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Neil L. Kao, M.D. Assistant Professor of Medicine U.S.C. School of Medicine Director of Research ADAC Research, P.A. [Missions: teach, research, service]
Why should we care about asthma? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Management of Asthma ,[object Object],[object Object],[object Object],Source: http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf
2007 EPR-3 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Source: http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf
[object Object],[object Object],[object Object],EPR 3’s Six Key Messages ,[object Object],[object Object],[object Object],Source: http://www.nhlbi.nih.gov/guidelines/asthma/gip_rpt.pdf
Lung function and physiology ,[object Object],[object Object],[object Object],[object Object]
What is asthma? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Asthma pathophysiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Asthma histology ,[object Object],[object Object],[object Object]
Asthma triggers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Asthma diagnosis triad ,[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosing Asthma on Exam ,[object Object],[object Object],[object Object],[object Object]
Diagnosing Asthma:   Spirometry ,[object Object]
New in EPR-3: Allergy Testing for All Patients With Persistent Asthma ,[object Object],[object Object],[object Object],[object Object],National Heart, Lung, and Blood Institute.  Guidelines for the Diagnosis and Management of Asthma (EPR-3) 2007 . Bethesda, MD: US Department of Health and Human Services, National Institutes of Health; August 2007. NIH publication no. 08-4051.
 
Goals of asthma treatment: Reduce impairment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Goals of asthma treatment: Reduce risk ,[object Object],[object Object],[object Object],[object Object]
New in EPR-3: Differentiating   Severity, Control, and Responsiveness ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],National Heart, Lung, and Blood Institute.  Guidelines for the Diagnosis and Management of Asthma (EPR-3) 2007 . Bethesda, MD: US Department of Health and Human Services, National Institutes of Health; August 2007. NIH publication no. 08-4051.
Severity: Impairment and Risk Domains
Defining Disease Control in Asthma Is Difficult FEV 1 =forced expiratory volume at 1 second. PEF=peak expiratory flow. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Kao’s Asthma step therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Medications to Treat Asthma ,[object Object],[object Object],[object Object],[object Object]
Asthma rescue medications ,[object Object],[object Object],[object Object],[object Object]
Reliever medication names ,[object Object],[object Object],[object Object],[object Object]
Asthma controller medications ,[object Object],[object Object],[object Object],[object Object],[object Object]
Long-acting bronchodilating Agents (LABA) ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
Allergen Immunotherapy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Asthma Control Test ,[object Object],[object Object],[object Object],[object Object],[object Object]
Why recommend referral to an asthma specialist for co-management? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Asthma Summary ,[object Object],[object Object],[object Object],[object Object]
 

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Understanding Asthma: Causes, Symptoms, Diagnosis and Treatment

  • 1.  
  • 2. Neil L. Kao, M.D. Assistant Professor of Medicine U.S.C. School of Medicine Director of Research ADAC Research, P.A. [Missions: teach, research, service]
  • 3.
  • 4.
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  • 20. Severity: Impairment and Risk Domains
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Editor's Notes

  1. An expert panel commissioned by the National Asthma Education and Prevention Program (NAEPP) Coordinating Committee (CC) developed the 2007 EPR 3 Guidelines on Asthma. The National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health coordinated the effort.
  2. The expert panel used the 1997 guidelines and the 2004 update as the framework to organize the literature review, and the final guidelines report for four essential components of asthma care: assessment and monitoring, patient education, control of factors contributing to asthma severity, and pharmacologic treatment. Here are a few highlights.
  3. Inhaled Corticosteroids Inhaled corticosteroids are the most effective medications for long-term management of persistent asthma, and they should be used by patients and clinicians as recommended in the guidelines for controlling asthma. Message: Asthma Action Plan All people who have asthma should receive a written asthma action plan to guide their self-management efforts. Message: Asthma Severity Message: All patients should have an initial severity assessment based on measures of current impairment and future risk to determine type and level of initial therapy needed. Message: Asthma Control Message: At planned follow-up visits, asthma patients should review the level of control with their health care providers on the basis of multiple measures of current impairment and future risk; this review can guide clinician decisions to either maintain or adjust therapy. Message: Follow-up Visits Patients who have asthma should be scheduled for planned follow-up visits at periodic intervals to assess their asthma control and to modify treatment if needed. Message: Allergen and Irritant Exposure Control Clinicians should review each patient’s sensitivity to allergens and irritants and provide a multipronged strategy to reduce exposure—i.e., avoid exposures that make the patient’s asthma worse.
  4. Diagnosing Asthma
  5. Diagnosing Asthma: Spirometry
  6. Key Point: “ Impairment” and “risk” are important concepts that you will hear much about in the future. This is how we look at severity and risk. In terms of SEVERITY, it must be understood as the PRE-TREATMENT ASSESSMENT of asthma. Slide Notes: Asthma “severity” has always been a tricky term. The correlation between the intensity of symptoms and the “severity” category into which a patient would fall often seems contradictory It is important to remember that severity is an assessment BEFORE treatment. Herein, one must consider both the near-term and long-term assessment of a patient to have a full understanding of severity This slide depicts some of the concepts that fall under the two main components of severity: “Impairment” and “Risk”
  7. Avoidance of allergens when possible is the most important aspect of allergy treatment. Decreasing exposure to allergens results in improvement in symptoms and less need for medications. Total avoidance of allergens is usually not possible, so medications are usually necessary. Fortunately we have many safe and effective medications for allergies. Allergy injections are usually reserved for those patients whose symptoms are not controlled by avoidance and medications. Allergy injections can be very effective in certain patients with certain allergies, but should be prescribed and administered by physicians with training or experience in this kind of therapy.
  8. Medications to Treat Asthma