This document discusses the physiological responses of the cardiovascular and respiratory systems to increased exertion during climbing. It explains how the body increases oxygen delivery and cardiac output during exercise through mechanisms like vasodilation, increased heart rate and stroke volume. It then discusses the additional challenges of climbing to high altitudes, where lower barometric pressure and oxygen levels lead to hypoxia. Symptoms of hypoxia are described along with possible treatments like acclimatization, oxygen supplementation, or seeking medical care.