This document presents a framework for the automated design of multiphase space missions using hybrid optimal control. The method uses two nested loops: an outer loop that handles the discrete mission structure and finds the optimal sequence of events (coast arcs, thrust arcs, impulses) using genetic algorithms; and an inner loop that performs trajectory optimization of the continuous dynamics for each sequence using direct transcription and nonlinear programming. The inner loop solver was automated to handle problems with variable structures, and a new method based on genetic algorithms was developed to generate robust initial guesses for the nonlinear programming problems. The solution of representative mission design problems demonstrated the effectiveness of the methods.