Antigens are large molecules, usually proteins, that induce an immune response when introduced to the body. They are found on pathogens like bacteria, viruses, and fungi. The body produces antibodies that specifically target antigens. Antigens have antigenic determinants that bind to antibodies and immune cells. To be immunogenic, antigens must be foreign to the body, large enough in size, chemically complex, and able to induce an adaptive immune response through B and T cells recognizing distinct epitopes. Genetic factors also influence individual immune responses to different antigens.
This document provides an overview of antigen-antibody interactions and the immune response. It discusses how antigens activate B lymphocytes to produce antibodies, the structure and types of antibodies, and how antibodies function through direct interaction with antigens and activation of the complement system. It also describes clinical applications of immunization and passive immunity. Key topics covered include antigenicity, haptens, superantigens, primary versus secondary immune responses, and tests used to detect antigen-antibody reactions.
This document discusses the immune system and immunology. It covers topics such as innate immunity, acquired immunity, antigens, antibodies, and the structure and function of the immune system. The key components of the immune system are described, including phagocytic cells, lymphocytes, and the lymphoreticular system. Different immune responses like humoral immunity and cell-mediated immunity are also summarized. The roles of antigens, antibodies, and their reactions are defined.
This document summarizes key topics in immunology including:
- Innate and acquired immunity and the cells involved like T cells, B cells, and phagocytes.
- Antigens and antibodies and their specific reaction.
- Structure and function of the immune system including lymphoid organs and cells.
- Immune response mechanisms like phagocytosis, complement system, and antibody production.
- Types of immunity, vaccines, and factors affecting immunity.
What is antigen
What is epitope & paratope?
Classification of antigen
Pro antigen
Superantigens
Antigenicity
Determinants of antigenicity
Test for antigen detection
Antigens are substances that induce a specific immune response and react with the products of that response. They stimulate the immune system to produce antibodies and each antigen has a distinct epitope. Antigens can be proteins, lipids, carbohydrates or nucleic acids and are generally found on bacteria, viruses, fungi or in allergens. They cause diseases or allergic reactions. Epitopes are the immunologically active regions of antigens that antibodies or lymphocytes bind to. Antigens can be exogenous (external), endogenous (internal) or autoantigens involved in autoimmune diseases.
The document defines key immunological concepts such as antigen, immunogen, epitope, hapten, and different types of antigens. It describes the properties of immunogenicity and antigenicity. Antigens can induce immune responses and bind to antibodies/T-cell receptors. The size, structure, and foreignness of an antigen influence its immunogenicity. Antigens are classified as self, non-self, and superantigens based on their relationship to the host and ability to activate immune responses. Adjuvants can enhance antigen immunogenicity.
This document defines and discusses antigens from several perspectives:
1) It provides a brief history of the term "antigen" and its definition as a substance that stimulates antibody production.
2) It classifies antigens based on their immunogenicity as complete or incomplete antigens.
3) It categorizes antigens based on their origin as exogenous, endogenous, autoantigens, isoantigens, or heterophile antigens.
4) It lists 10 properties that determine an antigen's ability to stimulate an immune response, including foreignness, size, chemical nature, and specificity.
5) It briefly discusses superantigens and common tests used to detect antigens.
This document discusses antigens and their properties. It defines an antigen as a substance that generates an immune response through antibodies or T cells. Antigens have epitopes that bind to immune cells. Examples of antigens include autoantigens from one's own body, alloantigens from the same species, and heterophile antigens found across species. The document also examines the chemical nature of antigens as mostly proteins and polysaccharides, and properties such as size, degradability, and dose that influence antigenicity. Superantigens are described as antigens that can polyclonally activate a large fraction of T cells. Finally, some common tests for detecting antigens are listed.
This document provides an overview of antigen-antibody interactions and the immune response. It discusses how antigens activate B lymphocytes to produce antibodies, the structure and types of antibodies, and how antibodies function through direct interaction with antigens and activation of the complement system. It also describes clinical applications of immunization and passive immunity. Key topics covered include antigenicity, haptens, superantigens, primary versus secondary immune responses, and tests used to detect antigen-antibody reactions.
This document discusses the immune system and immunology. It covers topics such as innate immunity, acquired immunity, antigens, antibodies, and the structure and function of the immune system. The key components of the immune system are described, including phagocytic cells, lymphocytes, and the lymphoreticular system. Different immune responses like humoral immunity and cell-mediated immunity are also summarized. The roles of antigens, antibodies, and their reactions are defined.
This document summarizes key topics in immunology including:
- Innate and acquired immunity and the cells involved like T cells, B cells, and phagocytes.
- Antigens and antibodies and their specific reaction.
- Structure and function of the immune system including lymphoid organs and cells.
- Immune response mechanisms like phagocytosis, complement system, and antibody production.
- Types of immunity, vaccines, and factors affecting immunity.
What is antigen
What is epitope & paratope?
Classification of antigen
Pro antigen
Superantigens
Antigenicity
Determinants of antigenicity
Test for antigen detection
Antigens are substances that induce a specific immune response and react with the products of that response. They stimulate the immune system to produce antibodies and each antigen has a distinct epitope. Antigens can be proteins, lipids, carbohydrates or nucleic acids and are generally found on bacteria, viruses, fungi or in allergens. They cause diseases or allergic reactions. Epitopes are the immunologically active regions of antigens that antibodies or lymphocytes bind to. Antigens can be exogenous (external), endogenous (internal) or autoantigens involved in autoimmune diseases.
The document defines key immunological concepts such as antigen, immunogen, epitope, hapten, and different types of antigens. It describes the properties of immunogenicity and antigenicity. Antigens can induce immune responses and bind to antibodies/T-cell receptors. The size, structure, and foreignness of an antigen influence its immunogenicity. Antigens are classified as self, non-self, and superantigens based on their relationship to the host and ability to activate immune responses. Adjuvants can enhance antigen immunogenicity.
This document defines and discusses antigens from several perspectives:
1) It provides a brief history of the term "antigen" and its definition as a substance that stimulates antibody production.
2) It classifies antigens based on their immunogenicity as complete or incomplete antigens.
3) It categorizes antigens based on their origin as exogenous, endogenous, autoantigens, isoantigens, or heterophile antigens.
4) It lists 10 properties that determine an antigen's ability to stimulate an immune response, including foreignness, size, chemical nature, and specificity.
5) It briefly discusses superantigens and common tests used to detect antigens.
This document discusses antigens and their properties. It defines an antigen as a substance that generates an immune response through antibodies or T cells. Antigens have epitopes that bind to immune cells. Examples of antigens include autoantigens from one's own body, alloantigens from the same species, and heterophile antigens found across species. The document also examines the chemical nature of antigens as mostly proteins and polysaccharides, and properties such as size, degradability, and dose that influence antigenicity. Superantigens are described as antigens that can polyclonally activate a large fraction of T cells. Finally, some common tests for detecting antigens are listed.
This document discusses plant virus serology and the history of serological techniques. It provides background on the principles of antigen-antibody reactions, including how antibodies are produced in response to antigens. Different types of antigens and antibodies are described. The interactions between antigens and antibodies are explored, such as the binding forces involved and concepts of affinity. A variety of serological techniques developed over time are also summarized.
This document discusses antigens and epitopes. It defines antigens as substances that induce an immune response and react with immune system products. Antigens include molecules like proteins, polysaccharides, and lipids. Epitopes are specific regions of antigens that interact with antibodies. A single antigen can have multiple epitopes that each bind to a different antibody. Factors that determine antigenicity include size, chemical nature, complexity, structural stability, foreignness, and an individual's genetic makeup.
The document discusses antigenicity and immunogenicity. It defines antigens as substances that bind to antibodies or immune cell receptors, while immunogens are antigens capable of inducing an immune response. All immunogens are antigens, but not all antigens are immunogenic. The document outlines key characteristics that determine a substance's immunogenicity, including its foreignness, chemical composition, complexity, size, and dose. It also discusses factors like the host's genetic makeup and route of entry that influence the immune response. Overall, the document provides an overview of the differences between antigens and immunogens, and the features that determine a substance's ability to induce immunity.
An antigen is a substance that triggers the immune system to produce antibodies. Antigens react with both T cells and antibodies. They have multiple epitopes that antibodies can bind to. For a substance to be immunogenic, it must be foreign, macromolecular, chemically complex, and stable. The dosage, route of administration, and use of adjuvants can impact a substance's immunogenicity. Antigens are recognized by B cells and T cells through their epitopes, which antibodies and T cells bind to through their paratopes. Antigens can be complete or incomplete, self or foreign, and T cell dependent or independent.
The document discusses the nature of antigens and the major histocompatibility complex (MHC). It defines immunogens and antigens, noting that immunogens can trigger an immune response while not all antigens are immunogens. Antigens are usually large proteins or polysaccharides from foreign organisms. Factors like age, health, dose, and route of exposure can influence the immune response. The document also discusses epitopes, haptens, adjuvants, and the relationship of antigens to the host (autoantigens, alloantigens, heteroantigens). It provides details on MHC genes, class I and class II MHC structure and function in antigen processing and presentation to T cells.
1) An antigen is a substance that stimulates the production of antibodies when introduced into the body.
2) Antigens can be classified as complete or incomplete based on their ability to induce antibody formation, and as exogenous, endogenous, autoantigens, or isoantigens based on their origin.
3) Key properties of antigens include foreignness, size, chemical nature, susceptibility to enzymes, antigenic specificity, species specificity, and the ability to cause heterogenic or organ-specific immune responses. Superantigens can polyclonally activate a large fraction of T cells.
This document defines and describes antigens and what makes an effective antigen. It notes that an antigen is any substance that induces an immune response and antibodies specifically bind to antigens. The best antigens are large, complex proteins that are foreign to the host. Characteristics like size, stability, complexity and foreignness influence a substance's ability to act as an antigen. Bacterial proteins, viral capsids and parasitic molecules can all serve as antigens. The document also discusses epitopes, haptens, adjuvants and cross-reactivity in antigen-antibody binding.
1. An immunogen is an agent capable of inducing an immune response, while an antigen is any agent capable of binding to components of the immune system. All immunogens are antigens, but not all antigens are immunogens.
2. Haptens are low molecular weight compounds that are incapable of inducing an immune response alone but can do so when conjugated to a carrier molecule like a protein.
3. For a substance to be immunogenic, it must be foreign, have a high molecular weight and chemical complexity, be degradable, and interact with MHC molecules.
Antigens are the substances which induce specific immune reactions in the body.
Antigens include molecules such as proteins, nucleoproteins, polysaccharides, lipoprotein and some glycolipids.
The ability of a molecule to function as an antigen depends on its size, structural complexity, chemical nature, and degree of foreignness to the host.
Types of antigens
Antigens are of two types:
1. Autoantigens or self antigens present on the body’s own cells such as ‘A’ antigen and ‘B’ antigen in RBCs.
2. Foreign antigen s or non-self antigens that enter the body from outside.
Following are non-self antigens:
1. Receptors on the cell membrane of microbial organisms such as bacteria, viruses and fungi.
2. Toxins from microbial organisms.
3. Materials from transplanted organs or incompatible blood cells.
4. Allergens or allergic substances like pollen grains.
The document summarizes antigen-antibody reactions. It discusses how antigens and antibodies specifically interact through molecular shapes called epitopes. The interaction forms a complex that triggers an immune response. There are different types of antigen-antibody reactions like precipitation, agglutination, and ELISA. The reaction occurs in two stages - an initial reversible interaction followed by a slower irreversible binding with visible effects. Antigen-antibody reactions have important applications like blood typing for transfusion and detecting substances through immunoassays.
Natural killer (NK) cells are a type of lymphocyte that plays a major role in the innate immune system by killing tumor cells and virally infected cells. NK cells are cytotoxic and contain granules with proteins like perforin and granzymes that can induce apoptosis in target cells. Patients deficient in NK cells are highly susceptible to herpes virus infections. NK cells recognize and kill tumor or infected cells but can also communicate signals to block destruction of tumors or viruses depending on the signals they receive. They are activated through killer activating receptors. [END SUMMARY]
This document discusses immunity and antigen-antibody reactions. It begins with definitions of immunity, antigens, and antibodies. It describes the components of the immune system including antigen specificity and types of antigens. It then explains antigen-antibody reactions and how they are used for diagnostic tests. Different diagnostic tests are also summarized, including precipitation reactions, agglutination, immunofluorescence, radioimmunoassay, and ELISA. Potential sources of markers for periodontal disease activity are also listed.
The document discusses various properties of antigens that determine their antigenicity including molecular size, foreignness, chemical complexity, stability, and more. It also describes different types of antigenic determinants recognized by B cells and T cells as well as factors like dosage, route of administration, and adjuvants that influence immunogenicity. Finally, it covers antigen specificity and different types of antigens such as haptens, superantigens, and isoantigens.
Antigen ,Antibody and Ag-Ab reactions ppt by DR.C.P.PRINCEDR.PRINCE C P
An immunogen refers to a molecule that is capable of eliciting an immune response, whereas an antigen refers to a molecule that is capable of binding to the product of that immune response (Ab).
So, an immunogen is necessarily an antigen, but an antigen may not necessarily be an immunogen
The terms immunogen and antigen are often used interchangeably but the later is more common.
Antibodies are Globulin Protein (Immunoglobulin) that are synthesized in the Serum and Tissue fluids.
It reacts specifically with the antigen that stimulated their production.
There are two types serum proteins: albumin and globulin
There are Three types of globulins .
1. Alpha globulin
2. Beta globulin
3. Gamma globulin (Antibodies)
Gamma globulins are responsible for immunity. So they are called as Immunoglobulin (Ig)
The binding of an antibody with an antigen of the type that stimulated the formation of antibody that results in the following reaction
Agglutination
Precipitation
Complement fixation
Phagocytosis
Neutralization of an exotoxin
Opsonization
Tissue fixation
Chemotaxis
Activation of mast cells and basophils
PPT prepared by:
DR.PRINCE C P
Associate Professor , Department of Microbiology,
Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution)
This document provides an overview of immunology and the immune system. It discusses key topics such as:
- Innate and acquired immunity, including active and passive immunity. Innate immunity provides non-specific protection while acquired immunity is adaptive and provides long-lasting protection.
- Antigens and antibodies. Antigens stimulate antibody production while antibodies provide specific responses to antigens. Antigen-antibody reactions include precipitation and agglutination.
- The complement system, which enhances antigen-antibody reactions and mediates immune responses.
- Structure and function of the immune system, including humoral responses involving B cells and antibodies, and cellular responses involving T cells.
- Hypersensitivity reactions
Antigen is a substance that induces an immune response through the formation of antibodies or activation of T cells. Antigens can be proteins, polysaccharides, nucleic acids, or lipids. Immunogens are antigens that are capable of inducing an immune response on their own due to their large size, while haptens require a carrier molecule. Antigenicity refers to the ability to bind antibodies, while immunogenicity is the ability to induce an immune response. Factors like molecular size, chemical composition, dose, and route of administration can influence a substance's immunogenicity. Adjuvants are substances that enhance the immune response to an immunogen when used together.
Presentation for immunology and microbiologyriazsohail448
Antigens are substances that can induce an immune response. They are typically found on pathogens but can also be produced by the body's own cells. Antigens vary in their source (exogenous or endogenous), molecular structure (proteins, polysaccharides etc.), and ability to elicit immune responses. The immune system recognizes specific regions of antigens called epitopes. Antigens are important for vaccine development and play a role in diseases, transplants, and immunotherapy.
The document discusses various aspects of acquired immunity and antigens. It describes how the adaptive immune system recognizes and remembers specific pathogens to generate immunity. Antigens are foreign substances that induce an immune response. Effective antigens tend to be proteins and polysaccharides, while lipids and DNA are rarely antigenic. Antibodies are Y-shaped proteins that recognize antigens. There are five major antibody classes (IgM, IgA, IgG, IgE, IgD) that have different structures and functions. Antigen-antibody binding can lead to agglutination, opsonization, neutralization, or complement activation. Upon secondary exposure, antibodies switch classes from IgM to IgG. T cells help and regulate the immune response. Cytok
Antigens can be proteins, polysaccharides, nucleic acids, or lipids that elicit an immune response. Antigens are recognized by B cell receptors or T cell receptors when complexed with MHC. Antigenicity refers to the ability of an antigen to bind antibodies, while immunogenicity is the ability to induce an immune response. Antibodies are Y-shaped glycoprotein molecules composed of light and heavy chains that bind to antigens with high specificity and affinity. There are five classes of antibodies (IgG, IgM, IgA, IgD, IgE) that have different structures and functions in the immune response.
This document discusses plant virus serology and the history of serological techniques. It provides background on the principles of antigen-antibody reactions, including how antibodies are produced in response to antigens. Different types of antigens and antibodies are described. The interactions between antigens and antibodies are explored, such as the binding forces involved and concepts of affinity. A variety of serological techniques developed over time are also summarized.
This document discusses antigens and epitopes. It defines antigens as substances that induce an immune response and react with immune system products. Antigens include molecules like proteins, polysaccharides, and lipids. Epitopes are specific regions of antigens that interact with antibodies. A single antigen can have multiple epitopes that each bind to a different antibody. Factors that determine antigenicity include size, chemical nature, complexity, structural stability, foreignness, and an individual's genetic makeup.
The document discusses antigenicity and immunogenicity. It defines antigens as substances that bind to antibodies or immune cell receptors, while immunogens are antigens capable of inducing an immune response. All immunogens are antigens, but not all antigens are immunogenic. The document outlines key characteristics that determine a substance's immunogenicity, including its foreignness, chemical composition, complexity, size, and dose. It also discusses factors like the host's genetic makeup and route of entry that influence the immune response. Overall, the document provides an overview of the differences between antigens and immunogens, and the features that determine a substance's ability to induce immunity.
An antigen is a substance that triggers the immune system to produce antibodies. Antigens react with both T cells and antibodies. They have multiple epitopes that antibodies can bind to. For a substance to be immunogenic, it must be foreign, macromolecular, chemically complex, and stable. The dosage, route of administration, and use of adjuvants can impact a substance's immunogenicity. Antigens are recognized by B cells and T cells through their epitopes, which antibodies and T cells bind to through their paratopes. Antigens can be complete or incomplete, self or foreign, and T cell dependent or independent.
The document discusses the nature of antigens and the major histocompatibility complex (MHC). It defines immunogens and antigens, noting that immunogens can trigger an immune response while not all antigens are immunogens. Antigens are usually large proteins or polysaccharides from foreign organisms. Factors like age, health, dose, and route of exposure can influence the immune response. The document also discusses epitopes, haptens, adjuvants, and the relationship of antigens to the host (autoantigens, alloantigens, heteroantigens). It provides details on MHC genes, class I and class II MHC structure and function in antigen processing and presentation to T cells.
1) An antigen is a substance that stimulates the production of antibodies when introduced into the body.
2) Antigens can be classified as complete or incomplete based on their ability to induce antibody formation, and as exogenous, endogenous, autoantigens, or isoantigens based on their origin.
3) Key properties of antigens include foreignness, size, chemical nature, susceptibility to enzymes, antigenic specificity, species specificity, and the ability to cause heterogenic or organ-specific immune responses. Superantigens can polyclonally activate a large fraction of T cells.
This document defines and describes antigens and what makes an effective antigen. It notes that an antigen is any substance that induces an immune response and antibodies specifically bind to antigens. The best antigens are large, complex proteins that are foreign to the host. Characteristics like size, stability, complexity and foreignness influence a substance's ability to act as an antigen. Bacterial proteins, viral capsids and parasitic molecules can all serve as antigens. The document also discusses epitopes, haptens, adjuvants and cross-reactivity in antigen-antibody binding.
1. An immunogen is an agent capable of inducing an immune response, while an antigen is any agent capable of binding to components of the immune system. All immunogens are antigens, but not all antigens are immunogens.
2. Haptens are low molecular weight compounds that are incapable of inducing an immune response alone but can do so when conjugated to a carrier molecule like a protein.
3. For a substance to be immunogenic, it must be foreign, have a high molecular weight and chemical complexity, be degradable, and interact with MHC molecules.
Antigens are the substances which induce specific immune reactions in the body.
Antigens include molecules such as proteins, nucleoproteins, polysaccharides, lipoprotein and some glycolipids.
The ability of a molecule to function as an antigen depends on its size, structural complexity, chemical nature, and degree of foreignness to the host.
Types of antigens
Antigens are of two types:
1. Autoantigens or self antigens present on the body’s own cells such as ‘A’ antigen and ‘B’ antigen in RBCs.
2. Foreign antigen s or non-self antigens that enter the body from outside.
Following are non-self antigens:
1. Receptors on the cell membrane of microbial organisms such as bacteria, viruses and fungi.
2. Toxins from microbial organisms.
3. Materials from transplanted organs or incompatible blood cells.
4. Allergens or allergic substances like pollen grains.
The document summarizes antigen-antibody reactions. It discusses how antigens and antibodies specifically interact through molecular shapes called epitopes. The interaction forms a complex that triggers an immune response. There are different types of antigen-antibody reactions like precipitation, agglutination, and ELISA. The reaction occurs in two stages - an initial reversible interaction followed by a slower irreversible binding with visible effects. Antigen-antibody reactions have important applications like blood typing for transfusion and detecting substances through immunoassays.
Natural killer (NK) cells are a type of lymphocyte that plays a major role in the innate immune system by killing tumor cells and virally infected cells. NK cells are cytotoxic and contain granules with proteins like perforin and granzymes that can induce apoptosis in target cells. Patients deficient in NK cells are highly susceptible to herpes virus infections. NK cells recognize and kill tumor or infected cells but can also communicate signals to block destruction of tumors or viruses depending on the signals they receive. They are activated through killer activating receptors. [END SUMMARY]
This document discusses immunity and antigen-antibody reactions. It begins with definitions of immunity, antigens, and antibodies. It describes the components of the immune system including antigen specificity and types of antigens. It then explains antigen-antibody reactions and how they are used for diagnostic tests. Different diagnostic tests are also summarized, including precipitation reactions, agglutination, immunofluorescence, radioimmunoassay, and ELISA. Potential sources of markers for periodontal disease activity are also listed.
The document discusses various properties of antigens that determine their antigenicity including molecular size, foreignness, chemical complexity, stability, and more. It also describes different types of antigenic determinants recognized by B cells and T cells as well as factors like dosage, route of administration, and adjuvants that influence immunogenicity. Finally, it covers antigen specificity and different types of antigens such as haptens, superantigens, and isoantigens.
Antigen ,Antibody and Ag-Ab reactions ppt by DR.C.P.PRINCEDR.PRINCE C P
An immunogen refers to a molecule that is capable of eliciting an immune response, whereas an antigen refers to a molecule that is capable of binding to the product of that immune response (Ab).
So, an immunogen is necessarily an antigen, but an antigen may not necessarily be an immunogen
The terms immunogen and antigen are often used interchangeably but the later is more common.
Antibodies are Globulin Protein (Immunoglobulin) that are synthesized in the Serum and Tissue fluids.
It reacts specifically with the antigen that stimulated their production.
There are two types serum proteins: albumin and globulin
There are Three types of globulins .
1. Alpha globulin
2. Beta globulin
3. Gamma globulin (Antibodies)
Gamma globulins are responsible for immunity. So they are called as Immunoglobulin (Ig)
The binding of an antibody with an antigen of the type that stimulated the formation of antibody that results in the following reaction
Agglutination
Precipitation
Complement fixation
Phagocytosis
Neutralization of an exotoxin
Opsonization
Tissue fixation
Chemotaxis
Activation of mast cells and basophils
PPT prepared by:
DR.PRINCE C P
Associate Professor , Department of Microbiology,
Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution)
This document provides an overview of immunology and the immune system. It discusses key topics such as:
- Innate and acquired immunity, including active and passive immunity. Innate immunity provides non-specific protection while acquired immunity is adaptive and provides long-lasting protection.
- Antigens and antibodies. Antigens stimulate antibody production while antibodies provide specific responses to antigens. Antigen-antibody reactions include precipitation and agglutination.
- The complement system, which enhances antigen-antibody reactions and mediates immune responses.
- Structure and function of the immune system, including humoral responses involving B cells and antibodies, and cellular responses involving T cells.
- Hypersensitivity reactions
Antigen is a substance that induces an immune response through the formation of antibodies or activation of T cells. Antigens can be proteins, polysaccharides, nucleic acids, or lipids. Immunogens are antigens that are capable of inducing an immune response on their own due to their large size, while haptens require a carrier molecule. Antigenicity refers to the ability to bind antibodies, while immunogenicity is the ability to induce an immune response. Factors like molecular size, chemical composition, dose, and route of administration can influence a substance's immunogenicity. Adjuvants are substances that enhance the immune response to an immunogen when used together.
Presentation for immunology and microbiologyriazsohail448
Antigens are substances that can induce an immune response. They are typically found on pathogens but can also be produced by the body's own cells. Antigens vary in their source (exogenous or endogenous), molecular structure (proteins, polysaccharides etc.), and ability to elicit immune responses. The immune system recognizes specific regions of antigens called epitopes. Antigens are important for vaccine development and play a role in diseases, transplants, and immunotherapy.
The document discusses various aspects of acquired immunity and antigens. It describes how the adaptive immune system recognizes and remembers specific pathogens to generate immunity. Antigens are foreign substances that induce an immune response. Effective antigens tend to be proteins and polysaccharides, while lipids and DNA are rarely antigenic. Antibodies are Y-shaped proteins that recognize antigens. There are five major antibody classes (IgM, IgA, IgG, IgE, IgD) that have different structures and functions. Antigen-antibody binding can lead to agglutination, opsonization, neutralization, or complement activation. Upon secondary exposure, antibodies switch classes from IgM to IgG. T cells help and regulate the immune response. Cytok
Antigens can be proteins, polysaccharides, nucleic acids, or lipids that elicit an immune response. Antigens are recognized by B cell receptors or T cell receptors when complexed with MHC. Antigenicity refers to the ability of an antigen to bind antibodies, while immunogenicity is the ability to induce an immune response. Antibodies are Y-shaped glycoprotein molecules composed of light and heavy chains that bind to antigens with high specificity and affinity. There are five classes of antibodies (IgG, IgM, IgA, IgD, IgE) that have different structures and functions in the immune response.
Anemia BHAARATH medical college and hospital.pptxAkashVigneshwar
Anemia is a major health problem in India that affects many women and children. It occurs when there is a low level of red blood cells or hemoglobin in the blood. There are many types of anemia that can be caused by iron deficiency, vitamin deficiency, blood loss, or genetic disorders. Common symptoms include fatigue, weakness, pale skin, and shortness of breath. Treatment depends on the underlying cause but may involve dietary changes, iron supplements, blood transfusions, or medications. Prevention focuses on consuming an iron-rich diet along with foods containing vitamin C, folate, and B12 to help the body absorb iron.
The document summarizes different classes of diuretic drugs, including their mechanisms of action, pharmacokinetics, uses, and side effects. It discusses loop diuretics like furosemide that act in the loop of Henle, thiazide diuretics like hydrochlorothiazide that act in the distal tubule, potassium-sparing diuretics like spironolactone that antagonize aldosterone, and osmotic diuretics like mannitol that cause water diuresis through osmosis. Loop and thiazide diuretics can cause hypokalemia and metabolic alterations while potassium-sparing diuretics risk hyperkalemia if not carefully monitored. Di
This document provides information on Neisseria meningitidis, including its taxonomy, morphology, culture characteristics, virulence factors, diseases caused, and laboratory diagnosis. It describes N. meningitidis as a gram-negative diplococcus that can cause meningitis and sepsis. Key information includes that there are 13 serogroups classified by capsular polysaccharides, and serogroups A, B, and C are most associated with disease. Diagnosis involves culturing the organism from cerebrospinal fluid or other samples and identifying it based on morphological and biochemical characteristics.
Alkylating agents and platinum analogs are chemotherapy drugs that treat cancer by alkylating DNA and inhibiting DNA synthesis. Alkylating agents like cyclophosphamide are commonly used to treat cancers such as lymphoma, leukemia, and myeloma. Cyclophosphamide is administered orally or intravenously and has immunosuppressant effects. It can cause cystitis which can be prevented with medications. Platinum analogs like cisplatin and carboplatin are less toxic alternatives to alkylating agents that are used to treat solid tumors but can still cause side effects like nausea, hearing loss, and kidney toxicity. Carboplatin has advantages over cisplatin such as less kidney toxicity and vomiting.
Methotrexate is a folate antagonist antimetabolite drug. It works by inhibiting dihydrofolate reductase and preventing the formation of tetrahydrofolate, which is essential for DNA, RNA, and protein synthesis. This inhibition of folate metabolism results in the suppression of these macromolecule syntheses, especially in rapidly dividing cells like cancer and immune cells. Methotrexate is well absorbed orally or can be given parenterally. It is metabolized in the liver to polyglutamates that remain in cells and inhibit dihydrofolate reductase. Common side effects include bone marrow suppression, nausea, and dermatitis. It is used to treat cancers like chorioc
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...rightmanforbloodline
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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2. INTRODUCTION
Antigens are large molecules of proteins
Present on the surface of the pathogen- such as bacteria, fungi viruses, and
other foreign particles.
When these harmful agents enter the body, it induces an immune response
in the body for the production of antibodies.
For example: When a common cold virus enters the body, it causes the
body to produce antibodies to prevent from getting sick.
3. Specificity will be regulated due to recognition of antigenic
determinants or epitopes on the surface of the Antigen
Epitopes = immunologically active regions that bind to:
Ag-specific membrane receptors on lymphocytes
Already secreted antibodies
Many epitopes can be found on single molecule
INTRODUCTION
4. PROPERTIES OF ANTIGENS
The antigen should be a foreign substance to induce an immune response.
The antigens have a molecular mass of more than 5000 Da.
They are mainly proteins and polysaccharides.
The more chemically complex they are, the more immunogenic they will be.
Antigens are species-specific.
The age influences the immunogenicity.
Very young and very old people exhibit very low immunogenicity.
5. TYPES OF ANTIGENS
BASED ON ORIGIN
Exogenous Antigens
Endogenous Antigens
Autoantigens
Tumour Antigens
6. EXOGENOUS ANTIGENS
Exogenous antigens are the external antigens that enter the body from
outside.E.g. inhalation, injection, etc.
This include food allergen, pollen, aerosols, etc. and are the most
common type of antigens.
ENDOGENOUS ANTIGENS
Endogenous antigens are generated inside the body due to viral or bacterial
infections
7. AUTO ANTIGENS
Autoantigens are the ‘self’ proteins or nucleic acids that due to some genetic or
environmental alterations get attacked by their own immune system causing
autoimmune diseases.
TUMOUR ANTIGENS
It is an antigenic substance present on the surface of tumour cells that induces
an immune response in the host.
Many tumors develop a mechanism to evade the immune system of the body.
Native Antigens
An antigen that is not yet processed by an antigen-presenting cell is known as
native antigens.
8. ATTRIBUTES OF ANTIGENECITY
INDUCTION OF IMMUNE RESPONSE – IMMUNOGENECITY
SPECIFIC REACTION WITH ANTIBODIES - IMMUNOLOGICAL REACTIVITY
An antigen introduced in the body specifically reacts with those particular
immunocytes (B or T Lymphocytes) which carry unique markers which produce
specific antibodies or complementary cells.
Antibody such produced will react with only that particular Antigen.
9. BASED ON IMMUNE RESPONSE
Antigens can be classified as:
IMMUNOGEN OR COMPLETE ANTIGEN
These may be proteins or polysaccharides and can generate an immune response
on their own.
Ability to produce observable and specific activity with the antibody
HAPTEN
These are non-protein, foreign substances that require a carrier molecule to
induce an immune response.
10. Immunogenicity = ability to induce humoral and/or cell- mediated immune response
Antigenicity = ability to combine specifically with the final products of the above
responses (i.e., antibodies and/or cell-surface receptors).
Haptens, small molecules, are antigenic but incapable of inducing specific immune
response
Immunogenicity and Antigenicity
11. ANTIGENS VS IMMUNOGENS
An immunogen refers to a molecule that is capable of producing an immune
response by the immune system.
An antigen refers to a molecule that is capable of binding to the product of
that immune response.
So, an immunogen is necessarily an antigen, but an antigen may not
necessarily be an immunogen.
Vaccines are examples of antigens in an immunogenic form, which are
intentionally administered to a recipient to induce the memory function
towards antigens of the pathogen invading that recipient
12. STRUCTURE OF ANTIGENS
The epitopes or antigenic determinants are the components of antigen.
Every antigen has several epitopes.
An antibody has at least two binding sites that can bind to specific epitopes on antigens.
The antigens combine with the antibody according to the lock and key mechanism.
The ability of the body to act against the disease-causing agents and antigens by the
immune system is termed as the immunity. This immunity may be either inborn or
acquired from vaccinations.
13. EPITOPE
SMALLEST AREA ON THE ANTIGEN
MOSTLY CONSIST OF 4 OR 5 AMINOACIDS OR A MONOSACCHARIDE
POSSESS A SPECIFIC CHEMICAL STRUCTURE
ELECTIRCAL CHARGE
SPATIAL CONFIGURATION
CAPABLE OF SENSITISING AN IMMUNOCYTE AND REACT WITH THE
COMPLIMENTARY SITE ON THE ANTIBODY OR T CELL RECEPTOR
IT MAY BE LINEAR SEQUENTIAL SEGMENT OR
BRINGING TOGETHER RESIDUES FROM DIFFERENT SITES OF THE PEPTIDE MAKING
A CONFORMATIONAL EPITOPE.
14. IMMUNE CELLS DO NOT INTERACT WITH, OR RECOGNIZE, ENTIRE IMMUNOGEN MOLECULE
LYMPHOCYTES RECOGNIZE DISCRETE SITES ON IMMUNOGEN MOLECULE CALLED EPITOPES, OR
ANTIGENIC DETERMINANTS.
EPITOPES ARE THE IMMUNOLOGICALLY ACTIVE REGIONS OF AN IMMUNOGEN THAT BIND TO
ANTIGEN-SPECIFIC MEMBRANE RECEPTORS ON LYMPHOCYTES OR TO SECRETED ANTIBODIES
STUDIES WITH SMALL ANTIGENS REVEAL THAT B AND T CELLS RECOGNIZE DIFFERENT EPITOPES
ON SAME ANTIGENIC MOLECULE
EPITOPE
15. RECOGNITION OF EPITOPES
T CELL RECOGNISES SEQUENTIAL EPITOPE
B CELL RECOGNISES TERTIARY STRUCTURE OF THE CONFORMATIONAL EPITOPE
THE COMBINING AREA ON THE ANTIBODY CORRESPONDING TO THE EPITOPE IS CALLED THE
PARATOPE
EPITOPE AND THE PARATOPE DETERMINE THE SPECIFICITY OF THE IMMUNOLOGICAL REACTIONS
ANTIGENS ON THE BACTERIA AND VIRUSES CARRY DIFFERENT TYPES OF EPITOPES PRESENTING
AN ANTIGENIS MOSAIC.
PRESENCE OF THE SAME OR DIFFERENT EPITOPES ON DIFFERENT ANTIGENS ACCOUNTS OF
ANTIGENIC CROSS REACTIONS.
19. BASIC PROPERTIES ARE KNOWN TO BE ESSENTIAL TO
MAKE A ANTIGENS
Foreign Nature
Molecular Size
Antigenic Determinants and Cross-Reactivity
Molecular Rigidity and Complexity
Genetic Factors in the Individual.
20. FOREIGN NATURE
The important requirement for immunogenicity is that the substance should be foreign to the body of
recipient.
With result the immune system must be able to distinguish between normal body components and foreign
substances.
Normally the body has no tendency to recognize its own components as antigens, therefore does not
initiate an immune response against these.
For example, if serum albumin from a mouse is injected back into the same mouse or into another
mouse, no antibody production will occur. On the other hand, if the albumin is infected into an animal of
another species, antibody may be produced.
21. MOLECULAR STRUCTURES
The substance or molecule must have certain physio-chemical properties, where molecular
size is an important factor.
It is established that a molecule must have a minimum size (generally > 5000 Da) before it
can be considered as antigen.
Hence small molecules like amino acids or monosaccharides are usually not antigenic.
However, low molecular substance can demonstrate immunogenicity, if coupled to a suitable
carrier molecule like protein.
These low molecular substances are called haptens which are considered as ‘partial
antigens’ that contain at least one of the determinant groups of an antigen. Hapten can thus
reacts with specific antibody but is not immunogenic in absence of a carrier molecule.
Example of Haptens: Drugs, peptide hormones, and steroid hormones
23. ANTIGENIC DETERMINANTS
Only limited parts of the large antigen molecule are involved in the binding to
antibodies.
These parts are called antigenic determinants. It is established that a molecule must
have at least two antigenic determinants in order to stimulate antibody production.
For this reason a small molecule does not function as antigen. Because it is not
possible for a small molecule to have more than one antigenic determinant.
The number of antigenic determinants on a small molecule varies with molecular
size. Say for example, human serum albumin (Mol. wt.70 KDa) has at least six
different antigenic determinants, that means at least six antibodies of different
specificities can be produced after immunization.
It is established that antibodies recognize the three dimensional structure of the
antigen rather than their primary amino acid sequence.
24. CROSS-REACTIVITY
In some cases antibodies can bind to an antigen other than one which initiated antibody
production. This is known as cross-reactivity.
For example, the homologous ‘antigen a’ has induced
production of the antibody specific for antigen a and
cross-reacts with non-identical ‘antigen b’ (Fig.10.2).
Through cross-reactivity an allergic reaction can be
initiated by a substance with which the individual has
never been in contact before.
25. RIGIDITY AND COMPLEXITY
The firm and stiff nature and complexity of the molecule are the important factors for
immunogenicity.
A rigid molecule is a good antigen, probably because it is easier to raise antibodies to
certain structures than to others.
The immunogenicity is very much dependent on the complexity of the antigens.
For example, a molecule containing a repeating unit of only one amino acid is generally
poor immunogen, even if the molecule is large; while a molecule with two or three
repeating amino acids can, however, function well as an immunogen.
26. GENETIC FACTORS IN THE INDIVIDUAL
Genetic factors are of prime importance for the immunogenicity.
It was Wyman (1872) who for the first time reported that allergy runs in
families and some families suffer more than others.
All individuals within a species need not show the same allergic response
against a particular antigen.
Anyone can develop an allergy but the probability is increased if one or both
the parents suffer from some kind of allergic condition.
The highest frequency of hypersensitivity among children is observed where
both parents are atopic and with same manifestation.
So the frequency of allergy among children is progressively increased
according to the nature and intensity of allergy in parents.
It is evident that about 10-20% of the population suffer from aeroallergens
such as pollen grains and spores.