ANTI CANCER DRUGS[ANTI-NEOPLASTIC DRUGS] MEDICINAL CHEMISTRY BY P. RAVISANKAR.Dr. Ravi Sankar
what is cancer?, History,Malignent tumor, non-malignent tumor(benign tumor),Largest tumor ever removed, tumour growth kinitics, doubling tume, angiogenesis, causes of cancer, drugs, treatment of cancer, classification of anti-cancer agents, mechanism of actions,alkylating agents,anti metabolites, vinka alkaloids, best ways to reducing cancer.
BY P. RAVISANKAR
VIGNAN PHARMACY COLLEGE
VADLAMUDI
GUNTUR
ANDHRA PRADESH
INDIA.
ANTI CANCER DRUGS[ANTI-NEOPLASTIC DRUGS] MEDICINAL CHEMISTRY BY P. RAVISANKAR.Dr. Ravi Sankar
what is cancer?, History,Malignent tumor, non-malignent tumor(benign tumor),Largest tumor ever removed, tumour growth kinitics, doubling tume, angiogenesis, causes of cancer, drugs, treatment of cancer, classification of anti-cancer agents, mechanism of actions,alkylating agents,anti metabolites, vinka alkaloids, best ways to reducing cancer.
BY P. RAVISANKAR
VIGNAN PHARMACY COLLEGE
VADLAMUDI
GUNTUR
ANDHRA PRADESH
INDIA.
Antitubercular antibiotics
Tuberculosis is caused by either mycobacterium tuberculosis (in Humans) or by mycobacterium bovis (in animals)
Tuberculosis is a disease of respiratory transmission.
A person gets infected when it comes in contact with the environmental contaminated with viable tubercle Bacilli.
This bacilli are expelled by coughing , sneezing , shouting and singing of a patient with active tuberculosis.
Tubercles are formed in the infected organs during the course of the disease , hence the disease is known as tuberculosis.
Main symptoms are :- cough, tachycardia ,respiratory failure, cynosis (Bluish or greyish colour of the skin, nails, lips or around the eyes.)
The agents or antibiotics which are used to treat tuberculosis these are known as the antitubercular antibiotics.
Drugs includes :-
Rifampicin , streptomycin , cycloserine , capreomycin sulfate and Refabutin
Rifampicine
Orally active bactericidal semi synthetic derivative of Rifamycin B.
This antibiotic is produced by the streptomyces Mediterranei.
It is the first line agent.
Mechanism of Action :-
DNA-dependent-RNA polymerase (DDRP) enzyme is required for the synthesis of RNA.
- Rifampicin binds to Beta subunit of enzyme DDRP and make it inactive.
- so it causes inhibition of bacterial RNA synthesis.
hence there is tuberculocidal effect
SAR
Free OH group is required at C-1, C-8, C-21, and C- 23 .
These group must be in one plane.
Opening of ring will destroy the activity of antibiotic.
Rifampicin is active against both Gram Negative and Gram Positive Bacteria.
resistance is developed when mutation occurs in beta subunit of DDRP.
bacterial resistance develop rapidly if rifampicin taken alone, though the combination with Isoniazid or ethambutol are preferable used.
Adverse effects :
Nausea, Vomiting, headache, erythema, nervousness, emotional disturbances , pulmonary edema, increased cardiac output and cardiac arrythmias
Tetracyclines,Biological sources,History,Sturctures,SAR,Mechanism of action,Spectrum of activity,Important structural units and the three acidity constants in the tetracycline molucule,amphoteric nature,epimerisation, chelation with metals,toxicity and uses.
CANCER: A REVIEW: WORLD'S SECOND MOST FEARED DIAGNOSISCharu Pundir
It is a basic review presentation on cancer, world's second most dreadful disease followed by cardiovascular events, involving basic defination, pathophysiology, screening methods, types of tumor, tumor origin, cancer cell lines, treatment, recent advancements made in the field and diagnosis.
Antitubercular antibiotics
Tuberculosis is caused by either mycobacterium tuberculosis (in Humans) or by mycobacterium bovis (in animals)
Tuberculosis is a disease of respiratory transmission.
A person gets infected when it comes in contact with the environmental contaminated with viable tubercle Bacilli.
This bacilli are expelled by coughing , sneezing , shouting and singing of a patient with active tuberculosis.
Tubercles are formed in the infected organs during the course of the disease , hence the disease is known as tuberculosis.
Main symptoms are :- cough, tachycardia ,respiratory failure, cynosis (Bluish or greyish colour of the skin, nails, lips or around the eyes.)
The agents or antibiotics which are used to treat tuberculosis these are known as the antitubercular antibiotics.
Drugs includes :-
Rifampicin , streptomycin , cycloserine , capreomycin sulfate and Refabutin
Rifampicine
Orally active bactericidal semi synthetic derivative of Rifamycin B.
This antibiotic is produced by the streptomyces Mediterranei.
It is the first line agent.
Mechanism of Action :-
DNA-dependent-RNA polymerase (DDRP) enzyme is required for the synthesis of RNA.
- Rifampicin binds to Beta subunit of enzyme DDRP and make it inactive.
- so it causes inhibition of bacterial RNA synthesis.
hence there is tuberculocidal effect
SAR
Free OH group is required at C-1, C-8, C-21, and C- 23 .
These group must be in one plane.
Opening of ring will destroy the activity of antibiotic.
Rifampicin is active against both Gram Negative and Gram Positive Bacteria.
resistance is developed when mutation occurs in beta subunit of DDRP.
bacterial resistance develop rapidly if rifampicin taken alone, though the combination with Isoniazid or ethambutol are preferable used.
Adverse effects :
Nausea, Vomiting, headache, erythema, nervousness, emotional disturbances , pulmonary edema, increased cardiac output and cardiac arrythmias
Tetracyclines,Biological sources,History,Sturctures,SAR,Mechanism of action,Spectrum of activity,Important structural units and the three acidity constants in the tetracycline molucule,amphoteric nature,epimerisation, chelation with metals,toxicity and uses.
CANCER: A REVIEW: WORLD'S SECOND MOST FEARED DIAGNOSISCharu Pundir
It is a basic review presentation on cancer, world's second most dreadful disease followed by cardiovascular events, involving basic defination, pathophysiology, screening methods, types of tumor, tumor origin, cancer cell lines, treatment, recent advancements made in the field and diagnosis.
Oncology - For nursing students - tumors classification, cancer, differences between benign and malignant neoplasm,spread of cancer, pathophysiology with cancer cells, carcinogenesis, etiology, cancer screening, cancer prevention, management of cancer, radiation therapy, chemotherapy, bone marrow transplantation, oncologic emergencies
A tumor marker is a substance found in your blood, urine, or body tissue. The term "tumor markers" may refer to proteins that are made by both healthy
....
Delve into the complex world of tumors with our insightful presentation. From benign growths to malignant masses, we'll navigate through the intricacies of tumor biology, diagnosis, and treatment. Through a comprehensive exploration of key concepts and cutting-edge research, discover how tumors develop, evade the body's defenses, and influence health outcomes. Join us as we decode the language of oncology, examining tumor types, classifications, and the latest advancements in therapeutic interventions. Whether you're a healthcare professional, researcher, or simply curious about the science behind tumors, this presentation promises to enlighten and inspire.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Model Attribute Check Company Auto PropertyCeline George
In Odoo, the multi-company feature allows you to manage multiple companies within a single Odoo database instance. Each company can have its own configurations while still sharing common resources such as products, customers, and suppliers.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
2.
Cancer* is a term used for diseases in which abnormal cells divide without control and are able to
invade other tissues. Cancer cells can spread to other parts of the body through the blood and
lymph systems, this process is called metastasis.
•
Characteristics of Cancer Cells:
Cancer involves the development and reproduction of abnormal cells•
Cancer cells are usually nonfunctional•
Cancer cell growth is not subject to normal body control mechanisms
2
7. WHAT IS CANCER???
• Cancer is a term used for diseases in which
abnormal cells divide without control and
are able to invade other tissues. Cancer cells
can spread to other parts of the body
through the blood and lymph systems.
8.
9. TYPES OF CANCER
• Carcinoma - cancer that begins in the skin or in tissues that line or cover
internal organs. There are a number of subtypes of carcinoma,
including adenocarcinoma basal cell carcinoma, squamous cell carcinoma
and transitional cell carcinoma.
• Sarcoma - cancer that begins in bone, cartilage, fat, muscle, blood vessels,
or other connective or supportive tissue.
• Leukemia - cancer that starts in blood-forming tissue such as the bone
marrow and causes large numbers of abnormal blood cells to be produced
and enter the blood.
• Lymphoma and myeloma - cancers that begin in the cells of the immune
system
10.
11.
12. TYPES OF TUMORS
• Not all tumors are cancerous; tumors can be benign or
malignant.
• Benign tumors aren't cancerous. They can often be
removed, and, in most cases, they do not come back. Cells
in benign tumors do not spread to other parts of the body.
• Malignant tumors are cancerous. Cells in these tumors can
invade nearby tissues and spread to other parts of the
body. The spread of cancer from one part of the body to
another is called metastasis.
13. 10
Cancer Therapeutic Modalities (classical)
1. Surgery
2. Radiation
3. Chemotherapy
1/3 of patients without metastasis
Respond to surgery and radiation.
If diagnosed at early stage,
close to 50% cancer
could be cured.
50% patients will undergo chemotherapy,
to remove micrometastasis. However,
chemotherapy is able to cure only about 10-15%
of all cancer patients.
24. MECHANISM OF ACTION: ALKYLATING AGENT
• Alkylating agents exert their cytotoxic effects via transfer
of their alkyl groups to various cellular constituents.
• Alkylations of DNA within the nucleus probably represent
the major interactions that lead to cell death.
• The major site of alkylation within DNA is the n7 position
of guanine; however, other bases are also alkylated to
lesser degrees, including n1 and n3 of adenine, n3 of
cytosine, and o6 of guanine
25. • These compounds produce highly reactive carbonium ion intermediates
which transfer alkyl groups to cellular macro molecules by forming
covalent bonds.
• Alkylation results in cross linking / abnormal base pairing/scission of
DNA.
27. MOA: ANTI METABOLITES
• Antimetabolites are drugs that are
structurally related to naturally occurring
compounds, such as vitamins, amino acids,
and nucleotides.
• These drugs can compete for binding sites
on enzymes or can themselves become
incorporated into DNA or RNA and thus
interfere with cell growth and
proliferation.
28.
29. • Methotrxate
• Inhibits DNA synthesis by competitively and irreversibly inhibiting
enzyme, dihydrofolate reductase (DHFR) which converts
dihydrofolate to tetrahydrofolate essential for DNA synthesis.