloth
Place vessel in cellar fro specific time period for Sadhana
Filter
Asava
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Properties:
Should be Clear
No foam should be produced
Should not become sour on standing
It has characteristic, aromatic & alcoholic
odour
During fermentation, Alcohol is produced
which facilitates extraction of active
constituents contained in the drug
Alcohol also serve as preservative in the
product
Earlier, The wooden pots are fumigated with
pippali powder and also smeared with ghee
before the fermentation liquids are pour into
them
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Shelf Life:
Much longer time
Storage Conditions:
Should be stored in air tight container
Narrow mouthed
Store in cool place
Away from sunlight
7. Parameters for Standardization of
Asava And Arishta
Ayurvedic parameters :
Clear liquid without any forth
Pleasant aromatic odour of alcohol
Should not have sour taste
No effervescence sound
Additive sink to the bottom
Burning candle burns brightly when
placed in or just above the Sandhana
Paatra
Mrs Pradnya Wadekar Bapat 7
8. Parameters for Standardization of
Asava And Arishta
Organoleptic evaluation: colour, odour, taste, nature and
texture
Physical evaluation:- pH, Specific gravity at 25°c and total
solid
Alcohol content
Reducing sugar
Non- reducing Sugar
Test for Methanol
Total Acidity
Chromatography
Shelf life
Viscosity Mrs Pradnya Wadekar Bapat 8
9. Acid Value :
Extcractive values
Chemical evaluation:???
Toxicilogical evaluation: pesticide
residue, heavy metal presence, mos
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Lehyas/ Leham/ Avaleha/Paka
Semisolids
Semisolid Ayurvedic dosage form, which are
thickened, sweetened extracts of single or
combination of herbs/animal & mineral
matter.
Preparation comprises of:
Decoction or other liquid
Jaggery/ sugar/ honey
Powder or Pulp of drug
Ghee or Oil
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Preparation of Leha
Sugar/ Jaggery + Liquid
• ↓ Boiled & Dissolved (Ghee or Oil if any)
Powdered drugs in small quantities
Stirred continuously
Homogenous mass is formed
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Properties:
Can be lifted in a spoon
When pressed between fingers, show
threads during stretching
Sinks in water without getting easily
dissolved
Finger leaves impression on it
Components of lehyas are easily
absorbed by the body, starting from
the mouth
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Storage:
Kept in Glass/ Porcelain Jar or suitable plastic
or metal container which is inert.
Wide mouthed container is used
Air tight
Keep away from hot & humid conditions
Shelf Life:
Used with in a year
Examples:
Brahma rasayanam
Sukumara rasayanam
Draksavaleha
Chyavanprasha
15. Parameters for
standardization of Avaleha
Organoleptic
Physical
Reducing sugar
Total sugar
Chromatography
Test for heavy metals
Microbial contamination
Shelf life
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16. Physical evaluation: •
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Loss on
drying at
105°c
Total ash Acid insoluble
ash
pH
Specific gravity Total solid
contents
Fat contents
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Bhasmas are powdered form of ayurvedic
preparations, obtained by calcination of
metals, minerals or animal products by a
special process in closed crucibles or pits
covered by cow dung cakes (puta).
Examples: Swarn bhasma, Shnakha bhasma
and Tamra bhasma
Bhasmas
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Preparation of Bhasma:
Shodhana
• is a process of purification and detoxification by which physical
and chemical blemishes and toxic materials are eliminated.
substances are subjected for further processing.
• Remove harmful substances and impurities present in the drugs.
Marna
• is a process in which metals and minerals are made into paste
with various drugs and juices. Objective to make bhasma and
this drugs are reduced to finest particles.
Jarana
• is a process of decomposing the particles by subjected to fire
treatment in a measured manner for reducing them to ashes. To
make it absorbable.
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Types:
On the basis of color grey, whitish, yellowish or
black colored.
A more scientific way of classification is on the
basis of metal and mineral group like: Rajata
group, Tamra group, Loha group etc.
Shelf Life:
Quite stable products, maintain potency for a
long time
Properties:
Bhasma has great therapeutic value because
they get absorbed easily into body even in very
small doses
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Quality Control of Bhasma:
There should be not metallic lusture
When a small quantity is spread on cold
and still water, it should float on the
surface
The bhasma should not revert to original
state.
Storage:
Store in cool & Dry place
Keep away from moisture & sunlight
21. Parameters for assessment
of Bhasma:
Qualitative Analysis: Information regarding the
presence or absence of one or more
components of the sample.
Quantitative Analysis: Information which is finally
obtained by measuring the physical property that
is characteristically related to the component.
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22. Methods of Analysis: Conventional
Chemical analysis by volumetric & Gravimetric
method analysis.
Physical analysis.
Instrumental methods of analysis by using analytical
instrumentation.
The Bhasmas are mainly examined in terms of
physical test and chemical test. The tests
mentioned below are applicable totally or
partially to the Bhasmas of different drugs. All
the tests are not applicable to all Bhasmas;
selected tests are applicable for particular
Bhasmas.
Mrs Pradnya Wadekar Bapat 22
23. Description/Colour/Odour
Identification –chemical composition
Particle size mesh size — 200 – 300
Loss on drying at 105 C
Total – ash
Acid – insoluble ash
Water soluble ash
Assay of element (s)
Ayurvedic specifications
Lustreless (Nishchandrica)
Fine enough to enter the crevices of
finger (Rekha purnatva)
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24. Floats on water (Varitara)
Smokeless (Nirdhoom)
Tasteless (Niswadu)
Irreversible (Apunar bhav)
NPST Namburi Phased Spot Test: This
technique is based on the principles of
liquid chromatography, which helps for
the differential identification of each
Bhasma from the other Bhasmas having
same element as the main constituent.
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Important bhasmas and their main
ingredient
No. Bhasma Main Ingredient
1. Loha bhasma Iron oxide
2 Naga bhasma Lead
3 Abhrak bhasma Mica
4 Yasad Bhasma Zinc Oxide
5 Swarn Bhasma Gold
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Churna:
Dried ayurvedic dosage form
comprises of fine powder of drug/s is
known as churna.
Drug can be any dried part of plant:
stem, leaves, root, bark, fruit etc.
The churna is free flowing powder.
The principle of using Churnas is
due to the fact that therapeutic value of
most of the substances greatly
increases when they are reduces to
vary fine state of subdivion and is
particularly notable in the cases of
antacids, protective and adsorbents.
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Procedure:
Drugs mentioned in formula,
Separated Powders
1. Cleaned properly
2. Dried thoroughly
3. Pulverised (reduced to small size)
4. Sieved (80 mesh size).
Weighed
Mixed together uniformly
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Shelf Life:
If stored properly, retains potency for one
year.
Storage conditions:
Air tight container, Kept away from
moisture
Store in a cool & dry place
Advantages:
They are also easily administrable
specially in the cases of children where
they can not swallow pills, tablets or
capsules
29. Standardization of Churna
Organoleptic evaluation
Microscopic evaluation
Physical analysis
Phytochemical analysis
Particle size
Test for heavy metals & toxins
Microbial contamination
Test for specific pathogen
Test for alfa toxin
Pesticide residue
Shelf life Mrs Pradnya Wadekar Bapat 29
32. Mrs Pradnya Wadekar Bapat 32
Taila:
Also called Medicated Oil
Liquid ayurvedic dosage form intended for
external & internal use comprises of
compounds with medicinal value or
phytoconstituents present in oil
The Taila preferably should be fresh
There are usually 3 or 4 essential
components in the manufacture of Taila
◦ Drava [Any liquid medium as prescribed in the
composition]
◦ Kalka [Fine paste of the specified drug]
◦ Sneha dravya [Taila]
◦ Gandha dravya [Perfuming agents]
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Pack it in tightly closed glass containers
Filter while hot (about 800) and allow to cool.
The process of boiling is to be continued till the whole amount of
moisture gets evaporated
Appearance of foam at surface
Avoid charring of the paste at bottom
Stir Continuously,
Heat at 50-90 0 C
Sneha Dravya (Taila) (4 Part) + Drava [Any liquid medium] (16 part)+
Kalka [Fine paste of drugs] (1 part)
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Properties:
The medicated Taila will have the odour,
colour and taste of the drugs used in the
process.
Protect from light and moisture
Tailas are preserved in good quality of
glass, steel or polythene containers.
Shelf Life:
These medicated preparations retain the
therapeutic efficacy for sixteen months.
Usage:
Used as a internally and topically
They are taken internally with warm water
or warm milk
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Gutika/ Modaka/ Vati/ Vadagam/
Tablets/ Pills
Soild ayurvedic dosage form made up of
one or more drugs of plant, animal or
mineral origin by the process of powdered,
sieving, & mixing with prescribed liquids
and triturated till attained the consistency
suitable for making gutika.
Vatika is in tablet form prepared by
compressin
Gutika is in the Pills form.
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The drugs of plant origin are dried and made
into fine powders, separately.
The minerals are made into bhasma
put into a suitable container & ground to a soft
paste with the prescribed fluids. When more
than one liquid is mentioned for grinding, they
are used in succession.
When the mass is properly ground and is in a
condition to be made into pills.
Mass is rolled manually or with the help of
suitable machine, compressed into gutikas/
vati.
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Storage:
Air tight container
Preparation containing vegetable drugs
can be used for 2 years
Preparations containing minerals or
metals can be used for indefinite period
Pills and vatis should not lose their
original color, smell, taste and form.
When sugar, salt is an ingredient, the pills
should be kept away from moisture.
41. Pharmaceutical parameters for
standardization
Hardness
Uniformity in weight
Uniformity in diameter
Friability test
Dissolution time
Disintegration time
Mrs Pradnya Wadekar Bapat 41