1. LYMPHATIC DRAINAGELYMPHATIC DRAINAGE
OF HEAD AND NECKOF HEAD AND NECK
Presented by:
Dr.Ayesha Taha (JR I)
Department of Pedodontics
and Preventive Dentistry
SPPGIDMS, Lucknow
4. Introduction
ďOf all the body systems, the lymphatic system is
perhaps the least familiar to most people. Yet without
it, neither the circulatory system nor the immune
system could functionâcirculation would shut down
from fluid loss, and the body would be overrun by
infection for lack of immunity.
ďThe lymphatic system is an endothelium-lined network
of blind-ended capillaries found in nearly all tissues,
draining via collecting vessels into large vascular trunks
that eventually empty via an evolutionarily conserved
drainage point into the blood circulatory system.
6. 1. Fluid recovery
Each day, we lose an excess of 2 to 4 L of water and
one-quarter to one-half of the plasma protein. The
lymphatic system absorbs this excess fluid and
returns it to the bloodstream by way of the lymphatic
vessels.
2. Immunity
As the lymphatic system recovers excess tissue fluid,
it
also picks up foreign cells and chemicals from the
tissues. On its way back to the bloodstream, the fluid
passes through lymph nodes, where immune cells stand
guard against foreign matter. When they detect it,
they
7. 3. Lipid absorption.
In the small intestine, special lymphatic vessels called
lacteals absorb dietary lipids that are not absorbed by
the blood capillaries.
9. Lymph:
Lymph is usually a clear, colorless fluid, similar to blood
plasma but low in protein. Its composition varies
substantially from place to place.
Origin of Lymph :-
Lymph originates in microscopic vessels called
lymphatic capillaries. These vessels penetrate nearly
every tissue of the body but are absent from the central
nervous system, cartilage, bone, and bone marrow.
The gaps between lymphatic endothelial cells are so
large that bacteria and other cells can enter along with
the fluid.
10. Lymphatic Vessels:
They have a tunica interna with an endothelium
and valve, a tunica media with elastic fibers and
smooth muscle, and a thin outer tunica externa.
Their walls are thinner and their valves are more
numerous than those of the veins.
11. Flow of Lymph :-
Lymph takes the following route from the tissues back
to the bloodstream:
Thus, there is a continual recycling of fluid from blood to
tissue fluid to lymph and back to the blood.
12.
13. Lymphatic Cells and Tissues:
T lymphocytes (T cells):
These are so-named because they develop for a time in
the thymus and later depend on thymic hormones.
B lymphocytes (B cells):
These are named after an organ in birds (the bursa of
Fabricius) in which they were first discovered. When
activated, B cells differentiate into plasma cells, which
produce circulating antibodies.
14. Macrophages:
These cells, derived from monocytes of the blood,
phagocytize foreign matter (antigens) and âdisplayâ
fragments of it to certain T cells, thus alerting the
immune system to the presence of an enemy.
Macrophages and other cells that do this are
collectively called antigen-presenting cells (APCs).
Dendritic cells:
These are APCs found in the epidermis, mucous
membranes, and lymphatic organs. (In the skin, they
are often called Langerhans cells.)
15. Reticular cells:
These are branched cells that contribute to the stroma
(connective tissue framework) of the lymphatic organs
and act as APCs in the thymus.
16. Mucosa-associated Lymphatic
Tissue.
The simplest form of
lymphatic tissue is diffuse
lymphatic tissueâa sprinkling of
lymphocytes in the mucous
membranes and connective
tissues of many organs.
It is particularly
prevalent in body passages that
are open to the exteriorâthe
respiratory, digestive, urinary,
and reproductive tractsâwhere
it is called Mucosa-Associated
Lymphatic Tissue (MALT).
17. Peyers patches:
In some places, lymphocytes and
other cells congregate in dense
masses called lymphatic nodules
(follicles).
Lymphatic nodules are, however,
a relatively constant feature of
the lymph nodes and tonsils.
They also form clusters called
Peyers patches in the ileum, the
last segment of the small
intestine.
18. Lymphatic Organs:
PRIMARY LYMPHATIC ORGANS :-
Lymphatic (lymphoid) organs contain large numbers of
lymphocytes, a type of white blood cell that plays a pivotal
role in immunity.
The primary lymphatic organs are
Red bone marrow and
Thymus gland
Lymphocytes originate and/or mature in these organs.
19.
20. Red Bone Marrow
It is the site of stem cells that are ever capable of dividing
and producing blood cells.
Some of these cells become the various types of white
blood cells: neutrophils, eosinophils, basophils,
lymphocytes, and monocytes.
In a child, most of the bones have red bone marrow, but in
an adult it is limited to the sternum, vertebrae, ribs, part
of the pelvic girdle, and the proximal heads of the humerus
and femur.
21. THYMUS
The thymus is a member of both the lymphatic and
endocrine systems.
It houses developing lymphocytes and secretes hormones
that regulate their activity.
It is located between the sternum and aortic arch in the
superior mediastinum.
The thymus is very large in the fetus and grows slightly
during childhood, when it is most active.
After age 14, however, it begins to undergo involution
(shrinkage) so that it is quite small in adults.
22.
23. THE SECONDARY LYMPHATIC ORGANS: are
the spleen,
the lymph nodes and
other organs, such as the tonsils.
All the secondary organs are the places where lymphocytes
encounter and bind with antigens, after which they
proliferate and become actively engaged cells.
24. SPLEEN
The spleen is the bodyâs largest lymphatic organ. It is
located in the left hypochondriac region, just inferior
to the diaphragm and dorsolateral to the stomach.
Its parenchyma exhibits two types of tissue named
for their appearance in fresh specimens (not in
stained sections):
red pulp, which consists of sinuses gorged with
concentrated erythrocytes, and
white pulp, which consists of lymphocytes and
macrophages aggregated like sleeves along small
branches of the splenic artery.
25. Functions:
It produces blood cells in the
fetus and may resume this role in
adults in the event of extreme
anemia.
It monitors the blood for foreign
antigens.
Lymphocytes and macrophages of
the white pulp are quick to detect
foreign antigens in the blood and
activate immune reactions.
Position of the spleen in the
upper left quadrant of the
abdominal cavity.
26. The spleen is an âerythrocyte graveyardââold, fragile
RBCs rupture as they squeeze through the capillary walls
into the sinuses. Splenic macrophages phagocytize their
remains, just as they dispose of blood-borne bacteria and
other cellular debris.
The spleen also compensates for excessive blood volume by
transferring plasma from the bloodstream into the
lymphatic system.
A person can live without a spleen, but is somewhat more
vulnerable to infections.
27. LYMPH NODES
It serve two functions:
ďto cleanse the lymph and
ďalert the immune system to pathogens.
There are hundreds of lymph nodes in the body.
They are especially concentrated in the cervical, axillary,
and inguinal regions close to the body surface, and in
thoracic, abdominal, and pelvic groups deep in the body
cavities.
Most of them are embedded in fat.
A lymph node is an elongated or bean-shaped structure,
usually less than 3 cm long, often with an indentation
called the hilum on one side.
28. Anatomy of a Lymph Node.
(a) Bisected lymph node showing pathway of lymph flow.
(b) Detail in the boxed region.
29. TONSIL
The tonsils are patches of lymphatic tissue located at the
entrance to the pharynx, where they guard against
ingested and inhaled pathogens.
There are three main sets of tonsils:
ď a single medial pharyngeal tonsil (adenoids) on the wall of the
pharynx just behind the nasal cavity,
ďa pair of palatine tonsils at the posterior margin of the oral
cavity, and
ďnumerous lingual tonsils, concentrated in a patch on each side
of the root of the tongue.
The palatine tonsils are the largest and most often infected.
30. ďAll lymph vessels of the head and neck drain into
the deep cervical nodes, either directly from the
tissues or indirectly via nodes in outlying groups.
ďLymph is returned to the systemic venous
circulation via either the right lymphatic duct or
the thoracic duct.
ďAll lymph vessels of the head and neck drain into
the deep cervical nodes, either directly from the
tissues or indirectly via nodes in outlying groups.
ďLymph is returned to the systemic venous
circulation via either the right lymphatic duct or
the thoracic duct.
LYMPHATIC DRAINAGE OF HEAD &
NECK
31. The lymph nodes in the head
and neck region can be
grouped into:
⢠Superficial nodes
⢠Deep nodes
Classification of nodes
in head and neck region
32. ďĄ The superficial cervical lymph nodes lie above theabove the
investing layer of the deep fasciainvesting layer of the deep fascia.
ďĄ They consist of a few small nodes that lie
superficial to the external jugular and anterior
jugular veins.
The superficial Lymph nodesThe superficial Lymph nodes
38. 1. Upper deep cervical
2. Lower deep cervical
3. Waldyerâs ring
4. Nodes of midline
The Deep lymph nodes:The Deep lymph nodes:
39. 1. The upper deep cervical:
Jugulo-digastric group: lie along the upper part of
internal jugular vein deep to the sternomastoid muscle.
Structures drained: Tonsil and Tongue.
2. The lower deep cervical:
Jugulo-omohyoid group: arranged along the lower part
internal jugular vein deep also to the sternomastoid
muscle.
Structures drained: Tongue.
41. 3.The waldyerâs ring:The ring consists of the (from
superior to inferior):
ď1 Pharyngeal Tonsils (or nasopharyngeal tonsil(s), due
to the location; also known as 'adenoid(s)' when
inflamed/swollen.
ď2 Tubal Tonsil (bilaterally).
ď2 Palatine Tonsils (commonly called "the tonsils" in
the vernacular, less commonly termed "faucial
tonsils"; located in the oropharynx.
ď1 lingual Tonsils (on the posterior tongue)
42.
43. 4. Midline nodes are termed in
correspondence to the anatomical area
where they exist:
A. Infrahyoid
B. Prelaryngeal
C. Pretracheal
D. Paratracheal
44. The skin of the head and neck drains :
⢠The scalp drains into the occipital, mastoid and
parotid nodes.
⢠Lower eye lid and anterior cheek drains into buccal
nodes.
⢠The cheeks drain into the parotid, buccal and
submandibular nodes.
⢠The upper lips and sides of the lower lips drain into
the submandibular nodes.
⢠While the middle third of the lower lip drains into the
submental nodes.
⢠The skin of the neck drains into the cervical nodes.
45. The drainage of the oral structures
⢠The Gingivae drain into the submandibular, submental
and upper deep cervical lymph nodes.
⢠The palate drains via lymph vessels that pass through
the pharyngeal wall to the upper deep cervical nodes.
⢠Anterior part of mouth floor drain into submental and
upper deep cervical
⢠while posterior part into submandibular and upper deep
cervical.
47. Lymph drainage of external noseLymph drainage of external nose
Lymph drainage of external nose is primarily
to the submandibular group of nodes although
lymph from the root of the nose drains to
superficial parotid nodes.
48. Lymphatic drainage of nasal cavity
Lymph vessels from the anterior region of the nasal cavity pass
superficially to join those draining the external nasal skin, and
end in the submandibular nodes.
The rest of the nasal cavity, paranasal sinuses, nasopharynx
and pharyngeal end of the pharyngotympanic tube, all drain to
the upper deep cervical nodes either directly or through the
retropharyngeal nodes.
The posterior nasal floor drains to the parotid nodes.
49. Lymphatic drainage of tongue:
The lymphatic drainage of the tongue can be divided into 3
main regions: Marginal, Central and Dorsal.
The anterior region of the tongue drains into marginal and
central vessels, and the posterior part of the tongue behind
the circumvallate papillae drains into the dorsal lymph
vessels.
The more central regions drain bilaterally into sub-mental
and sub-mandibular nodes.
50.
51. Lymphatic drainage of teeth:
The lymph vessels from the teeth usually run directly into
the ipsi-lateral submandibular lymph nodes.
Lymph from the mandibular incisors, however, drains into
the submental lymph nodes.
Occasionally, lymph from the molars may pass directly into
the jugulo-digastric group of nodes.
52. APPLIED ASPECT:
When a lymph node is under challenge from a foreign
antigen, it may become swollen and painful to the touchâ a
condition called lymphadenitis.
Commonly palpated and accessible lymph nodes are - the
cervical, axillary, and inguinal.
Lymph nodes are common sites of metastatic cancer
because cancer cells from almost any organ can break loose,
enter the lymphatic capillaries, and lodge in the nodes.
Lymphadenopathy is a collective term for all lymph node
diseases.
53. Differential Diagnosis of cervical Lymphadenopathy based
on palpatory findings. TEXTURE OF LYMPH NODES
54. Conclusion :-
ďIn conclusion, the lymphatic system and its organs are
widespread and scattered throughout the body.
ďBecause the vessels of the lymphatic system span the
entire body it becomes an easy portal for the spread of
cancer and other diseases, which is why disorders and
diseases of this system can be very devastating.
ďA sound knowledge of the regional lymph nodes of the
head and neck is very important for dentists because it
is a reliable guide towards the origin of problem, and
because of the possible involvement of the lymphatic
system in the spread of infection or the spread of
malignant tumour cells (metastasis).
55. ďTextbook of Head and Neck Anatomy (Hiatt â Gartner) 4th
Ed. 2010
ďGrant's Atlas of Anatomy,13th
Ed.
ďGray's Anatomy â 40th
Ed.
ďAnatomy of the Human Body - Henry Gray
ďSaladin: Anatomy & Physiology: The Unity of Form and Function, 3rd
Edition
ďEmbryology Atlas , John F Neas
ďLife Map â Embryonic development & stem cell compendium
ďButler M G, Isogai S, Weinstein B M. Lymphatic development, Birth
Defects Res C Embryo Today. 2009 September ; 87(3): 222â231.
ďAlbrecht I, Christofori G, Molecular mechanisms of
lymphangiogenesis in development and cancer; Int. J. Dev. Biol.
55: 483-494
References :-
56. Ferrer R, Lymphadenopathy: Differential Diagnosis and Evaluation;
Am Fam Physician. 1998 Oct 15;58(6):1313-1320
Som P M, Hugh D C, Mancuso A A, An imaging-based classification
for the cervical nodes designed as an adjunct to recent clinically
based nodal classification;Arch Otolaryngol Head Neck Surg.
1999;125:388-396.
Oliver G, Detmar M, The rediscovery of the lymphatic system: old
and new insights intothe development and biological function of
the lymphatic vasculature; Genes Dev. 2002,16: 773-783
Sambandan T, Mabel C R, Cervical lymphadenopathy- a review;
JIADS,2011,2,1:31-33.
Torabi M, Aquino S L, Harisinghani M G, Current concept in lymph
node imaging; J Nucl Med, 2004; 45:1509-1518.
Connor SEJ, Olliff JFC, Imaging of malignant cervical
lymphadenopathy â a review; Dentomaxillofacial Radiology,
2000;29:133-143.
57. âThe earliest evidence of ancient dentistry -an amazingly detailed dental
work on a mummy from ancient Egypt that archaeologists have dated to
2000 BCE. The work shows intricate gold work around the teeth. This
mummy was found with two donor teeth that had holes drilled into
them. Wires were strung through the holes and then around the
neighboring teeth.â Source: metalonmetal blog.
Editor's Notes
1. Fluid recovery Each day, they lose an excess of 2 to 4 L of water and one-quarter to one-half of the plasma protein. The lymphatic system absorbs this excess fluid and returns it to the bloodstream by way of the lymphatic vessels.
2. Immunity. As the lymphatic system recovers excess tissue fluid, it also picks up foreign cells and chemicals from the tissues. On its way back to the bloodstream, the fluid passes through lymph nodes, where immune cells stand guard against foreign matter. When they detect it, they activate a protective immune response.
3. Lipid absorption. In the small intestine, special lymphatic vessels called lacteals absorb dietary lipids that are not absorbed by the blood capillaries
A lymphatic capillary consists of a sac of thin endothelial cells that loosely overlap each other like the shingles of a roof. The cells are tethered to surrounding tissue by protein filaments that prevent the sac from collapsing. Unlike the endothelial cells of blood capillaries, lymphatic endothelial cells are not joined by tight junctions. The gaps between them are so large that bacteria and other cells can enter along with the fluid.
Lymphatic vessels form in the embryo by budding from the veins, so it is not surprising that the larger ones have a similar histology.
The lymphatic capillaries converge to form collecting vessels. These often travel alongside veins and arteries and share a common connective tissue sheath with them. Numerous lymph nodes occur along the course of the collecting vessels, receiving and filtering the lymph. The collecting vessels converge to form larger lymphatic trunks, each of which drains a major portion of the body. The principal lymphatic trunks are the lumbar, intestinal, intercostal, bronchomediastinal, subclavian, and jugular trunks. Their names indicate their locations and parts of the body they drain; the lumbar trunk also drains the lower extremities.
The lymphatic trunks converge to form two collecting ducts, the largest of the lymphatic vessels:
(1) The right lymphatic duct begins in the right thoracic cavity with the union of the right jugular, subclavian, and bronchomediastinal trunks. It receives lymphatic drainage from the right arm and right side of the thorax and head and empties into the right subclavian vein (fig. 21.6a).
(2) The thoracic duct, on the left, is larger and longer. It begins as a prominent sac in the abdominal cavity called the cisterna chyli and then passes through the diaphragm and up the mediastinum. It receives lymph from all parts of the body below the diaphragm and from the left arm and left side of the head, neck, and thorax (fig. 21.6b). It empties into the left subclavian vein.
The T stands for thymus-dependent.
1. which come and go as pathogens invade the tissues and the immune system answers the challenge.