An autoimmune disease occurs when the immune system mistakenly attacks the body's own cells. Some potential triggers are microorganisms, drugs, or genetic factors. Common autoimmune diseases include Graves' disease, rheumatoid arthritis, thyroiditis, type 1 diabetes, and multiple sclerosis. Symptoms can vary widely but include fatigue, rashes, pain, and organ damage. Diagnosis involves blood tests and examinations. Treatment options include medications that suppress the immune system. Lifestyle and dietary changes may also help manage autoimmune conditions.

1. Presented By
Dr. Shivam Mishra

2. An autoimmune disease is a condition in which your immune system
mistakenly attacks your body.
The immune system normally guards against germs like bacteria and
viruses. ... Normally, the immune system can tell the difference
between foreign cells and your own cells.

3. Horror autotoxicus:
Literally, the horror of self-
toxicity.
A term coined by the
German immunologist Paul
Ehrlich (1854-1915) to
describe the body's innate
aversion to immunological
self-destruction.

4. • The exact cause of autoimmune disorders is unknown.
• One theory is that some microorganisms (such as bacteria or
viruses) or drugs may trigger changes that confuse the immune
system.
• This may happen more often in people who have genes that
make them more prone to autoimmune disorders

5. • Genetic susceptibility
• Environmental stimuli
• Defective immune regulation ( T-cells )

8. Most Common Autoimmune Diseases
• Graves’ disease
• Rheumatoid arthritis
• Thyroiditis/hypothyroidism
• Vitiligo
• Type 1 diabetes
• Pernicious anemia
• Multiple sclerosis
• Glomerulonephritis
• Systemic lupus erythematosus
• Sjögren’s syndrome
• Uveitis
• Scleroderma

9. • Addison’s disease
• Autoimmune hemolytic anemia
• Autoimmune hepatitis
• Goodpasture’s syndrome
• Autoimmune thrombocytopenic purpura
• Myasthenia gravis
• Myocarditis
• Pemphigus
• Polymyositis/dermatomyositis
• Primary biliary cirrhosis
• Rheumatic heart disease
• Relapsing polychondritis
Most Common Autoimmune Diseases

10. • Tiredness
• Depression
• Weight gain
• Weight loss
• Muscle weakness
• Cramps
• Irritability
• Sweating
• Shaky
• Swelling
• Rash
• Body pains
• Tremors
• Numbness
• Fatigue
• Loss of appetite
• Insomnia
• Coordination loss
Many different symptoms make autoimmune diseases hard
to diagnose
Many times there are no symptoms!

14. Autoimmune diseases are more prevalent in women
than men. ... The most striking sex differences are
observed in Sjogren's syndrome, SLE, autoimmune
thyroid disease (Hashimoto's thyroiditis and well as
Graves' disease) and scleroderma, which represent a
spectrum of diseases in which the patient population
is >80% women

16. • Autoimmunity can be caused by immunological, genetic,
viral, drug-induced, and hormonal factors.
• There are 4 immunological mechanisms of
autoimmunity.
• All mechanisms cause abnormal B or T cell activation.
• Centrality of the Ternary Complex
• Most instances of autoimmune diseases occur with
multiple mechanisms, which makes treatment difficult.

17. • No single test can diagnose most autoimmune
diseases. Your doctor will use a combination of
tests and a review of your symptoms and
physical examination to diagnose you.

18. • Antinuclear antibody test ( ANA)
• CBC, comprehensive metabolic panel
• Cytokine analysis
• Elevated IGg label
• CRP, ESR, LFT, Ferritin
• Immunoglobulins
• Other Diseases specific test

19. • You might need to visit a specialist, depending on the type of
disease you have.
• Rheumatologists treat joint diseases, like rheumatoid arthritis
as well as other autoimmune diseases like Sjögren’s syndrome
and SLE.
• Gastroenterologists treat diseases of the GI tract, such as celiac
and Crohn’s disease.
• Endocrinologists treat conditions of the glands, including
Graves’ disease, Hashimoto’s thyroiditis, and Addison’s
disease.
• Dermatologists treat skin conditions, such as psoriasis.

20. • Nonsteroidal anti-inflammatory drugs
(NSAIDs), such as ibuprofen (Motrin, Advil) and naproxen (Naprosyn)
• Immune-suppressing drugs
Such as azathioprine, mycophenolate mofetil,
methotrexate
• Glucocorticoid
Such as Betamethasone, Dexamethasone,
Hydrocortisone, Methylprednisolone

21. • Thymectomy
Removal of thymus from patients with myasthenia
gravis
• Plasmapheresis
Removes antigen-antibody complexes for a
short- term reduction in symptoms

22. • In Ayurveda panchkarm is the best option for
correcting the immune system
• Panchkarm purify the body and correct the all
abnormal system of the body.

23. • meat and fish, preferably not factory raised
• vegetables (but not nightshades, such as tomatoes, eggplants, peppers,
and potatoes)
• sweet potatoes
• fruit (in small quantities)
• coconut milk
• avocado, olive, and coconut oil
• dairy-free fermented foods, such as kombucha, kefir made with coconut
milk, sauerkraut, and kimchi
• honey or maple syrup (but only to be used occasionally, in small
quantities)
• fresh non-seed herbs, such as basil, mint, and oregano
• green tea and non-seed herbal teas
• bone broth
• vinegars, such as apple cider and balsamic

24. • all grains, such as oats, rice, and wheat
• all dairy
• eggs
• legumes, such as beans and peanuts
• nightshade vegetables (tomatoes, eggplants, peppers, and
potatoes)
• all sugars, including sugar replacements (except for
occasional use of honey)
• butter and ghee
• all oils (except for avocado, coconut, and olive)
• food additives
• alcohol

25. THANK YOU