Assisted hatching is a lab technique used during IVF to enhance the chances of pregnancy by facilitating embryo hatching, which may not occur naturally. Methods include micro-manipulation, chemical breaching, and laser-assisted techniques to create a small opening in the zona pellucida for easier implantation. This procedure is particularly beneficial for women with a history of failed IVF cycles, advanced maternal age, poor embryo quality, or specific hormonal levels, but comes with risks such as potential embryo damage and the possibility of multiple pregnancies.

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2. Assisted Hatching
Assisted hatching is a micro manipulation technique performed in a lab during IVF procedure to
improve the chance of pregnancy. It is also known as Zona Hatching, Drilling or Thinning. In natural
conception, hatching takes place on its own. During 5-7 days of hatching the lining of the fertilised
embryo is covered by a shell known as zona pellucida. After entering the uterus the outer shell of the
embryo dissolves partially and the hatched embryo gets implanted in the uterus wall resulting in
conception. In IVF procedure it has been found that sometimes the embryos don’t hatch on its own
requiring a lab technique to help successful implant. This artificial thinning or breaching of zona is
performed to improve the chances of pregnancy. This procedure is performed before embryo transfer
of the patient and used for the mother and the surrogate mother.

3. In this assisted hatching procedure, various methods
are used to make this artificial hole. The embryologist
might use a micro needle to make a hole to help tear
the zona so that the embryo can come out of its shell
and implant easily. In chemical hatching tiny amounts
of acid is used to breach the zona. In laser assisted
hatching specialised laser is used to breach the zona.
This is considered to be the safest method as the hole
of the embryo can be made with much more precision
than the needle. Apart from this, drilling and
mechanical expansion of the zona is also used. In
expansion the zona will get diluted like it gets in
natural conception. All these procedures are meant to
get over the hurdles that are preventing the embryo to
stick to the uterus wall for implant. However, it
requires a great deal of expertise for the embryologist
to perform such procedures.

4. Why is assisted hatching performed?
Assisted hatching is performed where patients have history of failed IVF cycles as this technique is perceived to be
helping in successful conception. IVF and Surrogacy in India has evolved a great deal in its use of technology and
manipulation to achieve greater success. Women with higher age like 35 years and above would require this. Also
when the embryo quality is poor, this technique is used. It is also used for frozen embryo replacements and women
who has high FSH levels. Sometimes a distinct thickening of the zona is also noted by the embryologist preventing
hatching.
What are the risks involved?
The risks involved are, this process might damage the embryo if not done professionally. Twin pregnancies can
happen. It is very important to ask the doctor to know the reason behind such hatching if suggested by the clinic.
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