This document discusses antioxidants in dermatology. It defines antioxidants as molecules that mitigate oxidative stress. Reactive oxygen species like superoxide can damage cells and tissues, but antioxidants balance this through several mechanisms. The document outlines major antioxidants like ascorbic acid, alpha-tocopherol, carotenoids, polyphenols, uric acid, glutathione, and superoxide dismutase. It describes their sources, mechanisms of action, limitations, and roles in reducing inflammation and protecting lipids, DNA, and proteins from free radical damage.
This document discusses antioxidants and their role in protecting against free radical damage. It defines antioxidants as substances that inhibit oxidation reactions and describes how free radicals form and damage cells. The document then classifies antioxidants, describes how they work to neutralize free radicals, and lists important antioxidant vitamins and foods containing them. It discusses the role of antioxidants in protecting against various oral diseases and conditions like cancer and periodontal disease.
The document discusses reactive oxygen species (ROS) and antioxidants. ROS such as superoxide, hydrogen peroxide, and hydroxyl radicals are produced through normal cellular processes but can cause tissue damage if levels become too high. Antioxidants help prevent this damage by neutralizing ROS. The document outlines various antioxidants like vitamins C and E, carotenoids, polyphenols, glutathione, and superoxide dismutase. It also describes how ROS can damage proteins, lipids, and DNA and discusses the role of antioxidants and ROS in periodontal disease pathogenesis.
This document discusses antioxidants and provides information on their types, mechanisms of action, origins, and functions. It summarizes that antioxidants delay or prevent oxidation reactions by reacting with free radicals and reactive oxygen species. Antioxidants can be categorized by their mode of action, location, solubility, and whether they are enzymatic or non-enzymatic nutrients and non-nutrients. The document outlines several major groups of antioxidants found in plants and discusses some important individual antioxidant compounds like vitamins C and E, carotenoids, polyphenols, and melatonin. It concludes by describing the biological roles of antioxidants in boosting immunity, preventing diseases, and promoting cardiovascular and eye health.
1. The document discusses antioxidants and their role in the body. It describes how antioxidants mitigate the harmful effects of free radicals and lists some of the major antioxidant enzymes like superoxide dismutase, catalase, and glutathione peroxidase.
2. Antioxidants are classified based on their location in the body or plasma, cell membranes, intracellular spaces. They are also classified based on their nature as enzymatic or non-enzymatic antioxidants which include nutrient and metabolic antioxidants.
3. Important nutrient antioxidants discussed include vitamins C and E, carotenoids like beta-carotene and lycopene, selenium, and alpha-lipoic acid. Metabolic antioxid
This document discusses antioxidants and their role in reducing oxidative stress and free radical damage in the body. It provides information on sources of antioxidants such as fruits and vegetables, and how different cooking methods can affect the antioxidant levels in foods. Some key points include:
- Antioxidants help neutralize free radicals and reduce oxidative stress, which is associated with diseases like cancer and heart disease. Major sources of antioxidants are fruits and vegetables.
- Cooking methods like boiling, baking, and frying can impact the antioxidant levels in foods, with some methods causing greater losses than others. Proper cooking is important to maximize antioxidant retention.
- The document outlines various assays used to measure antioxidant capacity and free radical
Introduction
Oxidation
What are antioxidants?
Antioxidants
Source of Antioxidants
Antioxidants produced by Plants
Major Antioxidant compounds in Plants
Fruits and Vegetables with highest Antioxidant content
Conclusion
This document discusses various endogenous antioxidants and their roles in defending the body against free radical damage. It describes two main types of endogenous antioxidants - enzymatic and non-enzymatic. The key enzymatic antioxidants discussed are superoxide dismutase, catalase, glutathione peroxidase and glutathione. These enzymes work to neutralize reactive oxygen species such as superoxide radicals, hydrogen peroxide and lipid peroxides. Glutathione is a non-enzymatic antioxidant that plays an important role in detoxification and maintenance of redox homeostasis. Endogenous antioxidants form multiple lines of defense against free radical induced oxidative stress and damage.
Antioxidants - protective activity of certain important antioxidantsAYESHA NAZEER
Introduction to free radicals, antioxidants, types of antioxidants, biological importance and protective role of certain important antioxidants in diseases.
This document discusses antioxidants and their role in protecting against free radical damage. It defines antioxidants as substances that inhibit oxidation reactions and describes how free radicals form and damage cells. The document then classifies antioxidants, describes how they work to neutralize free radicals, and lists important antioxidant vitamins and foods containing them. It discusses the role of antioxidants in protecting against various oral diseases and conditions like cancer and periodontal disease.
The document discusses reactive oxygen species (ROS) and antioxidants. ROS such as superoxide, hydrogen peroxide, and hydroxyl radicals are produced through normal cellular processes but can cause tissue damage if levels become too high. Antioxidants help prevent this damage by neutralizing ROS. The document outlines various antioxidants like vitamins C and E, carotenoids, polyphenols, glutathione, and superoxide dismutase. It also describes how ROS can damage proteins, lipids, and DNA and discusses the role of antioxidants and ROS in periodontal disease pathogenesis.
This document discusses antioxidants and provides information on their types, mechanisms of action, origins, and functions. It summarizes that antioxidants delay or prevent oxidation reactions by reacting with free radicals and reactive oxygen species. Antioxidants can be categorized by their mode of action, location, solubility, and whether they are enzymatic or non-enzymatic nutrients and non-nutrients. The document outlines several major groups of antioxidants found in plants and discusses some important individual antioxidant compounds like vitamins C and E, carotenoids, polyphenols, and melatonin. It concludes by describing the biological roles of antioxidants in boosting immunity, preventing diseases, and promoting cardiovascular and eye health.
1. The document discusses antioxidants and their role in the body. It describes how antioxidants mitigate the harmful effects of free radicals and lists some of the major antioxidant enzymes like superoxide dismutase, catalase, and glutathione peroxidase.
2. Antioxidants are classified based on their location in the body or plasma, cell membranes, intracellular spaces. They are also classified based on their nature as enzymatic or non-enzymatic antioxidants which include nutrient and metabolic antioxidants.
3. Important nutrient antioxidants discussed include vitamins C and E, carotenoids like beta-carotene and lycopene, selenium, and alpha-lipoic acid. Metabolic antioxid
This document discusses antioxidants and their role in reducing oxidative stress and free radical damage in the body. It provides information on sources of antioxidants such as fruits and vegetables, and how different cooking methods can affect the antioxidant levels in foods. Some key points include:
- Antioxidants help neutralize free radicals and reduce oxidative stress, which is associated with diseases like cancer and heart disease. Major sources of antioxidants are fruits and vegetables.
- Cooking methods like boiling, baking, and frying can impact the antioxidant levels in foods, with some methods causing greater losses than others. Proper cooking is important to maximize antioxidant retention.
- The document outlines various assays used to measure antioxidant capacity and free radical
Introduction
Oxidation
What are antioxidants?
Antioxidants
Source of Antioxidants
Antioxidants produced by Plants
Major Antioxidant compounds in Plants
Fruits and Vegetables with highest Antioxidant content
Conclusion
This document discusses various endogenous antioxidants and their roles in defending the body against free radical damage. It describes two main types of endogenous antioxidants - enzymatic and non-enzymatic. The key enzymatic antioxidants discussed are superoxide dismutase, catalase, glutathione peroxidase and glutathione. These enzymes work to neutralize reactive oxygen species such as superoxide radicals, hydrogen peroxide and lipid peroxides. Glutathione is a non-enzymatic antioxidant that plays an important role in detoxification and maintenance of redox homeostasis. Endogenous antioxidants form multiple lines of defense against free radical induced oxidative stress and damage.
Antioxidants - protective activity of certain important antioxidantsAYESHA NAZEER
Introduction to free radicals, antioxidants, types of antioxidants, biological importance and protective role of certain important antioxidants in diseases.
This document discusses the role of antioxidants in health and disease. It defines free radicals and describes how they are produced endogenously through metabolism and exogenously through environmental factors. Free radicals can cause oxidative damage but are balanced by the body's antioxidant defense system, which includes antioxidant enzymes like catalase and glutathione peroxidase, chain breaking antioxidants like vitamin E and beta-carotene, and transition metal binding proteins. The document outlines the sources and roles of various reactive oxygen species and antioxidants in the body.
The document discusses antioxidants and their role in human health. It defines antioxidants as molecules that inhibit the oxidation of other molecules and prevent free radical damage. Free radicals are unstable molecules that can damage cells, but antioxidant enzymes work to stabilize free radicals. Many health conditions are linked to oxidative stress caused by free radicals, including aging, cancer, diabetes and neurodegenerative diseases. The body has both endogenous and dietary antioxidant systems to protect against free radical damage through catalytic removal of radicals and protection of macromolecules.
PPT on Protective Activity Of Certain Important Antioxidant Naveen K L
This document categorizes and describes various antioxidants. It discusses how antioxidants are classified based on their mode of action, location, and solubility. The major groups of antioxidants found in plants are enzymes, minerals, low and high molecular weight compounds, vitamins, hormones, and essential oils. Antioxidants play an important biological role in boosting the immune system, preventing neurodegenerative disorders, and promoting cardiovascular health. They can also be used therapeutically for conditions like Alzheimer's, cataracts, diabetes, and skin aging.
1. Free radicals are highly reactive molecules with unpaired electrons that are formed through normal cell metabolism and can damage cells.
2. Antioxidants protect tissues from free radical damage by interacting with and neutralizing free radicals. Common antioxidants include vitamins C and E, carotenoids, glutathione, and various enzymes.
3. Free radical damage has been linked to diseases while diets high in antioxidants from fruits, vegetables, nuts and oils may help prevent disease by reducing oxidative stress in the body.
in this presentation, the light is focused on discussing the Reactive oxygen species, oxidative stress, how it forms, how it affects the body and what are the diseases that correlate with oxidative stress.
nevertheless, how it can be balanced by the antioxidants and what is their role in oxidative stress.
Free radicals are molecules with unpaired electrons that can damage cells. They are generated through normal cell processes but also environmental exposures. Antioxidants protect against free radical damage by neutralizing them. There are two main classes of antioxidants - enzymatic and non-enzymatic. Enzymatic antioxidants include superoxide dismutase and catalase while non-enzymatic antioxidants include vitamins C and E, carotenoids, and polyphenols. These antioxidants help prevent chronic diseases associated with oxidative stress and aging.
Phytochemical community open house dalhousie university truro campusUniversité Laval
Phytochemicals are broad & diverse group of compounds that are produced & accumulated in plants. Phytochemical-rich foods include: fruits & vegetables, some cocoa products, as well as whole grains, beverages such as tea & wine. Phytochemicals can alter metabolic & cellular processes.
The document discusses free radicals and antioxidants. It begins by outlining the topics to be covered, including an introduction to antioxidants, types of antioxidants, and their mechanisms of action. It then explains that free radicals are generated endogenously through metabolic processes or exposure to external factors and can cause oxidative stress if not neutralized by antioxidants. The body has enzymatic and non-enzymatic antioxidant defenses to balance free radicals. When this balance is impaired, free radicals can damage biomolecules and trigger diseases. The document further describes different types of antioxidants, their classification, and mechanisms of scavenging or preventing free radicals.
Natural toxins can be found in foods from three main sources:
1) Naturally occurring in plants and animals, such as cyanogenic glycosides in cassava which can release cyanide, and glucosinolates in cruciferous vegetables which can interfere with iodine uptake.
2) As contaminants, such as mycotoxins from mold growth on crops.
3) Formed during food processing, such as biogenic amines produced by microbial decarboxylation of amino acids in fermented or aged foods.
Chronic ingestion of many natural toxins is generally safe but some can cause acute toxicity, carcinogenicity, or other health issues depending on amount and individual susceptibility
Scavengers, Protective mechanisms and Reduction of free radical production in...AlyaaKaram1
This document discusses the production of free radicals in the body and the protective mechanisms that reduce them. It describes how scavengers remove undesired free radicals generated during mitochondrial reactions. It then outlines the various antioxidant defense systems in the body that act to convert oxidants into weaker molecules or repair damaged biomolecules. These include intracellular antioxidants like superoxide dismutase, catalase, glutathione peroxidase and glutathione, as well as dietary antioxidants such as ascorbic acid, alpha-tocopherol and carotenoids. Finally, it lists common food sources of these antioxidants that help protect the body from oxidative stress and damage.
This document discusses various types of rodenticides, including their classification, mechanisms of action, clinical signs, diagnosis, and treatment. It covers both inorganic rodenticides such as arsenic, phosphorus, and thallium sulfate as well as organic rodenticides like anticoagulants, fluoroacetate derivatives, vitamin D compounds, ANTU, bromethalin, metaldehyde, and strychnine. For each rodenticide, a brief overview of its mechanism of toxicity, associated clinical signs in poisoned animals, and recommended treatment approaches are provided. The document serves as a comprehensive reference for information on different rodenticide chemicals that are commonly used.
This document discusses lipid oxidation and peroxidation. It defines fatty acids and the difference between saturated and unsaturated fatty acids. It also defines oxidation, free radicals, and explains why fatty acids are prone to oxidation. The document outlines the mechanism of peroxidation including initiation, propagation, and termination. It discusses the impact of fatty acid oxidation and the types of oxidation that can occur. Factors that affect fatty acid oxidation both in vitro and in vivo are also summarized along with the harmful effects of lipid peroxidation and ways to prevent it.
Free radicals are unstable molecules with unpaired electrons that can cause oxidative damage. They are produced during normal metabolism but also due to environmental toxins and radiation. Antioxidants help stabilize free radicals and prevent cellular damage. The body has endogenous antioxidants like glutathione, vitamin C and E, and antioxidant enzymes. Exogenous antioxidants from foods and supplements can further support the antioxidant defense system. Oxidative stress occurs when there is an imbalance between free radicals and antioxidants leading to diseases. Maintaining adequate antioxidant levels through diet and lifestyle can help reduce oxidative damage and disease risk.
Defence mechanism of antioxidant in Human BodyImad Khan
This document summarizes the antioxidant defense mechanism in the human body. It discusses what free radicals are and their main sources, as well as the antioxidant defense system that protects the body from free radical damage. The defense system includes antioxidant compounds and enzymes that act at different levels - prevention, interception, and repair - to neutralize free radicals. Some key antioxidant compounds and their roles are also described.
This document discusses antioxidants, which are molecules that inhibit oxidation reactions and protect cells from damage by reactive oxygen species. It describes the main types of antioxidants and free radicals in the body, how antioxidants work to eliminate free radicals, and their importance in preventing disease and aging. Foods contain varying amounts of antioxidants, which must be obtained through diet as the body cannot produce them. Measurement methods are used to determine the antioxidant levels and capacities of foods, juices and other substances.
An antioxidant is a molecule capable of inhibiting the oxidation of other molecules.
Oxidation reactions can form free radicals and these start chain reactions that damage cells .
Antioxidants terminate these chain reactions by removing free radical intermediates and inhibit other oxidation reactions
This document discusses antioxidants and free radicals. It defines free radicals as highly reactive oxygen molecules that can damage cells. Antioxidants prevent this damage by slowing or inhibiting oxidation reactions. The summary describes the main types of antioxidants like vitamins C and E, glutathione, minerals, and enzymes like superoxide dismutase that protect against free radicals. It also summarizes the mechanisms of antioxidant action and their clinical significance in reducing disease risks.
Phytonutrients are biologically active compounds found in plants that provide health benefits beyond basic nutrition. They include carotenoids, polyphenols like flavonoids and phenolic acids, phytoestrogens, organosulfides found in garlic, and isothiocyanates found in cruciferous vegetables. Many phytonutrients have antioxidant and anti-inflammatory properties and may help reduce the risk of chronic diseases. However, their bioavailability can vary depending on factors like food processing and an individual's gut microbiome, and more research is still needed to fully understand their health impacts.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdfrightmanforbloodline
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
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This document discusses the role of antioxidants in health and disease. It defines free radicals and describes how they are produced endogenously through metabolism and exogenously through environmental factors. Free radicals can cause oxidative damage but are balanced by the body's antioxidant defense system, which includes antioxidant enzymes like catalase and glutathione peroxidase, chain breaking antioxidants like vitamin E and beta-carotene, and transition metal binding proteins. The document outlines the sources and roles of various reactive oxygen species and antioxidants in the body.
The document discusses antioxidants and their role in human health. It defines antioxidants as molecules that inhibit the oxidation of other molecules and prevent free radical damage. Free radicals are unstable molecules that can damage cells, but antioxidant enzymes work to stabilize free radicals. Many health conditions are linked to oxidative stress caused by free radicals, including aging, cancer, diabetes and neurodegenerative diseases. The body has both endogenous and dietary antioxidant systems to protect against free radical damage through catalytic removal of radicals and protection of macromolecules.
PPT on Protective Activity Of Certain Important Antioxidant Naveen K L
This document categorizes and describes various antioxidants. It discusses how antioxidants are classified based on their mode of action, location, and solubility. The major groups of antioxidants found in plants are enzymes, minerals, low and high molecular weight compounds, vitamins, hormones, and essential oils. Antioxidants play an important biological role in boosting the immune system, preventing neurodegenerative disorders, and promoting cardiovascular health. They can also be used therapeutically for conditions like Alzheimer's, cataracts, diabetes, and skin aging.
1. Free radicals are highly reactive molecules with unpaired electrons that are formed through normal cell metabolism and can damage cells.
2. Antioxidants protect tissues from free radical damage by interacting with and neutralizing free radicals. Common antioxidants include vitamins C and E, carotenoids, glutathione, and various enzymes.
3. Free radical damage has been linked to diseases while diets high in antioxidants from fruits, vegetables, nuts and oils may help prevent disease by reducing oxidative stress in the body.
in this presentation, the light is focused on discussing the Reactive oxygen species, oxidative stress, how it forms, how it affects the body and what are the diseases that correlate with oxidative stress.
nevertheless, how it can be balanced by the antioxidants and what is their role in oxidative stress.
Free radicals are molecules with unpaired electrons that can damage cells. They are generated through normal cell processes but also environmental exposures. Antioxidants protect against free radical damage by neutralizing them. There are two main classes of antioxidants - enzymatic and non-enzymatic. Enzymatic antioxidants include superoxide dismutase and catalase while non-enzymatic antioxidants include vitamins C and E, carotenoids, and polyphenols. These antioxidants help prevent chronic diseases associated with oxidative stress and aging.
Phytochemical community open house dalhousie university truro campusUniversité Laval
Phytochemicals are broad & diverse group of compounds that are produced & accumulated in plants. Phytochemical-rich foods include: fruits & vegetables, some cocoa products, as well as whole grains, beverages such as tea & wine. Phytochemicals can alter metabolic & cellular processes.
The document discusses free radicals and antioxidants. It begins by outlining the topics to be covered, including an introduction to antioxidants, types of antioxidants, and their mechanisms of action. It then explains that free radicals are generated endogenously through metabolic processes or exposure to external factors and can cause oxidative stress if not neutralized by antioxidants. The body has enzymatic and non-enzymatic antioxidant defenses to balance free radicals. When this balance is impaired, free radicals can damage biomolecules and trigger diseases. The document further describes different types of antioxidants, their classification, and mechanisms of scavenging or preventing free radicals.
Natural toxins can be found in foods from three main sources:
1) Naturally occurring in plants and animals, such as cyanogenic glycosides in cassava which can release cyanide, and glucosinolates in cruciferous vegetables which can interfere with iodine uptake.
2) As contaminants, such as mycotoxins from mold growth on crops.
3) Formed during food processing, such as biogenic amines produced by microbial decarboxylation of amino acids in fermented or aged foods.
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This document discusses the production of free radicals in the body and the protective mechanisms that reduce them. It describes how scavengers remove undesired free radicals generated during mitochondrial reactions. It then outlines the various antioxidant defense systems in the body that act to convert oxidants into weaker molecules or repair damaged biomolecules. These include intracellular antioxidants like superoxide dismutase, catalase, glutathione peroxidase and glutathione, as well as dietary antioxidants such as ascorbic acid, alpha-tocopherol and carotenoids. Finally, it lists common food sources of these antioxidants that help protect the body from oxidative stress and damage.
This document discusses various types of rodenticides, including their classification, mechanisms of action, clinical signs, diagnosis, and treatment. It covers both inorganic rodenticides such as arsenic, phosphorus, and thallium sulfate as well as organic rodenticides like anticoagulants, fluoroacetate derivatives, vitamin D compounds, ANTU, bromethalin, metaldehyde, and strychnine. For each rodenticide, a brief overview of its mechanism of toxicity, associated clinical signs in poisoned animals, and recommended treatment approaches are provided. The document serves as a comprehensive reference for information on different rodenticide chemicals that are commonly used.
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Free radicals are unstable molecules with unpaired electrons that can cause oxidative damage. They are produced during normal metabolism but also due to environmental toxins and radiation. Antioxidants help stabilize free radicals and prevent cellular damage. The body has endogenous antioxidants like glutathione, vitamin C and E, and antioxidant enzymes. Exogenous antioxidants from foods and supplements can further support the antioxidant defense system. Oxidative stress occurs when there is an imbalance between free radicals and antioxidants leading to diseases. Maintaining adequate antioxidant levels through diet and lifestyle can help reduce oxidative damage and disease risk.
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This document discusses antioxidants, which are molecules that inhibit oxidation reactions and protect cells from damage by reactive oxygen species. It describes the main types of antioxidants and free radicals in the body, how antioxidants work to eliminate free radicals, and their importance in preventing disease and aging. Foods contain varying amounts of antioxidants, which must be obtained through diet as the body cannot produce them. Measurement methods are used to determine the antioxidant levels and capacities of foods, juices and other substances.
An antioxidant is a molecule capable of inhibiting the oxidation of other molecules.
Oxidation reactions can form free radicals and these start chain reactions that damage cells .
Antioxidants terminate these chain reactions by removing free radical intermediates and inhibit other oxidation reactions
This document discusses antioxidants and free radicals. It defines free radicals as highly reactive oxygen molecules that can damage cells. Antioxidants prevent this damage by slowing or inhibiting oxidation reactions. The summary describes the main types of antioxidants like vitamins C and E, glutathione, minerals, and enzymes like superoxide dismutase that protect against free radicals. It also summarizes the mechanisms of antioxidant action and their clinical significance in reducing disease risks.
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antioxidants-150430104011-conversion-gate01.pptx
1. MODERATOR- Dr PUNEET BHARGAVA SIR
PRESENTOR-Dr AATISH TAMTA
ANTIOXIDANTS IN DERMATOLOGY
2. Intoduction …..
⦁ Antioxidants:
⦁ Antioxidants are exogenous or endogenous
molecules that mitigate any form of oxidative
/nitrosative stress or its consequences.
3. ⦁ Any species capable of independent existence that
contains one or more unpaired electrons.
⦁ Highly unstable & reactive
⦁ Toxic – react with DNA & cell membrane
4. REACTIVE
OXYGEN
SPECIES
ANTI-
OXIDANTS
R
E
D
O
X
S
T
A
T
E
In health a balance exists between pro oxidant and the antioxidant mechanisms
but in disease this balance is tipped in favour of the former.
ANTI-OXIDANT
STATE
ANTI-INFLAMMATORY
STATE
PRO-INFLAMMATORY
STATE
OXIDATIVE
STRESS
TISSUE
REPAIR
CELL/TISSUE
PROTECTION
INDIRECT TISSUE
DAMAGE
DIRECT TISSUE
DAMAGE
Intoduction …..
9. Nitric oxide
•Nitric oxide synthases.
• Macrophage-derived nitric oxide synthase 2
•When released simultaneously with superoxide it forms the
reactive nitrogen species peroxynitrite anion .
Free radicals…..
10. Peroxynitrite
Responsible for many of the cytotoxic effects:
• lipid peroxidation;
• glutathione depletion by oxidation;
• inhibition of superoxide dismutase activity;
• DNAdamage by nitrosilation, deamination and oxidation;
• high concentrations cause rapid cellular necrosis
• low concentrations cause apoptosis.
Free radicals…..
12. Hydrogen Peroxide
• Aweak ROS
•Hydrogen peroxide - as a second messenger in nuclear factor-
κB activation.
Free radicals…..
13. Where inflammation is present it may:
• increase adhesion molecule expression;
• cell proliferation;
• induce apoptosis;
• modulate platelet aggregation.
Free radicals…..
14. The principal enzymes charged with removal of H2O2 are :
• Catalase - predominantly acts intracellularly,
• Glutathione peroxidase - within mitochondria and extracellularly
• Thioredoxin linked peroxidases
Free radicals…..
15. Hydroxyl Radical
•Most potent species.
•Cellular targets include:
• Lipids - lipid peroxidation
• Carbohydrates - forming carbohydrate radicals or
depolymerizing mucopolysaccharides
• Protein - most potent in oxidizing aliphatic amino acids
- hydroxylation of tyrosine, tryptophan, phenylalanine etc
• DNA -most significant damage.
Free radicals…..
17. Ideal antioxidants:
⦁ No harmful effects
⦁ Effective in low concentration
⦁ Fat soluble
⦁ Readily available
⦁ Not contribute to objectionable flavor ,odor or colour
to the fat.
19. Mechanisms by which antioxidants may offer protection
⦁ prevention of formation of free radicals
⦁ interception of free radicals
⦁ facilitating the repair
⦁ providing a favourable environment
Antioxidants ….
20. Antioxidants can be categorized by several methods:
⦁ Types
• Mode of action
• Location
• Solubility
⦁ Structural dependents
⦁ Origin
29. α-Tocopherol (vitamin E)
•Most important and effective lipid-soluble antioxidant
•Vital to maintaining cell membrane integrity
•Requires other antioxidant species to be re-constituted
(co-enzyme Q10 and ascorbic acid)
•Levels in plasma - significantly compromised in smokers.
SOURCES : Unsaturated fats like sunflower, safflower,
olive, and wheat germ oils, whole-wheat flour
30. Vitamin E possesses anti-inflammatory & antioxidant properties
•Inhibition of protein kinase C and subsequent platelet
aggregation
• Inhibition of nitric oxide production by vascular endothelium
•Inhibition of superoxide production by macrophages and
neutrophils
31. The limitations as an antioxidant are the result of :
• Its limited mobility within cell membranes
•Its lack of water solubility (many ROS are generated in the
aqueous phase).
32. Carotenoids
• lycopene
• α-carotene
• β-carotene
• cryptoxanthine
• retinol (vitaminA1)
• dehydroretinol (vitaminA2)
SOURCES : Deep orange, red, yellow fruits & vegetables
like carrots,pumpkin, sweet potatoes,red grapes ,watermelon,
tomatoes
Carotenoids are tetraterpines with over 600 variants.
33. Lycopene
•2 times as great as carotenes
•Cooked tomatoes are better than raw ones
•Protective against cancer of lung, stomach,& prostate
VitaminAis controversial as an antioxidant
Behavior depends upon the oxygen tension of the immediate
environment.
SOURCES: Tomatoes,apricots,guava,watermelon,papaya
34. •At low partial oxygen pressures found in most tissues
- as an antioxidant
•At higher oxygen tensions
- Pro oxidant behaviour
35. Polyphenols (Flavenoids)
•Absorbed following dietary intake of vegetables, red wine, tea.
•There are over 4,000 known flavenoids
•Most researched - catechin,epigallocatechin gallate, polyphenol,
• radical scavenging
• terminating lipid peroxidation
• iron chelation
36. Uric acid
Major radical scavengers within plasma, urine, and saliva.
• Scavenger of singlet oxygen
• Scavenger of hydroxyl radicals
• Scavenger of hypochlorous acid
• Protection of a1-antitrypsin
• Preventing fenton chemistry by binding of divalent metal ions .
37. Reduced Glutathione
•Anon essential tripeptide
• Reduced form (GSH)- an antioxidant (radical scavenger).
• Regulation of IL-2 dependent T-lymphocyte proliferation.
• Maintains intracellular redox balance - signaling pathways
• Aneurotransmitter
• Preservation and restoration of other antioxidant species
38. •Innate and fundamental defense strategy at exposed epithelial
surfaces.
•Smoking of a single cigarette – significantly reduces salivary &
plasma glutathione
• Protects against the cytotoxic actions of nicotine on fibroblasts.
•Some periodontal pathogens convert it to the cytotoxic H2S
39. Superoxide Dismutase
•It is one of the most potent intracellular enzymatic antioxidants
and it catalyzes the conversion of superoxide anions to dioxygen
and hydrogen peroxide.
•SD 1 – a Cu2+/Zn2+-dependent enzyme found within the cytosol
•SD 2 – the Mn2+-dependent enzyme located within the
mitochondria;
•SD 3 – at low levels extracellularly