Society has benefited tremendously from the development and utilization of mechanical devices which are implanted inside the body and are used to replace bones and joints, increase blood flow, and even measure blood chemistry. To further enhance the performance of these devices, the application of thin films to the external surfaces is an ongoing research and development interest at many companies. Engineers have a choice of a variety of technologies to apply these liquid coatings to these often complex surfaces ranging from vacuum technology to direct liquid application. The decision on what technology to use is a function of the liquid precursor used, the mechanism of coating formation and the geometry of the object to be coated. A critical quality and process control criterion is the consistency of the coating on the surface. Fluid delivery technology can play an important part in maintaining coating consistency. Pumps and liquid flow controllers are technologies being used today. For vapor coating processes, liquid vaporization technology is a critical link in the fluid delivery system. New flow and vaporization technology is available that can be applied to fluid delivery to improve the application of medical device coatings.
In This PPT Various Equipments Used In Pharma Industry Are Discussed. It can Be Used As Source Of Knowledge For Studnets Who Want To Gain Knowledge Other Than Books.
Study of sliding wear rate of hot rolled steel specimen subjected to Zirconia...IJERA Editor
Wear is nothing but loss of material by usage. In a mechanical industry mechanical components will operate
under severe load, temperature and high speeds. Under such a type of situation, when metal to metal contact take
place the surfaces that comes in contact is subjected to wear. These should be considered as a serious affair in an
industry because if the process of wear continues it can reduce service life of the component and also to the
entire mechanical system to which the component has been used. In the light of the above the present work
mainly deals with the study of wear behavior of hot rolled steel with and without zirconia coating on the contact
surface and the effect of zirconia coating with varying thickness.
Microtomy, or the preparation of tissue slides, is the foremost technique used in histological studies. This presentation is a brief overview of the technique and the steps involved.
In This PPT Various Equipments Used In Pharma Industry Are Discussed. It can Be Used As Source Of Knowledge For Studnets Who Want To Gain Knowledge Other Than Books.
Study of sliding wear rate of hot rolled steel specimen subjected to Zirconia...IJERA Editor
Wear is nothing but loss of material by usage. In a mechanical industry mechanical components will operate
under severe load, temperature and high speeds. Under such a type of situation, when metal to metal contact take
place the surfaces that comes in contact is subjected to wear. These should be considered as a serious affair in an
industry because if the process of wear continues it can reduce service life of the component and also to the
entire mechanical system to which the component has been used. In the light of the above the present work
mainly deals with the study of wear behavior of hot rolled steel with and without zirconia coating on the contact
surface and the effect of zirconia coating with varying thickness.
Microtomy, or the preparation of tissue slides, is the foremost technique used in histological studies. This presentation is a brief overview of the technique and the steps involved.
A stent is a small, expandable tube. During a procedure called angioplasty, the stent is inserted into a coronary artery and expanded using a small balloon. A stent is used to open a narrowed or clotted artery.
Precision coating and adhesive dispensing for medical devices Brian Schmaltz
The human body is quite possibly the harshest and most complex environment known for microelectronic / micromechanical assemblies. Medical device assemblies are decreasing in size to provide access and comfort for extracorporeal and in situ devices. In addition the scale of electronic components will continue to consistently become smaller and denser with the advances and improvements in technology. Packaging and assembling these devices is requiring a much higher level of precision than ever before, whether conformal coating for environmental protection or dispensing medical adhesive for assembly. Non-contact jetting of conformal coating as well as semiconductor packaging fluids represents a paradigm shift to a higher level of precision in the method of applying coatings and adhesives versus traditional dispensing methods. This paper will cover the advancements in manufacturing methods for high precision environmental coating and adhesive dispensing.
Prediction of coating process parameters on scaleup/scale downSatishPuttachari
This ppt discuss about the CPP impacting the coating process parameters & optimisation. U can find validated excel sheet which calculates the CPP for the scale up/down or changing the equipment.
IJRET : InIJRET : International Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technologyternational Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technology
Simulative analysis of tube hydroforming processeSAT Journals
Abstract The tube hydro forming process (THF) is an unconventional metal forming process, where in tube is deformed internally and thus it is forced to expand and conform to the shape of the surrounding die. The performance of this process depends on various parameters like internal pressure, axial loading etc. For FEA simulation, it requires proper combination of material selection, part design and boundary conditions. The estimated process parameters are optimized using FEA simulations. In this work, free bulge shaped tube die was modeled by using Auto CAD. Subsequently, the processes were simulated using DEFORM-3D and it has been verified with experimental work under proper boundary and loading condition. Process parameters study also been conducted. It has been found that the estimated process parameters, developed branch height and the wall thickness distribution along different planes are in good coincidence with experimental results. Keywords: Tube hydroforming, Free bulge forming, DE-FORM Software, EN-31, Axial feeding, internal fluid pressure, FEA Simulation, loading path.
A stent is a small, expandable tube. During a procedure called angioplasty, the stent is inserted into a coronary artery and expanded using a small balloon. A stent is used to open a narrowed or clotted artery.
Precision coating and adhesive dispensing for medical devices Brian Schmaltz
The human body is quite possibly the harshest and most complex environment known for microelectronic / micromechanical assemblies. Medical device assemblies are decreasing in size to provide access and comfort for extracorporeal and in situ devices. In addition the scale of electronic components will continue to consistently become smaller and denser with the advances and improvements in technology. Packaging and assembling these devices is requiring a much higher level of precision than ever before, whether conformal coating for environmental protection or dispensing medical adhesive for assembly. Non-contact jetting of conformal coating as well as semiconductor packaging fluids represents a paradigm shift to a higher level of precision in the method of applying coatings and adhesives versus traditional dispensing methods. This paper will cover the advancements in manufacturing methods for high precision environmental coating and adhesive dispensing.
Prediction of coating process parameters on scaleup/scale downSatishPuttachari
This ppt discuss about the CPP impacting the coating process parameters & optimisation. U can find validated excel sheet which calculates the CPP for the scale up/down or changing the equipment.
IJRET : InIJRET : International Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technologyternational Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technology
Simulative analysis of tube hydroforming processeSAT Journals
Abstract The tube hydro forming process (THF) is an unconventional metal forming process, where in tube is deformed internally and thus it is forced to expand and conform to the shape of the surrounding die. The performance of this process depends on various parameters like internal pressure, axial loading etc. For FEA simulation, it requires proper combination of material selection, part design and boundary conditions. The estimated process parameters are optimized using FEA simulations. In this work, free bulge shaped tube die was modeled by using Auto CAD. Subsequently, the processes were simulated using DEFORM-3D and it has been verified with experimental work under proper boundary and loading condition. Process parameters study also been conducted. It has been found that the estimated process parameters, developed branch height and the wall thickness distribution along different planes are in good coincidence with experimental results. Keywords: Tube hydroforming, Free bulge forming, DE-FORM Software, EN-31, Axial feeding, internal fluid pressure, FEA Simulation, loading path.
Conceptual design of transfer mould tool for rubber bumper springeSAT Publishing House
IJRET : International Journal of Research in Engineering and Technology is an international peer reviewed, online journal published by eSAT Publishing House for the enhancement of research in various disciplines of Engineering and Technology. The aim and scope of the journal is to provide an academic medium and an important reference for the advancement and dissemination of research results that support high-level learning, teaching and research in the fields of Engineering and Technology. We bring together Scientists, Academician, Field Engineers, Scholars and Students of related fields of Engineering and Technology
Providing uniform heat to semiconductor devices in degassing chambers is essential in extracting impurities. This can only be achieved if a heating device has the proper fit and temperature uniformity for a given chamber. It is for this very application that BCE was approached by a large semiconductor company from Silicon Valley. In order to heat this company’s semiconductor wafers, it was critical that the heating device be manufactured to fit precisely into a large and circular degassing chamber posing manufacturing challenges due to dimensional and application parameters. BCE was able to provide extensive design consultations, 3D CAD modeling and lean manufacturing capabilities to this semiconductor giant at a competitive price. All these services were rendered while catering to all requirements needed to successfully manufacture their products.
A compact, fast responding electric heating element for clean gases in fuel cell, bio-med, laboratory, food, and pharmaceutical applications. The SuperCirc gas heater is designed for applications where fast heating of clean gases is required. All parts exposed to gas flow are constructed of 316SS (other materials available) rather than exposing process media to exposed resistance elements. This ensures that no foreign matter contaminates gas.
General Specification for Thermofoil Heater, All-Polyimide, Space ApplicationsBelilove Company-Engineers
Purpose. This specification establishes the requirements for thermofoil heaters of an all- polyimide (adhesive-less) construction for high reliability space applications. It defines the process, test verification, and inspections required by product used in space flight applications.
One of the biggest challenges facing the vacuum industry is to collect multiple readings from complex assemblies while being limited by the number of existing feedthrough ports in a vacuum chamber. With BCE’s Multi-TC, Flanged Feedthrough, companies no longer need to invest in adding more ports for a greater collection of temperatures from a vacuum environment as multiple thermocouples are embedded in just one feedthrough. The number, type and lengths of the thermocouples can be altered to match specific application requirements meeting each customers’ unique needs. As the thermocouples can be adapted to meet unique design constraints, so can this feedthrough’s flange. All sizes used are standard and are easily mountable with readily available hardware. No complicated assemblies are required for the most complicated of vacuum setups.
With most vacuum feedthroughs, troubleshooting can be difficult as well when multiple fixed elements are involved. If one element fails, generally the entire vacuum feedthrough is rendered useless. With BCE’s Multi-TC, Flanged Feedthrough, arduous troubleshooting procedures are a thing of the past. In fact, this feedthrough’s thermocouples are replaceable as they can be extracted from the compression fittings with great ease. This means that if thermocouples fail, they can be removed, tested and replaced within minutes. Thus, this no-hassle design allows for faster, more accurate and more cost-effective thermal data collection. Trust BCE’s Multi-TC, Flanged Feedthrough for your most complicated thermal detection needs.
Practice:
Well made, clamped, and temperature stabilized circular O-rings should be used in the design of
reliable, reusable and long life seals in vacuum sealing applications. Benefits:
Leak free flanges as well as low/undetectable outgassing of the elastomeric materials can be achieved at pressure levels as low as 10-8 Torr by using well made O-rings in a static vacuum seal environment. The use of O-rings has provided ease for running environmental tests on the ground using space simulation chambers.
The Air Process heater will provide hot air and gas up to 1000 degree Fahrenheit (540 C) with infinite control by varying the voltage and air velocity supplied. Units are fitted with a tubing "T" for convenient power lead outlet, while larger diameters can be supplied with post terminals on the sheath for direct electrical connections.
Orion Instruments specializes in high-visibility magnetic level indication and high-accuracy magnetostrictive level transmitters. Magnetic level indicators provide high visibility local indication of liquid level in tanks and vessels.
BARTON 7000 Series liquid turbine meters are designed for a broad range of precise liquid measurement applications. Based on more than 40 years of turbine manufacturing experience, this built-to-order series features a range of sizes, materials, bearing systems, and options.
DCS/PLC and SCADA control systems, though they provide immense capability, share a common weakness. Both are subject to cyber attack from external sources. The potential impact of this vulnerability should not be dismissed. An annunciator system can be put in place that will monitor critical process elements and provide notification of abnormalities. The systems, whether hardwired or software based, are isolated, allowing them to act as a failsafe or backup to the main control and monitoring system.
Companies in the process industry need the ability to visually monitor liquid levels in vessels (boilers, storage tanks, processing units, etc.). Traditionally, armored glass sight gauges have been used. However, many companies want an alternative to sight gauges to avoid problems such as breakage, leaks, or bursting at high pressures and extreme temperatures. In addition, the visibility of the sight glass can be poor and often affected by moisture, corrosion, or oxidation.
Magnetic level indicators (MLIs) do not have the shortcomings of glass sight gauges and are suitable for a wide variety of installations.
Designed for semiconductor, MOCVD and other gas flow control applications, the GF100 series exceeds the semiconductor industry standard for reliability, ensuring repeatable, highly stable performance over time. Standard MultiFlo technology enables one MFC to support thousands of gas types and range combinations without removing it from the gas line or compromising on accuracy.
Process Heaters, Furnaces and Fired Heaters: Improving Efficiency and Reducin...Belilove Company-Engineers
A process heater is a direct-fired heat exchanger that uses the hot gases of combustion to raise the temperature of a feed owing through coils of tubes aligned throughout the heater. Depending on the use, these are also called furnaces or red heaters. Some heaters simply deliver the feed at a predetermined temperature to the next stage of the reaction process; others perform reactions on the feed while it travels through the tubes.
Process level measurement has greatly evolved over the years with new technologies. Instrumentation engineers have more demanding requirements that make it essential to have reliable and accurate liquid level measurements. Although based on a more traditional level measurement technology, one of the most trusted devices for continuous liquid level measurement remains the displacer level transmitter
Ammonia is found naturally in water, but when found at higher than natural levels even in very low concentrations) it is toxic to fish and other aquatic organisms. Discharge of ammonia from wastewater treatment plants (WWTPs), large farms, and landfills is an important topic across the United States. Many states adopted new rules addressing total ammonia discharge. Selecting the proper sensor for accurate and repeatable ammonia and nitrate concentration is critical.
The HYDRA Ammonium Sensor is designed to monitor the nutrient load (NH4+) directly in the aeration basin of a Waste Water Treatment Plant. The HYDRA uses ISE technology to measure the ammonium, potassium and pH. Compensation for the pH dependent concentration equilibrium and potassium ion interference on the ammonium electrode are preformed automatically in the HYDRA C22 analyzer.
To identify key areas in the steam generation cycle, condensate recovery system and waste heat recovery process where cost-effective instrumentation solutions offer a tangible return on investment over the short term. The goal is to reduce heat rate, environmental impact, fuel and water consumption, water treatment and maintenance costs in commercial and heavy industries where steam generation is essential to the production processes.
Control Valves for the Power Generation Industry" A Product and Applications ...Belilove Company-Engineers
TrimTeck, a USA manufacturer of industrial control valves, put together this outstanding explanation of where and how control valves are used in a power generation facility.
The reliable identification of low combustion oxygen in a red heater or boiler has always been critical to the effectiveness of the Burner Management System for proper control and safety.
Low emission burners and aggressive ring control points to achieve increased efficiency and emission reductions have driven the industry to tighter control measures. But tighter control measures also hold a greater potential for combustion damage. Reducing the risk of a combustion event has become a priority and has led to the implementation of Safety Instrumented Systems (SIS). This additional layer of safety is added to the Basic Process Control System.
An Intrinsically Safe Barrier is a device which limits the power (energy) which can be delivered from a safe area into a hazardous zone. Explosions are prevented; not just contained in explosion-proof conduit and housings. Not only is electrical energy (voltage and current) held within safe limits, but total energy is also contained, eliminating the possibility of an explosion due to excessive heat. Use of barriers and a total intrinsically safe design philosophy offers considerable advantages from cost and safety standpoints.
THE NEED
Equipment manufacturers and scientific researchers are continually challenged with supplying power, fiber-optic, control, and monitoring cables through sealed vacuum vessels. Whether due to space restrictions, special geometries, or number and type of conductors, standard glass-to-metal or ceramic feedthroughs never quite fit the bill. Unfortunately, because of limited options, many designers are forced to compromise and go for an off-the-shelf solution.
EPOXY TO THE RESCUE.
During the past decade, new epoxy compounds have been developed that rival glass and ceramic in performance. BCE is at the forefront of this development.
With modern epoxy feedthroughs, any kind of standard or custom connector is sealed in a completely potted, high-performance, clear epoxy compound. Epoxy seals offer countless design options, and most amazingly, performance equal to or better than glass or ceramic. Better yet, pricing is very competitive and quick turn-around for prototypes and short production runs are not a problem.
Welcome to WIPAC Monthly the magazine brought to you by the LinkedIn Group Water Industry Process Automation & Control.
In this month's edition, along with this month's industry news to celebrate the 13 years since the group was created we have articles including
A case study of the used of Advanced Process Control at the Wastewater Treatment works at Lleida in Spain
A look back on an article on smart wastewater networks in order to see how the industry has measured up in the interim around the adoption of Digital Transformation in the Water Industry.
CFD Simulation of By-pass Flow in a HRSG module by R&R Consult.pptxR&R Consult
CFD analysis is incredibly effective at solving mysteries and improving the performance of complex systems!
Here's a great example: At a large natural gas-fired power plant, where they use waste heat to generate steam and energy, they were puzzled that their boiler wasn't producing as much steam as expected.
R&R and Tetra Engineering Group Inc. were asked to solve the issue with reduced steam production.
An inspection had shown that a significant amount of hot flue gas was bypassing the boiler tubes, where the heat was supposed to be transferred.
R&R Consult conducted a CFD analysis, which revealed that 6.3% of the flue gas was bypassing the boiler tubes without transferring heat. The analysis also showed that the flue gas was instead being directed along the sides of the boiler and between the modules that were supposed to capture the heat. This was the cause of the reduced performance.
Based on our results, Tetra Engineering installed covering plates to reduce the bypass flow. This improved the boiler's performance and increased electricity production.
It is always satisfying when we can help solve complex challenges like this. Do your systems also need a check-up or optimization? Give us a call!
Work done in cooperation with James Malloy and David Moelling from Tetra Engineering.
More examples of our work https://www.r-r-consult.dk/en/cases-en/
Water scarcity is the lack of fresh water resources to meet the standard water demand. There are two type of water scarcity. One is physical. The other is economic water scarcity.
1. Brooks Instrument Brooks Instrument Brooks Instrument
407 West Vine Street Neonstraat 3, 6718 WX 1-4-4, Kitasuna, Koto-Ku
PO Box 903 PO Box 428, 6710 BK Tokyo, 136-0073
Hatfield, PA 19440, USA Ede, The Netherlands Japan
T: (215) 362-3500 T: +31 (0) 318-549-300 T: 81-3-5633-7124
E: BrooksAM@BrooksInstrument.com E: BrooksEU@BrooksInstrument.com E: BrooksAS@BrooksInstrument.com
www.BrooksInstrument.com
Brooks Instrument
Applying Thin Film Coatings Used in Medical Devices │
Business White Paper
Wesley Sund, New Technology Marketing Manager, Brooks Instrument
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Copyright 2008, Brooks Instrument, LLC Page 2 of 10
Applying Thin Film Coatings Used in Medical Devices
Society has benefited tremendously from the development and utilization of mechanical devices
which are implanted inside the body and are used to replace bones and joints, increase blood
flow, and even measure blood chemistry. To further enhance the performance of these devices,
the application of thin films to the external surfaces is an ongoing research and development
interest at many companies. Engineers have a choice of a variety of technologies to apply these
liquid coatings to these often complex surfaces ranging from vacuum technology to direct liquid
application. The decision on what technology to use is a function of the liquid precursor used, the
mechanism of coating formation and the geometry of the object to be coated. A critical quality
and process control criterion is the consistency of the coating on the surface. Fluid delivery
technology can play an important part in maintaining coating consistency. Pumps and liquid flow
controllers are technologies being used today. For vapor coating processes, liquid vaporization
technology is a critical link in the fluid delivery system. New flow and vaporization technology is
available that can be applied to fluid delivery to improve the application of medical device
coatings.
Why Coating
The human body has defense mechanisms that normally treat foreign objects as a threat. This is
great when the foreign body is a bacteria or a virus, but in relation to medical devices, this
response can affect their performance. Certain metals and plastics have surface properties that
make them somewhat compatible in the body. In many applications, these materials don’t have
the proper physical properties to make them useful for a specific function. Other materials might
be better from a mechanical standpoint, but are more irritating to the body. Coatings are also
used to extend the useful life of the device in the body. Here are just some of the uses of medical
coatings.
• To reduce friction of the medical device in the body to improve the placement of the
device and also minimize irritation and inflammation
• To reduce the formation of scar tissue surrounding implanted devices
• To encourage the growth of tissues to help the healing process
• To reduce the chance of infection related to the implanted device
• To “hide” the device from the body’s self defense mechanism
• To measure body chemistry in real time
The coatings applied to the surface can be as simple as a thin metal coating or as complex as
polymer coating interlaced with precise pores that time-release drugs.
Coating Challenges and Solutions
Applying a coating to a device that is placed in the body is a very critical process. The potential
detrimental affects of the coating must be thoroughly investigated prior to official approval for
market introduction. Here are some of the many challenges facing an engineer when designing
techniques for coating medical device structures.
• Complex substrate geometry
• Even coating over the complete surface
• Consistent thickness and mass of coating across a production lot
• Eliminating bridging across web structures
• Coating adhesion and eliminating post implant particle generation
• Applying high molecular weight active drug molecules
• Creating porous films that allow time release of drugs
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Copyright 2008, Brooks Instrument, LLC Page 3 of 10
To create the coating, an engineer has a choice of a variety of technologies. These include:
• Dipping the object in a liquid and removal to create a thin surface film
• Spray coating to deposit a thin film
• Physical vapor deposition to transfer a solid source to a surface film
• Chemical vapor deposition for a surface reactions to create film
• Freeze condensation of vapor to create a thin film of frozen liquid
• Surface condensation to create a film of liquid
• Surface polymerization to create a film from a monomer vapor
• Ink jet placement of coating via impingement of tiny droplets
In each of these technologies, coating thickness and uniformity are functions of the rate of
delivery of liquid or the vapor concentration at the surface of the part.
Example of a Coated Medical Device - Drug Coated Cardiac Stents
A porous polymer matrix containing time release drugs is now being used to coat bare metal
stents to inhibit restenosis. The implantation of stents using balloon angioplasty is an acceptable
treatment for opening a constricted or partially blocked artery. An intricately laser cut metal stent
is placed in the blockage and expanded to open the artery. The expanded stent keeps the artery
open. However, in approximately 25% of patients, restenosis will occur, which is scar tissue
build-up around the stent that can cause a re-blockage. Drugs have been developed that inhibit
scar tissue cell formation and are fixed in a polymer matrix for time release to the surrounding
tissue. The coating has to be pliable to withstand stretching as the stent is expanded and must
also have high adhesion to the stent’s surface to prevent the coating from breaking off the surface
and into the bloodstream. The final coating surface has to be smooth and continuous over all
areas. Figure 1 illustrates the complex shape of the stent and the polymer drug coating on the
surface of the stent.
Spray Coating Technology
Simple dip coating has not been successfully used for stent coating because polymeric bridges
can be formed between web elements. Spray coating, as illustrated in Figure 2, is a technology
that has been successfully used for depositing a polymer film on stents. Ultrasonic spray nozzles
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Copyright 2008, Brooks Instrument, LLC Page 4 of 10
are used for creating the correct droplet size that when impacting the surface will adhere and dry
at the proper rate to create a smooth finished film. A low flow of gas carries the ultrasonic created
droplets to the surface of the stent in a narrow pattern. The sprayed liquid consists of a
polymer/drug system dissolved in a suitable solvent to a concentration of 0.5 to 2% by weight.
Pump Liquid Delivery Control
Control of spray density to the stent surface is determined by the accuracy and consistency of the
liquid and gas feed rate to the spray nozzle. Spray density will determine the coating thickness
on the surface. A common liquid flow control solution is the use of a syringe pump as illustrated
in Figure 3. A syringe pump is a positive displacement liquid flow control technology that uses a
digital stepper motor to incrementally move a piston in a barrel in small discrete movements. A
control circuit maintains the speed of the piston in the barrel to deliver fluid at a specific rate. The
quantity of liquid dispensed per step is determined by the travel distance per step and the cross
sectional area of the barrel. To increase low flow resolution, the diameter of the barrel can be
decreased. The problem this introduces in production environments is at the end of the piston
stroke, the barrel has to be refilled by withdrawing the piston slowly and pulling liquid from an
external reservoir. A common problem when refilling the barrel is the formation of a gas bubble
as the pressure of the liquid is reduced. The gas bubble has to be removed to keep the liquid
incompressible for good flow control.
The step-like movement of the piston in the barrel will result in pressure fluctuations in liquid flow
to the spray nozzle. These fluctuations result in short term unsteady spray density which can
result in uneven part coating coverage.
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Copyright 2008, Brooks Instrument, LLC Page 5 of 10
Precision Spray Technology
In continuous production environments an alternative liquid delivery control technology is desired.
Precision spray control systems utilize active control devices for liquid and gas flow. The spray
density is directly proportional to the liquid mass flow rate to the spray nozzle as illustrated in
Figure 4. The benefit of such a system is the spray mass delivery rate to the part can be
precisely controlled. Flow can also be started and stopped quickly to minimize the consumption
of expensive materials. The key elements of a precision spray control system can be visualized
as a chain, with reliability dependent on the strength of the weakest link. The key elements of the
supply chain consist of the liquid and gas supply system, the liquid and gas flow controller
technology and the spray nozzle technology. A gas pressurized liquid in a container supplies the
fluid to the system. The size of the container can be sized for a typical lot to improve productivity
of the process.
Gas and Liquid Flow Control
One of the key attributes of a precision spray system is the active control of liquid and gas feed
rates to the spray nozzle. A simple pressure regulator is not sufficient to control the flow of gas to
the spray nozzle. This active control allows the process engineer to precisely set the mass feed
rate of the precursor to the nozzle. The accuracy and precision of the liquid and gas feed
controllers will reduce the part-to-part variability of film deposition rate.
Carrier gas flow control is accomplished using a thermal sensor mass flow controller (MFC) as
illustrated in Figure 5. This device uses the heat capacity of a pure gas to infer the mass flow
rate of gas to the vaporizer. The equation to be solved is a simple one: mass flow = (heat added
to the gas)/((T2-T1) x (heat capacity of the gas)). A laminar flow element is used to create a linear
relationship between pressure drop and flow. The created pressure drop forces a very small
portion of the gas to pass through the sensor tube in proportion to the overall flow. An integrated
control valve, along with digital electronics completes the gas mass flow controller.
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In the last few years a new mass flow technology, based on Coriolis principles, has been utilized
for liquid mass flow control in precision spray systems. Coriolis mass flow measurement
technology has been historically used in many industries where accurate, reliable measurement
of liquid mass is a requirement. Advances in sensor design and electronics processing have
allowed Coriolis sensors to be reduced in size in order to measure the low flows found in medical
device coating.
A Coriolis sensor utilizes a vibrating tube to measure the mass flow of liquid. The momentum of
the moving fluid changes the shape of the vibrating tube. A U shaped tube is a typical sensor
design for these low flow sensors as illustrated in Figure 6. Every Coriolis mass meter has 3 key
components: the sensor tube which is mounted rigidly on a base, position sensors which
measure the inlet and outlet legs of the tube, and a magnetic drive which vibrates the tube. All of
the flow goes through the sensor tube, and so there is no bypass as in the thermal mass flow
device.
In a no-flow condition, the inlet and outlet legs of the tube vibrate in unison and the result is a
differential electrical signal from the two position sensors of zero time. In a flowing condition, the
inlet and outlet legs of the tube vibrate out of phase and the result is a differential electrical signal
from the two sensors with a specific time lag. When the sensor is factory calibrated using an inert
fluid, the amount of time lag created by the moving fluid is directly proportional and linear to the
fluid mass flow. Thus, a Coriolis sensor is a universal mass flow measurement device with
measurement accuracy independent of the physical and thermal properties of the fluid. This
makes Coriolis sensing technology ideally suited for accurate measurement and control of fluids
with unknown properties such as advanced multi-component coating fluids. Coriolis sensors are
also very fast in responding to changes in flow.
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Copyright 2008, Brooks Instrument, LLC Page 7 of 10
The natural resonant frequency of a Coriolis sensor can be used to determine fluid density. A
heavy fluid in the tube will reduce the natural frequency while a light fluid or gas will increase the
natural frequency. Fluid density measurement is very useful to determine when a solvent has
flushed out the coating fluid from the system.
Quality and Production Control Benefits
The benefit of a closed loop control precision liquid coating system is the presence of flow
measurement devices. These devices not only maintain flows to an exact setpoint but also
generate data that can be used by quality control personnel to be able to minimize variability in
the process. Software alarms warn if the fluid flow rates cannot be maintained and allow the
process to be modified before out of spec product is produced.
Liquid Vaporization Coating Technology
In some applications the required coating is so thin or the material must be reacted on the surface
to create a film that spray coating technologies are inadequate. An alternate technology for
coating is to convert the liquid flow to a vapor and then immerse the part in the vapor where a thin
film is formed on the surface. This is illustrated in Figure 7. The mechanisms for vapor film
formation include:
• Surface reactions
• Surface polymerization
• Surface condensation
• Surface freezing
Flash Vaporizer
Conventional vaporizers, also called flash vaporizers as illustrated in Figure 8, rely on direct liquid
contact with a heated metal to transmit the energy required for vaporization. A carrier gas is used
to dilute the vapor, which reduces its dew point and also transports the vapor to the chamber.
Three factors can influence the rate of heat transfer to a liquid during this heating step: the
temperature difference between the liquid and the metal heating surface, the area of the
metal/liquid surface to transfer the heat, and the overall heat transfer coefficient for the system.
This is summarized in the following simple equation: m ∆H = kAdT where k is the heat transfer
coefficient of the system (function of the properties of the liquid, gas and metal, usually is a
constant), A is the area available for heat transfer, dT is the temperature difference between the
liquid and the heating surface, m is the mass flow of precursor and ∆H is the enthalpy of
vaporization
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A flash vaporizer relies on a small surface area to transmit the heat to the liquid. The net result is
the temperature of the metal must be high enough to transfer heat to the liquid in a short time
period. Vaporizers typically operate at pressures near the chamber pressure. A phenomenon
can occur during flash vaporization at the heated surface in contact with the liquid, where vapor is
generated at this interface and, as it expands, can lift the liquid off the surface. The vapor then
acts as an insulator and stops the heat transfer to the liquid which, after cooling, contacts the
surface again.
This is similar to the dancing of a droplet of water on a hot cooking surface. When this happens
in a vaporizer, the vapor production is not at a steady state. Fogging can be a result of this
unsteady behavior at the outlet of the vaporizer. Contact of the liquid with the high temperature
metal can also result in thermal decomposition which can eventually plug the vaporizer and
create particles.
Low Temperature Vaporization
Many liquids that must be vaporized for film formation have very low vapor pressures and are
also sensitive to thermal decomposition. A vaporizer design for thermally sensitive precursors
would create a very large surface area (in the form of droplets as illustrated in Figure 9) to
transmit heat to the liquid. Increasing the effective vaporization surface by a factor of a thousand
results in a greatly reduced differential temperature required to drive heat into the liquid. The
electrical heater should also have a very large area to reduce the heat flux or surface temperature
of the heater. Liquid to metal contact is avoided by using the carrier gas to conduct energy from
the electric heater to the liquid surface.
A phenomenon called wet bulb depression will occur that helps to reduce the liquid temperature
during vaporization. The term “wet bulb temperature” comes from meteorology and is the lowest
temperature that can be obtained when evaporating water into air. Wet bulb depression is the
difference between the water temperature during evaporation and the actual air temperature.
The same terminology can be applied to evaporating high boiling liquids into a dry gas.
The temperature of these liquids in contact with a hot gas will be substantially lower than the gas
temperature. Decomposition reactions occur much faster in a liquid than a vapor. Keeping the
liquid cool during the vaporization step will reduce decomposition and solid formation.
Increasing the surface area also reduces the time required to vaporizer liquid. The calculated
vaporization time for liquids with high surface area is very short.
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The final result of such a design is a gentle vaporization of liquids used to create films in medical
devices. Low temperature vaporizers are now being employed to create films used in the
production of implantable blood chemistry sensors.
Conclusion
The development of new coatings to enhance the performance of medical devices will continue to
be an area of intense research interest. New flow control technologies have been developed that
improve the production process, especially in the area of liquid spray coating technology.
Improved coating uniformity and part-to-part repeatability are benefits of using this technology. If
direct liquid coating cannot be applied, new vaporization technology is available which can
generate controlled vapor flow for precision coating applications.
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About the Author
Wesley Sund, New Technology Marketing Manager, Brooks Instrument
Wesley Sund has a BS in Chemical Engineering. He has over 30 years experience in chemical
processing and process instrumentation. Recently he has been working with the medical device
industry to develop advanced coating solutions for medical devices.