The document outlines aseptic techniques for manipulating compounded sterile products to prevent contamination, emphasizing methods for handling ampules, syringes, and vials. Key steps include proper cleaning, avoiding touch contamination, and utilizing appropriate equipment such as filter needles and luer-lock syringes. It stresses the critical importance of maintaining sterility to ensure patient safety, as contaminated products can lead to severe adverse effects.

1. A SEPTIC
TECHNIQUE
PP2Assignment
Aseptic Technique refers to manipulations
of compounded sterile products &
parenteral preparations that prevents
contamination.
This includes manipulations of syringes,
needles, vials,
ampules, removal
of packaging,
assembling of
sterile products,
hand placement,
etc.
Annisa H ayatunnufus
(012014052438)
AM PULES
- Stepsto break ampule:
a. Clean ampule neck with
alcohol swab
b. Leave swab in place
c. Grasp ampule neck with
thumb and index finger
d. Use quick, firm, snapping
motion away from body
towardsside wall of hood
e. Do not break towards heap
filter
-
- Steps to withdraw medication
from ampule:
a. Tilt ampule
b. Place needle bevel in corner
space near opening
c. Pull back syringe plunger
- Steps to avoid glass
contamination of ampule
solution:
a. Use 5 micron filter needle to
filter glass as solution is
pushed out of the syringe
b. A filter needle can only be
used in one direction,
otherwise glass particles
originally filtered are
reintroduced
REMEMBER!
- Giving patient a contaminated
product can cause serious adverse
effectsincludingdeath.
- Discard any potentially
contaminated product and inform
the pharmacist that product was
discarded.
SU M M A RY
In assembling all the
product, great caremust
beexcersied to prevent
any touch contamination
of critical edgesor
component surfaces

2. CORING,VIALS,SW AB
- Do not touch the tip nor plunger.
- Preferably use Luer-lock syringe than slip-tip
syringe. Even though the latter cost less, the
needle connection islesssecure.
- Do not use syringeswhose gradationsare greater
than twice the volume being measured.
- Use glass syringes in rare compounding
scenarios (ie. Preparing certain chemotherapy
products or drug is incompatible with syringe
components).
125
145
290
* * *
SYRINGE
NEEDLES
- Choose the size according to the length and
gauge (the larger, the finer the diameter of
needle?sbore)
- Do not touch any part of the needle
- Open needle package within hood to maintain
sterility
- Do not swab the needle with alcohol before use.
Discard immediately in a sharps container even
in the slightest contamination
To prevent coring, insert the bevel tip
first, then press downward toward the
bevel so the tip and heel enter at the
samepoint.
CORING
Coring is the
creation of a hole
in the rubber
stopper of a vial
due to improper
insertion of
needle.
Note
theslight
bendof needle
andthecritical
areasfor vial,
needle, and
syringe.
- Prevent contamination: swab rubber
closure with 70%alcohol using firm
strokesin thesamedirection.
VIALS
- Prevent core
formation:
insert needleto
penetrate the
rubber closure
at the same
point with
both tip and
heel of bevel.
- Prevent vacuum formation:
inject equal amount of air for the
volumeof fluidtoberemoved.
- Reconstituting drug powder:
remove equal amount of air for
thevolumeof diluent added
- Saturated swab should be wiped
onceacrossthecritical site.
- Avoid vigorously rubbing the
swab back and forth across the
critical site. Thisaction may leave
small fibers behind that could
contaminatesterileenvironment.
SW AB